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Fusion gene ID: 13119 |
FusionGeneSummary for FBXL3_IER3IP1 |
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Fusion gene information | Fusion gene name: FBXL3_IER3IP1 | Fusion gene ID: 13119 | Hgene | Tgene | Gene symbol | FBXL3 | IER3IP1 | Gene ID | 26224 | 51124 |
Gene name | F-box and leucine rich repeat protein 3 | immediate early response 3 interacting protein 1 | |
Synonyms | FBL3|FBL3A|FBXL3A | HSPC039|MEDS|PRO2309 | |
Cytomap | 13q22.3 | 18q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | F-box/LRR-repeat protein 3F-box and leucine-rich repeat protein 3AF-box protein Fbl3aF-box/LRR-repeat protein 3A | immediate early response 3-interacting protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UKT7 | Q9Y5U9 | |
Ensembl transtripts involved in fusion gene | ENST00000355619, ENST00000477982, | ENST00000588705, ENST00000256433, | |
Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 4 X 3 X 3=36 |
# samples | 7 | 4 | |
** MAII score | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FBXL3 [Title/Abstract] AND IER3IP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FBXL3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 17463251 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG291321 | FBXL3 | chr13 | 77580631 | - | IER3IP1 | chr18 | 44702716 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000355619 | ENST00000588705 | FBXL3 | chr13 | 77580631 | - | IER3IP1 | chr18 | 44702716 | - |
intron-5UTR | ENST00000355619 | ENST00000256433 | FBXL3 | chr13 | 77580631 | - | IER3IP1 | chr18 | 44702716 | - |
intron-intron | ENST00000477982 | ENST00000588705 | FBXL3 | chr13 | 77580631 | - | IER3IP1 | chr18 | 44702716 | - |
intron-5UTR | ENST00000477982 | ENST00000256433 | FBXL3 | chr13 | 77580631 | - | IER3IP1 | chr18 | 44702716 | - |
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FusionProtFeatures for FBXL3_IER3IP1 |
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Hgene | Tgene |
FBXL3 | IER3IP1 |
Substrate-recognition component of the SCF(FBXL3) E3ubiquitin ligase complex involved in circadian rhythm function.Plays a key role in the maintenance of both the speed and therobustness of the circadian clock oscillation (PubMed:17463251,PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainlyacts in the nucleus and mediates ubiquitination and subsequentdegradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855,PubMed:27565346). Activity of the SCF(FBXL3) complex iscounteracted by the SCF(FBXL21) complex (PubMed:23452855).{ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855,ECO:0000269|PubMed:27565346}. | May be implicated in the regulation of apoptosis. May beinvolved in protein transport between endoplasmic reticulum andGolgi apparatus (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBXL3_IER3IP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBXL3_IER3IP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBXL3_IER3IP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXL3_IER3IP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FBXL3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | IER3IP1 | C3280240 | MICROCEPHALY, EPILEPSY, AND DIABETES SYNDROME | 1 | ORPHANET;UNIPROT |