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Fusion gene ID: 12988 |
FusionGeneSummary for FAT1_STAT6 |
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Fusion gene information | Fusion gene name: FAT1_STAT6 | Fusion gene ID: 12988 | Hgene | Tgene | Gene symbol | FAT1 | STAT6 | Gene ID | 2195 | 6778 |
Gene name | FAT atypical cadherin 1 | signal transducer and activator of transcription 6 | |
Synonyms | CDHF7|CDHR8|FAT|ME5|hFat1 | D12S1644|IL-4-STAT|STAT6B|STAT6C | |
Cytomap | 4q35.2 | 12q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homolog | signal transducer and activator of transcription 6STAT, interleukin4-inducedsignal transducer and activator of transcription 6, interleukin-4 inducedtranscription factor IL-4 STAT | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q14517 | P42226 | |
Ensembl transtripts involved in fusion gene | ENST00000441802, ENST00000512347, | ENST00000300134, ENST00000538913, ENST00000543873, ENST00000556155, ENST00000537215, ENST00000454075, | |
Fusion gene scores | * DoF score | 10 X 10 X 7=700 | 37 X 8 X 15=4440 |
# samples | 13 | 43 | |
** MAII score | log2(13/700*10)=-2.42884329880387 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(43/4440*10)=-3.36815111164801 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FAT1 [Title/Abstract] AND STAT6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | STAT6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8810328 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-8680-01A | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000441802 | ENST00000300134 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000441802 | ENST00000538913 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000441802 | ENST00000543873 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000441802 | ENST00000556155 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000441802 | ENST00000537215 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000441802 | ENST00000454075 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000512347 | ENST00000300134 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000512347 | ENST00000538913 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000512347 | ENST00000543873 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000512347 | ENST00000556155 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000512347 | ENST00000537215 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
intron-intron | ENST00000512347 | ENST00000454075 | FAT1 | chr4 | 187508949 | - | STAT6 | chr12 | 57496773 | - |
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FusionProtFeatures for FAT1_STAT6 |
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Hgene | Tgene |
FAT1 | STAT6 |
Plays an essential role for cellular polarization,directed cell migration and modulating cell-cell contact.{ECO:0000250}. | Carries out a dual function: signal transduction andactivation of transcription. Involved in IL4/interleukin-4- andIL3/interleukin-3-mediated signaling.{ECO:0000269|PubMed:17210636}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAT1_STAT6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAT1_STAT6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAT1 | HDAC6, NUB1, UBC, NOS2, VASP, AIRE, ILK, RPS6KA2, KLK11, TAZ, NXPH2, TRAC, SUSD4, DNASE2B, CALR3, VEGFB, CD96, LIPH, GPHA2, C2orf48, CLK1, EZH2, NIPSNAP1, SH3RF1, TRAF4, NOXA1, ND1, SORBS2, IGLL1, PSG8, XAGE1B, PDGFB, SLAMF1, GML, IFNE, DKKL1, SIRT6, BRINP3, ST8SIA4 | STAT6 | NCOA1, CREBBP, IRF4, EP300, NFKB1, SND1, ANXA2, TP53, STAT3, TRIM24, DAZAP2, CEBPZ, WWP1, RLIM, ANKZF1, ZNF407, ZBTB2, ZNF92, PARP14, NCOA3, NCOA2, JUN, SFPQ, IGHE, FCER2, CEBPE, SSSCA1, SRXN1, PPM1G, RAD23B, SEC24A, NUBP2, AHCYL1, DSTN, IGBP1, SH3BGRL, PSAT1, STAT2, IFNAR1, IL4R, IFNG, JAK1, PTPN2, VKORC1, LITAF, JAK3, TRIM28, RCN3, EEF1A1, API5, EHD1, PDE12, PGGT1B, USP8, PPARG, KDM3A, AACS, GART, TSTA3, KIF22, POLK |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAT1_STAT6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAT1_STAT6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FAT1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | FAT1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | FAT1 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | FAT1 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
Hgene | FAT1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | FAT1 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
Hgene | FAT1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | STAT6 | C1266119 | Solitary fibrous tumor | 2 | CTD_human |
Tgene | STAT6 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
Tgene | STAT6 | C0013604 | Edema | 1 | CTD_human |
Tgene | STAT6 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |