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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 13027

FusionGeneSummary for FBL_RYR1

check button Fusion gene summary
Fusion gene informationFusion gene name: FBL_RYR1
Fusion gene ID: 13027
HgeneTgene
Gene symbol

FBL

RYR1

Gene ID

2091

6261

Gene namefibrillarinryanodine receptor 1
SynonymsFIB|FLRN|Nop1|RNU3IP1CCO|MHS|MHS1|PPP1R137|RYDR|RYR|RYR-1|SKRR
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionrRNA 2'-O-methyltransferase fibrillarin34 kDa nucleolar scleroderma antigen34-kD nucleolar scleroderma antigenRNA, U3 small nucleolar interacting protein 1histone-glutamine methyltransferaseryanodine receptor 1central core disease of muscleprotein phosphatase 1, regulatory subunit 137ryanodine receptor 1 (skeletal)sarcoplasmic reticulum calcium release channelskeletal muscle calcium release channelskeletal muscle ryanodine receptortyp
Modification date2018052320180523
UniProtAcc

P22087

P21817

Ensembl transtripts involved in fusion geneENST00000221801, ENST00000593503, 
ENST00000355481, ENST00000360985, 
ENST00000359596, 
Fusion gene scores* DoF score6 X 5 X 4=1208 X 6 X 5=240
# samples 58
** MAII scorelog2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBL [Title/Abstract] AND RYR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBL

GO:1990258

histone glutamine methylation

24352239

TgeneRYR1

GO:0001666

response to hypoxia

19120137


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A19T-01AFBLchr19

40336931

-RYR1chr19

39055599

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000221801ENST00000355481FBLchr19

40336931

-RYR1chr19

39055599

+
In-frameENST00000221801ENST00000360985FBLchr19

40336931

-RYR1chr19

39055599

+
In-frameENST00000221801ENST00000359596FBLchr19

40336931

-RYR1chr19

39055599

+
intron-3CDSENST00000593503ENST00000355481FBLchr19

40336931

-RYR1chr19

39055599

+
intron-3CDSENST00000593503ENST00000360985FBLchr19

40336931

-RYR1chr19

39055599

+
intron-3CDSENST00000593503ENST00000359596FBLchr19

40336931

-RYR1chr19

39055599

+

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FusionProtFeatures for FBL_RYR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBL

P22087

RYR1

P21817

S-adenosyl-L-methionine-dependent methyltransferase thathas the ability to methylate both RNAs and proteins. Involved inpre-rRNA processing by catalyzing the site-specific 2'-hydroxylmethylation of ribose moieties in pre-ribosomal RNA. Sitespecificity is provided by a guide RNA that base pairs with thesubstrate. Methylation occurs at a characteristic distance fromthe sequence involved in base pairing with the guide RNA. Alsoacts as a protein methyltransferase by mediating methylation of'Gln-105' of histone H2A (H2AQ104me), a modification that impairsbinding of the FACT complex and is specifically present at 35Sribosomal DNA locus (PubMed:24352239).{ECO:0000269|PubMed:24352239}. Calcium channel that mediates the release of Ca(2+) fromthe sarcoplasmic reticulum into the cytoplasm and thereby plays akey role in triggering muscle contraction following depolarizationof T-tubules (PubMed:11741831, PubMed:16163667). Repeated veryhigh-level exercise increases the open probability of the channeland leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335).Can also mediate the release of Ca(2+) from intracellular storesin neurons, and may thereby promote prolonged Ca(2+) signaling inthe brain. Required for normal embryonic development of musclefibers and skeletal muscle. Required for normal heartmorphogenesis, skin development and ossification duringembryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0,ECO:0000269|PubMed:18268335, ECO:0000305|PubMed:11741831,ECO:0000305|PubMed:16163667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054462_453242035034Compositional biasNote=Pro-rich
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064462_453242085039Compositional biasNote=Pro-rich
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054462_453242035034Compositional biasNote=Pro-rich
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054881_490042035034IntramembranePore-forming
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064881_490042085039IntramembranePore-forming
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054881_490042035034IntramembranePore-forming
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054895_490142035034MotifSelectivity filter
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064895_490142085039MotifSelectivity filter
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054895_490142035034MotifSelectivity filter
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054210_421442035034Nucleotide bindingATP
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054955_496042035034Nucleotide bindingATP
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054980_498642035034Nucleotide bindingATP
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064210_421442085039Nucleotide bindingATP
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064955_496042085039Nucleotide bindingATP
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064980_498642085039Nucleotide bindingATP
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054210_421442035034Nucleotide bindingATP
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054955_496042035034Nucleotide bindingATP
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054980_498642035034Nucleotide bindingATP
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054581_464142035034Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054663_478042035034Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054804_480442035034Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054822_483642035034Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054858_488042035034Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054901_492042035034Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054942_503842035034Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064581_464142085039Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064663_478042085039Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064804_480442085039Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064822_483642085039Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064858_488042085039Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064901_492042085039Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064942_503842085039Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054581_464142035034Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054663_478042035034Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054804_480442035034Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054822_483642035034Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054858_488042035034Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054901_492042035034Topological domainLumenal
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054942_503842035034Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054560_458042035034TransmembraneHelical%3B Name%3D1
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054642_466242035034TransmembraneHelical%3B Name%3D2
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054781_480342035034TransmembraneHelical%3B Name%3D3
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054805_482142035034TransmembraneHelical%3B Name%3D4
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054837_485742035034TransmembraneHelical%3B Name%3D5
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054921_494142035034TransmembraneHelical%3B Name%3D6
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064560_458042085039TransmembraneHelical%3B Name%3D1
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064642_466242085039TransmembraneHelical%3B Name%3D2
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064781_480342085039TransmembraneHelical%3B Name%3D3
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064805_482142085039TransmembraneHelical%3B Name%3D4
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064837_485742085039TransmembraneHelical%3B Name%3D5
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064921_494142085039TransmembraneHelical%3B Name%3D6
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054560_458042035034TransmembraneHelical%3B Name%3D1
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054642_466242035034TransmembraneHelical%3B Name%3D2
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054781_480342035034TransmembraneHelical%3B Name%3D3
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054805_482142035034TransmembraneHelical%3B Name%3D4
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054837_485742035034TransmembraneHelical%3B Name%3D5
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054921_494142035034TransmembraneHelical%3B Name%3D6

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBLchr19:40336931chr19:39055599ENST00000221801-198_773322Compositional biasNote=DMA/Gly-rich
HgeneFBLchr19:40336931chr19:39055599ENST00000221801-19172_1733322RegionS-adenosyl-L-methionine binding
HgeneFBLchr19:40336931chr19:39055599ENST00000221801-19191_1923322RegionNote=S-adenosyl-L-methionine binding
HgeneFBLchr19:40336931chr19:39055599ENST00000221801-19216_2173322RegionNote=S-adenosyl-L-methionine binding
HgeneFBLchr19:40336931chr19:39055599ENST00000221801-19236_2393322RegionNote=S-adenosyl-L-methionine binding
HgeneFBLchr19:40336931chr19:39055599ENST00000221801-19274_3063322RegionHelical
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881051873_192442035034Compositional biasNote=Glu-rich (acidic)
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891061873_192442085039Compositional biasNote=Glu-rich (acidic)
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881051873_192442035034Compositional biasNote=Glu-rich (acidic)
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881051013_120842035034DomainB30.2/SPRY 2
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881051356_157042035034DomainB30.2/SPRY 3
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+88105159_20442035034DomainMIR 2
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+88105210_26442035034DomainMIR 3
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+88105270_32742035034DomainMIR 4
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+88105335_39242035034DomainMIR 5
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881054074_410242035034DomainEF-hand
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+88105581_79742035034DomainB30.2/SPRY 1
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+8810597_15242035034DomainMIR 1
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891061013_120842085039DomainB30.2/SPRY 2
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891061356_157042085039DomainB30.2/SPRY 3
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+89106159_20442085039DomainMIR 2
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+89106210_26442085039DomainMIR 3
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+89106270_32742085039DomainMIR 4
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+89106335_39242085039DomainMIR 5
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891064074_410242085039DomainEF-hand
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+89106581_79742085039DomainB30.2/SPRY 1
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+8910697_15242085039DomainMIR 1
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881051013_120842035034DomainB30.2/SPRY 2
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881051356_157042035034DomainB30.2/SPRY 3
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+88105159_20442035034DomainMIR 2
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+88105210_26442035034DomainMIR 3
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+88105270_32742035034DomainMIR 4
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+88105335_39242035034DomainMIR 5
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881054074_410242035034DomainEF-hand
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+88105581_79742035034DomainB30.2/SPRY 1
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+8810597_15242035034DomainMIR 1
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+88105841_295942035034RegionNote=6 X approximate repeats
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+89106841_295942085039RegionNote=6 X approximate repeats
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+88105841_295942035034RegionNote=6 X approximate repeats
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881051344_135942035034RepeatNote=3%3B truncated
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881051372_138742035034RepeatNote=4%3B truncated
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881052726_284542035034RepeatNote=5
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881052846_295942035034RepeatNote=6
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+88105841_95442035034RepeatNote=1
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+88105955_106842035034RepeatNote=2
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891061344_135942085039RepeatNote=3%3B truncated
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891061372_138742085039RepeatNote=4%3B truncated
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891062726_284542085039RepeatNote=5
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891062846_295942085039RepeatNote=6
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+89106841_95442085039RepeatNote=1
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+89106955_106842085039RepeatNote=2
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881051344_135942035034RepeatNote=3%3B truncated
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881051372_138742035034RepeatNote=4%3B truncated
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881052726_284542035034RepeatNote=5
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881052846_295942035034RepeatNote=6
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+88105841_95442035034RepeatNote=1
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+88105955_106842035034RepeatNote=2
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881051_455942035034Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891061_455942085039Topological domainCytoplasmic
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881051_455942035034Topological domainCytoplasmic


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FusionGeneSequence for FBL_RYR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FBL_ENST00000221801_chr19_40336931_-_RYR1_ENST00000355481_chr19_39055599_+_834aa
MKPGEGVQAPVHLRRGERGRRGXEDGALREFLRGHHLRDADRRADLGARGRAGDRRGRGRGRGGGGRGRRGGGRGGARGHGGHGGGGGDG
AGCGGRRPGPARPQLPQPAAARAAAAAAYGPRGGHRSGGAALGSSDARWGRWRGGGGGRAGPALGLAVRRRPGGGRQEGDGDRAPGRHAR
PHQRRGARRAAGRAGRRRRRRGCQRGRWRRRGGRWRRGGGGARGRAGRCRRGGGRDRWGPLPARRGWRSRGHGGHDACGTAHTRGLSHPQ
EEIGGGWSGGGAPARARARAGTRAGAGESRCREWGEGRSSRAHTRAPQEASTSLTPSKEGGSWRRILGRTGGAEGEVPELPVPELLHPAV
PCPLLGICHQLHLAVLXGLRLSTRGGRHGRLSCWGCVRCRLWWQLWLGLGGRRGGRGRXGXEHGVLLPGGKHRLHGTRPAVSEPPAYTGG
LSLHHWLXLSQGAPGNLXAGEGAGPEAGVXWPVHHGAAXGRXREGAVGPTGAQHAVFPXQLLGQVCQAQGPGQTWGHLRAGADCXATGHG
PGHTRDHSPQXAQAQPAARAADLAHVHRCQVPDLEVRGHLHRQLLPVPGLVYGDVPLGTLQQLLLCCPSPGHRHGGQDAAHHPVLCHPQW
ETAGDDRGPSGGGRLPVHRGGLQLLPQVLQQERGXGXTXHEVXXHDDVLPVSHVRGCPGWRRHWGRDRGPRGXRIRALQGGLRHHLLLLR
HRHPVGHHPGSDHRRFWXAPRPTRASEGGYGDQVLHLWNRQXLLXYDTAWLRDSHAGGAQPGQLHVFPDVFDKQGXDRTHGSGVLCLEDV

>In-frame_FBL_ENST00000221801_chr19_40336931_-_RYR1_ENST00000360985_chr19_39055599_+_834aa
MKPGEGVQAPVHLRRGERGRRGXEDGALREFLRGHHLRDADRRADLGARGRAGDRRGRGRGRGGGGRGRRGGGRGGARGHGGHGGGGGDG
AGCGGRRPGPARPQLPQPAAARAAAAAAYGPRGGHRSGGAALGSSDARWGRWRGGGGGRAGPALGLAVRRRPGGGRQEGDGDRAPGRHAR
PHQRRGARRAAGRAGRRRRRRGCQRGRWRRRGGRWRRGGGGARGRAGRCRRGGGRDRWGPLPARRGWRSRGHGGHDACGTAHTRGLSHPQ
EEIGGGWSGGGAPARARARAGTRAGAGESRCREWGEGRSSRAHTRAPQEASTSLTPSKEGGSWRRILGRTGGAEGEVPELPVPELLHPAV
PCPLLGICHQLHLAVLXGLRLSTRGGRHGRLSCWGCVRCRLWWQLWLGLGGRRGGRGRXGXEHGVLLPGGKHRLHGTRPAVSEPPAYTGG
LSLHHWLXLSQGAPGNLXAGEGAGPEAGVXWPVHHGAAXGRXREGAVGPTGAQHAVFPXQLLGQVCQAQGPGQTWGHLRAGADCXATGHG
PGHTRDHSPQXAQAQPAARAADLAHVHRCQVPDLEVRGHLHRQLLPVPGLVYGDVPLGTLQQLLLCCPSPGHRHGGQDAAHHPVLCHPQW
ETAGDDRGPSGGGRLPVHRGGLQLLPQVLQQERGXGXTXHEVXXHDDVLPVSHVRGCPGWRRHWGRDRGPRGXRIRALQGGLRHHLLLLR
HRHPVGHHPGSDHRRFWXAPRPTRASEGGYGDQVLHLWNRQXLLXYDTAWLRDSHAGGAQPGQLHVFPDVFDKQGXDRTHGSGVLCLEDV

>In-frame_FBL_ENST00000221801_chr19_40336931_-_RYR1_ENST00000359596_chr19_39055599_+_834aa
MKPGEGVQAPVHLRRGERGRRGXEDGALREFLRGHHLRDADRRADLGARGRAGDRRGRGRGRGGGGRGRRGGGRGGARGHGGHGGGGGDG
AGCGGRRPGPARPQLPQPAAARAAAAAAYGPRGGHRSGGAALGSSDARWGRWRGGGGGRAGPALGLAVRRRPGGGRQEGDGDRAPGRHAR
PHQRRGARRAAGRAGRRRRRRGCQRGRWRRRGGRWRRGGGGARGRAGRCRRGGGRDRWGPLPARRGWRSRGHGGHDACGTAHTRGLSHPQ
EEIGGGWSGGGAPARARARAGTRAGAGESRCREWGEGRSSRAHTRAPQEASTSLTPSKEGGSWRRILGRTGGAEGEVPELPVPELLHPAV
PCPLLGICHQLHLAVLXGLRLSTRGGRHGRLSCWGCVRCRLWWQLWLGLGGRRGGRGRXGXEHGVLLPGGKHRLHGTRPAVSEPPAYTGG
LSLHHWLXLSQGAPGNLXAGEGAGPEAGVXWPVHHGAAXGRXREGAVGPTGAQHAVFPXQLLGQVCQAQGPGQTWGHLRAGADCXATGHG
PGHTRDHSPQXAQAQPAARAADLAHVHRCQVPDLEVRGHLHRQLLPVPGLVYGDVPLGTLQQLLLCCPSPGHRHGGQDAAHHPVLCHPQW
ETAGDDRGPSGGGRLPVHRGGLQLLPQVLQQERGXGXTXHEVXXHDDVLPVSHVRGCPGWRRHWGRDRGPRGXRIRALQGGLRHHLLLLR
HRHPVGHHPGSDHRRFWXAPRPTRASEGGYGDQVLHLWNRQXLLXYDTAWLRDSHAGGAQPGQLHVFPDVFDKQGXDRTHGSGVLCLEDV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FBL_ENST00000221801_chr19_40336931_-_RYR1_ENST00000355481_chr19_39055599_+_2503nt
ATGAAGCCAGGTGAAGGAGTCCAAGCGCCAGTTCATCTTCGACGTGGTGAACGAGGGCGGCGAGGCTGAGAAGATGGAGCTCTTCGTGAG
TTTCTGCGAGGACACCATCTTCGAGATGCAGATCGCCGCGCAGATCTCGGAGCCCGAGGGCGAGCCGGAGACCGACGAGGACGAGGGCGC
GGGCGCGGCGGAGGCGGGCGCGGAAGGCGCGGAGGAGGGCGCGGCGGGGCTCGAGGGCACGGCGGCCACGGCGGCGGCGGGGGCGACGGC
GCGGGTTGTGGCGGCCGCAGGCCGGGCCCTGCGAGGCCTCAGCTACCGCAGCCTGCGGCGGCGCGTGCGGCGGCTGCGGCGGCTTACGGC
CCGCGAGGCGGCCACCGCAGTGGCGGCGCTGCTCTGGGCAGCAGTGACGCGCGCTGGGGCCGCTGGCGCGGGGGCGGCGGCGGGCGCGCT
GGGCCTGCTCTGGGGCTCGCTGTTCGGCGGCGGCCTGGTGGAGGGCGCCAAGAAGGTGACGGTGACCGAGCTCCTGGCAGGCATGCCCGA
CCCCACCAGCGACGAGGTGCACGGCGAGCAGCCGGCCGGGCCGGGCGGAGACGCAGACGGCGAGGGTGCCAGCGAGGGCGCTGGAGACGC
CGCGGAGGGCGCTGGAGACGAGGAGGAGGCGGTGCACGAGGCCGGGCCGGGCGGTGCCGACGGGGCGGTGGCCGTGACCGATGGGGGCCC
CTTCCGGCCCGAAGGGGCTGGCGGTCTCGGGGACATGGGGGACACGACGCCTGCGGAACCGCCCACACCCGAGGGCTCTCCCATCCTCAA
GAGGAAATTGGGGGTGGATGGAGTGGAGGAGGAGCTCCCGCCAGAGCCAGAGCCCGAGCCGGAACCAGAGCTGGAGCCGGAGAAAGCCGA
TGCCGAGAATGGGGAGAAGGAAGAAGTTCCCGAGCCCACACCAGAGCCCCCCAAGAAGCAAGCACCTCCCTCACCCCCTCCAAAGAAGGA
GGAAGCTGGAGGCGAATTCTGGGGAGAACTGGAGGTGCAGAGGGTGAAGTTCCTGAACTACCTGTCCCGGAACTTTTACACCCTGCGGTT
CCTTGCCCTCTTCTTGGCATTTGCCATCAACTTCATCTTGCTGTTTTATAAGGTCTCAGACTCTCCACCAGGGGAGGACGACATGGAAGG
CTCAGCTGCTGGGGATGTGTCAGGTGCAGGCTCTGGTGGCAGCTCTGGCTGGGGCTTGGGGGCCGGAGAGGAGGCAGAGGGCGATGAGGA
TGAGAACATGGTGTACTACTTCCTGGAGGAAAGCACAGGCTACATGGAACCCGCCCTGCGGTGTCTGAGCCTCCTGCATACACTGGTGGC
CTTTCTCTGCATCATTGGCTATAATTGTCTCAAGGTGCCCCTGGTAATCTTTAAGCGGGAGAAGGAGCTGGCCCGGAAGCTGGAGTTTGA
TGGCCTGTACATCACGGAGCAGCCTGAGGACGATGACGTGAAGGGGCAGTGGGACCGACTGGTGCTCAACACGCCGTCTTTCCCTAGCAA
CTACTGGGACAAGTTTGTCAAGCGCAAGGTCCTGGACAAACATGGGGACATCTACGGGCGGGAGCGGATTGCTGAGCTACTGGGCATGGA
CCTGGCCACACTAGAGATCACAGCCCACAATGAGCGCAAGCCCAACCCGCCGCCAGGGCTGCTGACCTGGCTCATGTCCATCGATGTCAA
GTACCAGATCTGGAAGTTCGGGGTCATCTTCACAGACAACTCCTTCCTGTACCTGGGCTGGTATATGGTGATGTCCCTCTTGGGACACTA
CAACAACTTCTTCTTTGCTGCCCATCTCCTGGACATCGCCATGGGGGTCAAGACGCTGCGCACCATCCTGTCCTCTGTCACCCACAATGG
GAAACAGCTGGTGATGACCGTGGGCCTTCTGGCGGTGGTCGTCTACCTGTACACCGTGGTGGCCTTCAACTTCTTCCGCAAGTTCTACAA
CAAGAGCGAGGATGAGGATGAACCTGACATGAAGTGTGATGACATGATGACGTGTTACCTGTTTCACATGTACGTGGGTGTCCGGGCTGG
CGGAGGCATTGGGGACGAGATCGAGGACCCCGCGGGTGACGAATACGAGCTCTACAGGGTGGTCTTCGACATCACCTTCTTCTTCTTCGT
CATCGTCATCCTGTTGGCCATCATCCAGGGTCTGATCATCGACGCTTTTGGTGAGCTCCGAGACCAACAAGAGCAAGTGAAGGAGGATAT
GGAGACCAAGTGCTTCATCTGTGGAATCGGCAGTGACTACTTTGATACGACACCGCATGGCTTCGAGACTCACACGCTGGAGGAGCACAA
CCTGGCCAATTACATGTTTTTCCTGATGTATTTGATAAACAAGGATGAGACAGAACACACGGGTCAGGAGTCTTATGTCTGGAAGATGTA

>In-frame_FBL_ENST00000221801_chr19_40336931_-_RYR1_ENST00000360985_chr19_39055599_+_2503nt
ATGAAGCCAGGTGAAGGAGTCCAAGCGCCAGTTCATCTTCGACGTGGTGAACGAGGGCGGCGAGGCTGAGAAGATGGAGCTCTTCGTGAG
TTTCTGCGAGGACACCATCTTCGAGATGCAGATCGCCGCGCAGATCTCGGAGCCCGAGGGCGAGCCGGAGACCGACGAGGACGAGGGCGC
GGGCGCGGCGGAGGCGGGCGCGGAAGGCGCGGAGGAGGGCGCGGCGGGGCTCGAGGGCACGGCGGCCACGGCGGCGGCGGGGGCGACGGC
GCGGGTTGTGGCGGCCGCAGGCCGGGCCCTGCGAGGCCTCAGCTACCGCAGCCTGCGGCGGCGCGTGCGGCGGCTGCGGCGGCTTACGGC
CCGCGAGGCGGCCACCGCAGTGGCGGCGCTGCTCTGGGCAGCAGTGACGCGCGCTGGGGCCGCTGGCGCGGGGGCGGCGGCGGGCGCGCT
GGGCCTGCTCTGGGGCTCGCTGTTCGGCGGCGGCCTGGTGGAGGGCGCCAAGAAGGTGACGGTGACCGAGCTCCTGGCAGGCATGCCCGA
CCCCACCAGCGACGAGGTGCACGGCGAGCAGCCGGCCGGGCCGGGCGGAGACGCAGACGGCGAGGGTGCCAGCGAGGGCGCTGGAGACGC
CGCGGAGGGCGCTGGAGACGAGGAGGAGGCGGTGCACGAGGCCGGGCCGGGCGGTGCCGACGGGGCGGTGGCCGTGACCGATGGGGGCCC
CTTCCGGCCCGAAGGGGCTGGCGGTCTCGGGGACATGGGGGACACGACGCCTGCGGAACCGCCCACACCCGAGGGCTCTCCCATCCTCAA
GAGGAAATTGGGGGTGGATGGAGTGGAGGAGGAGCTCCCGCCAGAGCCAGAGCCCGAGCCGGAACCAGAGCTGGAGCCGGAGAAAGCCGA
TGCCGAGAATGGGGAGAAGGAAGAAGTTCCCGAGCCCACACCAGAGCCCCCCAAGAAGCAAGCACCTCCCTCACCCCCTCCAAAGAAGGA
GGAAGCTGGAGGCGAATTCTGGGGAGAACTGGAGGTGCAGAGGGTGAAGTTCCTGAACTACCTGTCCCGGAACTTTTACACCCTGCGGTT
CCTTGCCCTCTTCTTGGCATTTGCCATCAACTTCATCTTGCTGTTTTATAAGGTCTCAGACTCTCCACCAGGGGAGGACGACATGGAAGG
CTCAGCTGCTGGGGATGTGTCAGGTGCAGGCTCTGGTGGCAGCTCTGGCTGGGGCTTGGGGGCCGGAGAGGAGGCAGAGGGCGATGAGGA
TGAGAACATGGTGTACTACTTCCTGGAGGAAAGCACAGGCTACATGGAACCCGCCCTGCGGTGTCTGAGCCTCCTGCATACACTGGTGGC
CTTTCTCTGCATCATTGGCTATAATTGTCTCAAGGTGCCCCTGGTAATCTTTAAGCGGGAGAAGGAGCTGGCCCGGAAGCTGGAGTTTGA
TGGCCTGTACATCACGGAGCAGCCTGAGGACGATGACGTGAAGGGGCAGTGGGACCGACTGGTGCTCAACACGCCGTCTTTCCCTAGCAA
CTACTGGGACAAGTTTGTCAAGCGCAAGGTCCTGGACAAACATGGGGACATCTACGGGCGGGAGCGGATTGCTGAGCTACTGGGCATGGA
CCTGGCCACACTAGAGATCACAGCCCACAATGAGCGCAAGCCCAACCCGCCGCCAGGGCTGCTGACCTGGCTCATGTCCATCGATGTCAA
GTACCAGATCTGGAAGTTCGGGGTCATCTTCACAGACAACTCCTTCCTGTACCTGGGCTGGTATATGGTGATGTCCCTCTTGGGACACTA
CAACAACTTCTTCTTTGCTGCCCATCTCCTGGACATCGCCATGGGGGTCAAGACGCTGCGCACCATCCTGTCCTCTGTCACCCACAATGG
GAAACAGCTGGTGATGACCGTGGGCCTTCTGGCGGTGGTCGTCTACCTGTACACCGTGGTGGCCTTCAACTTCTTCCGCAAGTTCTACAA
CAAGAGCGAGGATGAGGATGAACCTGACATGAAGTGTGATGACATGATGACGTGTTACCTGTTTCACATGTACGTGGGTGTCCGGGCTGG
CGGAGGCATTGGGGACGAGATCGAGGACCCCGCGGGTGACGAATACGAGCTCTACAGGGTGGTCTTCGACATCACCTTCTTCTTCTTCGT
CATCGTCATCCTGTTGGCCATCATCCAGGGTCTGATCATCGACGCTTTTGGTGAGCTCCGAGACCAACAAGAGCAAGTGAAGGAGGATAT
GGAGACCAAGTGCTTCATCTGTGGAATCGGCAGTGACTACTTTGATACGACACCGCATGGCTTCGAGACTCACACGCTGGAGGAGCACAA
CCTGGCCAATTACATGTTTTTCCTGATGTATTTGATAAACAAGGATGAGACAGAACACACGGGTCAGGAGTCTTATGTCTGGAAGATGTA

>In-frame_FBL_ENST00000221801_chr19_40336931_-_RYR1_ENST00000359596_chr19_39055599_+_2503nt
ATGAAGCCAGGTGAAGGAGTCCAAGCGCCAGTTCATCTTCGACGTGGTGAACGAGGGCGGCGAGGCTGAGAAGATGGAGCTCTTCGTGAG
TTTCTGCGAGGACACCATCTTCGAGATGCAGATCGCCGCGCAGATCTCGGAGCCCGAGGGCGAGCCGGAGACCGACGAGGACGAGGGCGC
GGGCGCGGCGGAGGCGGGCGCGGAAGGCGCGGAGGAGGGCGCGGCGGGGCTCGAGGGCACGGCGGCCACGGCGGCGGCGGGGGCGACGGC
GCGGGTTGTGGCGGCCGCAGGCCGGGCCCTGCGAGGCCTCAGCTACCGCAGCCTGCGGCGGCGCGTGCGGCGGCTGCGGCGGCTTACGGC
CCGCGAGGCGGCCACCGCAGTGGCGGCGCTGCTCTGGGCAGCAGTGACGCGCGCTGGGGCCGCTGGCGCGGGGGCGGCGGCGGGCGCGCT
GGGCCTGCTCTGGGGCTCGCTGTTCGGCGGCGGCCTGGTGGAGGGCGCCAAGAAGGTGACGGTGACCGAGCTCCTGGCAGGCATGCCCGA
CCCCACCAGCGACGAGGTGCACGGCGAGCAGCCGGCCGGGCCGGGCGGAGACGCAGACGGCGAGGGTGCCAGCGAGGGCGCTGGAGACGC
CGCGGAGGGCGCTGGAGACGAGGAGGAGGCGGTGCACGAGGCCGGGCCGGGCGGTGCCGACGGGGCGGTGGCCGTGACCGATGGGGGCCC
CTTCCGGCCCGAAGGGGCTGGCGGTCTCGGGGACATGGGGGACACGACGCCTGCGGAACCGCCCACACCCGAGGGCTCTCCCATCCTCAA
GAGGAAATTGGGGGTGGATGGAGTGGAGGAGGAGCTCCCGCCAGAGCCAGAGCCCGAGCCGGAACCAGAGCTGGAGCCGGAGAAAGCCGA
TGCCGAGAATGGGGAGAAGGAAGAAGTTCCCGAGCCCACACCAGAGCCCCCCAAGAAGCAAGCACCTCCCTCACCCCCTCCAAAGAAGGA
GGAAGCTGGAGGCGAATTCTGGGGAGAACTGGAGGTGCAGAGGGTGAAGTTCCTGAACTACCTGTCCCGGAACTTTTACACCCTGCGGTT
CCTTGCCCTCTTCTTGGCATTTGCCATCAACTTCATCTTGCTGTTTTATAAGGTCTCAGACTCTCCACCAGGGGAGGACGACATGGAAGG
CTCAGCTGCTGGGGATGTGTCAGGTGCAGGCTCTGGTGGCAGCTCTGGCTGGGGCTTGGGGGCCGGAGAGGAGGCAGAGGGCGATGAGGA
TGAGAACATGGTGTACTACTTCCTGGAGGAAAGCACAGGCTACATGGAACCCGCCCTGCGGTGTCTGAGCCTCCTGCATACACTGGTGGC
CTTTCTCTGCATCATTGGCTATAATTGTCTCAAGGTGCCCCTGGTAATCTTTAAGCGGGAGAAGGAGCTGGCCCGGAAGCTGGAGTTTGA
TGGCCTGTACATCACGGAGCAGCCTGAGGACGATGACGTGAAGGGGCAGTGGGACCGACTGGTGCTCAACACGCCGTCTTTCCCTAGCAA
CTACTGGGACAAGTTTGTCAAGCGCAAGGTCCTGGACAAACATGGGGACATCTACGGGCGGGAGCGGATTGCTGAGCTACTGGGCATGGA
CCTGGCCACACTAGAGATCACAGCCCACAATGAGCGCAAGCCCAACCCGCCGCCAGGGCTGCTGACCTGGCTCATGTCCATCGATGTCAA
GTACCAGATCTGGAAGTTCGGGGTCATCTTCACAGACAACTCCTTCCTGTACCTGGGCTGGTATATGGTGATGTCCCTCTTGGGACACTA
CAACAACTTCTTCTTTGCTGCCCATCTCCTGGACATCGCCATGGGGGTCAAGACGCTGCGCACCATCCTGTCCTCTGTCACCCACAATGG
GAAACAGCTGGTGATGACCGTGGGCCTTCTGGCGGTGGTCGTCTACCTGTACACCGTGGTGGCCTTCAACTTCTTCCGCAAGTTCTACAA
CAAGAGCGAGGATGAGGATGAACCTGACATGAAGTGTGATGACATGATGACGTGTTACCTGTTTCACATGTACGTGGGTGTCCGGGCTGG
CGGAGGCATTGGGGACGAGATCGAGGACCCCGCGGGTGACGAATACGAGCTCTACAGGGTGGTCTTCGACATCACCTTCTTCTTCTTCGT
CATCGTCATCCTGTTGGCCATCATCCAGGGTCTGATCATCGACGCTTTTGGTGAGCTCCGAGACCAACAAGAGCAAGTGAAGGAGGATAT
GGAGACCAAGTGCTTCATCTGTGGAATCGGCAGTGACTACTTTGATACGACACCGCATGGCTTCGAGACTCACACGCTGGAGGAGCACAA
CCTGGCCAATTACATGTTTTTCCTGATGTATTTGATAAACAAGGATGAGACAGAACACACGGGTCAGGAGTCTTATGTCTGGAAGATGTA


