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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13120

FusionGeneSummary for FBXL3_KLF5

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL3_KLF5
Fusion gene ID: 13120
HgeneTgene
Gene symbol

FBXL3

KLF5

Gene ID

26224

688

Gene nameF-box and leucine rich repeat protein 3Kruppel like factor 5
SynonymsFBL3|FBL3A|FBXL3ABTEB2|CKLF|IKLF
Cytomap

13q22.3

13q22.1

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 3F-box and leucine-rich repeat protein 3AF-box protein Fbl3aF-box/LRR-repeat protein 3AKrueppel-like factor 5(intestinal Kruppel-like factorBTE-binding protein 2GC box binding protein 2Klf5C isoformKruppel-like factor 5 (intestinal)basic transcription element binding protein 2colon krueppel-like factorcolon kruppel-like factorintes
Modification date2018052320180527
UniProtAcc

Q9UKT7

Q13887

Ensembl transtripts involved in fusion geneENST00000355619, ENST00000477982, 
ENST00000477333, ENST00000539231, 
ENST00000377687, 
Fusion gene scores* DoF score5 X 4 X 5=1004 X 2 X 3=24
# samples 74
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FBXL3 [Title/Abstract] AND KLF5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXL3

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

17463251

TgeneKLF5

GO:0045944

positive regulation of transcription by RNA polymerase II

16595680

TgeneKLF5

GO:0099156

cell-cell signaling via exosome

28408180

TgeneKLF5

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

28408180


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A2P6-01AFBXL3chr13

77600962

-KLF5chr13

73635999

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000355619ENST00000477333FBXL3chr13

77600962

-KLF5chr13

73635999

+
5UTR-5UTRENST00000355619ENST00000539231FBXL3chr13

77600962

-KLF5chr13

73635999

+
5UTR-5UTRENST00000355619ENST00000377687FBXL3chr13

77600962

-KLF5chr13

73635999

+
intron-3UTRENST00000477982ENST00000477333FBXL3chr13

77600962

-KLF5chr13

73635999

+
intron-5UTRENST00000477982ENST00000539231FBXL3chr13

77600962

-KLF5chr13

73635999

+
intron-5UTRENST00000477982ENST00000377687FBXL3chr13

77600962

-KLF5chr13

73635999

+

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FusionProtFeatures for FBXL3_KLF5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL3

Q9UKT7

KLF5

Q13887

Substrate-recognition component of the SCF(FBXL3) E3ubiquitin ligase complex involved in circadian rhythm function.Plays a key role in the maintenance of both the speed and therobustness of the circadian clock oscillation (PubMed:17463251,PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainlyacts in the nucleus and mediates ubiquitination and subsequentdegradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855,PubMed:27565346). Activity of the SCF(FBXL3) complex iscounteracted by the SCF(FBXL21) complex (PubMed:23452855).{ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855,ECO:0000269|PubMed:27565346}. Transcription factor that binds to GC box promoterelements. Activates the transcription of these genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXL3_KLF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXL3_KLF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBXL3CUL1, SKP1, UBE2D2, CDC34, BTG1, BTG2, HSP90AA1, CAND1, CRY1, CRY2, RFX2, RFX1, PPP2R5DKLF5SET, EP300, NFKB1, PRKCA, CREBBP, GTF2B, TBP, WWP1, ESR1, HDAC1, FBXW7, GSK3B, HDAC2, RARA, TRIM25, ESR2, SMURF2, WWTR1, ELAVL1, YAP1, SMAD2, RRBP1, SMAD4, SMAD3, ZBTB17, CTNNB1, SREBF1, SUMO1, UBE2I, NCOR2, NCOR1, PPARG, ANP32B, PARP1, TP53, GTF2E2, GTF2F2, ATXN3L, XPO1, ACTR5, RXRA, CEBPB, CEBPG, CSRP3, CEBPA, JUN, BAP1, HCFC1, OGT, ACTA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXL3_KLF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXL3_KLF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBXL3C0005586Bipolar Disorder1PSYGENET
TgeneKLF5C0007137Squamous cell carcinoma1CTD_human
TgeneKLF5C0030297Pancreatic Neoplasm1CTD_human
TgeneKLF5C0036341Schizophrenia1PSYGENET
TgeneKLF5C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneKLF5C2936380Neointima1CTD_human