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Fusion gene ID: 1318 |
FusionGeneSummary for AKAP13_MYL5 |
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Fusion gene information | Fusion gene name: AKAP13_MYL5 | Fusion gene ID: 1318 | Hgene | Tgene | Gene symbol | AKAP13 | MYL5 | Gene ID | 11214 | 4636 |
Gene name | A-kinase anchoring protein 13 | myosin light chain 5 | |
Synonyms | AKAP-13|AKAP-Lbc|ARHGEF13|BRX|HA-3|Ht31|LBC|PRKA13|PROTO-LB|PROTO-LBC|c-lbc|p47 | MYLC2 | |
Cytomap | 15q25.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | A-kinase anchor protein 13A kinase (PRKA) anchor protein 13LBC oncogenebreast cancer nuclear receptor-binding auxiliary proteinguanine nucleotide exchange factor Lbchuman thyroid-anchoring protein 31lymphoid blast crisis oncogenenon-oncogenic Rho G | myosin light chain 5myosin regulatory light chain 5myosin, light chain 5, regulatorymyosin, light polypeptide 5, regulatorysuperfast myosin regulatory light chain 2 | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | Q12802 | Q02045 | |
Ensembl transtripts involved in fusion gene | ENST00000560302, ENST00000394518, ENST00000361243, ENST00000560579, ENST00000394510, | ENST00000506838, ENST00000505477, ENST00000511290, ENST00000400159, | |
Fusion gene scores | * DoF score | 21 X 16 X 12=4032 | 2 X 2 X 2=8 |
# samples | 22 | 2 | |
** MAII score | log2(22/4032*10)=-4.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: AKAP13 [Title/Abstract] AND MYL5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AKAP13 | GO:0007186 | G-protein coupled receptor signaling pathway | 11546812 |
Hgene | AKAP13 | GO:0035025 | positive regulation of Rho protein signal transduction | 11546812 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-BC-A217-01A | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000560302 | ENST00000506838 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000560302 | ENST00000505477 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000560302 | ENST00000511290 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000560302 | ENST00000400159 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000394518 | ENST00000506838 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000394518 | ENST00000505477 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000394518 | ENST00000511290 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000394518 | ENST00000400159 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000361243 | ENST00000506838 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000361243 | ENST00000505477 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000361243 | ENST00000511290 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
5UTR-3CDS | ENST00000361243 | ENST00000400159 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
intron-3CDS | ENST00000560579 | ENST00000506838 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
intron-3CDS | ENST00000560579 | ENST00000505477 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
intron-3CDS | ENST00000560579 | ENST00000511290 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
intron-3CDS | ENST00000560579 | ENST00000400159 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
intron-3CDS | ENST00000394510 | ENST00000506838 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
intron-3CDS | ENST00000394510 | ENST00000505477 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
intron-3CDS | ENST00000394510 | ENST00000511290 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
intron-3CDS | ENST00000394510 | ENST00000400159 | AKAP13 | chr15 | 85924029 | + | MYL5 | chr4 | 675682 | + |
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FusionProtFeatures for AKAP13_MYL5 |
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Hgene | Tgene |
AKAP13 | MYL5 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AKAP13_MYL5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AKAP13_MYL5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AKAP13 | BAK1, YWHAB, GNA12, PRKAR2A, RHOA, GNAQ, CTNNAL1, RXRB, ESR1, PPARA, THRA, RANBP2, YWHAG, PRKD1, PRKACA, MAP1LC3A, RTKN, PRKAR2B, UBB, MTR, FBXW11, PRKCH, PRKCA, APP, SRPK2, APC, TRIM25 | MYL5 | IKBKG, APP, MYL2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AKAP13_MYL5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AKAP13_MYL5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AKAP13 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | AKAP13 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |