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Fusion gene ID: 13023 |
FusionGeneSummary for FBLN7_ACAN |
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Fusion gene information | Fusion gene name: FBLN7_ACAN | Fusion gene ID: 13023 | Hgene | Tgene | Gene symbol | FBLN7 | ACAN | Gene ID | 129804 | 176 |
Gene name | fibulin 7 | aggrecan | |
Synonyms | TM14 | AGC1|AGCAN|CSPG1|CSPGCP|MSK16|SEDK|SSOAOD | |
Cytomap | 2q13-q14.1 | 15q26.1 | |
Type of gene | protein-coding | protein-coding | |
Description | fibulin-7FIBL-7 | aggrecan core proteincartilage-specific proteoglycan core proteinchondroitin sulfate proteoglycan core protein 1large aggregating proteoglycan | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q53RD9 | ||
Ensembl transtripts involved in fusion gene | ENST00000331203, ENST00000409903, ENST00000409667, ENST00000409450, ENST00000472377, | ENST00000439576, ENST00000558207, ENST00000559004, ENST00000352105, ENST00000561243, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 5 X 3=75 |
# samples | 2 | 5 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FBLN7 [Title/Abstract] AND ACAN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF061357 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000331203 | ENST00000439576 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
3UTR-intron | ENST00000331203 | ENST00000558207 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
3UTR-intron | ENST00000331203 | ENST00000559004 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
3UTR-intron | ENST00000331203 | ENST00000352105 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
3UTR-intron | ENST00000331203 | ENST00000561243 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
3UTR-3CDS | ENST00000409903 | ENST00000439576 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
3UTR-intron | ENST00000409903 | ENST00000558207 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
3UTR-intron | ENST00000409903 | ENST00000559004 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
3UTR-intron | ENST00000409903 | ENST00000352105 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
3UTR-intron | ENST00000409903 | ENST00000561243 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-3CDS | ENST00000409667 | ENST00000439576 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000409667 | ENST00000558207 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000409667 | ENST00000559004 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000409667 | ENST00000352105 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000409667 | ENST00000561243 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-3CDS | ENST00000409450 | ENST00000439576 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000409450 | ENST00000558207 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000409450 | ENST00000559004 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000409450 | ENST00000352105 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000409450 | ENST00000561243 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-3CDS | ENST00000472377 | ENST00000439576 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000472377 | ENST00000558207 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000472377 | ENST00000559004 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000472377 | ENST00000352105 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
intron-intron | ENST00000472377 | ENST00000561243 | FBLN7 | chr2 | 112945649 | - | ACAN | chr15 | 89401959 | - |
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FusionProtFeatures for FBLN7_ACAN |
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Hgene | Tgene |
FBLN7 | ACAN |
An adhesion molecule that interacts with extracellularmatrix molecules in developing teeth and may play important rolesin differentiation and maintenance of odontoblasts as well as indentin formation. {ECO:0000250}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBLN7_ACAN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBLN7_ACAN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBLN7_ACAN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBLN7_ACAN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ACAN | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | ACAN | C0032273 | Pneumoconiosis | 1 | CTD_human |
Tgene | ACAN | C0238288 | Muscular Dystrophy, Facioscapulohumeral | 1 | CTD_human |
Tgene | ACAN | C2748544 | Spondyloepimetaphyseal Dysplasia, Aggrecan Type | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | ACAN | C3665488 | Familial Osteochondritis Dissecans | 1 | CTD_human;ORPHANET;UNIPROT |