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Fusion gene ID: 12985 |
FusionGeneSummary for FAT1_NTRK3 |
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Fusion gene information | Fusion gene name: FAT1_NTRK3 | Fusion gene ID: 12985 | Hgene | Tgene | Gene symbol | FAT1 | NTRK3 | Gene ID | 2195 | 4916 |
Gene name | FAT atypical cadherin 1 | neurotrophic receptor tyrosine kinase 3 | |
Synonyms | CDHF7|CDHR8|FAT|ME5|hFat1 | GP145-TrkC|TRKC|gp145(trkC) | |
Cytomap | 4q35.2 | 15q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homolog | NT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor C | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q14517 | Q16288 | |
Ensembl transtripts involved in fusion gene | ENST00000441802, ENST00000512347, | ENST00000394480, ENST00000557856, ENST00000357724, ENST00000355254, ENST00000360948, ENST00000542733, ENST00000558676, ENST00000317501, ENST00000558306, ENST00000540489, | |
Fusion gene scores | * DoF score | 10 X 10 X 7=700 | 9 X 7 X 9=567 |
# samples | 13 | 20 | |
** MAII score | log2(13/700*10)=-2.42884329880387 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/567*10)=-1.5033487351675 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FAT1 [Title/Abstract] AND NTRK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NTRK3 | GO:0000187 | activation of MAPK activity | 23027130 |
Tgene | NTRK3 | GO:0001933 | negative regulation of protein phosphorylation | 23027130 |
Tgene | NTRK3 | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 23027130 |
Tgene | NTRK3 | GO:0008284 | positive regulation of cell proliferation | 23027130 |
Tgene | NTRK3 | GO:0010628 | positive regulation of gene expression | 23027130 |
Tgene | NTRK3 | GO:0030335 | positive regulation of cell migration | 23027130 |
Tgene | NTRK3 | GO:0032148 | activation of protein kinase B activity | 23027130 |
Tgene | NTRK3 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 23027130 |
Tgene | NTRK3 | GO:0050927 | positive regulation of positive chemotaxis | 23027130 |
Tgene | NTRK3 | GO:0090630 | activation of GTPase activity | 23027130 |
Tgene | NTRK3 | GO:2000251 | positive regulation of actin cytoskeleton reorganization | 23027130 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CESC | TCGA-HM-A3JK-01A | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000441802 | ENST00000394480 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
Frame-shift | ENST00000441802 | ENST00000557856 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
Frame-shift | ENST00000441802 | ENST00000357724 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
Frame-shift | ENST00000441802 | ENST00000355254 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
Frame-shift | ENST00000441802 | ENST00000360948 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
Frame-shift | ENST00000441802 | ENST00000542733 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
Frame-shift | ENST00000441802 | ENST00000558676 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
Frame-shift | ENST00000441802 | ENST00000317501 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
5CDS-intron | ENST00000441802 | ENST00000558306 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
5CDS-intron | ENST00000441802 | ENST00000540489 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-3CDS | ENST00000512347 | ENST00000394480 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-3CDS | ENST00000512347 | ENST00000557856 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-3CDS | ENST00000512347 | ENST00000357724 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-3CDS | ENST00000512347 | ENST00000355254 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-3CDS | ENST00000512347 | ENST00000360948 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-3CDS | ENST00000512347 | ENST00000542733 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-3CDS | ENST00000512347 | ENST00000558676 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-3CDS | ENST00000512347 | ENST00000317501 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-intron | ENST00000512347 | ENST00000558306 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
intron-intron | ENST00000512347 | ENST00000540489 | FAT1 | chr4 | 187627717 | - | NTRK3 | chr15 | 88680792 | - |
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FusionProtFeatures for FAT1_NTRK3 |
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Hgene | Tgene |
FAT1 | NTRK3 |
Plays an essential role for cellular polarization,directed cell migration and modulating cell-cell contact.{ECO:0000250}. | Receptor tyrosine kinase involved in nervous system andprobably heart development. Upon binding of its ligandNTF3/neurotrophin-3, NTRK3 autophosphorylates and activatesdifferent signaling pathways, including the phosphatidylinositol3-kinase/AKT and the MAPK pathways, that control cell survival anddifferentiation. {ECO:0000269|PubMed:25196463}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAT1_NTRK3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAT1_NTRK3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAT1 | HDAC6, NUB1, UBC, NOS2, VASP, AIRE, ILK, RPS6KA2, KLK11, TAZ, NXPH2, TRAC, SUSD4, DNASE2B, CALR3, VEGFB, CD96, LIPH, GPHA2, C2orf48, CLK1, EZH2, NIPSNAP1, SH3RF1, TRAF4, NOXA1, ND1, SORBS2, IGLL1, PSG8, XAGE1B, PDGFB, SLAMF1, GML, IFNE, DKKL1, SIRT6, BRINP3, ST8SIA4 | NTRK3 | NTF3, FRS2, SHC1, PLCG1, SQSTM1, PTPN1, APP, HSP90AA1, IRAK3, TNK2, NTRK1, SH3BP4, PTPRS, MYADM, C1GALT1, GNB2, C6orf120, MTOR, LGALS1, PTCD2, TMEM11, PAG1, EFR3A, TBC1D24, GNB4, TMEM192, INTS7, DENND4A, FAM171A2, KIAA0391, EPHA2, ATP7B, CXCR4, ACAD10, HRAS, EHD4, RPTOR, HEATR6, SLC39A11 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAT1_NTRK3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAT1_NTRK3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FAT1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | FAT1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | FAT1 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | FAT1 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
Hgene | FAT1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | FAT1 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
Hgene | FAT1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | NTRK3 | C0036341 | Schizophrenia | 3 | PSYGENET |
Tgene | NTRK3 | C0041696 | Unipolar Depression | 2 | PSYGENET |
Tgene | NTRK3 | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
Tgene | NTRK3 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | NTRK3 | C0017638 | Glioma | 1 | CTD_human |
Tgene | NTRK3 | C0038220 | Status Epilepticus | 1 | CTD_human |
Tgene | NTRK3 | C0525045 | Mood Disorders | 1 | PSYGENET |