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Fusion gene ID: 13120 |
FusionGeneSummary for FBXL3_KLF5 |
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Fusion gene information | Fusion gene name: FBXL3_KLF5 | Fusion gene ID: 13120 | Hgene | Tgene | Gene symbol | FBXL3 | KLF5 | Gene ID | 26224 | 688 |
Gene name | F-box and leucine rich repeat protein 3 | Kruppel like factor 5 | |
Synonyms | FBL3|FBL3A|FBXL3A | BTEB2|CKLF|IKLF | |
Cytomap | 13q22.3 | 13q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | F-box/LRR-repeat protein 3F-box and leucine-rich repeat protein 3AF-box protein Fbl3aF-box/LRR-repeat protein 3A | Krueppel-like factor 5(intestinal Kruppel-like factorBTE-binding protein 2GC box binding protein 2Klf5C isoformKruppel-like factor 5 (intestinal)basic transcription element binding protein 2colon krueppel-like factorcolon kruppel-like factorintes | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q9UKT7 | Q13887 | |
Ensembl transtripts involved in fusion gene | ENST00000355619, ENST00000477982, | ENST00000477333, ENST00000539231, ENST00000377687, | |
Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 4 X 2 X 3=24 |
# samples | 7 | 4 | |
** MAII score | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FBXL3 [Title/Abstract] AND KLF5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FBXL3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 17463251 |
Tgene | KLF5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16595680 |
Tgene | KLF5 | GO:0099156 | cell-cell signaling via exosome | 28408180 |
Tgene | KLF5 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 28408180 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-E2-A2P6-01A | FBXL3 | chr13 | 77600962 | - | KLF5 | chr13 | 73635999 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3UTR | ENST00000355619 | ENST00000477333 | FBXL3 | chr13 | 77600962 | - | KLF5 | chr13 | 73635999 | + |
5UTR-5UTR | ENST00000355619 | ENST00000539231 | FBXL3 | chr13 | 77600962 | - | KLF5 | chr13 | 73635999 | + |
5UTR-5UTR | ENST00000355619 | ENST00000377687 | FBXL3 | chr13 | 77600962 | - | KLF5 | chr13 | 73635999 | + |
intron-3UTR | ENST00000477982 | ENST00000477333 | FBXL3 | chr13 | 77600962 | - | KLF5 | chr13 | 73635999 | + |
intron-5UTR | ENST00000477982 | ENST00000539231 | FBXL3 | chr13 | 77600962 | - | KLF5 | chr13 | 73635999 | + |
intron-5UTR | ENST00000477982 | ENST00000377687 | FBXL3 | chr13 | 77600962 | - | KLF5 | chr13 | 73635999 | + |
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FusionProtFeatures for FBXL3_KLF5 |
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Hgene | Tgene |
FBXL3 | KLF5 |
Substrate-recognition component of the SCF(FBXL3) E3ubiquitin ligase complex involved in circadian rhythm function.Plays a key role in the maintenance of both the speed and therobustness of the circadian clock oscillation (PubMed:17463251,PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainlyacts in the nucleus and mediates ubiquitination and subsequentdegradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855,PubMed:27565346). Activity of the SCF(FBXL3) complex iscounteracted by the SCF(FBXL21) complex (PubMed:23452855).{ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855,ECO:0000269|PubMed:27565346}. | Transcription factor that binds to GC box promoterelements. Activates the transcription of these genes. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBXL3_KLF5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBXL3_KLF5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FBXL3 | CUL1, SKP1, UBE2D2, CDC34, BTG1, BTG2, HSP90AA1, CAND1, CRY1, CRY2, RFX2, RFX1, PPP2R5D | KLF5 | SET, EP300, NFKB1, PRKCA, CREBBP, GTF2B, TBP, WWP1, ESR1, HDAC1, FBXW7, GSK3B, HDAC2, RARA, TRIM25, ESR2, SMURF2, WWTR1, ELAVL1, YAP1, SMAD2, RRBP1, SMAD4, SMAD3, ZBTB17, CTNNB1, SREBF1, SUMO1, UBE2I, NCOR2, NCOR1, PPARG, ANP32B, PARP1, TP53, GTF2E2, GTF2F2, ATXN3L, XPO1, ACTR5, RXRA, CEBPB, CEBPG, CSRP3, CEBPA, JUN, BAP1, HCFC1, OGT, ACTA2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBXL3_KLF5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXL3_KLF5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FBXL3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | KLF5 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | KLF5 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Tgene | KLF5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | KLF5 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | KLF5 | C2936380 | Neointima | 1 | CTD_human |