* Fusion transcript sequences (Full-length transcript).
>In-frame_FBL_ENST00000221801_chr19_40336931_-_RYR1_ENST00000355481_chr19_39055599_+_2761nt
GCGTCACGCAGCGCACGTCGCCGCGCGCCTGCGCTCTTTTCCACGTGCGAAAGCCCCGGACTCGTGGAGTTGTGAACGCCGCGGACTCCG
GAGCCGCACAAACCAGGGCTCGCCATGAAGCCAGGTGAAGGAGTCCAAGCGCCAGTTCATCTTCGACGTGGTGAACGAGGGCGGCGAGGC
TGAGAAGATGGAGCTCTTCGTGAGTTTCTGCGAGGACACCATCTTCGAGATGCAGATCGCCGCGCAGATCTCGGAGCCCGAGGGCGAGCC
GGAGACCGACGAGGACGAGGGCGCGGGCGCGGCGGAGGCGGGCGCGGAAGGCGCGGAGGAGGGCGCGGCGGGGCTCGAGGGCACGGCGGC
CACGGCGGCGGCGGGGGCGACGGCGCGGGTTGTGGCGGCCGCAGGCCGGGCCCTGCGAGGCCTCAGCTACCGCAGCCTGCGGCGGCGCGT
GCGGCGGCTGCGGCGGCTTACGGCCCGCGAGGCGGCCACCGCAGTGGCGGCGCTGCTCTGGGCAGCAGTGACGCGCGCTGGGGCCGCTGG
CGCGGGGGCGGCGGCGGGCGCGCTGGGCCTGCTCTGGGGCTCGCTGTTCGGCGGCGGCCTGGTGGAGGGCGCCAAGAAGGTGACGGTGAC
CGAGCTCCTGGCAGGCATGCCCGACCCCACCAGCGACGAGGTGCACGGCGAGCAGCCGGCCGGGCCGGGCGGAGACGCAGACGGCGAGGG
TGCCAGCGAGGGCGCTGGAGACGCCGCGGAGGGCGCTGGAGACGAGGAGGAGGCGGTGCACGAGGCCGGGCCGGGCGGTGCCGACGGGGC
GGTGGCCGTGACCGATGGGGGCCCCTTCCGGCCCGAAGGGGCTGGCGGTCTCGGGGACATGGGGGACACGACGCCTGCGGAACCGCCCAC
ACCCGAGGGCTCTCCCATCCTCAAGAGGAAATTGGGGGTGGATGGAGTGGAGGAGGAGCTCCCGCCAGAGCCAGAGCCCGAGCCGGAACC
AGAGCTGGAGCCGGAGAAAGCCGATGCCGAGAATGGGGAGAAGGAAGAAGTTCCCGAGCCCACACCAGAGCCCCCCAAGAAGCAAGCACC
TCCCTCACCCCCTCCAAAGAAGGAGGAAGCTGGAGGCGAATTCTGGGGAGAACTGGAGGTGCAGAGGGTGAAGTTCCTGAACTACCTGTC
CCGGAACTTTTACACCCTGCGGTTCCTTGCCCTCTTCTTGGCATTTGCCATCAACTTCATCTTGCTGTTTTATAAGGTCTCAGACTCTCC
ACCAGGGGAGGACGACATGGAAGGCTCAGCTGCTGGGGATGTGTCAGGTGCAGGCTCTGGTGGCAGCTCTGGCTGGGGCTTGGGGGCCGG
AGAGGAGGCAGAGGGCGATGAGGATGAGAACATGGTGTACTACTTCCTGGAGGAAAGCACAGGCTACATGGAACCCGCCCTGCGGTGTCT
GAGCCTCCTGCATACACTGGTGGCCTTTCTCTGCATCATTGGCTATAATTGTCTCAAGGTGCCCCTGGTAATCTTTAAGCGGGAGAAGGA
GCTGGCCCGGAAGCTGGAGTTTGATGGCCTGTACATCACGGAGCAGCCTGAGGACGATGACGTGAAGGGGCAGTGGGACCGACTGGTGCT
CAACACGCCGTCTTTCCCTAGCAACTACTGGGACAAGTTTGTCAAGCGCAAGGTCCTGGACAAACATGGGGACATCTACGGGCGGGAGCG
GATTGCTGAGCTACTGGGCATGGACCTGGCCACACTAGAGATCACAGCCCACAATGAGCGCAAGCCCAACCCGCCGCCAGGGCTGCTGAC
CTGGCTCATGTCCATCGATGTCAAGTACCAGATCTGGAAGTTCGGGGTCATCTTCACAGACAACTCCTTCCTGTACCTGGGCTGGTATAT
GGTGATGTCCCTCTTGGGACACTACAACAACTTCTTCTTTGCTGCCCATCTCCTGGACATCGCCATGGGGGTCAAGACGCTGCGCACCAT
CCTGTCCTCTGTCACCCACAATGGGAAACAGCTGGTGATGACCGTGGGCCTTCTGGCGGTGGTCGTCTACCTGTACACCGTGGTGGCCTT
CAACTTCTTCCGCAAGTTCTACAACAAGAGCGAGGATGAGGATGAACCTGACATGAAGTGTGATGACATGATGACGTGTTACCTGTTTCA
CATGTACGTGGGTGTCCGGGCTGGCGGAGGCATTGGGGACGAGATCGAGGACCCCGCGGGTGACGAATACGAGCTCTACAGGGTGGTCTT
CGACATCACCTTCTTCTTCTTCGTCATCGTCATCCTGTTGGCCATCATCCAGGGTCTGATCATCGACGCTTTTGGTGAGCTCCGAGACCA
ACAAGAGCAAGTGAAGGAGGATATGGAGACCAAGTGCTTCATCTGTGGAATCGGCAGTGACTACTTTGATACGACACCGCATGGCTTCGA
GACTCACACGCTGGAGGAGCACAACCTGGCCAATTACATGTTTTTCCTGATGTATTTGATAAACAAGGATGAGACAGAACACACGGGTCA
GGAGTCTTATGTCTGGAAGATGTACCAAGAGAGATGTTGGGATTTCTTCCCAGCTGGTGATTGTTTCCGTAAGCAGTATGAGGACCAGCT
TAGCTGACACACCCCCAGCTGGCCCTCCACCCCCACCTCAAGTGCCTTATTCTCACAGCAAGCCCCTTAGTCCCCAAGCCCCTCCCCCTA

>In-frame_FBL_ENST00000221801_chr19_40336931_-_RYR1_ENST00000360985_chr19_39055599_+_2761nt
GCGTCACGCAGCGCACGTCGCCGCGCGCCTGCGCTCTTTTCCACGTGCGAAAGCCCCGGACTCGTGGAGTTGTGAACGCCGCGGACTCCG
GAGCCGCACAAACCAGGGCTCGCCATGAAGCCAGGTGAAGGAGTCCAAGCGCCAGTTCATCTTCGACGTGGTGAACGAGGGCGGCGAGGC
TGAGAAGATGGAGCTCTTCGTGAGTTTCTGCGAGGACACCATCTTCGAGATGCAGATCGCCGCGCAGATCTCGGAGCCCGAGGGCGAGCC
GGAGACCGACGAGGACGAGGGCGCGGGCGCGGCGGAGGCGGGCGCGGAAGGCGCGGAGGAGGGCGCGGCGGGGCTCGAGGGCACGGCGGC
CACGGCGGCGGCGGGGGCGACGGCGCGGGTTGTGGCGGCCGCAGGCCGGGCCCTGCGAGGCCTCAGCTACCGCAGCCTGCGGCGGCGCGT
GCGGCGGCTGCGGCGGCTTACGGCCCGCGAGGCGGCCACCGCAGTGGCGGCGCTGCTCTGGGCAGCAGTGACGCGCGCTGGGGCCGCTGG
CGCGGGGGCGGCGGCGGGCGCGCTGGGCCTGCTCTGGGGCTCGCTGTTCGGCGGCGGCCTGGTGGAGGGCGCCAAGAAGGTGACGGTGAC
CGAGCTCCTGGCAGGCATGCCCGACCCCACCAGCGACGAGGTGCACGGCGAGCAGCCGGCCGGGCCGGGCGGAGACGCAGACGGCGAGGG
TGCCAGCGAGGGCGCTGGAGACGCCGCGGAGGGCGCTGGAGACGAGGAGGAGGCGGTGCACGAGGCCGGGCCGGGCGGTGCCGACGGGGC
GGTGGCCGTGACCGATGGGGGCCCCTTCCGGCCCGAAGGGGCTGGCGGTCTCGGGGACATGGGGGACACGACGCCTGCGGAACCGCCCAC
ACCCGAGGGCTCTCCCATCCTCAAGAGGAAATTGGGGGTGGATGGAGTGGAGGAGGAGCTCCCGCCAGAGCCAGAGCCCGAGCCGGAACC
AGAGCTGGAGCCGGAGAAAGCCGATGCCGAGAATGGGGAGAAGGAAGAAGTTCCCGAGCCCACACCAGAGCCCCCCAAGAAGCAAGCACC
TCCCTCACCCCCTCCAAAGAAGGAGGAAGCTGGAGGCGAATTCTGGGGAGAACTGGAGGTGCAGAGGGTGAAGTTCCTGAACTACCTGTC
CCGGAACTTTTACACCCTGCGGTTCCTTGCCCTCTTCTTGGCATTTGCCATCAACTTCATCTTGCTGTTTTATAAGGTCTCAGACTCTCC
ACCAGGGGAGGACGACATGGAAGGCTCAGCTGCTGGGGATGTGTCAGGTGCAGGCTCTGGTGGCAGCTCTGGCTGGGGCTTGGGGGCCGG
AGAGGAGGCAGAGGGCGATGAGGATGAGAACATGGTGTACTACTTCCTGGAGGAAAGCACAGGCTACATGGAACCCGCCCTGCGGTGTCT
GAGCCTCCTGCATACACTGGTGGCCTTTCTCTGCATCATTGGCTATAATTGTCTCAAGGTGCCCCTGGTAATCTTTAAGCGGGAGAAGGA
GCTGGCCCGGAAGCTGGAGTTTGATGGCCTGTACATCACGGAGCAGCCTGAGGACGATGACGTGAAGGGGCAGTGGGACCGACTGGTGCT
CAACACGCCGTCTTTCCCTAGCAACTACTGGGACAAGTTTGTCAAGCGCAAGGTCCTGGACAAACATGGGGACATCTACGGGCGGGAGCG
GATTGCTGAGCTACTGGGCATGGACCTGGCCACACTAGAGATCACAGCCCACAATGAGCGCAAGCCCAACCCGCCGCCAGGGCTGCTGAC
CTGGCTCATGTCCATCGATGTCAAGTACCAGATCTGGAAGTTCGGGGTCATCTTCACAGACAACTCCTTCCTGTACCTGGGCTGGTATAT
GGTGATGTCCCTCTTGGGACACTACAACAACTTCTTCTTTGCTGCCCATCTCCTGGACATCGCCATGGGGGTCAAGACGCTGCGCACCAT
CCTGTCCTCTGTCACCCACAATGGGAAACAGCTGGTGATGACCGTGGGCCTTCTGGCGGTGGTCGTCTACCTGTACACCGTGGTGGCCTT
CAACTTCTTCCGCAAGTTCTACAACAAGAGCGAGGATGAGGATGAACCTGACATGAAGTGTGATGACATGATGACGTGTTACCTGTTTCA
CATGTACGTGGGTGTCCGGGCTGGCGGAGGCATTGGGGACGAGATCGAGGACCCCGCGGGTGACGAATACGAGCTCTACAGGGTGGTCTT
CGACATCACCTTCTTCTTCTTCGTCATCGTCATCCTGTTGGCCATCATCCAGGGTCTGATCATCGACGCTTTTGGTGAGCTCCGAGACCA
ACAAGAGCAAGTGAAGGAGGATATGGAGACCAAGTGCTTCATCTGTGGAATCGGCAGTGACTACTTTGATACGACACCGCATGGCTTCGA
GACTCACACGCTGGAGGAGCACAACCTGGCCAATTACATGTTTTTCCTGATGTATTTGATAAACAAGGATGAGACAGAACACACGGGTCA
GGAGTCTTATGTCTGGAAGATGTACCAAGAGAGATGTTGGGATTTCTTCCCAGCTGGTGATTGTTTCCGTAAGCAGTATGAGGACCAGCT
TAGCTGACACACCCCCAGCTGGCCCTCCACCCCCACCTCAAGTGCCTTATTCTCACAGCAAGCCCCTTAGTCCCCAAGCCCCTCCCCCTA

>In-frame_FBL_ENST00000221801_chr19_40336931_-_RYR1_ENST00000359596_chr19_39055599_+_2617nt
GCGTCACGCAGCGCACGTCGCCGCGCGCCTGCGCTCTTTTCCACGTGCGAAAGCCCCGGACTCGTGGAGTTGTGAACGCCGCGGACTCCG
GAGCCGCACAAACCAGGGCTCGCCATGAAGCCAGGTGAAGGAGTCCAAGCGCCAGTTCATCTTCGACGTGGTGAACGAGGGCGGCGAGGC
TGAGAAGATGGAGCTCTTCGTGAGTTTCTGCGAGGACACCATCTTCGAGATGCAGATCGCCGCGCAGATCTCGGAGCCCGAGGGCGAGCC
GGAGACCGACGAGGACGAGGGCGCGGGCGCGGCGGAGGCGGGCGCGGAAGGCGCGGAGGAGGGCGCGGCGGGGCTCGAGGGCACGGCGGC
CACGGCGGCGGCGGGGGCGACGGCGCGGGTTGTGGCGGCCGCAGGCCGGGCCCTGCGAGGCCTCAGCTACCGCAGCCTGCGGCGGCGCGT
GCGGCGGCTGCGGCGGCTTACGGCCCGCGAGGCGGCCACCGCAGTGGCGGCGCTGCTCTGGGCAGCAGTGACGCGCGCTGGGGCCGCTGG
CGCGGGGGCGGCGGCGGGCGCGCTGGGCCTGCTCTGGGGCTCGCTGTTCGGCGGCGGCCTGGTGGAGGGCGCCAAGAAGGTGACGGTGAC
CGAGCTCCTGGCAGGCATGCCCGACCCCACCAGCGACGAGGTGCACGGCGAGCAGCCGGCCGGGCCGGGCGGAGACGCAGACGGCGAGGG
TGCCAGCGAGGGCGCTGGAGACGCCGCGGAGGGCGCTGGAGACGAGGAGGAGGCGGTGCACGAGGCCGGGCCGGGCGGTGCCGACGGGGC
GGTGGCCGTGACCGATGGGGGCCCCTTCCGGCCCGAAGGGGCTGGCGGTCTCGGGGACATGGGGGACACGACGCCTGCGGAACCGCCCAC
ACCCGAGGGCTCTCCCATCCTCAAGAGGAAATTGGGGGTGGATGGAGTGGAGGAGGAGCTCCCGCCAGAGCCAGAGCCCGAGCCGGAACC
AGAGCTGGAGCCGGAGAAAGCCGATGCCGAGAATGGGGAGAAGGAAGAAGTTCCCGAGCCCACACCAGAGCCCCCCAAGAAGCAAGCACC
TCCCTCACCCCCTCCAAAGAAGGAGGAAGCTGGAGGCGAATTCTGGGGAGAACTGGAGGTGCAGAGGGTGAAGTTCCTGAACTACCTGTC
CCGGAACTTTTACACCCTGCGGTTCCTTGCCCTCTTCTTGGCATTTGCCATCAACTTCATCTTGCTGTTTTATAAGGTCTCAGACTCTCC
ACCAGGGGAGGACGACATGGAAGGCTCAGCTGCTGGGGATGTGTCAGGTGCAGGCTCTGGTGGCAGCTCTGGCTGGGGCTTGGGGGCCGG
AGAGGAGGCAGAGGGCGATGAGGATGAGAACATGGTGTACTACTTCCTGGAGGAAAGCACAGGCTACATGGAACCCGCCCTGCGGTGTCT
GAGCCTCCTGCATACACTGGTGGCCTTTCTCTGCATCATTGGCTATAATTGTCTCAAGGTGCCCCTGGTAATCTTTAAGCGGGAGAAGGA
GCTGGCCCGGAAGCTGGAGTTTGATGGCCTGTACATCACGGAGCAGCCTGAGGACGATGACGTGAAGGGGCAGTGGGACCGACTGGTGCT
CAACACGCCGTCTTTCCCTAGCAACTACTGGGACAAGTTTGTCAAGCGCAAGGTCCTGGACAAACATGGGGACATCTACGGGCGGGAGCG
GATTGCTGAGCTACTGGGCATGGACCTGGCCACACTAGAGATCACAGCCCACAATGAGCGCAAGCCCAACCCGCCGCCAGGGCTGCTGAC
CTGGCTCATGTCCATCGATGTCAAGTACCAGATCTGGAAGTTCGGGGTCATCTTCACAGACAACTCCTTCCTGTACCTGGGCTGGTATAT
GGTGATGTCCCTCTTGGGACACTACAACAACTTCTTCTTTGCTGCCCATCTCCTGGACATCGCCATGGGGGTCAAGACGCTGCGCACCAT
CCTGTCCTCTGTCACCCACAATGGGAAACAGCTGGTGATGACCGTGGGCCTTCTGGCGGTGGTCGTCTACCTGTACACCGTGGTGGCCTT
CAACTTCTTCCGCAAGTTCTACAACAAGAGCGAGGATGAGGATGAACCTGACATGAAGTGTGATGACATGATGACGTGTTACCTGTTTCA
CATGTACGTGGGTGTCCGGGCTGGCGGAGGCATTGGGGACGAGATCGAGGACCCCGCGGGTGACGAATACGAGCTCTACAGGGTGGTCTT
CGACATCACCTTCTTCTTCTTCGTCATCGTCATCCTGTTGGCCATCATCCAGGGTCTGATCATCGACGCTTTTGGTGAGCTCCGAGACCA
ACAAGAGCAAGTGAAGGAGGATATGGAGACCAAGTGCTTCATCTGTGGAATCGGCAGTGACTACTTTGATACGACACCGCATGGCTTCGA
GACTCACACGCTGGAGGAGCACAACCTGGCCAATTACATGTTTTTCCTGATGTATTTGATAAACAAGGATGAGACAGAACACACGGGTCA
GGAGTCTTATGTCTGGAAGATGTACCAAGAGAGATGTTGGGATTTCTTCCCAGCTGGTGATTGTTTCCGTAAGCAGTATGAGGACCAGCT


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FusionGenePPI for FBL_RYR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBLBAK1, ARRB2, RIOK3, PASK, DDX56, CDK2, RTCA, CD40, PRMT5, PRMT1, C1QBP, TUBA3C, TUBB1, MCRS1, NOP2, TBC1D17, SMN1, GEMIN2, DDX20, GEMIN4, PIN4, DDX5, MEPCE, MGMT, PRMT3, PRMT6, CENPA, H3F3A, NOP56, RUVBL2, RUVBL1, PIH1D1, KLF6, TAF9, UBC, MYC, TOP1, HDGF, SIRT7, TCF3, CUL3, COPS5, NAF1, DKC1, RPL6, RPS13, RPS11, NOP58, RPL4, NHP2L1, NOLC1, RPS8, RPL5, RPL17, RPL11, RPL18A, RPS15A, RPL7, RPS7, RPS6, RPL18, RPL15, GNL3, RPS2, EBNA1BP2, RPL23, EEF1A1, RPS4X, RPS5, RPS3, EIF6, RPS24, RPL19, RPS14, RSL1D1, U2AF1, BOP1, DHX15, NSUN2, FTSJ3, BANF1, NIFK, RRS1, POP1, MRTO4, PRPF3, PNO1, SRRM2, MAGOH, EIF4A3, VCAM1, FN1, ITGA4, CBX8, ARFGEF1, NCL, PAN2, TARDBP, RPA3, RPA2, RPA1, ERG, LIN28A, LIN28B, CEP250, TP53, ENO1, MOV10, NXF1, PHF6, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, RNF2, BMI1, EGFR, PXK, ABCE1, LARP7, KNOP1, TRO, ZFP91, GTF3C2, TERF2IP, ZNF93, ZNF430, ZNF629, ZNF324, UTP18, GTF3C3, RANBP6, RBM23, ZMYM4, GTF3C5, BCORL1, PINX1, NOL11, NOL8, SRFBP1, PRRC2C, TGS1, GTF3C1, NOM1, TERF2, NAP1L2, NAP1L3, RNF19B, TUBB8, GPATCH4, CCDC86, UTP15, RRP9, WDR36, ZNF496, PDCD11, AHDC1, WDR43, RIOK1, RSPRY1, CIRH1A, ARMCX3, ZNF318, GSG2, UTP3, PHAX, COPRS, ZNHIT3, ZNF644, ZNF281, CTCF, PWP2, WDR75, RECQL4, GXYLT2, YY1AP1, ZNF316, LRRC41, CHST8, BRIX1, DCAF13, DDX27, EIF2S2, EXOSC3, BYSL, DDX18, DDX24, EIF4G1, IPO5, KIAA0020, PABPC4, PES1, PWP1, RPL13A, GLYR1, GTF2B, GTPBP4, HNRNPR, KPNA1, KPNA5, KPNA6, MPHOSPH10, NAA15, NHP2, NOC2L, NOC3L, NOL6, PRPF31, PUS7, RBM19, RPL9, RSL24D1, SDAD1, TBL3, NTRK1, KRAS, XPO1, HNRNPU, NPM1, RPL10, CDC23, HEMGN, MCM2, MCM5, U2AF2, RC3H1, ZNF746, NEUROG3, PHF10, CDK1, COX15, DLD, DLST, SOAT1, VDAC1, G3BP1, HEY1, BRCA1, LMNA, MTF1RYR1TRDN, HOMER1, FKBP1A, RYR2, S100A1, HOMER2, HOMER3, ANK1, CALM1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+881053614_364342035034CALM
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+891063614_364342085039CALM
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+881053614_364342035034CALM
TgeneRYR1chr19:40336931chr19:39055599ENST00000355481+88105669_68042035034FKBP1A
TgeneRYR1chr19:40336931chr19:39055599ENST00000359596+89106669_68042085039FKBP1A
TgeneRYR1chr19:40336931chr19:39055599ENST00000360985+88105669_68042035034FKBP1A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBL_RYR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRYR1P21817DB00201CaffeineRyanodine receptor 1small moleculeapproved
TgeneRYR1P21817DB01219DantroleneRyanodine receptor 1small moleculeapproved|investigational
TgeneRYR1P21817DB04786SuraminRyanodine receptor 1small moleculeapproved|investigational
TgeneRYR1P21817DB09085TetracaineRyanodine receptor 1small moleculeapproved|vet_approved

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RelatedDiseases for FBL_RYR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBLC0004364Autoimmune Diseases3CTD_human
HgeneFBLC1458155Mammary Neoplasms1CTD_human
TgeneRYR1C0024591Malignant hyperpyrexia due to anesthesia49CTD_human;HPO;ORPHANET;UNIPROT
TgeneRYR1C0751951Central Core Myopathy (disorder)37CTD_human;ORPHANET;UNIPROT
TgeneRYR1C1850674MINICORE MYOPATHY WITH EXTERNAL OPHTHALMOPLEGIA (disorder)3CTD_human;ORPHANET;UNIPROT
TgeneRYR1C0007134Renal Cell Carcinoma1CTD_human
TgeneRYR1C0752282Congenital Structural Myopathy1CTD_human