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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 12983

FusionGeneSummary for FAT1_KIAA1430

check button Fusion gene summary
Fusion gene informationFusion gene name: FAT1_KIAA1430
Fusion gene ID: 12983
HgeneTgene
Gene symbol

FAT1

KIAA1430

Gene ID

2195

57587

Gene nameFAT atypical cadherin 1cilia and flagella associated protein 97
SynonymsCDHF7|CDHR8|FAT|ME5|hFat1KIAA1430|hmw
Cytomap

4q35.2

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homologcilia- and flagella-associated protein 97
Modification date2018051920180519
UniProtAcc

Q14517

Ensembl transtripts involved in fusion geneENST00000441802, ENST00000512347, 
ENST00000458385, ENST00000514798, 
ENST00000296775, ENST00000502992, 
Fusion gene scores* DoF score10 X 10 X 7=7003 X 2 X 3=18
# samples 133
** MAII scorelog2(13/700*10)=-2.42884329880387
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAT1 [Title/Abstract] AND KIAA1430 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-DQ-7588-01AFAT1chr4

187554838

-KIAA1430chr4

186085333

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000441802ENST00000458385FAT1chr4

187554838

-KIAA1430chr4

186085333

-
5CDS-intronENST00000441802ENST00000514798FAT1chr4

187554838

-KIAA1430chr4

186085333

-
5CDS-intronENST00000441802ENST00000296775FAT1chr4

187554838

-KIAA1430chr4

186085333

-
5CDS-intronENST00000441802ENST00000502992FAT1chr4

187554838

-KIAA1430chr4

186085333

-
intron-3CDSENST00000512347ENST00000458385FAT1chr4

187554838

-KIAA1430chr4

186085333

-
intron-intronENST00000512347ENST00000514798FAT1chr4

187554838

-KIAA1430chr4

186085333

-
intron-intronENST00000512347ENST00000296775FAT1chr4

187554838

-KIAA1430chr4

186085333

-
intron-intronENST00000512347ENST00000502992FAT1chr4

187554838

-KIAA1430chr4

186085333

-

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FusionProtFeatures for FAT1_KIAA1430


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAT1

Q14517

KIAA1430

Plays an essential role for cellular polarization,directed cell migration and modulating cell-cell contact.{ECO:0000250}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271035_113914414589DomainCadherin 9
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271140_124514414589DomainCadherin 10
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271246_135714414589DomainCadherin 11
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727150_25714414589DomainCadherin 2
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-72735_14914414589DomainCadherin 1
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727368_46314414589DomainCadherin 3
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727464_56914414589DomainCadherin 4
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727570_67314414589DomainCadherin 5
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727718_82214414589DomainCadherin 6
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727823_92714414589DomainCadherin 7
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-727928_103414414589DomainCadherin 8
TgeneKIAA1430chr4:187554838chr4:186085333ENST00000296775-04374_450-49454Coiled coilOntology_term=ECO:0000255
TgeneKIAA1430chr4:187554838chr4:186085333ENST00000514798-04374_450-87454Coiled coilOntology_term=ECO:0000255
TgeneKIAA1430chr4:187554838chr4:186085333ENST00000296775-04170_236-49454Compositional biasNote=Ser-rich
TgeneKIAA1430chr4:187554838chr4:186085333ENST00000514798-04170_236-87454Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271359_145614414589DomainCadherin 12
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271457_156214414589DomainCadherin 13
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271563_166714414589DomainCadherin 14
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271668_176514414589DomainCadherin 15
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271766_187914414589DomainCadherin 16
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271880_197914414589DomainCadherin 17
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7271980_208114414589DomainCadherin 18
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272082_218214414589DomainCadherin 19
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272183_228314414589DomainCadherin 20
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272284_239014414589DomainCadherin 21
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272391_249214414589DomainCadherin 22
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272493_259614414589DomainCadherin 23
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272597_270314414589DomainCadherin 24
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272704_280914414589DomainCadherin 25
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272810_291814414589DomainCadherin 26
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7272919_302314414589DomainCadherin 27
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273024_312514414589DomainCadherin 28
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273126_323014414589DomainCadherin 29
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273231_333514414589DomainCadherin 30
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273336_344014414589DomainCadherin 31
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273441_354514414589DomainCadherin 32
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273546_364714414589DomainCadherin 33
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273790_382714414589DomainEGF-like 1
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7273829_400914414589DomainLaminin G-like
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274013_405014414589DomainEGF-like 2
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274052_408814414589DomainEGF-like 3
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274089_412514414589DomainEGF-like 4
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274127_416314414589DomainEGF-like 5%3B calcium-binding
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274204_421414414589MotifNuclear localization signal
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274378_438214414589MotifPTB-like motif
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-72722_418114414589Topological domainExtracellular
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274203_458814414589Topological domainCytoplasmic
HgeneFAT1chr4:187554838chr4:186085333ENST00000441802-7274182_420214414589TransmembraneHelical
TgeneKIAA1430chr4:187554838chr4:186085333ENST00000458385-25374_450440533Coiled coilOntology_term=ECO:0000255
TgeneKIAA1430chr4:187554838chr4:186085333ENST00000458385-25170_236440533Compositional biasNote=Ser-rich


