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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 13122

FusionGeneSummary for FBXL3_ZNF76

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL3_ZNF76
Fusion gene ID: 13122
HgeneTgene
Gene symbol

FBXL3

ZNF76

Gene ID

26224

7629

Gene nameF-box and leucine rich repeat protein 3zinc finger protein 76
SynonymsFBL3|FBL3A|FBXL3AD6S229E|ZNF523|Zfp523
Cytomap

13q22.3

6p21.31

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 3F-box and leucine-rich repeat protein 3AF-box protein Fbl3aF-box/LRR-repeat protein 3Azinc finger protein 76zinc finger protein 523zinc finger protein 76 (expressed in testis)
Modification date2018052320180519
UniProtAcc

Q9UKT7

P36508

Ensembl transtripts involved in fusion geneENST00000355619, ENST00000477982, 
ENST00000373953, ENST00000440666, 
ENST00000339411, ENST00000482946, 
Fusion gene scores* DoF score5 X 4 X 5=1004 X 4 X 3=48
# samples 75
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FBXL3 [Title/Abstract] AND ZNF76 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXL3

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

17463251

TgeneZNF76

GO:0045944

positive regulation of transcription by RNA polymerase II

10893243


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-NA-A4QV-01AFBXL3chr13

77589544

-ZNF76chr6

35259055

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355619ENST00000373953FBXL3chr13

77589544

-ZNF76chr6

35259055

+
In-frameENST00000355619ENST00000440666FBXL3chr13

77589544

-ZNF76chr6

35259055

+
In-frameENST00000355619ENST00000339411FBXL3chr13

77589544

-ZNF76chr6

35259055

+
5CDS-intronENST00000355619ENST00000482946FBXL3chr13

77589544

-ZNF76chr6

35259055

+
5UTR-3CDSENST00000477982ENST00000373953FBXL3chr13

77589544

-ZNF76chr6

35259055

+
5UTR-3CDSENST00000477982ENST00000440666FBXL3chr13

77589544

-ZNF76chr6

35259055

+
5UTR-3CDSENST00000477982ENST00000339411FBXL3chr13

77589544

-ZNF76chr6

35259055

+
5UTR-intronENST00000477982ENST00000482946FBXL3chr13

77589544

-ZNF76chr6

35259055

+

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FusionProtFeatures for FBXL3_ZNF76


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL3

Q9UKT7

ZNF76

P36508

Substrate-recognition component of the SCF(FBXL3) E3ubiquitin ligase complex involved in circadian rhythm function.Plays a key role in the maintenance of both the speed and therobustness of the circadian clock oscillation (PubMed:17463251,PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainlyacts in the nucleus and mediates ubiquitination and subsequentdegradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855,PubMed:27565346). Activity of the SCF(FBXL3) complex iscounteracted by the SCF(FBXL21) complex (PubMed:23452855).{ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855,ECO:0000269|PubMed:27565346}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL3chr13:77589544chr6:35259055ENST00000355619-4534_81214429DomainNote=F-box
HgeneFBXL3chr13:77589544chr6:35259055ENST00000355619-45119_146214429RepeatNote=LRR 1
HgeneFBXL3chr13:77589544chr6:35259055ENST00000355619-45181_207214429RepeatNote=LRR 2
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+613225_249208516Zinc fingerC2H2-type 3
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+613255_279208516Zinc fingerC2H2-type 4
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+613285_309208516Zinc fingerC2H2-type 5
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+613315_339208516Zinc fingerC2H2-type 6
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+613345_368208516Zinc fingerC2H2-type 7
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+614225_249208571Zinc fingerC2H2-type 3
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+614255_279208571Zinc fingerC2H2-type 4
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+614285_309208571Zinc fingerC2H2-type 5
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+614315_339208571Zinc fingerC2H2-type 6
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+614345_368208571Zinc fingerC2H2-type 7

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL3chr13:77589544chr6:35259055ENST00000355619-45208_233214429RepeatNote=LRR 3
HgeneFBXL3chr13:77589544chr6:35259055ENST00000355619-45234_259214429RepeatNote=LRR 4
HgeneFBXL3chr13:77589544chr6:35259055ENST00000355619-45316_341214429RepeatNote=LRR 5
HgeneFBXL3chr13:77589544chr6:35259055ENST00000355619-45343_368214429RepeatNote=LRR 6
HgeneFBXL3chr13:77589544chr6:35259055ENST00000355619-45369_394214429RepeatNote=LRR 7
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+61334_99208516RegionNote=3 X 12 AA approximate repeats
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+61434_99208571RegionNote=3 X 12 AA approximate repeats
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+61334_45208516RepeatNote=1
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+61362_73208516RepeatNote=2
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+61388_99208516RepeatNote=3
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+61434_45208571RepeatNote=1
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+61462_73208571RepeatNote=2
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+61488_99208571RepeatNote=3
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+613165_189208516Zinc fingerC2H2-type 1
TgeneZNF76chr13:77589544chr6:35259055ENST00000339411+613195_219208516Zinc fingerC2H2-type 2
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+614165_189208571Zinc fingerC2H2-type 1
TgeneZNF76chr13:77589544chr6:35259055ENST00000373953+614195_219208571Zinc fingerC2H2-type 2


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FusionGeneSequence for FBXL3_ZNF76


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FBXL3_ENST00000355619_chr13_77589544_-_ZNF76_ENST00000373953_chr6_35259055_+_362aa
AMDXRATFVPTLVRNHTSAQRSCAARPSRPQETCRSMSVPTLVNARSSALLRAVAAPSPHLTSARYMCAPTQARGPTPARSPTVAAASPA
PPTIRITCASTQGRSHTFARCQAAGNASPSTRACISTTWCTHTASPTPAAPAARPTGRPPPWPCTSAVPTASWRPRRRASRPSMSSSNLR
PPLQPRRVRHPNDPGXLTFRRXRKREMTSQPRWRWXLKKMGPPRWLXSLRMVPSRSACPRKTCRPWGVPSVWSPSTAAPPSPSPVLMPTW
PHLAHIQSPWSAPMAPRRSPSQSLPLGLWWLRTQVXHLFVINRWHCWPQPTERTLQCSWRNSRPXRRPSMWPLRPCSKGLXPWRQQCRRV

>In-frame_FBXL3_ENST00000355619_chr13_77589544_-_ZNF76_ENST00000440666_chr6_35259055_+_362aa
AMDXRATFVPTLVRNHTSAQRSCAARPSRPQETCRSMSVPTLVNARSSALLRAVAAPSPHLTSARYMCAPTQARGPTPARSPTVAAASPA
PPTIRITCASTQGRSHTFARCQAAGNASPSTRACISTTWCTHTASPTPAAPAARPTGRPPPWPCTSAVPTASWRPRRRASRPSMSSSNLR
PPLQPRRVRHPNDPGXLTFRRXRKREMTSQPRWRWXLKKMGPPRWLXSLRMVPSRSACPRKTCRPWGVPSVWSPSTAAPPSPSPVLMPTW
PHLAHIQSPWSAPMAPRRSPSQSLPLGLWWLRTQVXHLFVINRWHCWPQPTERTLQCSWRNSRPXRRPSMWPLRPCSKGLXPWRQQCRRV

>In-frame_FBXL3_ENST00000355619_chr13_77589544_-_ZNF76_ENST00000339411_chr6_35259055_+_307aa
AMDXRATFVPTLVRNHTSAQRSCAARPSRPQETCRSMSVPTLVNARSSALLRAVAAPSPHLTSARYMCAPTQARGPTPARSPTVAAASPA
PPTIRITCASTQGRSHTFARCQAAGNASPSTRACISTTWCTHTASPTPAAPAARPTGRPPPWPCTSAVPTASWRPRRRASRPSMSSSNLR
PPLQPRRVRHPNDPGXLTFRRXRKREMTSQPRWRWXLKKMGPPRWLXSLRMVPSRSQSLPLGLWWLRTQVXHLFVINRWHCWPQPTERTL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FBXL3_ENST00000355619_chr13_77589544_-_ZNF76_ENST00000373953_chr6_35259055_+_1088nt
GCTATGGACTGAAGAGCCACGTTCGTACCCACACTGGTGAGAAACCATACAAGTGCCCAGAGGAGCTGTGCAGCAAGGCCTTCAAGACCT
CAGGAGACCTGCAGAAGCATGTCCGTACCCACACTGGTGAACGCCCGTTCCAGTGCCCTTTTGAGGGCTGTGGCCGCTCCTTCACCACAT
CTAACATCCGCAAGGTACATGTGCGCACCCACACAGGCGAGAGGCCCTACACCTGCCCGGAGCCCCACTGTGGCCGCGGCTTCACCAGCG
CCACCAACTATAAGAATCACGTGCGCATCCACACAGGGGAGAAGCCATACGTTTGCACGGTGCCAGGCTGCGGGAAACGCTTCACCGAGT
ACTCGAGCTTGTATAAGCACCACGTGGTGCACACACACTGCAAGCCCTACACCTGCAGCACCTGCGGCAAGACCTACCGGCAGACCTCCA
CCTTGGCCATGCACAAGCGCAGTGCCCACGGCGAGCTGGAGGCCACGGAGGAGAGCGAGCAGGCCCTCTATGAGCAGCAGCAACTTGAGG
CCGCCTCTGCAGCCGAGGAGAGTCCGCCACCCAAACGACCCCGGATAGCTTACCTTTCGGAGGTGAAGGAAGAGAGAGATGACATCCCAG
CCCAGGTGGCGATGGTGACTGAAGAAGATGGGGCCCCCCAGGTGGCTCTGATCACTCAGGATGGTGCCCAGCAGGTCAGCCTGTCCCCGG
AAGACCTGCAGGCCCTGGGGAGTGCCATCAGTATGGTCACCCAGCACGGCAGCACCACCCTCACCATCCCCAGTCCTGATGCCGACCTGG
CCACATCTGGCACACATACAGTCACCATGGTCAGCGCCGATGGCACCCAGACGCAGCCCGTCACAATCATTACCTCTGGGGCTGTGGTGG
CTGAGGACTCAAGTGTAGCATCTCTTCGTCATCAACAGGTGGCACTGTTGGCCACAGCCAACGGAACGCACATTGCAGTGCAGCTGGAGG
AACAGCAGACCTTAGAGGAGGCCATCAATGTGGCCACTGCGGCCATGCAGCAAGGGGCTGTGACCCTGGAGACAACAGTGTCGGAGAGTG

>In-frame_FBXL3_ENST00000355619_chr13_77589544_-_ZNF76_ENST00000440666_chr6_35259055_+_1088nt
GCTATGGACTGAAGAGCCACGTTCGTACCCACACTGGTGAGAAACCATACAAGTGCCCAGAGGAGCTGTGCAGCAAGGCCTTCAAGACCT
CAGGAGACCTGCAGAAGCATGTCCGTACCCACACTGGTGAACGCCCGTTCCAGTGCCCTTTTGAGGGCTGTGGCCGCTCCTTCACCACAT
CTAACATCCGCAAGGTACATGTGCGCACCCACACAGGCGAGAGGCCCTACACCTGCCCGGAGCCCCACTGTGGCCGCGGCTTCACCAGCG
CCACCAACTATAAGAATCACGTGCGCATCCACACAGGGGAGAAGCCATACGTTTGCACGGTGCCAGGCTGCGGGAAACGCTTCACCGAGT
ACTCGAGCTTGTATAAGCACCACGTGGTGCACACACACTGCAAGCCCTACACCTGCAGCACCTGCGGCAAGACCTACCGGCAGACCTCCA
CCTTGGCCATGCACAAGCGCAGTGCCCACGGCGAGCTGGAGGCCACGGAGGAGAGCGAGCAGGCCCTCTATGAGCAGCAGCAACTTGAGG
CCGCCTCTGCAGCCGAGGAGAGTCCGCCACCCAAACGACCCCGGATAGCTTACCTTTCGGAGGTGAAGGAAGAGAGAGATGACATCCCAG
CCCAGGTGGCGATGGTGACTGAAGAAGATGGGGCCCCCCAGGTGGCTCTGATCACTCAGGATGGTGCCCAGCAGGTCAGCCTGTCCCCGG
AAGACCTGCAGGCCCTGGGGAGTGCCATCAGTATGGTCACCCAGCACGGCAGCACCACCCTCACCATCCCCAGTCCTGATGCCGACCTGG
CCACATCTGGCACACATACAGTCACCATGGTCAGCGCCGATGGCACCCAGACGCAGCCCGTCACAATCATTACCTCTGGGGCTGTGGTGG
CTGAGGACTCAAGTGTAGCATCTCTTCGTCATCAACAGGTGGCACTGTTGGCCACAGCCAACGGAACGCACATTGCAGTGCAGCTGGAGG
AACAGCAGACCTTAGAGGAGGCCATCAATGTGGCCACTGCGGCCATGCAGCAAGGGGCTGTGACCCTGGAGACAACAGTGTCGGAGAGTG

>In-frame_FBXL3_ENST00000355619_chr13_77589544_-_ZNF76_ENST00000339411_chr6_35259055_+_923nt
GCTATGGACTGAAGAGCCACGTTCGTACCCACACTGGTGAGAAACCATACAAGTGCCCAGAGGAGCTGTGCAGCAAGGCCTTCAAGACCT
CAGGAGACCTGCAGAAGCATGTCCGTACCCACACTGGTGAACGCCCGTTCCAGTGCCCTTTTGAGGGCTGTGGCCGCTCCTTCACCACAT
CTAACATCCGCAAGGTACATGTGCGCACCCACACAGGCGAGAGGCCCTACACCTGCCCGGAGCCCCACTGTGGCCGCGGCTTCACCAGCG
CCACCAACTATAAGAATCACGTGCGCATCCACACAGGGGAGAAGCCATACGTTTGCACGGTGCCAGGCTGCGGGAAACGCTTCACCGAGT
ACTCGAGCTTGTATAAGCACCACGTGGTGCACACACACTGCAAGCCCTACACCTGCAGCACCTGCGGCAAGACCTACCGGCAGACCTCCA
CCTTGGCCATGCACAAGCGCAGTGCCCACGGCGAGCTGGAGGCCACGGAGGAGAGCGAGCAGGCCCTCTATGAGCAGCAGCAACTTGAGG
CCGCCTCTGCAGCCGAGGAGAGTCCGCCACCCAAACGACCCCGGATAGCTTACCTTTCGGAGGTGAAGGAAGAGAGAGATGACATCCCAG
CCCAGGTGGCGATGGTGACTGAAGAAGATGGGGCCCCCCAGGTGGCTCTGATCACTCAGGATGGTGCCCAGCAGGTCACAATCATTACCT
CTGGGGCTGTGGTGGCTGAGGACTCAAGTGTAGCATCTCTTCGTCATCAACAGGTGGCACTGTTGGCCACAGCCAACGGAACGCACATTG
CAGTGCAGCTGGAGGAACAGCAGACCTTAGAGGAGGCCATCAATGTGGCCACTGCGGCCATGCAGCAAGGGGCTGTGACCCTGGAGACAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_FBXL3_ENST00000355619_chr13_77589544_-_ZNF76_ENST00000373953_chr6_35259055_+_2793nt
GTTTGTGGCCCAGGTGCAGGAAGCTTACGCGGTGGCAGCCGCTCGCTGAGGTAGTCTCTCGCGGCGCCGGGGATCCCTGAACACAGACAG
CGCGGGACTGAGAAGGAAAGCTTCTTTCTGGGCAGCCAGAGCCGCAAAGGTGGAGCCGCGTTGGCGCCCTCCGCGGGACCAGCGCCTCGG
ATGCGGGCGGAGCGCGGGGGGCCGCGGCTGCGGGAGCGCGAAGCGGGGGGCCAGGGGCGCCTCATGTGAGAGCCGCGGGACCTGCAGCCG
CCGCCGTCCCCGGAGCACGGGGTGGTGTGTGGGGGAAGCCGCCCCCGGCAGCAGGATGAAACGAGGAGGAAGAGATAGTGACCGTAATTC
ATCAGAAGAAGGAACTGCAGAGAAATCCAAGAAACTGAGGACTACAAATGAGCATTCTCAGACTTGTGATTGGGGTAATCTCCTTCAGGA
CATTATTCTCCAAGTATTTAAATATTTGCCTCTTCTTGACCGGGCTCATGCTTCACAAGTTTGCCGCAACTGGAACCAGGTATTTCACAT
GCCTGACTTGTGGAGATGTTTTGAATTTGAACTGAATCAGCCAGCTACATCTTATTTGAAAGCTACCCATCCAGAGCTGATCAAACAGAT
TATTAAAAGACATTCAAACCATCTACAATATGTCAGCTTCAAGGTGGACAGCAGCAAGGAATCAGCTGAAGCAGCTTGTGATATACTATC
GCAACTTGTGAATTGCTCTTTAAAAACACTTGGACTTATTTCAACTGCTCGACCAAGCTTTATGGATTTACCAAAGTCTCACTTTATCTC
TGCACTGACAGTTGTGTTCGTAAACTCCAAATCCCTGTCTTCGCTTAAGATAGATGATACTCCAGTAGATGATCCATCTCTCAAAGTACT
AGTGGCCAACAATAGTGATACACTCAAGCTGTTGAAAATGAGCAGCTGTCCTCATGTCTCTCCAGCAGGCTATGGACTGAAGAGCCACGT
TCGTACCCACACTGGTGAGAAACCATACAAGTGCCCAGAGGAGCTGTGCAGCAAGGCCTTCAAGACCTCAGGAGACCTGCAGAAGCATGT
CCGTACCCACACTGGTGAACGCCCGTTCCAGTGCCCTTTTGAGGGCTGTGGCCGCTCCTTCACCACATCTAACATCCGCAAGGTACATGT
GCGCACCCACACAGGCGAGAGGCCCTACACCTGCCCGGAGCCCCACTGTGGCCGCGGCTTCACCAGCGCCACCAACTATAAGAATCACGT
GCGCATCCACACAGGGGAGAAGCCATACGTTTGCACGGTGCCAGGCTGCGGGAAACGCTTCACCGAGTACTCGAGCTTGTATAAGCACCA
CGTGGTGCACACACACTGCAAGCCCTACACCTGCAGCACCTGCGGCAAGACCTACCGGCAGACCTCCACCTTGGCCATGCACAAGCGCAG
TGCCCACGGCGAGCTGGAGGCCACGGAGGAGAGCGAGCAGGCCCTCTATGAGCAGCAGCAACTTGAGGCCGCCTCTGCAGCCGAGGAGAG
TCCGCCACCCAAACGACCCCGGATAGCTTACCTTTCGGAGGTGAAGGAAGAGAGAGATGACATCCCAGCCCAGGTGGCGATGGTGACTGA
AGAAGATGGGGCCCCCCAGGTGGCTCTGATCACTCAGGATGGTGCCCAGCAGGTCAGCCTGTCCCCGGAAGACCTGCAGGCCCTGGGGAG
TGCCATCAGTATGGTCACCCAGCACGGCAGCACCACCCTCACCATCCCCAGTCCTGATGCCGACCTGGCCACATCTGGCACACATACAGT
CACCATGGTCAGCGCCGATGGCACCCAGACGCAGCCCGTCACAATCATTACCTCTGGGGCTGTGGTGGCTGAGGACTCAAGTGTAGCATC
TCTTCGTCATCAACAGGTGGCACTGTTGGCCACAGCCAACGGAACGCACATTGCAGTGCAGCTGGAGGAACAGCAGACCTTAGAGGAGGC
CATCAATGTGGCCACTGCGGCCATGCAGCAAGGGGCTGTGACCCTGGAGACAACAGTGTCGGAGAGTGGCTGCTGAGTCCAAGAGGGCTG
GGTCCCACACCATGCTGGAGGAAGTGCCATCTGCATGGCCACTCTTGCCCCCAAGGGCCCAGGCTGTGGCTGACACATAGAAGGTGGCCA
CATAGGTCTCTGGGGTGAGAAGACAGCAAGAAAACTGCCTAACTGAAGGGAATGGGGGCCCTGCTCAAGAAGGGGGCCAGGCAGCTGGAA
TCAGGGGAGTGCATCATCCTCGGGAGCTGACAACAGCCAGGCTACACCAGGGCACCCGCCTCTCAAAATCAGCTGGGCGCCCACTCTCCT
CCTAAAGAACACCCTTCTGGCCCTCAGTCTGTTCCCCTTCTCAGGTAGAGATTGGGGCTGCTATGGGGACTGGCCCTGTAGGGTTGAGCC
ACAGACAGCTCTTCAGCCCAGTAGCAGTGGAGCAGGCCCTGTCCTGCCCTCCCAGCAATAACCACCTCCCTGGAGGCCAGCTGAGATGCC
TGGCTACTTGGCACCAGGGACTTCCTGACACCACAGTCAATTAATTCCTCAGGGGCCTGTGGCTGAAGAAAAGGTGCCCAGCCCCCACCA
CTCCTCAGCTGCCCCCCAACCTCTCTATGGCAGAGAGGCAGGGAGTGGCCCTGTACATAGACTGCTGGGGATTGGGTTTGATTTGTTTTG
TTTTTTTTAATTCCATTTTGATAATTTTTTTCCTGCTCTGGGTGGTGGTGGCACATGGATGAATGAGTATTTAATAAAAGTTCCAAATTT

>In-frame_FBXL3_ENST00000355619_chr13_77589544_-_ZNF76_ENST00000440666_chr6_35259055_+_2791nt
GTTTGTGGCCCAGGTGCAGGAAGCTTACGCGGTGGCAGCCGCTCGCTGAGGTAGTCTCTCGCGGCGCCGGGGATCCCTGAACACAGACAG
CGCGGGACTGAGAAGGAAAGCTTCTTTCTGGGCAGCCAGAGCCGCAAAGGTGGAGCCGCGTTGGCGCCCTCCGCGGGACCAGCGCCTCGG
ATGCGGGCGGAGCGCGGGGGGCCGCGGCTGCGGGAGCGCGAAGCGGGGGGCCAGGGGCGCCTCATGTGAGAGCCGCGGGACCTGCAGCCG
CCGCCGTCCCCGGAGCACGGGGTGGTGTGTGGGGGAAGCCGCCCCCGGCAGCAGGATGAAACGAGGAGGAAGAGATAGTGACCGTAATTC
ATCAGAAGAAGGAACTGCAGAGAAATCCAAGAAACTGAGGACTACAAATGAGCATTCTCAGACTTGTGATTGGGGTAATCTCCTTCAGGA
CATTATTCTCCAAGTATTTAAATATTTGCCTCTTCTTGACCGGGCTCATGCTTCACAAGTTTGCCGCAACTGGAACCAGGTATTTCACAT
GCCTGACTTGTGGAGATGTTTTGAATTTGAACTGAATCAGCCAGCTACATCTTATTTGAAAGCTACCCATCCAGAGCTGATCAAACAGAT
TATTAAAAGACATTCAAACCATCTACAATATGTCAGCTTCAAGGTGGACAGCAGCAAGGAATCAGCTGAAGCAGCTTGTGATATACTATC
GCAACTTGTGAATTGCTCTTTAAAAACACTTGGACTTATTTCAACTGCTCGACCAAGCTTTATGGATTTACCAAAGTCTCACTTTATCTC
TGCACTGACAGTTGTGTTCGTAAACTCCAAATCCCTGTCTTCGCTTAAGATAGATGATACTCCAGTAGATGATCCATCTCTCAAAGTACT
AGTGGCCAACAATAGTGATACACTCAAGCTGTTGAAAATGAGCAGCTGTCCTCATGTCTCTCCAGCAGGCTATGGACTGAAGAGCCACGT
TCGTACCCACACTGGTGAGAAACCATACAAGTGCCCAGAGGAGCTGTGCAGCAAGGCCTTCAAGACCTCAGGAGACCTGCAGAAGCATGT
CCGTACCCACACTGGTGAACGCCCGTTCCAGTGCCCTTTTGAGGGCTGTGGCCGCTCCTTCACCACATCTAACATCCGCAAGGTACATGT
GCGCACCCACACAGGCGAGAGGCCCTACACCTGCCCGGAGCCCCACTGTGGCCGCGGCTTCACCAGCGCCACCAACTATAAGAATCACGT
GCGCATCCACACAGGGGAGAAGCCATACGTTTGCACGGTGCCAGGCTGCGGGAAACGCTTCACCGAGTACTCGAGCTTGTATAAGCACCA
CGTGGTGCACACACACTGCAAGCCCTACACCTGCAGCACCTGCGGCAAGACCTACCGGCAGACCTCCACCTTGGCCATGCACAAGCGCAG
TGCCCACGGCGAGCTGGAGGCCACGGAGGAGAGCGAGCAGGCCCTCTATGAGCAGCAGCAACTTGAGGCCGCCTCTGCAGCCGAGGAGAG
TCCGCCACCCAAACGACCCCGGATAGCTTACCTTTCGGAGGTGAAGGAAGAGAGAGATGACATCCCAGCCCAGGTGGCGATGGTGACTGA
AGAAGATGGGGCCCCCCAGGTGGCTCTGATCACTCAGGATGGTGCCCAGCAGGTCAGCCTGTCCCCGGAAGACCTGCAGGCCCTGGGGAG
TGCCATCAGTATGGTCACCCAGCACGGCAGCACCACCCTCACCATCCCCAGTCCTGATGCCGACCTGGCCACATCTGGCACACATACAGT
CACCATGGTCAGCGCCGATGGCACCCAGACGCAGCCCGTCACAATCATTACCTCTGGGGCTGTGGTGGCTGAGGACTCAAGTGTAGCATC
TCTTCGTCATCAACAGGTGGCACTGTTGGCCACAGCCAACGGAACGCACATTGCAGTGCAGCTGGAGGAACAGCAGACCTTAGAGGAGGC
CATCAATGTGGCCACTGCGGCCATGCAGCAAGGGGCTGTGACCCTGGAGACAACAGTGTCGGAGAGTGGCTGCTGAGTCCAAGAGGGCTG
GGTCCCACACCATGCTGGAGGAAGTGCCATCTGCATGGCCACTCTTGCCCCCAAGGGCCCAGGCTGTGGCTGACACATAGAAGGTGGCCA
CATAGGTCTCTGGGGTGAGAAGACAGCAAGAAAACTGCCTAACTGAAGGGAATGGGGGCCCTGCTCAAGAAGGGGGCCAGGCAGCTGGAA
TCAGGGGAGTGCATCATCCTCGGGAGCTGACAACAGCCAGGCTACACCAGGGCACCCGCCTCTCAAAATCAGCTGGGCGCCCACTCTCCT
CCTAAAGAACACCCTTCTGGCCCTCAGTCTGTTCCCCTTCTCAGGTAGAGATTGGGGCTGCTATGGGGACTGGCCCTGTAGGGTTGAGCC
ACAGACAGCTCTTCAGCCCAGTAGCAGTGGAGCAGGCCCTGTCCTGCCCTCCCAGCAATAACCACCTCCCTGGAGGCCAGCTGAGATGCC
TGGCTACTTGGCACCAGGGACTTCCTGACACCACAGTCAATTAATTCCTCAGGGGCCTGTGGCTGAAGAAAAGGTGCCCAGCCCCCACCA
CTCCTCAGCTGCCCCCCAACCTCTCTATGGCAGAGAGGCAGGGAGTGGCCCTGTACATAGACTGCTGGGGATTGGGTTTGATTTGTTTTG
TTTTTTTTAATTCCATTTTGATAATTTTTTTCCTGCTCTGGGTGGTGGTGGCACATGGATGAATGAGTATTTAATAAAAGTTCCAAATTT

>In-frame_FBXL3_ENST00000355619_chr13_77589544_-_ZNF76_ENST00000339411_chr6_35259055_+_2626nt
GTTTGTGGCCCAGGTGCAGGAAGCTTACGCGGTGGCAGCCGCTCGCTGAGGTAGTCTCTCGCGGCGCCGGGGATCCCTGAACACAGACAG
CGCGGGACTGAGAAGGAAAGCTTCTTTCTGGGCAGCCAGAGCCGCAAAGGTGGAGCCGCGTTGGCGCCCTCCGCGGGACCAGCGCCTCGG
ATGCGGGCGGAGCGCGGGGGGCCGCGGCTGCGGGAGCGCGAAGCGGGGGGCCAGGGGCGCCTCATGTGAGAGCCGCGGGACCTGCAGCCG
CCGCCGTCCCCGGAGCACGGGGTGGTGTGTGGGGGAAGCCGCCCCCGGCAGCAGGATGAAACGAGGAGGAAGAGATAGTGACCGTAATTC
ATCAGAAGAAGGAACTGCAGAGAAATCCAAGAAACTGAGGACTACAAATGAGCATTCTCAGACTTGTGATTGGGGTAATCTCCTTCAGGA
CATTATTCTCCAAGTATTTAAATATTTGCCTCTTCTTGACCGGGCTCATGCTTCACAAGTTTGCCGCAACTGGAACCAGGTATTTCACAT
GCCTGACTTGTGGAGATGTTTTGAATTTGAACTGAATCAGCCAGCTACATCTTATTTGAAAGCTACCCATCCAGAGCTGATCAAACAGAT
TATTAAAAGACATTCAAACCATCTACAATATGTCAGCTTCAAGGTGGACAGCAGCAAGGAATCAGCTGAAGCAGCTTGTGATATACTATC
GCAACTTGTGAATTGCTCTTTAAAAACACTTGGACTTATTTCAACTGCTCGACCAAGCTTTATGGATTTACCAAAGTCTCACTTTATCTC
TGCACTGACAGTTGTGTTCGTAAACTCCAAATCCCTGTCTTCGCTTAAGATAGATGATACTCCAGTAGATGATCCATCTCTCAAAGTACT
AGTGGCCAACAATAGTGATACACTCAAGCTGTTGAAAATGAGCAGCTGTCCTCATGTCTCTCCAGCAGGCTATGGACTGAAGAGCCACGT
TCGTACCCACACTGGTGAGAAACCATACAAGTGCCCAGAGGAGCTGTGCAGCAAGGCCTTCAAGACCTCAGGAGACCTGCAGAAGCATGT
CCGTACCCACACTGGTGAACGCCCGTTCCAGTGCCCTTTTGAGGGCTGTGGCCGCTCCTTCACCACATCTAACATCCGCAAGGTACATGT
GCGCACCCACACAGGCGAGAGGCCCTACACCTGCCCGGAGCCCCACTGTGGCCGCGGCTTCACCAGCGCCACCAACTATAAGAATCACGT
GCGCATCCACACAGGGGAGAAGCCATACGTTTGCACGGTGCCAGGCTGCGGGAAACGCTTCACCGAGTACTCGAGCTTGTATAAGCACCA
CGTGGTGCACACACACTGCAAGCCCTACACCTGCAGCACCTGCGGCAAGACCTACCGGCAGACCTCCACCTTGGCCATGCACAAGCGCAG
TGCCCACGGCGAGCTGGAGGCCACGGAGGAGAGCGAGCAGGCCCTCTATGAGCAGCAGCAACTTGAGGCCGCCTCTGCAGCCGAGGAGAG
