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Fusion gene ID: 13017 |
FusionGeneSummary for FBLN1_MAP3K4 |
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Fusion gene information | Fusion gene name: FBLN1_MAP3K4 | Fusion gene ID: 13017 | Hgene | Tgene | Gene symbol | FBLN1 | MAP3K4 | Gene ID | 2192 | 4216 |
Gene name | fibulin 1 | mitogen-activated protein kinase kinase kinase 4 | |
Synonyms | FBLN|FIBL1 | MAPKKK4|MEKK 4|MEKK4|MTK1|PRO0412 | |
Cytomap | 22q13.31 | 6q26 | |
Type of gene | protein-coding | protein-coding | |
Description | fibulin-1 | mitogen-activated protein kinase kinase kinase 4MAP three kinase 1MAP/ERK kinase kinase 4MAPK/ERK kinase kinase 4MEK kinase 4SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog ofdJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)predicte | |
Modification date | 20180522 | 20180524 | |
UniProtAcc | P23142 | Q9Y6R4 | |
Ensembl transtripts involved in fusion gene | ENST00000348697, ENST00000402984, ENST00000262722, ENST00000327858, ENST00000442170, ENST00000340923, ENST00000476366, | ENST00000366919, ENST00000392142, ENST00000348824, ENST00000366920, ENST00000446500, | |
Fusion gene scores | * DoF score | 8 X 9 X 5=360 | 2 X 2 X 2=8 |
# samples | 10 | 2 | |
** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: FBLN1 [Title/Abstract] AND MAP3K4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FBLN1 | GO:0001933 | negative regulation of protein phosphorylation | 11792823 |
Hgene | FBLN1 | GO:0007162 | negative regulation of cell adhesion | 11792823 |
Hgene | FBLN1 | GO:0007229 | integrin-mediated signaling pathway | 11792823 |
Hgene | FBLN1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 11792823 |
Hgene | FBLN1 | GO:0072378 | blood coagulation, fibrin clot formation | 7642629 |
Hgene | FBLN1 | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 11792823 |
Hgene | FBLN1 | GO:2000146 | negative regulation of cell motility | 11792823 |
Hgene | FBLN1 | GO:2000647 | negative regulation of stem cell proliferation | 11238726 |
Tgene | MAP3K4 | GO:0000186 | activation of MAPKK activity | 9305639|9827804 |
Tgene | MAP3K4 | GO:0043507 | positive regulation of JUN kinase activity | 9305639 |
Tgene | MAP3K4 | GO:1900745 | positive regulation of p38MAPK cascade | 9305639 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CV372922 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000348697 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000348697 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000348697 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000348697 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000348697 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000402984 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000402984 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000402984 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000402984 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000402984 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000262722 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000262722 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000262722 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000262722 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000262722 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000327858 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000327858 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000327858 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000327858 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000327858 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000442170 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000442170 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000442170 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000442170 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000442170 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000340923 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000340923 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000340923 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000340923 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000340923 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000476366 | ENST00000366919 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000476366 | ENST00000392142 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000476366 | ENST00000348824 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000476366 | ENST00000366920 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
intron-intron | ENST00000476366 | ENST00000446500 | FBLN1 | chr22 | 45948280 | - | MAP3K4 | chr6 | 161498792 | - |
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FusionProtFeatures for FBLN1_MAP3K4 |
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Hgene | Tgene |
FBLN1 | MAP3K4 |
Component of a protein kinase signal transductioncascade. Activates the CSBP2, P38 and JNK MAPK pathways, but notthe ERK pathway. Specifically phosphorylates and activates MAP2K4and MAP2K6. {ECO:0000269|PubMed:12052864,ECO:0000269|PubMed:9305639}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBLN1_MAP3K4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBLN1_MAP3K4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBLN1_MAP3K4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBLN1_MAP3K4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FBLN1 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | FBLN1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | MAP3K4 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |