	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 13257

FusionGeneSummary for FCHSD2_CHRM1

Fusion gene summary

Fusion gene information	Fusion gene name: FCHSD2_CHRM1
	Fusion gene ID: 13257
		Hgene	Tgene
	Gene symbol	FCHSD2	CHRM1
	Gene ID	9873	1128
	Gene name	FCH and double SH3 domains 2	cholinergic receptor muscarinic 1
	Synonyms	NWK\|SH3MD3	HM1\|M1\|M1R
	Cytomap	11q13.4	11q12.3
	Type of gene	protein-coding	protein-coding
	Description	F-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homolog	muscarinic acetylcholine receptor M1acetylcholine receptor, muscarinic 1
	Modification date	20180523	20180523
	UniProtAcc	O94868	P11229
	Ensembl transtripts involved in fusion gene	ENST00000311172, ENST00000409314, ENST00000409418, ENST00000458644, ENST00000409853, ENST00000409263,	ENST00000306960,
Fusion gene scores	* DoF score	29 X 12 X 13=4524	3 X 1 X 3=9
	# samples	33	3
	** MAII score	log2(33/4524*10)=-3.777060999744 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FCHSD2 [Title/Abstract] AND CHRM1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	OV	TCGA-13-1405-01A	FCHSD2	chr11	72851076	-	CHRM1	chr11	62678650	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-5UTR	ENST00000311172	ENST00000306960	FCHSD2	chr11	72851076	-	CHRM1	chr11	62678650	-
5CDS-5UTR	ENST00000409314	ENST00000306960	FCHSD2	chr11	72851076	-	CHRM1	chr11	62678650	-
5CDS-5UTR	ENST00000409418	ENST00000306960	FCHSD2	chr11	72851076	-	CHRM1	chr11	62678650	-
5UTR-5UTR	ENST00000458644	ENST00000306960	FCHSD2	chr11	72851076	-	CHRM1	chr11	62678650	-
5UTR-5UTR	ENST00000409853	ENST00000306960	FCHSD2	chr11	72851076	-	CHRM1	chr11	62678650	-
intron-5UTR	ENST00000409263	ENST00000306960	FCHSD2	chr11	72851076	-	CHRM1	chr11	62678650	-

Top

FusionProtFeatures for FCHSD2_CHRM1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FCHSD2 O94868	CHRM1 P11229
	The muscarinic acetylcholine receptor mediates variouscellular responses, including inhibition of adenylate cyclase,breakdown of phosphoinositides and modulation of potassiumchannels through the action of G proteins. Primary transducingeffect is Pi turnover.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for FCHSD2_CHRM1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FCHSD2_CHRM1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
FCHSD2	CCDC158, CCDC85B, MAGI1, CASK, VCP, VCPIP1, HSPA5, SRP72, CFAP36, C2orf73, MSL1, CCT2, SH3BGR, CHKA, C9orf78, HSP90AB1, ITSN1, ITSN2, ELAVL1, DAPP1, WAS, WASL, KIFC3, PDE4DIP, MTUS2, ABCF3, FAM9B, FCHSD2, GOPC	CHRM1	GPRASP1, GPRASP2, CDC14A

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for FCHSD2_CHRM1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	CHRM1	P11229	DB00185	Cevimeline	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00202	Succinylcholine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00209	Trospium	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00215	Citalopram	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00219	Oxyphenonium	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00245	Benzatropine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00246	Ziprasidone	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00280	Disopyramide	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00321	Amitriptyline	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00332	Ipratropium bromide	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00340	Metixene	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00354	Buclizine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00363	Clozapine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00376	Trihexyphenidyl	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00383	Oxyphencyclimine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00387	Procyclidine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00392	Ethopropazine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00408	Loxapine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00411	Carbachol	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00424	Hyoscyamine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00434	Cyproheptadine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00454	Pethidine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00458	Imipramine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00540	Nortriptyline	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00543	Amoxapine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00543	Amoxapine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00670	Pirenzepine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00725	Homatropine Methylbromide	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00726	Trimipramine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00771	Clidinium	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00777	Propiomazine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00782	Propantheline	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00804	Dicyclomine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00805	Minaprine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00835	Brompheniramine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00979	Cyclopentolate	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB01019	Bethanechol	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB01148	Flavoxate	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB01224	Quetiapine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB01409	Tiotropium	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB01591	Solifenacin	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB01618	Molindone	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB03128	Acetylcholine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB04843	Mepenzolate	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB06702	Fesoterodine	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB06787	Hexocyclium	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB08897	Aclidinium	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB09076	Umeclidinium	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB09167	Dosulepin	Muscarinic acetylcholine receptor M1	small molecule	approved
Tgene	CHRM1	P11229	DB00907	Cocaine	Muscarinic acetylcholine receptor M1	small molecule	approved\|illicit
Tgene	CHRM1	P11229	DB00334	Olanzapine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00496	Darifenacin	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00555	Lamotrigine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00568	Cinnarizine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00622	Nicardipine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00715	Paroxetine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00747	Scopolamine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00809	Tropicamide	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00810	Biperiden	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00934	Maprotiline	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00940	Methantheline	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01036	Tolterodine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01062	Oxybutynin	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01069	Promethazine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01085	Pilocarpine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01142	Doxepin	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01151	Desipramine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01175	Escitalopram	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01233	Metoclopramide	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01238	Aripiprazole	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB01403	Methotrimeprazine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational
Tgene	CHRM1	P11229	DB00477	Chlorpromazine	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational\|vet_approved
Tgene	CHRM1	P11229	DB00986	Glycopyrronium	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational\|vet_approved
Tgene	CHRM1	P11229	DB00875	Flupentixol	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational\|withdrawn
Tgene	CHRM1	P11229	DB01239	Chlorprothixene	Muscarinic acetylcholine receptor M1	small molecule	approved\|investigational\|withdrawn
Tgene	CHRM1	P11229	DB00366	Doxylamine	Muscarinic acetylcholine receptor M1	small molecule	approved\|vet_approved
Tgene	CHRM1	P11229	DB00420	Promazine	Muscarinic acetylcholine receptor M1	small molecule	approved\|vet_approved
Tgene	CHRM1	P11229	DB00508	Triflupromazine	Muscarinic acetylcholine receptor M1	small molecule	approved\|vet_approved
Tgene	CHRM1	P11229	DB00572	Atropine	Muscarinic acetylcholine receptor M1	small molecule	approved\|vet_approved
Tgene	CHRM1	P11229	DB01221	Ketamine	Muscarinic acetylcholine receptor M1	small molecule	approved\|vet_approved
Tgene	CHRM1	P11229	DB11156	Pyrantel	Muscarinic acetylcholine receptor M1	small molecule	approved\|vet_approved
Tgene	CHRM1	P11229	DB00342	Terfenadine	Muscarinic acetylcholine receptor M1	small molecule	approved\|withdrawn

Top

RelatedDiseases for FCHSD2_CHRM1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FCHSD2	C3495559	Juvenile arthritis	1	CTD_human
Tgene	CHRM1	C0036572	Seizures	5	CTD_human
Tgene	CHRM1	C0036341	Schizophrenia	4	PSYGENET
Tgene	CHRM1	C0007786	Brain Ischemia	1	CTD_human
Tgene	CHRM1	C0014544	Epilepsy	1	CTD_human
Tgene	CHRM1	C0025261	Memory Disorders	1	CTD_human
Tgene	CHRM1	C0221765	Chronic schizophrenia	1	PSYGENET

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 13257

FusionGeneSummary for FCHSD2_CHRM1

FusionProtFeatures for FCHSD2_CHRM1

FusionGeneSequence for FCHSD2_CHRM1

FusionGenePPI for FCHSD2_CHRM1

RelatedDrugs for FCHSD2_CHRM1

RelatedDiseases for FCHSD2_CHRM1