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FusionGeneSequence for FAT1_KIAA1430


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FAT1_ENST00000441802_chr4_187554838_-_KIAA1430_ENST00000458385_chr4_186085333_-_1534aa
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS
NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKP
DRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPK
PSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILT
QALLKRLEAVKPTVGMKRSEQLMDYHRNMGYLNSSPLSRRARSTLGQYSPLRASRTSSATSGLSCRSERSAVDPSSGHPRRRPKPPNVRT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FAT1_ENST00000441802_chr4_187554838_-_KIAA1430_ENST00000458385_chr4_186085333_-_4602nt
ATGGGGAGACATTTGGCTTTGCTCCTGCTTCTGCTCCTTCTCTTCCAACATTTTGGAGACAGTGATGGCAGCCAACGACTTGAACAGACT
CCTCTGCAGTTTACACACCTCGAGTACAACGTCACCGTGCAGGAGAACTCTGCAGCTAAGACTTATGTGGGGCATCCTGTCAAGATGGGT
GTTTACATTACACATCCAGCGTGGGAAGTAAGGTACAAAATTGTTTCCGGAGACAGTGAAAACCTGTTCAAAGCTGAAGAGTACATTCTC
GGAGACTTTTGCTTTCTAAGAATAAGGACCAAAGGAGGAAATACAGCTATTCTTAATAGAGAAGTGAAGGATCACTACACATTGATAGTG
AAAGCACTTGAAAAAAATACTAATGTGGAGGCGCGAACAAAGGTCAGGGTGCAGGTGCTGGATACAAATGACTTGAGACCGTTATTCTCA
CCCACCTCATACAGCGTTTCTTTACCTGAAAACACAGCTATAAGGACCAGTATCGCAAGAGTCAGCGCCACGGATGCAGACATAGGAACC
AACGGGGAATTTTACTACAGTTTTAAAGATCGAACAGATATGTTTGCTATTCACCCAACCAGTGGTGTGATAGTGTTAACTGGTAGACTT
GATTACCTAGAGACCAAGCTCTATGAGATGGAAATCCTCGCTGCGGACCGTGGCATGAAGTTGTATGGGAGCAGTGGCATCAGCAGCATG
GCCAAGCTAACGGTGCACATCGAACAGGCCAATGAATGTGCTCCGGTGATAACAGCAGTGACATTGTCACCATCAGAACTGGACAGGGAC
CCAGCATATGCAATTGTGACAGTGGATGACTGCGATCAGGGTGCCAATGGTGACATAGCATCTTTAAGCATCGTGGCAGGTGACCTTCTC
CAGCAGTTTAGAACAGTGAGGTCCTTTCCAGGGAGTAAGGAGTATAAAGTCAAAGCCATCGGTGGCATTGATTGGGACAGTCATCCTTTC
GGCTACAATCTCACACTACAGGCTAAAGATAAAGGAACTCCGCCCCAGTTCTCTTCTGTTAAAGTCATTCACGTGACTTCTCCACAGTTC
AAAGCCGGGCCAGTCAAGTTTGAAAAGGATGTTTACAGAGCAGAAATAAGTGAATTTGCTCCTCCCAACACACCTGTGGTCATGGTAAAG
GCCATTCCTGCTTATTCCCATTTGAGGTATGTTTTTAAAAGTACACCTGGAAAAGCTAAATTCAGTTTAAATTACAACACTGGTCTCATT
TCTATTTTAGAACCAGTTAAAAGACAGCAGGCAGCCCATTTTGAACTTGAAGTAACAACAAGTGACAGAAAAGCGTCCACCAAGGTCTTG
GTGAAAGTCTTAGGTGCAAATAGCAATCCCCCTGAATTTACCCAGACAGCGTACAAAGCTGCTTTTGATGAGAACGTGCCCATTGGTACT
ACTGTCATGAGCCTGAGTGCCGTAGACCCTGATGAGGGTGAGAACGGGTACGTGACATACAGTATCGCAAATTTAAATCATGTGCCGTTT
GCGATTGACCATTTCACTGGTGCCGTGAGTACGTCAGAAAACCTGGACTACGAACTGATGCCTCGGGTTTATACTCTGAGGATTCGTGCA
TCAGACTGGGGCTTGCCGTACCGCCGGGAAGTCGAAGTCCTTGCTACAATTACTCTCAATAACTTGAATGACAACACACCTTTGTTTGAG
AAAATAAATTGTGAAGGGACAATTCCCAGAGATCTAGGCGTGGGAGAGCAAATAACCACTGTTTCTGCTATTGATGCAGATGAACTTCAG
TTGGTACAGTATCAGATTGAAGCTGGAAATGAACTGGATTTCTTTAGTTTAAACCCCAACTCGGGGGTATTGTCATTAAAGCGATCGCTA
ATGGATGGCTTAGGTGCAAAGGTGTCTTTCCACAGTCTGAGAATCACAGCTACAGATGGAGAAAATTTTGCCACACCATTATATATCAAC
ATAACAGTGGCTGCCAGTCACAAGCTGGTAAACTTGCAGTGTGAAGAGACTGGTGTTGCCAAAATGCTGGCAGAGAAGCTCCTGCAGGCA
AATAAATTACACAACCAGGGAGAGGTGGAGGATATTTTCTTCGATTCTCACTCTGTCAATGCTCACATACCGCAGTTTAGAAGCACTCTT
CCGACTGGTATTCAGGTAAAGGAAAACCAGCCTGTGGGTTCCAGTGTAATTTTCATGAACTCCACTGACCTTGACACTGGCTTCAATGGA
AAACTGGTCTATGCTGTTTCTGGAGGAAATGAGGATAGTTGCTTCATGATTGATATGGAAACAGGAATGCTGAAAATTTTATCTCCTCTT
GACCGTGAAACAACAGACAAATACACCCTGAATATTACCGTCTATGACCTTGGGATACCCCAGAAGGCTGCGTGGCGTCTTCTACATGTC
GTGGTTGTCGATGCCAATGATAATCCACCCGAGTTTTTACAGGAGAGCTATTTTGTGGAAGTGAGTGAAGACAAGGAGGTACATAGTGAA
ATCATCCAGGTTGAAGCCACAGATAAAGACCTGGGGCCCAACGGACACGTGACGTACTCAATTGTTACAGACACAGACACATTTTCAATT
GACAGCGTGACGGGTGTTGTTAACATCGCACGCCCTCTGGATCGAGAGCTGCAGCATGAGCACTCCTTAAAGATTGAGGCCAGGGACCAA
GCCAGAGAAGAGCCTCAGCTGTTCTCCACTGTCGTTGTGAAAGTATCACTAGAAGATGTTAATGACAACCCACCTACATTTATTCCACCT
AATTATCGTGTGAAAGTCCGAGAGGATCTTCCAGAAGGAACCGTCATCATGTGGTTAGAAGCCCACGATCCTGATTTAGGTCAGTCTGGT
CAGGTGAGATACAGCCTTCTGGACCACGGAGAAGGAAACTTCGATGTGGATAAACTCAGTGGAGCAGTTAGGATCGTCCAGCAGTTGGAC
TTTGAGAAGAAGCAAGTGTATAATCTCACTGTGAGGGCCAAAGACAAGGGAAAGCCAGTTTCTCTGTCTTCTACTTGCTATGTTGAAGTT
GAGGTGGTTGATGTGAATGAGAACCTGCACCCACCCGTGTTTTCCAGCTTTGTGGAAAAGGGGACAGTGAAAGAAGATGCACCTGTTGGT
TCATTGGTAATGACGGTGTCGGCTCATGATGAGGACGCCAGAAGAGATGGGGAGATCCGATACTCCATTAGAGATGGCTCTGGCGTTGGT
GTTTTCAAAATAGGTGAAGAGACAGGTGTCATAGAGACGTCAGATCGACTGGACCGTGAATCGACCTCCCATTATTGGCTAACAGTCTTT
GCAACCGATCAGGGTGTCGTGCCTCTTTCATCGTTCATAGAGATCTACATAGAGGTTGAGGATGTCAATGACAATGCACCACAGACATCA
GAGCCTGTTTATTACCCAGAAATCATGGAAAATTCTCCTAAAGATGTATCTGTGGTCCAGATCGAGGCATTTGATCCAGATTCGAGCTCT
AATGACAAGCTCATGTACAAAATTACAAGTGGAAATCCACAAGGATTCTTTTCAATACATCCTAAAACAGGTCTCATCACAACTACGTCA
AGGAAGCTAGACCGAGAACAGCAAGATGAACACATATTAGAGGTTACTGTGACAGACAATGGTAGTCCCCCCAAATCAACCATTGCAAGA
GTCATTGTGAAAATCCTTGATGAAAATGACAACAAACCTCAGTTTCTGCAAAAGTTCTACAAAATCAGACTCCCTGAGCGGGAAAAGCCA
GACCGAGAAAGAAATGCCAGACGGGAGCCGCTCTATCACGTCATAGCCACCGACAAGGATGAGGGCCCCAATGCAGAAATCTCCTACAGC
ATCGAAGACGGGAATGAGCATGGCAAATTTTTCATCGAACCGAAAACTGGAGTGGTTTCGTCCAAGAGGTTTTCAGCAGCTGGAGAATAT
GATATTCTTTCAATTAAGGCAGTTGACAATGGTCGCCCTCAAAAGTCATCAACCACCAGACTCCATATTGAATGGATCTCCAAGCCCAAA
CCGTCCCTGGAGCCCATTTCATTTGAAGAATCATTTTTTACCTTTACTGTGATGGAAAGTGACCCCGTTGCTCACATGATTGGAGTAATA
TCTGTGGAGCCTCCTGGCATACCCCTTTGGTTTGACATCACTGGTGGCAACTACGACAGTCACTTCGATGTGGACAAGGGAACTGGAACC
ATCATTGTTGCCAAACCTCTTGATGCAGAACAGAAGTCAAACTACAACCTCACAGTCGAGGCTACAGATGGAACCACCACTATCCTCACT
CAGGCTTTATTGAAAAGGCTTGAGGCCGTGAAACCAACAGTTGGTATGAAACGTTCAGAACAACTGATGGACTATCATCGCAATATGGGC
TATCTCAACTCATCACCATTGTCAAGACGGGCCAGATCCACTCTTGGCCAATATAGCCCATTAAGAGCTTCCAGGACATCCAGTGCTACG
AGTGGTCTCAGTTGTAGGAGTGAGCGATCAGCGGTTGACCCCTCCAGTGGCCACCCTCGAAGAAGACCTAAACCCCCTAATGTCCGTACA


* Fusion transcript sequences (Full-length transcript).
>In-frame_FAT1_ENST00000441802_chr4_187554838_-_KIAA1430_ENST00000458385_chr4_186085333_-_7945nt
AGCGTGAGGCGCCGGCGCCGAGCTGGGCGGCCGGGCGCGGGGAGAGGGCGCGGGAGCGGCTCGTGCGGCAGGTACCATGCGGACGCGCGA
GCCCGGCGAGGGCCCCGGCAGGCCCGGTCCCTGCTCGGGGGCGCGCTGAGACGGCGGGTGAGCTCCACGAGAGCGCCGTCGCCACTTCGG
GCCAACTTTGCGATTCCCGACAGTTAAGCAATGGGGAGACATTTGGCTTTGCTCCTGCTTCTGCTCCTTCTCTTCCAACATTTTGGAGAC
AGTGATGGCAGCCAACGACTTGAACAGACTCCTCTGCAGTTTACACACCTCGAGTACAACGTCACCGTGCAGGAGAACTCTGCAGCTAAG
ACTTATGTGGGGCATCCTGTCAAGATGGGTGTTTACATTACACATCCAGCGTGGGAAGTAAGGTACAAAATTGTTTCCGGAGACAGTGAA
AACCTGTTCAAAGCTGAAGAGTACATTCTCGGAGACTTTTGCTTTCTAAGAATAAGGACCAAAGGAGGAAATACAGCTATTCTTAATAGA
GAAGTGAAGGATCACTACACATTGATAGTGAAAGCACTTGAAAAAAATACTAATGTGGAGGCGCGAACAAAGGTCAGGGTGCAGGTGCTG
GATACAAATGACTTGAGACCGTTATTCTCACCCACCTCATACAGCGTTTCTTTACCTGAAAACACAGCTATAAGGACCAGTATCGCAAGA
GTCAGCGCCACGGATGCAGACATAGGAACCAACGGGGAATTTTACTACAGTTTTAAAGATCGAACAGATATGTTTGCTATTCACCCAACC
AGTGGTGTGATAGTGTTAACTGGTAGACTTGATTACCTAGAGACCAAGCTCTATGAGATGGAAATCCTCGCTGCGGACCGTGGCATGAAG
TTGTATGGGAGCAGTGGCATCAGCAGCATGGCCAAGCTAACGGTGCACATCGAACAGGCCAATGAATGTGCTCCGGTGATAACAGCAGTG
ACATTGTCACCATCAGAACTGGACAGGGACCCAGCATATGCAATTGTGACAGTGGATGACTGCGATCAGGGTGCCAATGGTGACATAGCA
TCTTTAAGCATCGTGGCAGGTGACCTTCTCCAGCAGTTTAGAACAGTGAGGTCCTTTCCAGGGAGTAAGGAGTATAAAGTCAAAGCCATC
GGTGGCATTGATTGGGACAGTCATCCTTTCGGCTACAATCTCACACTACAGGCTAAAGATAAAGGAACTCCGCCCCAGTTCTCTTCTGTT
AAAGTCATTCACGTGACTTCTCCACAGTTCAAAGCCGGGCCAGTCAAGTTTGAAAAGGATGTTTACAGAGCAGAAATAAGTGAATTTGCT
CCTCCCAACACACCTGTGGTCATGGTAAAGGCCATTCCTGCTTATTCCCATTTGAGGTATGTTTTTAAAAGTACACCTGGAAAAGCTAAA
TTCAGTTTAAATTACAACACTGGTCTCATTTCTATTTTAGAACCAGTTAAAAGACAGCAGGCAGCCCATTTTGAACTTGAAGTAACAACA
AGTGACAGAAAAGCGTCCACCAAGGTCTTGGTGAAAGTCTTAGGTGCAAATAGCAATCCCCCTGAATTTACCCAGACAGCGTACAAAGCT
GCTTTTGATGAGAACGTGCCCATTGGTACTACTGTCATGAGCCTGAGTGCCGTAGACCCTGATGAGGGTGAGAACGGGTACGTGACATAC
AGTATCGCAAATTTAAATCATGTGCCGTTTGCGATTGACCATTTCACTGGTGCCGTGAGTACGTCAGAAAACCTGGACTACGAACTGATG
CCTCGGGTTTATACTCTGAGGATTCGTGCATCAGACTGGGGCTTGCCGTACCGCCGGGAAGTCGAAGTCCTTGCTACAATTACTCTCAAT
AACTTGAATGACAACACACCTTTGTTTGAGAAAATAAATTGTGAAGGGACAATTCCCAGAGATCTAGGCGTGGGAGAGCAAATAACCACT
GTTTCTGCTATTGATGCAGATGAACTTCAGTTGGTACAGTATCAGATTGAAGCTGGAAATGAACTGGATTTCTTTAGTTTAAACCCCAAC
TCGGGGGTATTGTCATTAAAGCGATCGCTAATGGATGGCTTAGGTGCAAAGGTGTCTTTCCACAGTCTGAGAATCACAGCTACAGATGGA
GAAAATTTTGCCACACCATTATATATCAACATAACAGTGGCTGCCAGTCACAAGCTGGTAAACTTGCAGTGTGAAGAGACTGGTGTTGCC
AAAATGCTGGCAGAGAAGCTCCTGCAGGCAAATAAATTACACAACCAGGGAGAGGTGGAGGATATTTTCTTCGATTCTCACTCTGTCAAT
GCTCACATACCGCAGTTTAGAAGCACTCTTCCGACTGGTATTCAGGTAAAGGAAAACCAGCCTGTGGGTTCCAGTGTAATTTTCATGAAC
TCCACTGACCTTGACACTGGCTTCAATGGAAAACTGGTCTATGCTGTTTCTGGAGGAAATGAGGATAGTTGCTTCATGATTGATATGGAA
ACAGGAATGCTGAAAATTTTATCTCCTCTTGACCGTGAAACAACAGACAAATACACCCTGAATATTACCGTCTATGACCTTGGGATACCC
CAGAAGGCTGCGTGGCGTCTTCTACATGTCGTGGTTGTCGATGCCAATGATAATCCACCCGAGTTTTTACAGGAGAGCTATTTTGTGGAA
GTGAGTGAAGACAAGGAGGTACATAGTGAAATCATCCAGGTTGAAGCCACAGATAAAGACCTGGGGCCCAACGGACACGTGACGTACTCA
ATTGTTACAGACACAGACACATTTTCAATTGACAGCGTGACGGGTGTTGTTAACATCGCACGCCCTCTGGATCGAGAGCTGCAGCATGAG
CACTCCTTAAAGATTGAGGCCAGGGACCAAGCCAGAGAAGAGCCTCAGCTGTTCTCCACTGTCGTTGTGAAAGTATCACTAGAAGATGTT
AATGACAACCCACCTACATTTATTCCACCTAATTATCGTGTGAAAGTCCGAGAGGATCTTCCAGAAGGAACCGTCATCATGTGGTTAGAA
GCCCACGATCCTGATTTAGGTCAGTCTGGTCAGGTGAGATACAGCCTTCTGGACCACGGAGAAGGAAACTTCGATGTGGATAAACTCAGT
GGAGCAGTTAGGATCGTCCAGCAGTTGGACTTTGAGAAGAAGCAAGTGTATAATCTCACTGTGAGGGCCAAAGACAAGGGAAAGCCAGTT
TCTCTGTCTTCTACTTGCTATGTTGAAGTTGAGGTGGTTGATGTGAATGAGAACCTGCACCCACCCGTGTTTTCCAGCTTTGTGGAAAAG
GGGACAGTGAAAGAAGATGCACCTGTTGGTTCATTGGTAATGACGGTGTCGGCTCATGATGAGGACGCCAGAAGAGATGGGGAGATCCGA
TACTCCATTAGAGATGGCTCTGGCGTTGGTGTTTTCAAAATAGGTGAAGAGACAGGTGTCATAGAGACGTCAGATCGACTGGACCGTGAA
TCGACCTCCCATTATTGGCTAACAGTCTTTGCAACCGATCAGGGTGTCGTGCCTCTTTCATCGTTCATAGAGATCTACATAGAGGTTGAG
GATGTCAATGACAATGCACCACAGACATCAGAGCCTGTTTATTACCCAGAAATCATGGAAAATTCTCCTAAAGATGTATCTGTGGTCCAG
ATCGAGGCATTTGATCCAGATTCGAGCTCTAATGACAAGCTCATGTACAAAATTACAAGTGGAAATCCACAAGGATTCTTTTCAATACAT
CCTAAAACAGGTCTCATCACAACTACGTCAAGGAAGCTAGACCGAGAACAGCAAGATGAACACATATTAGAGGTTACTGTGACAGACAAT
GGTAGTCCCCCCAAATCAACCATTGCAAGAGTCATTGTGAAAATCCTTGATGAAAATGACAACAAACCTCAGTTTCTGCAAAAGTTCTAC
AAAATCAGACTCCCTGAGCGGGAAAAGCCAGACCGAGAAAGAAATGCCAGACGGGAGCCGCTCTATCACGTCATAGCCACCGACAAGGAT
GAGGGCCCCAATGCAGAAATCTCCTACAGCATCGAAGACGGGAATGAGCATGGCAAATTTTTCATCGAACCGAAAACTGGAGTGGTTTCG
TCCAAGAGGTTTTCAGCAGCTGGAGAATATGATATTCTTTCAATTAAGGCAGTTGACAATGGTCGCCCTCAAAAGTCATCAACCACCAGA
CTCCATATTGAATGGATCTCCAAGCCCAAACCGTCCCTGGAGCCCATTTCATTTGAAGAATCATTTTTTACCTTTACTGTGATGGAAAGT
GACCCCGTTGCTCACATGATTGGAGTAATATCTGTGGAGCCTCCTGGCATACCCCTTTGGTTTGACATCACTGGTGGCAACTACGACAGT
CACTTCGATGTGGACAAGGGAACTGGAACCATCATTGTTGCCAAACCTCTTGATGCAGAACAGAAGTCAAACTACAACCTCACAGTCGAG
GCTACAGATGGAACCACCACTATCCTCACTCAGGCTTTATTGAAAAGGCTTGAGGCCGTGAAACCAACAGTTGGTATGAAACGTTCAGAA
CAACTGATGGACTATCATCGCAATATGGGCTATCTCAACTCATCACCATTGTCAAGACGGGCCAGATCCACTCTTGGCCAATATAGCCCA
TTAAGAGCTTCCAGGACATCCAGTGCTACGAGTGGTCTCAGTTGTAGGAGTGAGCGATCAGCGGTTGACCCCTCCAGTGGCCACCCTCGA
AGAAGACCTAAACCCCCTAATGTCCGTACAGCTTGGTTATAAAACACTTTTTTACTTTAAACATTGTTCACACAACTTTTCTTGAAGTGC
TCGTGCATATTCCTATAATTCTCTGTGTAAACATCTAGAATACCGTTTTAGCAATTGAAGGTGTACAACAGTGAGTTGTAATGTATTGTT
ATTCAGTGCAAAATTATTGTCAAAAAACGATTTAATGTAAAAAGTGTTTCCTGAGGATGTATTTATATGAGATGTATGTGTTCTTAATAG
AGAAATAGTGGTATGCATGTGTATCTTCTAATTATTCAGTTGTCATGCTGTCAAAATAGTAGTGATAGTATCATTGCATGTCGTACCCAA
GATGGTCACTATAGTTTTCAATTTGTGTTATTTTCATTTCTTTATAAGTGTTATACCATGAGCTCAGCTCCTAAATTTGGCTGGCTTTGT
TTTTCATTTGCTTTAGAACTTATGTGGCATGACATAGCTCGATTGTATGAGATTTAACACTTATTATGAAACAAATCTTGAAATTTGTTT
TCACTGGTAGAGCTGATCTAGATTTGATGAGCAGATTGAGAGACGCTTCTATTGGAGCAATTCTTGTAATTCACCAGAGGTATCTAGTTG
TTGTATAAGTGCACTGAGTTAGATCTTAAAAGTTTGATCAATCATTCCAAACCATTTCAAATATGAATATTAGAAAGTTCAACTTAGAAG
CTTCCCTTTTGTGTTTTCATGCATTCAGGTAAAGTCCTATTTATGACTCTTAGAAATGAGGTAGGTTTTAGAGCTAGTCTTCTAACTCGT
GAATAGTTTAAGGACCACATCAGTTGCAAACCAAGTATTTGTTGAATCAGTAAAATGGCACTATCAGCATGAAGAGCCGAGAAGCAGATC
CTGAGGTGTGTCGGACAGTGTTTTAGGTAATTCAGTATTTATTATGTTATTAGAGAAGACTTAGCGTAAGAAAGAAATGCTTTAGAAATT
CCAGCAAGTATTTATAAGGCCTGAAAAAACTAAAATTTGAACAAAAAGGGAAATAAATCACACATTTGTTGAGGCTGCTGCTTTAAGTAT
TAGCTAATTTTCTTGTTTTGGTTTACTTTGATTTATTTGATTGAACCCTGGAAGTATTATTTTTACCAGTCCCACATTTAAAGACCTAGT
AATCTTGATGGAATTGGTAATGGCAGATAGGGTTTAATGTTGTTGACTTTTCAAATTAGAATTTTTTTTCTATGAAACTTAGGCTTTTAT
ATAACAAAGTATGTTATCTCATTGTTACCGCCGTTTTTCACTACTAGCCTTTTCAGTATGCCCTTAAAATGTATTGGAAAGGTTCCATGT
TAAATGACAAATATCTTTTTCAGTATGAATTTTTGATCTGTAGCCACAATAAGATTTTCATTTTTCAGTGCTCAGGCTCTGTAGCATGTA
TGCTGAATGCTTTTTTCCTTAGCACCTTTAACAGTAAGGTGTTACTGCATTTTACAAAACATCAATTCAACATGTCTTGGATTTAGTTTG
TATTCATAGATTTTGTTAAGGATCAGGCCTGTGAACATGGGCACAGTGAGGTTAAATAATTCACCTGGCCACAACCTGGCTTTGAGGTTC
TGCTTTTGGGGGCCATAATTTTCATTCAATGTTATTCGATGCTCTGTTCTGGTGAACAAGTTACTATACCTGCTGTGTATATAAGCTTGA
GCTATACTAAACCAAGGCTTTATTTTCTTTTGTTTTTTAACTTACTGTACTTTTACTGTTTATATAACCTATATTTCAAGAGAGAGAAGA
TAATGCTGAATTTTAAATTTAGCATTTGAACATCTGTCCAATAGTGAATTAATCAGTTTTTTTAAAATTGATTTTTAAGTTGTTCCAGAA
AAAAATATATATATATGTTTTATATATATAATCTTTTTATATATATAAAAAATCTTTTTTATAAATTTTATTTTAAAAATCTTTTAAAAA
AGATTTTTATATATATATAAAGATTATATATTTATATATAGTCTTTTCTGTTCATAATGGCATTAGTCTCTGAGTACATTTTATATTATC
TTTGTTGCCACATGTCAGGATACAACACAATAGTTTTATAAATAACAACTGTACTTTGATTTTAGGTACTAATTTAATGCTTTAGTTTTT
ACTACTTTGAAAGGGGAGGTTCATCTAAGTATTACTGATAACAGGGATCCAACTTAAAGTAAAAGTTGGAAAGGGCAAGAGTCTTTTAAG
CGGAACTTCAATTCTGTTGTCATGGTTACTTATATATAATGAATATAAATAGACAAATAGGACTTGGAAAATGTGGTATATTCTAAGTCA
AGATGCTATGAAGTTGTTATAGTTTAAGGGACATTCTTAAGAAGGAATTACTTAAGTACATTACTCTTCTCATTTCAAGGACATGAAAAA
GTAAAGGATGGTCTGGCACTATTTTATTTTATTTTTTTTTTGACTTGTACTGAATATATGTACTTTGAAGATTTACATCTATAACTAGAA
AGTATGCTAATCCGAGGTCTGGTTATTAGGCCAGATTCTTGTTCAGTTATTTTTTAAACTAATGTTGCCTCCTTTTTAGTAAGATTCTAC
GAAAGTTTTTTAACTATTAAAGTTATTTCTTAAGGGGTAGCTCTTATACTTCCTCTGCTCTCTTTTTCAGTTTCCATAAAAAGCTGTTTT
CTTAGCTATTACTCCAAATAAAGTTCTTTGGTTTGCTTAAAAATGTAGTGTAATGCAGTTGTTTTCTCTCCGCTAACCTGAGTGTCCACA
GTAGATATCGAGACAGCTTTAGGAAGGTGACGGTCATGGGTAAGTGACGGCTGTGCCTGTCATCTTCAGATTCTTCAAATACTGCAAACT
ATGAAACATGTTAAGACCAATATAAACCCAAAGATGTGAGTTGATTATACTTTAATAATTACATTCATAAAAAGTTTACTATCTTCAATG
CCAAAAAAGTCTTAACCTATAAATGATTATATACAATCTTAGAAAATGTGCTTAACAGTTATGGCTTCTTTATTTCTATGAGGAAAGATT
AGTAAGAAACTTAAAATTAACATCCTTTTAAGATTTTCTGTTCCATTTTAATGTATTTTAGGCATTTAGAACTAGCCTGGCATAATGAAG


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FusionGenePPI for FAT1_KIAA1430


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAT1HDAC6, NUB1, UBC, NOS2, VASP, AIRE, ILK, RPS6KA2, KLK11, TAZ, NXPH2, TRAC, SUSD4, DNASE2B, CALR3, VEGFB, CD96, LIPH, GPHA2, C2orf48, CLK1, EZH2, NIPSNAP1, SH3RF1, TRAF4, NOXA1, ND1, SORBS2, IGLL1, PSG8, XAGE1B, PDGFB, SLAMF1, GML, IFNE, DKKL1, SIRT6, BRINP3, ST8SIA4KIAA1430


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAT1_KIAA1430


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAT1_KIAA1430


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAT1C0009404Colorectal Neoplasms1CTD_human
HgeneFAT1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneFAT1C0017636Glioblastoma1CTD_human
HgeneFAT1C0018671Head and Neck Neoplasms1CTD_human
HgeneFAT1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFAT1C0036095Salivary Gland Neoplasms1CTD_human
HgeneFAT1C0279626Squamous cell carcinoma of esophagus1CTD_human