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Fusion gene ID: 12994 |
FusionGeneSummary for FAT4_STAMBPL1 |
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Fusion gene information | Fusion gene name: FAT4_STAMBPL1 | Fusion gene ID: 12994 | Hgene | Tgene | Gene symbol | FAT4 | STAMBPL1 | Gene ID | 79633 | 57559 |
Gene name | FAT atypical cadherin 4 | STAM binding protein like 1 | |
Synonyms | CDHF14|CDHR11|FAT-J|FATJ|HKLLS2|NBLA00548|VMLDS2 | ALMalpha|AMSH-FP|AMSH-LP|bA399O19.2 | |
Cytomap | 4q28.1 | 10q23.31 | |
Type of gene | protein-coding | protein-coding | |
Description | protocadherin Fat 4FAT tumor suppressor homolog 4cadherin family member 14cadherin-related family member 11fat-like cadherin protein FAT-Jputative protein product of Nbla00548 | AMSH-like proteaseassociated molecule with the SH3 domain of STAM (AMSH) - Family Proteinassociated molecule with the SH3 domain of STAM (AMSH) like protein | |
Modification date | 20180520 | 20180523 | |
UniProtAcc | Q6V0I7 | Q96FJ0 | |
Ensembl transtripts involved in fusion gene | ENST00000394329, ENST00000335110, | ENST00000371927, ENST00000371926, ENST00000461650, ENST00000371924, ENST00000371922, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 5 X 1=15 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/15*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FAT4 [Title/Abstract] AND STAMBPL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP231880 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000394329 | ENST00000371927 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
3UTR-intron | ENST00000394329 | ENST00000371926 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
3UTR-intron | ENST00000394329 | ENST00000461650 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
3UTR-intron | ENST00000394329 | ENST00000371924 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
3UTR-intron | ENST00000394329 | ENST00000371922 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
intron-intron | ENST00000335110 | ENST00000371927 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
intron-intron | ENST00000335110 | ENST00000371926 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
intron-intron | ENST00000335110 | ENST00000461650 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
intron-intron | ENST00000335110 | ENST00000371924 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
intron-intron | ENST00000335110 | ENST00000371922 | FAT4 | chr4 | 126413978 | + | STAMBPL1 | chr10 | 90712529 | - |
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FusionProtFeatures for FAT4_STAMBPL1 |
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Hgene | Tgene |
FAT4 | STAMBPL1 |
Cadherins are calcium-dependent cell adhesion proteins.FAT4 plays a role in the maintenance of planar cell polarity aswell as in inhibition of YAP1-mediated neuroprogenitor cellproliferation and differentiation (By similarity). {ECO:0000250}. | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linkedpolyubiquitin chains. {ECO:0000269|PubMed:18758443}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAT4_STAMBPL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAT4_STAMBPL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAT4_STAMBPL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAT4_STAMBPL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FAT4 | C3809875 | VAN MALDERGEM SYNDROME 2 | 2 | UNIPROT |
Hgene | FAT4 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | FAT4 | C0025202 | melanoma | 1 | CTD_human |
Hgene | FAT4 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | FAT4 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | FAT4 | C1691228 | Cystic Kidney Diseases | 1 | CTD_human |
Hgene | FAT4 | C1832390 | Van Maldergem Wetzburger Verloes syndrome | 1 | CTD_human;ORPHANET |
Hgene | FAT4 | C1842563 | Heterotopia, Periventricular, Autosomal Recessive | 1 | CTD_human |
Hgene | FAT4 | C4014939 | HENNEKAM LYMPHANGIECTASIA-LYMPHEDEMA SYNDROME 2 | 1 | UNIPROT |