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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13024

FusionGeneSummary for FBLN7_ALOXE3

check button Fusion gene summary
Fusion gene informationFusion gene name: FBLN7_ALOXE3
Fusion gene ID: 13024
HgeneTgene
Gene symbol

FBLN7

ALOXE3

Gene ID

129804

59344

Gene namefibulin 7arachidonate lipoxygenase 3
SynonymsTM14ARCI3|E-LOX|eLOX-3|eLOX3
Cytomap

2q13-q14.1

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionfibulin-7FIBL-7hydroperoxide isomerase ALOXE3Epidermal lipoxygenase-3e-LOX-3epidermal LOX-3epidermal lipoxygenaseepidermis-type lipoxygenase 3hydroperoxy icosatetraenoate dehydratase
Modification date2018052220180519
UniProtAcc

Q53RD9

Q9BYJ1

Ensembl transtripts involved in fusion geneENST00000331203, ENST00000409903, 
ENST00000409667, ENST00000409450, 
ENST00000472377, 
ENST00000380149, 
ENST00000448843, ENST00000318227, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: FBLN7 [Title/Abstract] AND ALOXE3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneALOXE3

GO:0006665

sphingolipid metabolic process

21558561

TgeneALOXE3

GO:0019369

arachidonic acid metabolic process

12881489|17045234

TgeneALOXE3

GO:0019372

lipoxygenase pathway

20921226

TgeneALOXE3

GO:0043651

linoleic acid metabolic process

12881489|17045234

TgeneALOXE3

GO:0051122

hepoxilin biosynthetic process

12881489|17045234


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A6YQ-01AFBLN7chr2

112942916

+ALOXE3chr17

8012572

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000331203ENST00000380149FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000331203ENST00000448843FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000331203ENST00000318227FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000409903ENST00000380149FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000409903ENST00000448843FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000409903ENST00000318227FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000409667ENST00000380149FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000409667ENST00000448843FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000409667ENST00000318227FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000409450ENST00000380149FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000409450ENST00000448843FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
Frame-shiftENST00000409450ENST00000318227FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
intron-3CDSENST00000472377ENST00000380149FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
intron-3CDSENST00000472377ENST00000448843FBLN7chr2

112942916

+ALOXE3chr17

8012572

-
intron-3CDSENST00000472377ENST00000318227FBLN7chr2

112942916

+ALOXE3chr17

8012572

-

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FusionProtFeatures for FBLN7_ALOXE3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBLN7

Q53RD9

ALOXE3

Q9BYJ1

An adhesion molecule that interacts with extracellularmatrix molecules in developing teeth and may play important rolesin differentiation and maintenance of odontoblasts as well as indentin formation. {ECO:0000250}. Non-heme iron-containing lipoxygenase which is atypicalin that it displays a prominent hydroperoxide isomerase activityand a reduced dioxygenase activity compared to otherlipoxygenases. The hydroperoxide isomerase activity catalyzes theisomerization of hydroperoxides, derived from arachidonic andlinoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. Thedioxygenase activity requires a step of activation of the enzymeby molecular oxygen. In presence of oxygen, oxygenatespolyunsaturated fatty acids, including arachidonic acid, toproduce fatty acid hydroperoxides. In the skin, acts downstream ofALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative,a crucial step in the conjugation of omega-hydroxyceramide tomembrane proteins. Therefore plays a crucial role in the synthesisof corneocytes lipid envelope and the establishment of the skinbarrier to water loss. In parallel, it may have a signalingfunction in barrier formation through the production of hepoxilinsmetabolites. Plays also a role in adipocyte differentiationthrough hepoxilin A3 and hepoxilin B3 production which in turnactivate PPARG. Through the production of hepoxilins in the spinalcord, it may regulate inflammatory tactile allodynia.{ECO:0000269|PubMed:12881489, ECO:0000269|PubMed:17045234,ECO:0000269|PubMed:20921226, ECO:0000269|PubMed:20923767,ECO:0000269|PubMed:21558561}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBLN7_ALOXE3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBLN7_ALOXE3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBLN7HSPA5, ASPH, TXNDC11, CLNS1A, EDEM2, EGFRALOXE3C20orf96, ALPK1, GLIPR1, DPPA4, B3GALNT1, PLEKHB2, VEGFB, GLYR1, NBEA, ZFHX4, DNAAF2, SRC, HSPA8, CCDC27, ZSCAN12, EDEM3, MORN3, HOOK1, PVRL2, HERC4, ZIC1, HSPD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBLN7_ALOXE3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBLN7_ALOXE3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneALOXE3C3539888ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 34UNIPROT
TgeneALOXE3C0033578Prostatic Neoplasms1CTD_human
TgeneALOXE3C0079154Congenital Nonbullous Ichthyosiform Erythroderma1CTD_human;ORPHANET