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Fusion gene ID: 13224 |
FusionGeneSummary for FBXW7_PRR4 |
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Fusion gene information | Fusion gene name: FBXW7_PRR4 | Fusion gene ID: 13224 | Hgene | Tgene | Gene symbol | FBXW7 | PRR4 | Gene ID | 55294 | 81607 |
Gene name | F-box and WD repeat domain containing 7 | nectin cell adhesion molecule 4 | |
Synonyms | AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4 | EDSS1|LNIR|PRR4|PVRL4|nectin-4 | |
Cytomap | 4q31.3 | 1q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | F-box/WD repeat-containing protein 7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)F-box protein FBW7F-box protein FBX30F-box protein SEL-10archipelagohomolog of | nectin-4Ig superfamily receptor LNIRnectin 4poliovirus receptor-related 4poliovirus receptor-related protein 4 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q969H0 | Q16378 | |
Ensembl transtripts involved in fusion gene | ENST00000281708, ENST00000603548, ENST00000604872, ENST00000296555, ENST00000263981, ENST00000393956, ENST00000603841, ENST00000604095, | ENST00000536668, ENST00000544994, ENST00000228811, ENST00000540107, | |
Fusion gene scores | * DoF score | 9 X 5 X 7=315 | 7 X 5 X 3=105 |
# samples | 10 | 7 | |
** MAII score | log2(10/315*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FBXW7 [Title/Abstract] AND PRR4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FBXW7 | GO:0016567 | protein ubiquitination | 12354302|15103331 |
Hgene | FBXW7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15103331|17434132 |
Hgene | FBXW7 | GO:0031398 | positive regulation of protein ubiquitination | 12628165 |
Hgene | FBXW7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 20208556 |
Hgene | FBXW7 | GO:0050821 | protein stabilization | 20208556 |
Hgene | FBXW7 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity | 12628165 |
Hgene | FBXW7 | GO:1901800 | positive regulation of proteasomal protein catabolic process | 23858059 |
Hgene | FBXW7 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | 23858059 |
Hgene | FBXW7 | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 20208556 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF089643 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000281708 | ENST00000536668 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000281708 | ENST00000544994 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000281708 | ENST00000228811 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000281708 | ENST00000540107 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-5UTR | ENST00000603548 | ENST00000536668 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000603548 | ENST00000544994 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000603548 | ENST00000228811 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000603548 | ENST00000540107 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-5UTR | ENST00000604872 | ENST00000536668 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000604872 | ENST00000544994 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000604872 | ENST00000228811 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000604872 | ENST00000540107 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-5UTR | ENST00000296555 | ENST00000536668 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000296555 | ENST00000544994 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000296555 | ENST00000228811 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000296555 | ENST00000540107 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-5UTR | ENST00000263981 | ENST00000536668 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000263981 | ENST00000544994 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000263981 | ENST00000228811 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000263981 | ENST00000540107 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-5UTR | ENST00000393956 | ENST00000536668 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000393956 | ENST00000544994 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000393956 | ENST00000228811 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000393956 | ENST00000540107 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-5UTR | ENST00000603841 | ENST00000536668 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000603841 | ENST00000544994 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000603841 | ENST00000228811 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000603841 | ENST00000540107 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-5UTR | ENST00000604095 | ENST00000536668 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000604095 | ENST00000544994 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000604095 | ENST00000228811 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
intron-3UTR | ENST00000604095 | ENST00000540107 | FBXW7 | chr4 | 153244074 | - | PRR4 | chr12 | 10998476 | + |
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FusionProtFeatures for FBXW7_PRR4 |
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Hgene | Tgene |
FBXW7 | PRR4 |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation oftarget proteins. Recognizes and binds phosphorylatedsites/phosphodegrons within target proteins and thereafter bringthem to the SCF complex for ubiquitination (PubMed:17434132).Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC,NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1,and probably PSEN1 (PubMed:11565034, PubMed:12354302,PubMed:11585921, PubMed:15103331, PubMed:14739463,PubMed:17558397, PubMed:17873522, PubMed:22608923,PubMed:29149593, PubMed:25775507, PubMed:28007894). Acts as anegative regulator of JNK signaling by binding to phosphorylatedJUN and promoting its ubiquitination and subsequent degradation(PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitinationand subsequent degradation of NFE2L1 (By similarity). Involved inbone homeostasis and negative regulation of osteoclastdifferentiation (PubMed:29149593). {ECO:0000250|UniProtKB:Q8VBV4,ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921,ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331,ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397,ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923,ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:28007894,ECO:0000269|PubMed:29149593, ECO:0000305|PubMed:12354302}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBXW7_PRR4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBXW7_PRR4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBXW7_PRR4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXW7_PRR4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FBXW7 | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 2 | CTD_human |
Hgene | FBXW7 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
Hgene | FBXW7 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | FBXW7 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | FBXW7 | C0017638 | Glioma | 1 | CTD_human |
Hgene | FBXW7 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | FBXW7 | C0919532 | Genomic Instability | 1 | CTD_human |
Hgene | FBXW7 | C1458155 | Mammary Neoplasms | 1 | CTD_human |