TCCGCCACCCAAACGACCCCGGATAGCTTACCTTTCGGAGGTGAAGGAAGAGAGAGATGACATCCCAGCCCAGGTGGCGATGGTGACTGA
AGAAGATGGGGCCCCCCAGGTGGCTCTGATCACTCAGGATGGTGCCCAGCAGGTCACAATCATTACCTCTGGGGCTGTGGTGGCTGAGGA
CTCAAGTGTAGCATCTCTTCGTCATCAACAGGTGGCACTGTTGGCCACAGCCAACGGAACGCACATTGCAGTGCAGCTGGAGGAACAGCA
GACCTTAGAGGAGGCCATCAATGTGGCCACTGCGGCCATGCAGCAAGGGGCTGTGACCCTGGAGACAACAGTGTCGGAGAGTGGCTGCTG
AGTCCAAGAGGGCTGGGTCCCACACCATGCTGGAGGAAGTGCCATCTGCATGGCCACTCTTGCCCCCAAGGGCCCAGGCTGTGGCTGACA
CATAGAAGGTGGCCACATAGGTCTCTGGGGTGAGAAGACAGCAAGAAAACTGCCTAACTGAAGGGAATGGGGGCCCTGCTCAAGAAGGGG
GCCAGGCAGCTGGAATCAGGGGAGTGCATCATCCTCGGGAGCTGACAACAGCCAGGCTACACCAGGGCACCCGCCTCTCAAAATCAGCTG
GGCGCCCACTCTCCTCCTAAAGAACACCCTTCTGGCCCTCAGTCTGTTCCCCTTCTCAGGTAGAGATTGGGGCTGCTATGGGGACTGGCC
CTGTAGGGTTGAGCCACAGACAGCTCTTCAGCCCAGTAGCAGTGGAGCAGGCCCTGTCCTGCCCTCCCAGCAATAACCACCTCCCTGGAG
GCCAGCTGAGATGCCTGGCTACTTGGCACCAGGGACTTCCTGACACCACAGTCAATTAATTCCTCAGGGGCCTGTGGCTGAAGAAAAGGT
GCCCAGCCCCCACCACTCCTCAGCTGCCCCCCAACCTCTCTATGGCAGAGAGGCAGGGAGTGGCCCTGTACATAGACTGCTGGGGATTGG
GTTTGATTTGTTTTGTTTTTTTTAATTCCATTTTGATAATTTTTTTCCTGCTCTGGGTGGTGGTGGCACATGGATGAATGAGTATTTAAT


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FusionGenePPI for FBXL3_ZNF76


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBXL3CUL1, SKP1, UBE2D2, CDC34, BTG1, BTG2, HSP90AA1, CAND1, CRY1, CRY2, RFX2, RFX1, PPP2R5DZNF76TBP, PIAS1, ELAVL1, CAND1, EP300, HDAC1, SMAD1, SHMT2, MOV10, NXF1, GRHL1, ZBTB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXL3_ZNF76


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXL3_ZNF76


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBXL3C0005586Bipolar Disorder1PSYGENET