![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 13193 |
FusionGeneSummary for FBXO46_ZNF90 |
![]() |
Fusion gene information | Fusion gene name: FBXO46_ZNF90 | Fusion gene ID: 13193 | Hgene | Tgene | Gene symbol | FBXO46 | ZNF90 | Gene ID | 23403 | 7643 |
Gene name | F-box protein 46 | zinc finger protein 90 | |
Synonyms | 20D7-FC4|FBXO34L|Fbx46 | HTF9 | |
Cytomap | 19q13.32 | 19p12 | |
Type of gene | protein-coding | protein-coding | |
Description | F-box only protein 46 | zinc finger protein 90zinc finger protein HTF9 | |
Modification date | 20180519 | 20180403 | |
UniProtAcc | Q6PJ61 | Q03938 | |
Ensembl transtripts involved in fusion gene | ENST00000317683, | ENST00000474284, ENST00000418063, | |
Fusion gene scores | * DoF score | 4 X 1 X 4=16 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: FBXO46 [Title/Abstract] AND ZNF90 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-L5-A891-01A | FBXO46 | chr19 | 46234107 | - | ZNF90 | chr19 | 20216030 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3UTR | ENST00000317683 | ENST00000474284 | FBXO46 | chr19 | 46234107 | - | ZNF90 | chr19 | 20216030 | + |
5UTR-3UTR | ENST00000317683 | ENST00000418063 | FBXO46 | chr19 | 46234107 | - | ZNF90 | chr19 | 20216030 | + |
Top |
FusionProtFeatures for FBXO46_ZNF90 |
![]() |
Hgene | Tgene |
FBXO46 | ZNF90 |
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. | May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FBXO46_ZNF90 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for FBXO46_ZNF90 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FBXO46 | SKP1, COPS5, TCP1, SLC25A11, DHX9, RUVBL1, DDX5, HNRNPR, MCM4, CUL1, FSD1, LRFN4, CAPZA2, MYO1C, MYO19, MYO18A, EMILIN1, SDC1, SLC25A41, NEXN, TRIM25 | ZNF90 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FBXO46_ZNF90 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FBXO46_ZNF90 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |