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Fusion gene ID: 13206 |
FusionGeneSummary for FBXW11_RBM11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXW11_RBM11 | Fusion gene ID: 13206 | Hgene | Tgene | Gene symbol | FBXW11 | RBM11 | Gene ID | 23291 | 54033 |
| Gene name | F-box and WD repeat domain containing 11 | RNA binding motif protein 11 | |
| Synonyms | BTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|Hos | - | |
| Cytomap | 5q35.1 | 21q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homolog | splicing regulator RBM11putative RNA-binding protein 11 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UKB1 | P57052 | |
| Ensembl transtripts involved in fusion gene | ENST00000296933, ENST00000265094, ENST00000393802, ENST00000425623, ENST00000522891, | ENST00000468643, ENST00000400577, | |
| Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 3 X 2 X 3=18 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FBXW11 [Title/Abstract] AND RBM11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FBXW11 | GO:0000209 | protein polyubiquitination | 20347421 |
| Hgene | FBXW11 | GO:0016567 | protein ubiquitination | 16885022 |
| Hgene | FBXW11 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 20347421 |
| Hgene | FBXW11 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 20347421 |
| Tgene | RBM11 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21984414 |
| Tgene | RBM11 | GO:0034599 | cellular response to oxidative stress | 21984414 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D3-A8GN-06A | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000296933 | ENST00000468643 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| 5CDS-3UTR | ENST00000296933 | ENST00000400577 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| 5CDS-3UTR | ENST00000265094 | ENST00000468643 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| 5CDS-3UTR | ENST00000265094 | ENST00000400577 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| 5CDS-3UTR | ENST00000393802 | ENST00000468643 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| 5CDS-3UTR | ENST00000393802 | ENST00000400577 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| intron-3UTR | ENST00000425623 | ENST00000468643 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| intron-3UTR | ENST00000425623 | ENST00000400577 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| intron-3UTR | ENST00000522891 | ENST00000468643 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
| intron-3UTR | ENST00000522891 | ENST00000400577 | FBXW11 | chr5 | 171433462 | - | RBM11 | chr21 | 15593418 | + |
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FusionProtFeatures for FBXW11_RBM11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXW11 | RBM11 |
| Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation oftarget proteins. Probably recognizes and binds to phosphorylatedtarget proteins. SCF(FBXW11) mediates the ubiquitination ofphosphorylated CTNNB1 and participates in Wnt signaling.SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA,which degradation frees the associated NFKB1 to translocate intothe nucleus and to activate transcription. SCF(FBXW11) mediatesthe ubiquitination of IFNAR1. SCF(FBXW11) mediates theubiquitination of CEP68; this is required for centriole separationduring mitosis (PubMed:25503564). Involved in the oxidativestress-induced a ubiquitin-mediated decrease in RCAN1. Mediatesthe degradation of CDC25A induced by ionizing radiation in cellsprogressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of theclock-dependent transcription via degradation of phosphorylatedPER1 and phosphorylated PER2. SCF(FBXW11) mediates theubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262).{ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795,ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623,ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323,ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781,ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421,ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:29420262}. (Microbial infection) Target of human immunodeficiencyvirus type 1 (HIV-1) protein VPU to polyubiquitinate and depleteBST2 from cells and antagonize its antiviral action.{ECO:0000269|PubMed:19730691}. | Tissue-specific splicing factor with potentialimplication in the regulation of alternative splicing duringneuron and germ cell differentiation. Antagonizes SRSF1-mediatedBCL-X splicing. May affect the choice of alternative 5' splicesites by binding to specific sequences in exons and antagonizingthe SR protein SRSF1. {ECO:0000269|PubMed:21984414}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBXW11_RBM11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBXW11_RBM11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FBXW11 | RPRM, FBXW11, SKP1, CUL1, BTRC, NFKBIA, AMER1, CDC25B, HIVEP1, HIVEP2, MYO10, NRD1, TFAP4, OGT, TUBGCP3, NUDC, CLPX, ATG4B, USP37, SUN2, ARIH1, PDCD4, ZRANB1, USP47, KHDRBS2, CLSPN, TRIM21, WEE1, CTNNB1, PER1, CDC25A, IFNAR1, PRLR, TNF, RBX1, CASP3, ATF4, DEPTOR, FAF1, MDM2, YAP1, KDR, EEF2K, CALML5, REST, COPS5, NEDD8, RCAN1, IRAK1, BCL2L11, BTG1, BTG2, SIPA1L1, FBXO5, FANCM, NFKB1, NFKB2, HSP90AA1, VCP, GHR, NUAK1, NUAK2, CDC34, UBE2D3, TRIM9, BHLHE40, RAP1GAP, DOCK1, DAP3, STK3, STK4, TBC1D4, RAPGEF2, GBF1, YWHAE, COPS7A, RELA, MAP1S, FLCN, PPP1R15B, ZNF704, TACC1, EZH2, LPIN2, SUZ12, NCKAP5L, PFDN4, CNOT7, VAPA, CHD1, LRCH4, TUBGCP6, DENND4C, HBP1, MAST2, ACBD5, FNIP1, HCFC1, MAST3, RASSF3, AXIN1, CTNNA1, KDM5B, MAX, TANC1, ZNF395, KEAP1, EML5, CNOT1, TIAM1, MTSS1, MTSS1L, FOXN2, AXIN2, VANGL1, AEBP2, ELMO2, USP54, C19orf26, TUBGCP4, CACHD1, PFDN5, UBE4B, NFE2L2, BOP1, LPIN1, GADD45GIP1, TFAM, ILF3, PTCD3, CLTC, DHX9, PABPC4, ZNF326, BORA, HNRNPU, SKP1P2, RASSF1, AATF, APC, C11orf84, CLPP, EIF4B, FAM120A, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPD, HNRNPH1, HNRNPH2, HNRNPH3, HNRNPR, HNRNPUL2, HNRNPDL, KPNA2, MRPL13, MRPL19, MRPL23, MRPL4, MRPL49, MRPS18A, MRPS22, MRPS23, MRPS27, MRPS28, MRPS34, MRPS9, MYCBP, NAT10, PLEKHH2, PPM1A, RBM19, RPL5, RPS10, RPS28, RPSA, SYNCRIP, UBE2R2, YWHAB, YWHAZ, ZFR, CSTF2T, CTNNA2, FLNA, FLNC, GGNBP2, IRS2, MAP1B, PUS1, UBAP2L, YWHAG, BHLHE41, PPP1CC, PPP2R5E, CSNK1E, PPP2R1B, PRKACA, GSK3B, PRMT8, DLD, TSC22D4, WWTR1, WBP1, SPANXN3, FAM219A, ZBTB46, WWC1, GTF2IRD1, CASC5, GLI3, PER2, AKAP13, GTF2I, LRCH2, SUPT16H, PRRC2A, HUWE1, CHAF1B, SBF1, DOCK7, AMBRA1, DNAJC7, CDK5, RBM5, GEMIN5, ZIC2, HLTF, PRPSAP1, MXI1, PTPN13, MAPK8IP2, NFE2L1, SIK2, NUP50, NAMPT, FAM193B, CHD8, EML4, UBL7, DYNC1H1, NAV1, HECTD1, FOXG1, PABPC1, FUS, FOXC1, THRAP3, PTCD1, DNAJB14, RANBP2, NOL11, NUP153, RPAP3, BAG3, TSEN34, BCOR, MOV10, FKBP4, PUM1, HNRNPUL1, AKAP8L, SSH1, GDAP2, KIF20A, SIPA1L2, TP53, TATDN2, YTHDC2, RBMX, PFAS, ADAR, AKAP8, DCAF8, WARS, SMG7, KIAA0355, PEX1, PLCH1, EIF4E2, HELZ, FLII, MTMR1, ZNF281, LARS2, BAG4, DDX3X, CCT8, BAG5, MATR3, POLR1A, HERC3, MTERF3, UBA1, UBE2G2, EIF4ENIF1, GALK1, RAE1, POLE, MRE11A, CRY2, EIF3D, WDR60, WDTC1, AARS2, RPUSD3, CASP7, FAM83H, SPATA5, EPRS, RBM10, ZKSCAN1, SF3B2, SPIRE1, SYBU, MCM4, WDR36, HJURP, PIK3C2A, PIGX, SBF2, UTP14A, DNAJB4, LLGL1, STK11IP, WIZ, ATP5B, DUSP11, MLF2, TRIM32, KHDRBS3, SON, SF3B1, PPAT, KHDRBS1, VPS33A, ZNF644, RTCB, LRPPRC, IFT140, ISYNA1, RNF115, PSMC4, ARMC6, WDR62, DCAF7, LONP2, WDR11, CCT6A, ELAVL1, APP, ERCC6L, NACA, HNRNPF, YBX1, DKC1, SHMT2, AUP1, PDCL3, RNASEH2A, SPATA5L1, PRPF39, MARCKS, UBR5, IFI16, UPF1, WDR12, TRAF7, TWISTNB, TRIOBP, ZC3H18, PLK4, STIL, NFKBIB, UHRF1, RBMXL1, PLEKHG5, LSP1, SH3BP5L, AHCYL2, GPR161, IL17RD, YTHDC1, FOXN3, DNAJB5, SPATA20, PRICKLE3, ISY1, CNOT11, TRUB2, MRPL57, APBA2, EED, QKI, COBL, RALY, MZT2B, ELAVL4, HNRNPC, NOP9, NGRN, MCPH1 | RBM11 | RHOXF2, PCBP1, LYN, GABPB1, SNRPC, QKI, ZNF774, SF3B2, SKIV2L2, USP7, SLC4A1AP, ZCCHC8, TTC33, APP, MED4, DAZAP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBXW11_RBM11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXW11_RBM11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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