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Fusion gene ID: 13157 |
FusionGeneSummary for FBXO31_USP10 |
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Fusion gene information | Fusion gene name: FBXO31_USP10 | Fusion gene ID: 13157 | Hgene | Tgene | Gene symbol | FBXO31 | USP10 | Gene ID | 79791 | 84669 |
Gene name | F-box protein 31 | ubiquitin specific peptidase 32 | |
Synonyms | FBX14|FBXO14|Fbx31|MRT45|pp2386 | NY-REN-60|USP10 | |
Cytomap | 16q24.2 | 17q23.1-q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | F-box only protein 31SCF ubiquitin ligase specificity factorputative breast cancer tumor-suppressor | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q5XUX0 | Q14694 | |
Ensembl transtripts involved in fusion gene | ENST00000311635, ENST00000563956, | ENST00000219473, ENST00000570191, ENST00000562743, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 6 X 5 X 5=150 |
# samples | 3 | 6 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FBXO31 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FBXO31 | GO:0006974 | cellular response to DNA damage stimulus | 19412162 |
Hgene | FBXO31 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 19412162 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-EJ-7218-01B | FBXO31 | chr16 | 87417011 | - | USP10 | chr16 | 84797692 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000311635 | ENST00000219473 | FBXO31 | chr16 | 87417011 | - | USP10 | chr16 | 84797692 | + |
Frame-shift | ENST00000311635 | ENST00000570191 | FBXO31 | chr16 | 87417011 | - | USP10 | chr16 | 84797692 | + |
5CDS-intron | ENST00000311635 | ENST00000562743 | FBXO31 | chr16 | 87417011 | - | USP10 | chr16 | 84797692 | + |
5UTR-3CDS | ENST00000563956 | ENST00000219473 | FBXO31 | chr16 | 87417011 | - | USP10 | chr16 | 84797692 | + |
5UTR-3CDS | ENST00000563956 | ENST00000570191 | FBXO31 | chr16 | 87417011 | - | USP10 | chr16 | 84797692 | + |
5UTR-intron | ENST00000563956 | ENST00000562743 | FBXO31 | chr16 | 87417011 | - | USP10 | chr16 | 84797692 | + |
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FusionProtFeatures for FBXO31_USP10 |
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Hgene | Tgene |
FBXO31 | USP10 |
Component of some SCF (SKP1-cullin-F-box) protein ligasecomplex that plays a central role in G1 arrest following DNAdamage. Specifically recognizes phosphorylated cyclin-D1 (CCND1),promoting its ubiquitination and degradation by the proteasome,resulting in G1 arrest. May act as a tumor suppressor.{ECO:0000269|PubMed:16357137, ECO:0000269|PubMed:19412162}. | Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBXO31_USP10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBXO31_USP10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FBXO31 | CUL1, SKP1, RBX1, CCND1, COPS5, PARD6A, MAP2K6, CDT1, STX3, PDLIM1, MRPS27, EFR3A, EDRF1, MYH6, PRPS1, CEP170P1, QSER1, C18orf21, ZCCHC9, FAM58A, DNAJC19, GHR, MDM2, ZNF131, FOXM1, FAM98A, STYX, SNAI2, SNAI1 | USP10 | G3BP1, SNX3, SCNN1A, EIF4G1, EIF4G3, G3BP2, CELF1, GAR1, ULK1, TP53, MDM2, CFTR, UBC, AR, WAPAL, ZC3H18, USP15, UBE2S, TSKS, TRPM8, ZNF281, PABPC1, VCP, TARDBP, ANKRD28, PPP6R1, PPP6R3, HECW2, PTEN, ZC3H12A, IKBKG, PCNA, TBX21, USP10, SIRT6, KLHDC3, SF3B3, NTRK1, RAD51, NPM1, RPL10, NOP56, IBTK, PRKAA1, PRKAA2, YBX1, KMT2E, CDC5L, TBP, TANK, TRAF6, HIST2H2AC, MSH2, SNAI1, ANKRD44, ANKRD52, AARSD1, SMEK1, GFAP, PPP6R2, PPP4R2, CYLD, ZEB1, RNF168, RPS6 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBXO31_USP10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXO31_USP10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |