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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13157

FusionGeneSummary for FBXO31_USP10

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO31_USP10
Fusion gene ID: 13157
HgeneTgene
Gene symbol

FBXO31

USP10

Gene ID

79791

84669

Gene nameF-box protein 31ubiquitin specific peptidase 32
SynonymsFBX14|FBXO14|Fbx31|MRT45|pp2386NY-REN-60|USP10
Cytomap

16q24.2

17q23.1-q23.2

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 31SCF ubiquitin ligase specificity factorputative breast cancer tumor-suppressorubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32
Modification date2018052320180523
UniProtAcc

Q5XUX0

Q14694

Ensembl transtripts involved in fusion geneENST00000311635, ENST00000563956, 
ENST00000219473, ENST00000570191, 
ENST00000562743, 
Fusion gene scores* DoF score3 X 2 X 3=186 X 5 X 5=150
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO31 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXO31

GO:0006974

cellular response to DNA damage stimulus

19412162

HgeneFBXO31

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

19412162


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-7218-01BFBXO31chr16

87417011

-USP10chr16

84797692

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000311635ENST00000219473FBXO31chr16

87417011

-USP10chr16

84797692

+
Frame-shitENST00000311635ENST00000570191FBXO31chr16

87417011

-USP10chr16

84797692

+
5CDS-intronENST00000311635ENST00000562743FBXO31chr16

87417011

-USP10chr16

84797692

+
5UTR-3CDSENST00000563956ENST00000219473FBXO31chr16

87417011

-USP10chr16

84797692

+
5UTR-3CDSENST00000563956ENST00000570191FBXO31chr16

87417011

-USP10chr16

84797692

+
5UTR-intronENST00000563956ENST00000562743FBXO31chr16

87417011

-USP10chr16

84797692

+

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FusionProtFeatures for FBXO31_USP10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO31

Q5XUX0

USP10

Q14694

Component of some SCF (SKP1-cullin-F-box) protein ligasecomplex that plays a central role in G1 arrest following DNAdamage. Specifically recognizes phosphorylated cyclin-D1 (CCND1),promoting its ubiquitination and degradation by the proteasome,resulting in G1 arrest. May act as a tumor suppressor.{ECO:0000269|PubMed:16357137, ECO:0000269|PubMed:19412162}. Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXO31_USP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXO31_USP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBXO31CUL1, SKP1, RBX1, CCND1, COPS5, PARD6A, MAP2K6, CDT1, STX3, PDLIM1, MRPS27, EFR3A, EDRF1, MYH6, PRPS1, CEP170P1, QSER1, C18orf21, ZCCHC9, FAM58A, DNAJC19, GHR, MDM2, ZNF131, FOXM1, FAM98A, STYX, SNAI2, SNAI1USP10G3BP1, SNX3, SCNN1A, EIF4G1, EIF4G3, G3BP2, CELF1, GAR1, ULK1, TP53, MDM2, CFTR, UBC, AR, WAPAL, ZC3H18, USP15, UBE2S, TSKS, TRPM8, ZNF281, PABPC1, VCP, TARDBP, ANKRD28, PPP6R1, PPP6R3, HECW2, PTEN, ZC3H12A, IKBKG, PCNA, TBX21, USP10, SIRT6, KLHDC3, SF3B3, NTRK1, RAD51, NPM1, RPL10, NOP56, IBTK, PRKAA1, PRKAA2, YBX1, KMT2E, CDC5L, TBP, TANK, TRAF6, HIST2H2AC, MSH2, SNAI1, ANKRD44, ANKRD52, AARSD1, SMEK1, GFAP, PPP6R2, PPP4R2, CYLD, ZEB1, RNF168, RPS6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXO31_USP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXO31_USP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource