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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13206

FusionGeneSummary for FBXW11_RBM11

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXW11_RBM11
Fusion gene ID: 13206
HgeneTgene
Gene symbol

FBXW11

RBM11

Gene ID

23291

54033

Gene nameF-box and WD repeat domain containing 11RNA binding motif protein 11
SynonymsBTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|Hos-
Cytomap

5q35.1

21q11.2

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homologsplicing regulator RBM11putative RNA-binding protein 11
Modification date2018052320180523
UniProtAcc

Q9UKB1

P57052

Ensembl transtripts involved in fusion geneENST00000296933, ENST00000265094, 
ENST00000393802, ENST00000425623, 
ENST00000522891, 
ENST00000468643, 
ENST00000400577, 
Fusion gene scores* DoF score5 X 2 X 4=403 X 2 X 3=18
# samples 55
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FBXW11 [Title/Abstract] AND RBM11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXW11

GO:0000209

protein polyubiquitination

20347421

HgeneFBXW11

GO:0016567

protein ubiquitination

16885022

HgeneFBXW11

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

20347421

HgeneFBXW11

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

TgeneRBM11

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

21984414

TgeneRBM11

GO:0034599

cellular response to oxidative stress

21984414


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A8GN-06AFBXW11chr5

171433462

-RBM11chr21

15593418

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000296933ENST00000468643FBXW11chr5

171433462

-RBM11chr21

15593418

+
5CDS-3UTRENST00000296933ENST00000400577FBXW11chr5

171433462

-RBM11chr21

15593418

+
5CDS-3UTRENST00000265094ENST00000468643FBXW11chr5

171433462

-RBM11chr21

15593418

+
5CDS-3UTRENST00000265094ENST00000400577FBXW11chr5

171433462

-RBM11chr21

15593418

+
5CDS-3UTRENST00000393802ENST00000468643FBXW11chr5

171433462

-RBM11chr21

15593418

+
5CDS-3UTRENST00000393802ENST00000400577FBXW11chr5

171433462

-RBM11chr21

15593418

+
intron-3UTRENST00000425623ENST00000468643FBXW11chr5

171433462

-RBM11chr21

15593418

+
intron-3UTRENST00000425623ENST00000400577FBXW11chr5

171433462

-RBM11chr21

15593418

+
intron-3UTRENST00000522891ENST00000468643FBXW11chr5

171433462

-RBM11chr21

15593418

+
intron-3UTRENST00000522891ENST00000400577FBXW11chr5

171433462

-RBM11chr21

15593418

+

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FusionProtFeatures for FBXW11_RBM11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXW11

Q9UKB1

RBM11

P57052

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation oftarget proteins. Probably recognizes and binds to phosphorylatedtarget proteins. SCF(FBXW11) mediates the ubiquitination ofphosphorylated CTNNB1 and participates in Wnt signaling.SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA,which degradation frees the associated NFKB1 to translocate intothe nucleus and to activate transcription. SCF(FBXW11) mediatesthe ubiquitination of IFNAR1. SCF(FBXW11) mediates theubiquitination of CEP68; this is required for centriole separationduring mitosis (PubMed:25503564). Involved in the oxidativestress-induced a ubiquitin-mediated decrease in RCAN1. Mediatesthe degradation of CDC25A induced by ionizing radiation in cellsprogressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of theclock-dependent transcription via degradation of phosphorylatedPER1 and phosphorylated PER2. SCF(FBXW11) mediates theubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262).{ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795,ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623,ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323,ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781,ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421,ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:29420262}. (Microbial infection) Target of human immunodeficiencyvirus type 1 (HIV-1) protein VPU to polyubiquitinate and depleteBST2 from cells and antagonize its antiviral action.{ECO:0000269|PubMed:19730691}. Tissue-specific splicing factor with potentialimplication in the regulation of alternative splicing duringneuron and germ cell differentiation. Antagonizes SRSF1-mediatedBCL-X splicing. May affect the choice of alternative 5' splicesites by binding to specific sequences in exons and antagonizingthe SR protein SRSF1. {ECO:0000269|PubMed:21984414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXW11_RBM11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXW11_RBM11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBXW11RPRM, FBXW11, SKP1, CUL1, BTRC, NFKBIA, AMER1, CDC25B, HIVEP1, HIVEP2, MYO10, NRD1, TFAP4, OGT, TUBGCP3, NUDC, CLPX, ATG4B, USP37, SUN2, ARIH1, PDCD4, ZRANB1, USP47, KHDRBS2, CLSPN, TRIM21, WEE1, CTNNB1, PER1, CDC25A, IFNAR1, PRLR, TNF, RBX1, CASP3, ATF4, DEPTOR, FAF1, MDM2, YAP1, KDR, EEF2K, CALML5, REST, COPS5, NEDD8, RCAN1, IRAK1, BCL2L11, BTG1, BTG2, SIPA1L1, FBXO5, FANCM, NFKB1, NFKB2, HSP90AA1, VCP, GHR, NUAK1, NUAK2, CDC34, UBE2D3, TRIM9, BHLHE40, RAP1GAP, DOCK1, DAP3, STK3, STK4, TBC1D4, RAPGEF2, GBF1, YWHAE, COPS7A, RELA, MAP1S, FLCN, PPP1R15B, ZNF704, TACC1, EZH2, LPIN2, SUZ12, NCKAP5L, PFDN4, CNOT7, VAPA, CHD1, LRCH4, TUBGCP6, DENND4C, HBP1, MAST2, ACBD5, FNIP1, HCFC1, MAST3, RASSF3, AXIN1, CTNNA1, KDM5B, MAX, TANC1, ZNF395, KEAP1, EML5, CNOT1, TIAM1, MTSS1, MTSS1L, FOXN2, AXIN2, VANGL1, AEBP2, ELMO2, USP54, C19orf26, TUBGCP4, CACHD1, PFDN5, UBE4B, NFE2L2, BOP1, LPIN1, GADD45GIP1, TFAM, ILF3, PTCD3, CLTC, DHX9, PABPC4, ZNF326, BORA, HNRNPU, SKP1P2, RASSF1, AATF, APC, C11orf84, CLPP, EIF4B, FAM120A, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPD, HNRNPH1, HNRNPH2, HNRNPH3, HNRNPR, HNRNPUL2, HNRNPDL, KPNA2, MRPL13, MRPL19, MRPL23, MRPL4, MRPL49, MRPS18A, MRPS22, MRPS23, MRPS27, MRPS28, MRPS34, MRPS9, MYCBP, NAT10, PLEKHH2, PPM1A, RBM19, RPL5, RPS10, RPS28, RPSA, SYNCRIP, UBE2R2, YWHAB, YWHAZ, ZFR, CSTF2T, CTNNA2, FLNA, FLNC, GGNBP2, IRS2, MAP1B, PUS1, UBAP2L, YWHAG, BHLHE41, PPP1CC, PPP2R5E, CSNK1E, PPP2R1B, PRKACA, GSK3B, PRMT8, DLD, TSC22D4, WWTR1, WBP1, SPANXN3, FAM219A, ZBTB46, WWC1, GTF2IRD1, CASC5, GLI3, PER2, AKAP13, GTF2I, LRCH2, SUPT16H, PRRC2A, HUWE1, CHAF1B, SBF1, DOCK7, AMBRA1, DNAJC7, CDK5, RBM5, GEMIN5, ZIC2, HLTF, PRPSAP1, MXI1, PTPN13, MAPK8IP2, NFE2L1, SIK2, NUP50, NAMPT, FAM193B, CHD8, EML4, UBL7, DYNC1H1, NAV1, HECTD1, FOXG1, PABPC1, FUS, FOXC1, THRAP3, PTCD1, DNAJB14, RANBP2, NOL11, NUP153, RPAP3, BAG3, TSEN34, BCOR, MOV10, FKBP4, PUM1, HNRNPUL1, AKAP8L, SSH1, GDAP2, KIF20A, SIPA1L2, TP53, TATDN2, YTHDC2, RBMX, PFAS, ADAR, AKAP8, DCAF8, WARS, SMG7, KIAA0355, PEX1, PLCH1, EIF4E2, HELZ, FLII, MTMR1, ZNF281, LARS2, BAG4, DDX3X, CCT8, BAG5, MATR3, POLR1A, HERC3, MTERF3, UBA1, UBE2G2, EIF4ENIF1, GALK1, RAE1, POLE, MRE11A, CRY2, EIF3D, WDR60, WDTC1, AARS2, RPUSD3, CASP7, FAM83H, SPATA5, EPRS, RBM10, ZKSCAN1, SF3B2, SPIRE1, SYBU, MCM4, WDR36, HJURP, PIK3C2A, PIGX, SBF2, UTP14A, DNAJB4, LLGL1, STK11IP, WIZ, ATP5B, DUSP11, MLF2, TRIM32, KHDRBS3, SON, SF3B1, PPAT, KHDRBS1, VPS33A, ZNF644, RTCB, LRPPRC, IFT140, ISYNA1, RNF115, PSMC4, ARMC6, WDR62, DCAF7, LONP2, WDR11, CCT6A, ELAVL1, APP, ERCC6L, NACA, HNRNPF, YBX1, DKC1, SHMT2, AUP1, PDCL3, RNASEH2A, SPATA5L1, PRPF39, MARCKS, UBR5, IFI16, UPF1, WDR12, TRAF7, TWISTNB, TRIOBP, ZC3H18, PLK4, STIL, NFKBIB, UHRF1, RBMXL1, PLEKHG5, LSP1, SH3BP5L, AHCYL2, GPR161, IL17RD, YTHDC1, FOXN3, DNAJB5, SPATA20, PRICKLE3, ISY1, CNOT11, TRUB2, MRPL57, APBA2, EED, QKI, COBL, RALY, MZT2B, ELAVL4, HNRNPC, NOP9, NGRN, MCPH1RBM11RHOXF2, PCBP1, LYN, GABPB1, SNRPC, QKI, ZNF774, SF3B2, SKIV2L2, USP7, SLC4A1AP, ZCCHC8, TTC33, APP, MED4, DAZAP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXW11_RBM11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXW11_RBM11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource