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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 13110

FusionGeneSummary for FBXL20_TLK2

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL20_TLK2
Fusion gene ID: 13110
HgeneTgene
Gene symbol

FBXL20

TLK2

Gene ID

84961

11011

Gene nameF-box and leucine rich repeat protein 20tousled like kinase 2
SynonymsFbl2|Fbl20HsHPK|PKU-ALPHA
Cytomap

17q12

17q23.2

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 20F-box protein FBL2serine/threonine-protein kinase tousled-like 2
Modification date2018052320180519
UniProtAcc

Q96IG2

Q86UE8

Ensembl transtripts involved in fusion geneENST00000583610, ENST00000394294, 
ENST00000264658, ENST00000577399, 
ENST00000582809, ENST00000577616, 
ENST00000326270, ENST00000346027, 
ENST00000343388, ENST00000542523, 
Fusion gene scores* DoF score40 X 12 X 14=67204 X 3 X 2=24
# samples 384
** MAII scorelog2(38/6720*10)=-4.14438990933518
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FBXL20 [Title/Abstract] AND TLK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTLK2

GO:0001672

regulation of chromatin assembly or disassembly

12660173

TgeneTLK2

GO:0006468

protein phosphorylation

12660173

TgeneTLK2

GO:0006974

cellular response to DNA damage stimulus

12660173

TgeneTLK2

GO:0018105

peptidyl-serine phosphorylation

20016786

TgeneTLK2

GO:0035556

intracellular signal transduction

12660173

TgeneTLK2

GO:0071480

cellular response to gamma radiation

12660173


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A09I-01AFBXL20chr17

37499433

-TLK2chr17

60637377

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000583610ENST00000582809FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000583610ENST00000577616FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000583610ENST00000326270FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000583610ENST00000346027FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000583610ENST00000343388FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000583610ENST00000542523FBXL20chr17

37499433

-TLK2chr17

60637377

+
Frame-shiftENST00000394294ENST00000582809FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000394294ENST00000577616FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000394294ENST00000326270FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000394294ENST00000346027FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000394294ENST00000343388FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000394294ENST00000542523FBXL20chr17

37499433

-TLK2chr17

60637377

+
Frame-shiftENST00000264658ENST00000582809FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000264658ENST00000577616FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000264658ENST00000326270FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000264658ENST00000346027FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000264658ENST00000343388FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000264658ENST00000542523FBXL20chr17

37499433

-TLK2chr17

60637377

+
Frame-shiftENST00000577399ENST00000582809FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000577399ENST00000577616FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000577399ENST00000326270FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000577399ENST00000346027FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000577399ENST00000343388FBXL20chr17

37499433

-TLK2chr17

60637377

+
5CDS-intronENST00000577399ENST00000542523FBXL20chr17

37499433

-TLK2chr17

60637377

+

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FusionProtFeatures for FBXL20_TLK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL20

Q96IG2

TLK2

Q86UE8

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neuraltransmission (By similarity). {ECO:0000250}. Serine/threonine-protein kinase involved in the processof chromatin assembly and probably also DNA replication,transcription, repair, and chromosome segregation. Phosphorylatesthe chromatin assembly factors ASF1A AND ASF1B. Phosphorylation ofASF1A prevents its proteasome-mediated degradation, therebyenhancing chromatin assembly. Negative regulator of amino acidstarvation-induced autophagy. {ECO:0000269|PubMed:10523312,ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173,ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786,ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTLK2chr17:37499433chr17:60637377ENST00000326270+823317_347240773Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000326270+823403_451240773Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000343388+721225_276208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000343388+721317_347208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000343388+721403_451208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000346027+822317_347240751Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000346027+822403_451240751Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000542523+721225_276208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000542523+721317_347208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000542523+721403_451208719Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000326270+823462_741240773DomainProtein kinase
TgeneTLK2chr17:37499433chr17:60637377ENST00000343388+721462_741208719DomainProtein kinase
TgeneTLK2chr17:37499433chr17:60637377ENST00000346027+822462_741240751DomainProtein kinase
TgeneTLK2chr17:37499433chr17:60637377ENST00000542523+721462_741208719DomainProtein kinase
TgeneTLK2chr17:37499433chr17:60637377ENST00000326270+823468_476240773Nucleotide bindingATP
TgeneTLK2chr17:37499433chr17:60637377ENST00000343388+721468_476208719Nucleotide bindingATP
TgeneTLK2chr17:37499433chr17:60637377ENST00000346027+822468_476240751Nucleotide bindingATP
TgeneTLK2chr17:37499433chr17:60637377ENST00000542523+721468_476208719Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-21522_6834437DomainF-box
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-21422_6834405DomainF-box
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-21622_6834411DomainF-box
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215101_12634437RepeatNote=LRR 2
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215127_15234437RepeatNote=LRR 3
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215153_17834437RepeatNote=LRR 4
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215179_20434437RepeatNote=LRR 5
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215205_23034437RepeatNote=LRR 6
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215231_25634437RepeatNote=LRR 7
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215257_28234437RepeatNote=LRR 8
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215283_30834437RepeatNote=LRR 9
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215309_33434437RepeatNote=LRR 10
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215335_36334437RepeatNote=LRR 11
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215364_38834437RepeatNote=LRR 12
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-215389_41434437RepeatNote=LRR 13
HgeneFBXL20chr17:37499433chr17:60637377ENST00000264658-21574_10034437RepeatNote=LRR 1
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214101_12634405RepeatNote=LRR 2
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214127_15234405RepeatNote=LRR 3
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214153_17834405RepeatNote=LRR 4
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214179_20434405RepeatNote=LRR 5
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214205_23034405RepeatNote=LRR 6
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214231_25634405RepeatNote=LRR 7
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214257_28234405RepeatNote=LRR 8
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214283_30834405RepeatNote=LRR 9
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214309_33434405RepeatNote=LRR 10
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214335_36334405RepeatNote=LRR 11
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214364_38834405RepeatNote=LRR 12
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-214389_41434405RepeatNote=LRR 13
HgeneFBXL20chr17:37499433chr17:60637377ENST00000394294-21474_10034405RepeatNote=LRR 1
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216101_12634411RepeatNote=LRR 2
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216127_15234411RepeatNote=LRR 3
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216153_17834411RepeatNote=LRR 4
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216179_20434411RepeatNote=LRR 5
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216205_23034411RepeatNote=LRR 6
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216231_25634411RepeatNote=LRR 7
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216257_28234411RepeatNote=LRR 8
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216283_30834411RepeatNote=LRR 9
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216309_33434411RepeatNote=LRR 10
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216335_36334411RepeatNote=LRR 11
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216364_38834411RepeatNote=LRR 12
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-216389_41434411RepeatNote=LRR 13
HgeneFBXL20chr17:37499433chr17:60637377ENST00000583610-21674_10034411RepeatNote=LRR 1
TgeneTLK2chr17:37499433chr17:60637377ENST00000326270+823225_276240773Coiled coilOntology_term=ECO:0000255
TgeneTLK2chr17:37499433chr17:60637377ENST00000346027+822225_276240751Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for FBXL20_TLK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FBXL20_ENST00000583610_chr17_37499433_-_TLK2_ENST00000582809_chr17_60637377_+_545aa
MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRPTVIXDGRLMNSKRCXRNTRNDXIDVXQXARNSLXKSQNKRRWRVEIRACKTAXD
WATLLLSDTEPHLLNSGQMVMLFRILSSNRKGXIHRGKRXKDNGKCXQSGNLLPWVRPLLQPMSRNSGKARPMELKMKRXRXQNTMNKKK
SSNSDXVILKRRKQRSRQSWRDXKGLEIYISGNXKGYIMKIIHNLKIIQRXMTDICCYIFWVEEVSVKFTRHLIXQSKDTXLXKFTSXIK
TGEMRKRRITTSMHVGNTGFIKSWIIPEXLSCMITFHWILTRFVQYXNTVREMIWTSTXNSTNXCRRKRPGPLSCRLXMLXSTXMKXNLP
SYTMTSNQVIFFXXMVQRVERXKLQILVFRRSWMMIATIQWMAWSXHHKVLVLIGIYHQSVLWLGKNHQRSQIKLMCGRWVXSSISVFME
GSLLAITSLSKTSYKRIRFLKLLKCSSRQSQXXHLKQRRLFDDAWPTERRTALMSSSWPVIPTCCLTSESQSLQVALLELLLHQPLGRPI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FBXL20_ENST00000583610_chr17_37499433_-_TLK2_ENST00000582809_chr17_60637377_+_1637nt
ATGAGGAGGGACGTGAACGGAGTGACCAAGAGCAGGTTTGAGATGTTCTCAAATAGTGATGAAGCTGTAATCAATAAAAAACTTCCCAAA
GAACTCCTGTTACGGCCAACTGTGATTTGAGACGGCAGATTGATGAACAGCAAAAGATGCTAGAGAAATACAAGGAACGATTAAATAGAT
GTGTGACAATGAGCAAGAAACTCCTTATAGAAAAGTCAAAACAAGAGAAGATGGCGTGTAGAGATAAGAGCATGCAAGACCGCTTGAGAC
TGGGCCACTTTACTACTGTCCGACACGGAGCCTCATTTACTGAACAGTGGACAGATGGTTATGCTTTTCAGAATCTTATCAAGCAACAGG
AAAGGATAAATTCACAGAGGGAAGAGATAGAAAGACAACGGAAAATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTG
CAACCAATGAGCAGAAACAGCGGAAAAGCAAGACCAATGGAGCTGAAAATGAAACGTTAACGTTAGCAGAATACCATGAACAAGAAGAAA
TCTTCAAACTCAGATTAGGTCATCTTAAAAAGGAGGAAGCAGAGATCCAGGCAGAGCTGGAGAGACTAGAAAGGGTTAGAAATCTACATA
TCAGGGAACTAAAAAGGATACATAATGAAGATAATTCACAATTTAAAGATCATCCAACGCTAAATGACAGATATTTGTTGTTACATCTTT
TGGGTAGAGGAGGTTTCAGTGAAGTTTACAAGGCATTTGATCTAACAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAA
ACTGGAGAGATGAGAAAAAGGAGAATTACCACAAGCATGCATGTAGGGAATACCGGATTCATAAAGAGCTGGATCATCCCAGAATAGTTA
AGCTGTATGATTACTTTTCACTGGATACTGACTCGTTTTGTACAGTATTAGAATACTGTGAGGGAAATGATCTGGACTTCTACCTGAAAC
AGCACAAATTAATGTCGGAGAAAGAGGCCCGGTCCATTATCATGCAGATTGTGAATGCTTTAAAGTACTTAAATGAAATAAAACCTCCCA
TCATACACTATGACCTCAAACCAGGTAATATTCTTTTAGTAAATGGTACAGCGTGTGGAGAGATAAAAATTACAGATTTTGGTCTTTCGA
AGATCATGGATGATGATAGCTACAATTCAGTGGATGGCATGGAGCTAACATCACAAGGTGCTGGTACTTATTGGTATTTACCACCAGAGT
GTTTTGTGGTTGGGAAAGAACCACCAAAGATCTCAAATAAAGTTGATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAA
GGAAGCCTTTTGGCCATAACCAGTCTCAGCAAGACATCCTACAAGAGAATACGATTCTTAAAGCTACTGAAGTGCAGTTCCCGCCAAAGC
CAGTAGTAACACCTGAAGCAAAGGCGTTTATTCGACGATGCTTGGCCTACCGAAAGGAGGACCGCATTGATGTCCAGCAGCTGGCCTGTG
ATCCCTACTTGTTGCCTCACATCCGAAAGTCAGTCTCTACAAGTAGCCCTGCTGGAGCTGCTATTGCATCAACCTCTGGGGCGTCCAATA


* Fusion transcript sequences (Full-length transcript).
>In-frame_FBXL20_ENST00000583610_chr17_37499433_-_TLK2_ENST00000582809_chr17_60637377_+_2990nt
GTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTG
GAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCC
GGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGA
ACGGAGTGACCAAGAGCAGGTTTGAGATGTTCTCAAATAGTGATGAAGCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTGTTACGGC
CAACTGTGATTTGAGACGGCAGATTGATGAACAGCAAAAGATGCTAGAGAAATACAAGGAACGATTAAATAGATGTGTGACAATGAGCAA
GAAACTCCTTATAGAAAAGTCAAAACAAGAGAAGATGGCGTGTAGAGATAAGAGCATGCAAGACCGCTTGAGACTGGGCCACTTTACTAC
TGTCCGACACGGAGCCTCATTTACTGAACAGTGGACAGATGGTTATGCTTTTCAGAATCTTATCAAGCAACAGGAAAGGATAAATTCACA
GAGGGAAGAGATAGAAAGACAACGGAAAATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTGCAACCAATGAGCAGAA
ACAGCGGAAAAGCAAGACCAATGGAGCTGAAAATGAAACGTTAACGTTAGCAGAATACCATGAACAAGAAGAAATCTTCAAACTCAGATT
AGGTCATCTTAAAAAGGAGGAAGCAGAGATCCAGGCAGAGCTGGAGAGACTAGAAAGGGTTAGAAATCTACATATCAGGGAACTAAAAAG
GATACATAATGAAGATAATTCACAATTTAAAGATCATCCAACGCTAAATGACAGATATTTGTTGTTACATCTTTTGGGTAGAGGAGGTTT
CAGTGAAGTTTACAAGGCATTTGATCTAACAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAAACTGGAGAGATGAGAA
AAAGGAGAATTACCACAAGCATGCATGTAGGGAATACCGGATTCATAAAGAGCTGGATCATCCCAGAATAGTTAAGCTGTATGATTACTT
TTCACTGGATACTGACTCGTTTTGTACAGTATTAGAATACTGTGAGGGAAATGATCTGGACTTCTACCTGAAACAGCACAAATTAATGTC
GGAGAAAGAGGCCCGGTCCATTATCATGCAGATTGTGAATGCTTTAAAGTACTTAAATGAAATAAAACCTCCCATCATACACTATGACCT
CAAACCAGGTAATATTCTTTTAGTAAATGGTACAGCGTGTGGAGAGATAAAAATTACAGATTTTGGTCTTTCGAAGATCATGGATGATGA
TAGCTACAATTCAGTGGATGGCATGGAGCTAACATCACAAGGTGCTGGTACTTATTGGTATTTACCACCAGAGTGTTTTGTGGTTGGGAA
AGAACCACCAAAGATCTCAAATAAAGTTGATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAAGGAAGCCTTTTGGCCA
TAACCAGTCTCAGCAAGACATCCTACAAGAGAATACGATTCTTAAAGCTACTGAAGTGCAGTTCCCGCCAAAGCCAGTAGTAACACCTGA
AGCAAAGGCGTTTATTCGACGATGCTTGGCCTACCGAAAGGAGGACCGCATTGATGTCCAGCAGCTGGCCTGTGATCCCTACTTGTTGCC
TCACATCCGAAAGTCAGTCTCTACAAGTAGCCCTGCTGGAGCTGCTATTGCATCAACCTCTGGGGCGTCCAATAACAGTTCTTCTAATTG
AGACTGACTCCAAGGCCACAAACTGTTCAACACACACAAAGTGGACAAATGGCGTTCAGCAGCGGGTTTGGAACATAGCGAATCCGAATG
GATCTGATGAAACCTGTACCAGGTGCTTTTATTTTCTTGCTTTTTTCCCATCCATAGAGCATGACAGCATCGATTCTCATTGAGGAGAAA
CCTTGGGCAGCTCCGGCCAGGCCTTGTAGGAAAAGGCCCCGCCCGAGGTTCCAGCGTCAACGGCCACTGTGTGTGGCTGCTCTGAGTGAG
GAAAAAATTAAAAAGAAAAACTGGTTCCATGTACTGTGAACTTGAAAACTTGCAGACTCAGGGGGGTCCCTGATGCAGTGCTTCAGATGA
AGAATGTGGACTTGAAAATACAGACTGGGCTAGTCCAGTGTCTATATTTAAACTTGTTCTTTTCTTTTAATAAAGTTTAGGTAACATCTC
CTGAAAAGCTTGTAGCACAAAGGCTCAGCTGGGGATGGTGTTTGACTTCGGAGGAAAAAAGTTGCTATTGCCCGTTAAAGGCACTAGAGT
TAGTGTTTTATCCCTAAATAATTTCAATTTTTAAAAACATGCAGCTTCCCTCTCCCCTTTTTTATTTTTGAAAGAATACATTTGGTCATA
AAGTGAAACCCGTATTAGCAAGTACGTGGCAATGTTCATTCCAATCAGATGCAGCTTTCTCCTCCGTCTGGTCTCCTGTTTGCAATTGCT
TCCCTCATCTCAGTAGGGAAAAAATTGAGTGGGAGTACTGAGATGTGTGGGTTTTTGCCATTGGACAAAGAATGAGGTTAGAAGACTGCA
GCTTGGAGTCTCTCTAGGTTTTCAACTATTTCTTCACAATTTGAACACTTGACGGTTGTCCCTTTTAATTTATTTGAAGTGCTATTTTTT
TAAATAAAGGTTCATCTGTCCATGCAGTCCTCTTGGATTCTCTGAATGTAGTAACTATGAAGCTATGCCAAAGGTAGGCAGAAAATGGGC
TTGGGAGCCAGACACTCCAGGGATCAGTAGTTCCTACCCATAGTCTTTGTGTGCTTGCTAAATGGTGTACATTTCTTGTTAACCACGTTA


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FusionGenePPI for FBXL20_TLK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBXL20CUL1, KRAS, YPEL3, PVR, YPEL1, RABGGTBTLK2ASF1B, ASF1A, TLK1, FEZ1, FEZ2, AURKA, IRF4, IRF7, ELAVL1, XPO7, XPO1, RPS6KA1, RFPL3, EID3, LHX6, STK24, NTRK1, DYNLL1, NFATC2, SPATA1, RPS27A, CABIN1, IL36A, DYNLL2, AMOTL1, IFFO1, CDADC1, SCML1, COBLL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXL20_TLK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXL20_TLK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource