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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12980

FusionGeneSummary for FAT1_APP

check button Fusion gene summary
Fusion gene informationFusion gene name: FAT1_APP
Fusion gene ID: 12980
HgeneTgene
Gene symbol

FAT1

APP

Gene ID

2195

351

Gene nameFAT atypical cadherin 1amyloid beta precursor protein
SynonymsCDHF7|CDHR8|FAT|ME5|hFat1AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4
Cytomap

4q35.2

21q21.3

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homologamyloid-beta A4 proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteincereb
Modification date2018051920180527
UniProtAcc

Q14517

P05067

Ensembl transtripts involved in fusion geneENST00000441802, ENST00000512347, 
ENST00000346798, ENST00000354192, 
ENST00000348990, ENST00000357903, 
ENST00000358918, ENST00000359726, 
ENST00000448388, ENST00000440126, 
ENST00000439274, ENST00000474136, 
Fusion gene scores* DoF score10 X 10 X 7=70016 X 17 X 6=1632
# samples 1320
** MAII scorelog2(13/700*10)=-2.42884329880387
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1632*10)=-3.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAT1 [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

TgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-PC-A5DN-01AFAT1chr4

187627717

-APPchr21

27372497

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000441802ENST00000346798FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000354192FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000348990FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000357903FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000358918FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000359726FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000448388FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000440126FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000439274FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000474136FAT1chr4

187627717

-APPchr21

27372497

-
intron-3CDSENST00000512347ENST00000346798FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000354192FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000348990FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000357903FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000358918FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000359726FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000448388FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000440126FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000439274FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000474136FAT1chr4

187627717

-APPchr21

27372497

-

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FusionProtFeatures for FAT1_APP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAT1

Q14517

APP

P05067

Plays an essential role for cellular polarization,directed cell migration and modulating cell-cell contact.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227150_25710884589DomainCadherin 2
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-22735_14910884589DomainCadherin 1
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227368_46310884589DomainCadherin 3
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227464_56910884589DomainCadherin 4
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227570_67310884589DomainCadherin 5
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227718_82210884589DomainCadherin 6
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227823_92710884589DomainCadherin 7
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227928_103410884589DomainCadherin 8
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016230_260-49696Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016274_280-49696Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015230_260-43640Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015274_280-43640Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017230_260-67715Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017274_280-67715Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518724_734288771MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518759_762288771MotifNote=NPXY motif%3B contains endocytosis signal
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016724_734-49696MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016759_762-49696MotifNote=NPXY motif%3B contains endocytosis signal
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015724_734-43640MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015759_762-43640MotifNote=NPXY motif%3B contains endocytosis signal
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517724_734288752MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517759_762288752MotifNote=NPXY motif%3B contains endocytosis signal
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517724_734288753MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517759_762288753MotifNote=NPXY motif%3B contains endocytosis signal
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017724_734-67715MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017759_762-67715MotifNote=NPXY motif%3B contains endocytosis signal
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517724_734283747MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517759_762283747MotifNote=NPXY motif%3B contains endocytosis signal
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518391_423288771RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518491_522288771RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518523_540288771RegionNote=Collagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016181_188-49696RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016391_423-49696RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016491_522-49696RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016523_540-49696RegionNote=Collagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-01696_110-49696RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015181_188-43640RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015391_423-43640RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015491_522-43640RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015523_540-43640RegionNote=Collagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-01596_110-43640RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517391_423288752RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517491_522288752RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517523_540288752RegionNote=Collagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517391_423288753RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517491_522288753RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517523_540288753RegionNote=Collagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017181_188-67715RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017391_423-67715RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017491_522-67715RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017523_540-67715RegionNote=Collagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-01796_110-67715RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517391_423283747RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517491_522283747RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517523_540283747RegionNote=Collagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518724_770288771Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-01618_699-49696Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016724_770-49696Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-01518_699-43640Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015724_770-43640Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517724_770288752Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517724_770288753Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-01718_699-67715Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017724_770-67715Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517724_770283747Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518700_723288771TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016700_723-49696TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015700_723-43640TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517700_723288752TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517700_723288753TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017700_723-67715TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517700_723283747TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271035_113910884589DomainCadherin 9
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271140_124510884589DomainCadherin 10
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271246_135710884589DomainCadherin 11
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271359_145610884589DomainCadherin 12
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271457_156210884589DomainCadherin 13
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271563_166710884589DomainCadherin 14
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271668_176510884589DomainCadherin 15
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271766_187910884589DomainCadherin 16
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271880_197910884589DomainCadherin 17
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271980_208110884589DomainCadherin 18
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272082_218210884589DomainCadherin 19
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272183_228310884589DomainCadherin 20
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272284_239010884589DomainCadherin 21
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272391_249210884589DomainCadherin 22
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272493_259610884589DomainCadherin 23
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272597_270310884589DomainCadherin 24
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272704_280910884589DomainCadherin 25
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272810_291810884589DomainCadherin 26
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272919_302310884589DomainCadherin 27
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273024_312510884589DomainCadherin 28
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273126_323010884589DomainCadherin 29
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273231_333510884589DomainCadherin 30
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273336_344010884589DomainCadherin 31
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273441_354510884589DomainCadherin 32
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273546_364710884589DomainCadherin 33
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273790_382710884589DomainEGF-like 1
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273829_400910884589DomainLaminin G-like
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274013_405010884589DomainEGF-like 2
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274052_408810884589DomainEGF-like 3
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274089_412510884589DomainEGF-like 4
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274127_416310884589DomainEGF-like 5%3B calcium-binding
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274204_421410884589MotifNuclear localization signal
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274378_438210884589MotifPTB-like motif
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-22722_418110884589Topological domainExtracellular
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274203_458810884589Topological domainCytoplasmic
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274182_420210884589TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518230_260288771Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518274_280288771Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517230_260288752Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517274_280288752Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517230_260288753Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517274_280288753Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517230_260283747Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517274_280283747Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518181_188288771RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-51896_110288771RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517181_188288752RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-51796_110288752RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517181_188288753RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-51796_110288753RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517181_188283747RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-51796_110283747RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-51818_699288771Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-51718_699288752Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-51718_699288753Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-51718_699283747Topological domainExtracellular


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FusionGeneSequence for FAT1_APP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FAT1_ENST00000441802_chr4_187627717_-_APP_ENST00000346798_chr21_27372497_-_1571aa
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETEVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAAS
TPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMAR
VEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYN
VPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPV
DARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FAT1_ENST00000441802_chr4_187627717_-_APP_ENST00000346798_chr21_27372497_-_4713nt
ATGGGGAGACATTTGGCTTTGCTCCTGCTTCTGCTCCTTCTCTTCCAACATTTTGGAGACAGTGATGGCAGCCAACGACTTGAACAGACT
CCTCTGCAGTTTACACACCTCGAGTACAACGTCACCGTGCAGGAGAACTCTGCAGCTAAGACTTATGTGGGGCATCCTGTCAAGATGGGT
GTTTACATTACACATCCAGCGTGGGAAGTAAGGTACAAAATTGTTTCCGGAGACAGTGAAAACCTGTTCAAAGCTGAAGAGTACATTCTC
GGAGACTTTTGCTTTCTAAGAATAAGGACCAAAGGAGGAAATACAGCTATTCTTAATAGAGAAGTGAAGGATCACTACACATTGATAGTG
AAAGCACTTGAAAAAAATACTAATGTGGAGGCGCGAACAAAGGTCAGGGTGCAGGTGCTGGATACAAATGACTTGAGACCGTTATTCTCA
CCCACCTCATACAGCGTTTCTTTACCTGAAAACACAGCTATAAGGACCAGTATCGCAAGAGTCAGCGCCACGGATGCAGACATAGGAACC
AACGGGGAATTTTACTACAGTTTTAAAGATCGAACAGATATGTTTGCTATTCACCCAACCAGTGGTGTGATAGTGTTAACTGGTAGACTT
GATTACCTAGAGACCAAGCTCTATGAGATGGAAATCCTCGCTGCGGACCGTGGCATGAAGTTGTATGGGAGCAGTGGCATCAGCAGCATG
GCCAAGCTAACGGTGCACATCGAACAGGCCAATGAATGTGCTCCGGTGATAACAGCAGTGACATTGTCACCATCAGAACTGGACAGGGAC
CCAGCATATGCAATTGTGACAGTGGATGACTGCGATCAGGGTGCCAATGGTGACATAGCATCTTTAAGCATCGTGGCAGGTGACCTTCTC
CAGCAGTTTAGAACAGTGAGGTCCTTTCCAGGGAGTAAGGAGTATAAAGTCAAAGCCATCGGTGGCATTGATTGGGACAGTCATCCTTTC
GGCTACAATCTCACACTACAGGCTAAAGATAAAGGAACTCCGCCCCAGTTCTCTTCTGTTAAAGTCATTCACGTGACTTCTCCACAGTTC
AAAGCCGGGCCAGTCAAGTTTGAAAAGGATGTTTACAGAGCAGAAATAAGTGAATTTGCTCCTCCCAACACACCTGTGGTCATGGTAAAG
GCCATTCCTGCTTATTCCCATTTGAGGTATGTTTTTAAAAGTACACCTGGAAAAGCTAAATTCAGTTTAAATTACAACACTGGTCTCATT
TCTATTTTAGAACCAGTTAAAAGACAGCAGGCAGCCCATTTTGAACTTGAAGTAACAACAAGTGACAGAAAAGCGTCCACCAAGGTCTTG
GTGAAAGTCTTAGGTGCAAATAGCAATCCCCCTGAATTTACCCAGACAGCGTACAAAGCTGCTTTTGATGAGAACGTGCCCATTGGTACT
ACTGTCATGAGCCTGAGTGCCGTAGACCCTGATGAGGGTGAGAACGGGTACGTGACATACAGTATCGCAAATTTAAATCATGTGCCGTTT
GCGATTGACCATTTCACTGGTGCCGTGAGTACGTCAGAAAACCTGGACTACGAACTGATGCCTCGGGTTTATACTCTGAGGATTCGTGCA
TCAGACTGGGGCTTGCCGTACCGCCGGGAAGTCGAAGTCCTTGCTACAATTACTCTCAATAACTTGAATGACAACACACCTTTGTTTGAG
AAAATAAATTGTGAAGGGACAATTCCCAGAGATCTAGGCGTGGGAGAGCAAATAACCACTGTTTCTGCTATTGATGCAGATGAACTTCAG
TTGGTACAGTATCAGATTGAAGCTGGAAATGAACTGGATTTCTTTAGTTTAAACCCCAACTCGGGGGTATTGTCATTAAAGCGATCGCTA
ATGGATGGCTTAGGTGCAAAGGTGTCTTTCCACAGTCTGAGAATCACAGCTACAGATGGAGAAAATTTTGCCACACCATTATATATCAAC
ATAACAGTGGCTGCCAGTCACAAGCTGGTAAACTTGCAGTGTGAAGAGACTGGTGTTGCCAAAATGCTGGCAGAGAAGCTCCTGCAGGCA
AATAAATTACACAACCAGGGAGAGGTGGAGGATATTTTCTTCGATTCTCACTCTGTCAATGCTCACATACCGCAGTTTAGAAGCACTCTT
CCGACTGGTATTCAGGTAAAGGAAAACCAGCCTGTGGGTTCCAGTGTAATTTTCATGAACTCCACTGACCTTGACACTGGCTTCAATGGA
AAACTGGTCTATGCTGTTTCTGGAGGAAATGAGGATAGTTGCTTCATGATTGATATGGAAACAGGAATGCTGAAAATTTTATCTCCTCTT
GACCGTGAAACAACAGACAAATACACCCTGAATATTACCGTCTATGACCTTGGGATACCCCAGAAGGCTGCGTGGCGTCTTCTACATGTC
GTGGTTGTCGATGCCAATGATAATCCACCCGAGTTTTTACAGGAGAGCTATTTTGTGGAAGTGAGTGAAGACAAGGAGGTACATAGTGAA
ATCATCCAGGTTGAAGCCACAGATAAAGACCTGGGGCCCAACGGACACGTGACGTACTCAATTGTTACAGACACAGACACATTTTCAATT
GACAGCGTGACGGGTGTTGTTAACATCGCACGCCCTCTGGATCGAGAGCTGCAGCATGAGCACTCCTTAAAGATTGAGGCCAGGGACCAA
GCCAGAGAAGAGCCTCAGCTGTTCTCCACTGTCGTTGTGAAAGTATCACTAGAAGATGTTAATGACAACCCACCTACATTTATTCCACCT
AATTATCGTGTGAAAGTCCGAGAGGATCTTCCAGAAGGAACCGTCATCATGTGGTTAGAAGCCCACGATCCTGATTTAGGTCAGTCTGGT
CAGGTGAGATACAGCCTTCTGGACCACGGAGAAGGAAACTTCGATGTGGATAAACTCAGTGGAGCAGTTAGGATCGTCCAGCAGTTGGAC
TTTGAGAAGAAGCAAGTGTATAATCTCACTGTGAGGGCCAAAGACAAGGGAAAGCCAGTTTCTCTGTCTTCTACTTGCTATGTTGAAGTT
GAGGTGGTTGATGTGAATGAGAACCTGCACCCACCCGTGTTTTCCAGCTTTGTGGAAAAGGGGACAGTGAAAGAAGATGCACCTGTTGGT
TCATTGGTAATGACGGTGTCGGCTCATGATGAGGACGCCAGAAGAGATGGGGAGATCCGATACTCCATTAGAGATGGCTCTGGCGTTGGT
GTTTTCAAAATAGGTGAAGAGACAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGAT
GTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTG
TGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGT
ACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCC
AAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCA
GTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGA
GTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTG
TTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCC
AAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAAC
GTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGACGTCTTGGCCAACATG
ATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAAT
GGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAACGAAGTTGAGCCTGTT
GATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAG
ATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGT
GCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCC
ATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAACGGCTACGAAAATCCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_FAT1_ENST00000441802_chr4_187627717_-_APP_ENST00000346798_chr21_27372497_-_6043nt
AGCGTGAGGCGCCGGCGCCGAGCTGGGCGGCCGGGCGCGGGGAGAGGGCGCGGGAGCGGCTCGTGCGGCAGGTACCATGCGGACGCGCGA
GCCCGGCGAGGGCCCCGGCAGGCCCGGTCCCTGCTCGGGGGCGCGCTGAGACGGCGGGTGAGCTCCACGAGAGCGCCGTCGCCACTTCGG
GCCAACTTTGCGATTCCCGACAGTTAAGCAATGGGGAGACATTTGGCTTTGCTCCTGCTTCTGCTCCTTCTCTTCCAACATTTTGGAGAC
AGTGATGGCAGCCAACGACTTGAACAGACTCCTCTGCAGTTTACACACCTCGAGTACAACGTCACCGTGCAGGAGAACTCTGCAGCTAAG
ACTTATGTGGGGCATCCTGTCAAGATGGGTGTTTACATTACACATCCAGCGTGGGAAGTAAGGTACAAAATTGTTTCCGGAGACAGTGAA
AACCTGTTCAAAGCTGAAGAGTACATTCTCGGAGACTTTTGCTTTCTAAGAATAAGGACCAAAGGAGGAAATACAGCTATTCTTAATAGA
GAAGTGAAGGATCACTACACATTGATAGTGAAAGCACTTGAAAAAAATACTAATGTGGAGGCGCGAACAAAGGTCAGGGTGCAGGTGCTG
GATACAAATGACTTGAGACCGTTATTCTCACCCACCTCATACAGCGTTTCTTTACCTGAAAACACAGCTATAAGGACCAGTATCGCAAGA
GTCAGCGCCACGGATGCAGACATAGGAACCAACGGGGAATTTTACTACAGTTTTAAAGATCGAACAGATATGTTTGCTATTCACCCAACC
AGTGGTGTGATAGTGTTAACTGGTAGACTTGATTACCTAGAGACCAAGCTCTATGAGATGGAAATCCTCGCTGCGGACCGTGGCATGAAG
TTGTATGGGAGCAGTGGCATCAGCAGCATGGCCAAGCTAACGGTGCACATCGAACAGGCCAATGAATGTGCTCCGGTGATAACAGCAGTG
ACATTGTCACCATCAGAACTGGACAGGGACCCAGCATATGCAATTGTGACAGTGGATGACTGCGATCAGGGTGCCAATGGTGACATAGCA
TCTTTAAGCATCGTGGCAGGTGACCTTCTCCAGCAGTTTAGAACAGTGAGGTCCTTTCCAGGGAGTAAGGAGTATAAAGTCAAAGCCATC
GGTGGCATTGATTGGGACAGTCATCCTTTCGGCTACAATCTCACACTACAGGCTAAAGATAAAGGAACTCCGCCCCAGTTCTCTTCTGTT
AAAGTCATTCACGTGACTTCTCCACAGTTCAAAGCCGGGCCAGTCAAGTTTGAAAAGGATGTTTACAGAGCAGAAATAAGTGAATTTGCT
CCTCCCAACACACCTGTGGTCATGGTAAAGGCCATTCCTGCTTATTCCCATTTGAGGTATGTTTTTAAAAGTACACCTGGAAAAGCTAAA
TTCAGTTTAAATTACAACACTGGTCTCATTTCTATTTTAGAACCAGTTAAAAGACAGCAGGCAGCCCATTTTGAACTTGAAGTAACAACA
AGTGACAGAAAAGCGTCCACCAAGGTCTTGGTGAAAGTCTTAGGTGCAAATAGCAATCCCCCTGAATTTACCCAGACAGCGTACAAAGCT
GCTTTTGATGAGAACGTGCCCATTGGTACTACTGTCATGAGCCTGAGTGCCGTAGACCCTGATGAGGGTGAGAACGGGTACGTGACATAC
AGTATCGCAAATTTAAATCATGTGCCGTTTGCGATTGACCATTTCACTGGTGCCGTGAGTACGTCAGAAAACCTGGACTACGAACTGATG
CCTCGGGTTTATACTCTGAGGATTCGTGCATCAGACTGGGGCTTGCCGTACCGCCGGGAAGTCGAAGTCCTTGCTACAATTACTCTCAAT
AACTTGAATGACAACACACCTTTGTTTGAGAAAATAAATTGTGAAGGGACAATTCCCAGAGATCTAGGCGTGGGAGAGCAAATAACCACT
GTTTCTGCTATTGATGCAGATGAACTTCAGTTGGTACAGTATCAGATTGAAGCTGGAAATGAACTGGATTTCTTTAGTTTAAACCCCAAC
TCGGGGGTATTGTCATTAAAGCGATCGCTAATGGATGGCTTAGGTGCAAAGGTGTCTTTCCACAGTCTGAGAATCACAGCTACAGATGGA
GAAAATTTTGCCACACCATTATATATCAACATAACAGTGGCTGCCAGTCACAAGCTGGTAAACTTGCAGTGTGAAGAGACTGGTGTTGCC
AAAATGCTGGCAGAGAAGCTCCTGCAGGCAAATAAATTACACAACCAGGGAGAGGTGGAGGATATTTTCTTCGATTCTCACTCTGTCAAT
GCTCACATACCGCAGTTTAGAAGCACTCTTCCGACTGGTATTCAGGTAAAGGAAAACCAGCCTGTGGGTTCCAGTGTAATTTTCATGAAC
TCCACTGACCTTGACACTGGCTTCAATGGAAAACTGGTCTATGCTGTTTCTGGAGGAAATGAGGATAGTTGCTTCATGATTGATATGGAA
ACAGGAATGCTGAAAATTTTATCTCCTCTTGACCGTGAAACAACAGACAAATACACCCTGAATATTACCGTCTATGACCTTGGGATACCC
CAGAAGGCTGCGTGGCGTCTTCTACATGTCGTGGTTGTCGATGCCAATGATAATCCACCCGAGTTTTTACAGGAGAGCTATTTTGTGGAA
GTGAGTGAAGACAAGGAGGTACATAGTGAAATCATCCAGGTTGAAGCCACAGATAAAGACCTGGGGCCCAACGGACACGTGACGTACTCA
ATTGTTACAGACACAGACACATTTTCAATTGACAGCGTGACGGGTGTTGTTAACATCGCACGCCCTCTGGATCGAGAGCTGCAGCATGAG
CACTCCTTAAAGATTGAGGCCAGGGACCAAGCCAGAGAAGAGCCTCAGCTGTTCTCCACTGTCGTTGTGAAAGTATCACTAGAAGATGTT
AATGACAACCCACCTACATTTATTCCACCTAATTATCGTGTGAAAGTCCGAGAGGATCTTCCAGAAGGAACCGTCATCATGTGGTTAGAA
GCCCACGATCCTGATTTAGGTCAGTCTGGTCAGGTGAGATACAGCCTTCTGGACCACGGAGAAGGAAACTTCGATGTGGATAAACTCAGT
GGAGCAGTTAGGATCGTCCAGCAGTTGGACTTTGAGAAGAAGCAAGTGTATAATCTCACTGTGAGGGCCAAAGACAAGGGAAAGCCAGTT
TCTCTGTCTTCTACTTGCTATGTTGAAGTTGAGGTGGTTGATGTGAATGAGAACCTGCACCCACCCGTGTTTTCCAGCTTTGTGGAAAAG
GGGACAGTGAAAGAAGATGCACCTGTTGGTTCATTGGTAATGACGGTGTCGGCTCATGATGAGGACGCCAGAAGAGATGGGGAGATCCGA
TACTCCATTAGAGATGGCTCTGGCGTTGGTGTTTTCAAAATAGGTGAAGAGACAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC
CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC
TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGAT
CCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCAT
TTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCA
AAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGA
CAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTG
CAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAG
CATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGC
ATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAA
AACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACG
AAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCA
GCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAAT
ATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTC
TTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTG
GTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCC
AAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTT
GGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTA
TCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACAT
TTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGA
TTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATC
GATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAA
CATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGAT
ATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTT
GTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTG
GTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGT
ATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGG
TGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAA
GGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATACAT


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FusionGenePPI for FAT1_APP


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAT1HDAC6, NUB1, UBC, NOS2, VASP, AIRE, ILK, RPS6KA2, KLK11, TAZ, NXPH2, TRAC, SUSD4, DNASE2B, CALR3, VEGFB, CD96, LIPH, GPHA2, C2orf48, CLK1, EZH2, NIPSNAP1, SH3RF1, TRAF4, NOXA1, ND1, SORBS2, IGLL1, PSG8, XAGE1B, PDGFB, SLAMF1, GML, IFNE, DKKL1, SIRT6, BRINP3, ST8SIA4APPAPPBP2, CLSTN1, APBB2, APBA2, FBLN1, APBA1, APBA3, DAB2, CALR, COL25A1, HSD17B10, CAV1, KLC1, NCSTN, BGN, APBB1, SNCA, SNCB, DAB1, ACHE, SHC1, NAE1, GSN, BLMH, APBB3, HGS, BCAP31, SET, PARK2, STUB1, HSPD1, HSPA4, HSP90AA1, SYVN1, NOTCH1, FBXL2, YWHAG, KAT5, GSK3B, UBQLN1, NAPG, UBB, MAPK8IP1, MAPRE1, GGA1, CLU, LRP2, CRYAB, HSPA8, UBE2M, TPPP, NOS3, DMTN, TCEANC, WIBG, MRPL19, C17orf85, PRR16, HOMER2, VIM, NSRP1, RPL30, RTF1, E2F8, SMTNL2, SLAIN2, GABARAPL2, PLK1, IGBP1, MAP2, KCNAB1, EIF4E2, TPRXL, MPG, DDX19B, ENY2, WDR5, AKNAD1, ZNF706, ADAP2, KIF3B, PDAP1, RAD51AP1, TCP10L, TPT1, GIMAP4, C1orf131, STAC, FAM114A2, UBXN10, RASL11B, CDK16, TSLP, RPAP3, YY1, BOD1, TOX2, TMA16, NTMT1, ATP6V1G1, AURKA, ELK1, PNMAL1, CTNNA1, MCM10, TCEAL2, FGF12, PRR15, MZT2A, TRPT1, DCX, HMCES, MRPL1, SLIT1-AS1, RGS3, PSRC1, C7orf50, TOP1, KIFC3, RPS19, C11orf63, ERMN, IRS1, SERBP1, TRUB1, TBC1D10C, C1orf87, POGZ, TMA7, C19orf57, COASY, G3BP1, FEN1, RPL12, ARID3A, LMCD1, CWF19L2, ZFYVE27, NOLC1, ZMYM5, ARGLU1, DDX54, GCC1, C9orf41, LIMCH1, CENPB, PTBP1, PPID, NKIRAS1, WHSC1, TOM1L2, CSAG1, ASPSCR1, CLIP4, PPP1R32, POLD3, MOB3A, RGS10, SCEL, SH3GLB1, PLIN3, RPS10, BRWD1, FANCM, CAT, UBXN6, TAF1B, PP2D1, NOP16, SNRNP70, DDX47, EIF1AX, SOCS3, TRIM41, LSM6, DIRAS1, RGS14, ARL4C, ZAP70, ARFGAP1, RSRC2, STXBP1, DDX55, HINT2, C9orf43, PHF7, C12orf65, TCEA1, SOX5, SEPT9, PATL1, RITA1, KLC4, ACO2, FLOT2, CIRH1A, IER3, ODF2, EIF1, HK1, SECISBP2, CDK17, ANKZF1, PTTG2, APRT, ATAT1, PYCR2, FAM126B, C1orf35, TPH1, VPS33B, STK25, MLLT6, NUAK1, C1orf110, HMGB2, PTPN7, DDX18, IFRD2, HERPUD1, CASZ1, LRRC59, FMNL1, QKI, TTLL7, CCNB1IP1, BLOC1S1, TAF9B, OAS2, LATS1, NMT2, APEX2, EPB41L2, CWC15, SSB, TACO1, AICDA, NAT6, RPS20, SENP2, TCF19, KIF2C, ECI2, TARBP2, C6orf201, MAPK13, PRDX5, RP9, FDX1L, RNPC3, LIG3, MOB3C, NPM1, MRPL34, TCP10, KLC2, SPATA2, PRRC2B, LCP2, SURF2, ZW10, TSSC4, MYL5, BUD31, TRIM52, CCDC149, FAM53A, CELF2, CEP57, TRMT2A, GAK, STOML2, PPFIBP2, AVPI1, GAPDH, TAB2, SERPIND1, ING2, DEF6, EIF5, NOB1, KCTD18, BCL7C, CTF1, ZC3HAV1L, FAM64A, C9orf78, ALDOB, ZC2HC1A, TIGD1, HP1BP3, THAP3, EIF3G, ARFIP2, KIAA0930, CXorf56, SCYL1, ASXL1, SASH3, ANXA9, POP7, GRB10, SH3RF2, CRIP2, TASP1, IKBIP, LRRC8D, PSMC1, ARL4D, GOLGA4, FAM32A, RASL10B, RASL12, TOB1, MXI1, EIF2S2, KRAS, EME1, DNM2, C1orf115, COPS7B, ZGRF1, APLF, MRPS24, CDKL3, EPB41L5, GADD45GIP1, TRIM63, RPL31, LACRT, RASA1, UNG, SPZ1, OR2W1, RPUSD2, BBX, NUAK2, ACSL4, RPF2, DLGAP1-AS2, C11orf52, USE1, CDKN1A, HIST1H2BM, EPB41L4A, ZADH2, GYG2, PAK4, ARHGAP24, DCLK1, PCBD2, C19orf40, PDZD4, DHX58, MAPKAPK3, DFFB, DYRK2, RPS9, NFKBIB, LNX1, CD74, ECH1, RPS12, GPANK1, CPLX2, BCAR3, GALK1, PADI4, PAK6, RPS16, BIN1, COIL, TLE3, PDE6H, GPT2, ANKRD50, AIMP1, PPP1R14A, MPP3, GORAB, C2orf49, MKNK1, ETV3, PAPSS2, SMAD3, MTG1, TSPYL1, CLEC3B, ACTR1B, SPANXN3, MCM7, BLOC1S2, GTF2E2, GTPBP1, FANCI, MESDC2, GBA2, MRPL49, PRRC1, MLX, BTF3, DDX43, CSNK1G2, ADRM1, RPL36, HSPBP1, DDX42, PLEKHG2, BIK, AMOT, TCP11, AFAP1L2, ADD2, CUL3, GOSR2, MED8, SH3GL2, SMAP1, DDRGK1, PAK2, RPL41, MRPL10, ZNF622, NR1D1, DDX17, DNAJC8, SP2, ZFYVE1, ZNF365, ABLIM1, AURKB, RASGRP3, IQCH, ASXL2, FNDC3A, KCNAB3, C19orf43, C1orf174, RGS5, OSBPL11, LYRM7, MSL3, TRAF3IP1, LOC541472, BLOC1S5, PNKD, SEPT5, CRADD, EEPD1, CLK3, BAIAP2, LARP4, SART1, MRPS18A, SOCS5, RGL1, AGPAT3, ZHX2, STK40, ARHGEF40, MRPL28, KIF3A, TAF6, DYNLRB2, LAP3, ABCF1, CCNB3, ARMC1, FUBP3, ISL1, GLRX5, PTP4A1, BYSL, PCIF1, RPL23, UTP23, UCHL5, TRAPPC2L, ORC6, RNF32, ROPN1L, RAP1B, ITGB3BP, SHOC2, ZNF684, LIMA1, PRKCI, NFYA, TTPA, SMIM11, NBPF3, LARP1B, POGK, RBM42, DEDD, IMP4, MAGEH1, BCKDK, HADH, TPD52L3, PLEKHO2, TGFBR2, ADH5, CDK3, ZNF22, TBCC, SERP1, MED24, SF3B6, HS3ST1, CCDC106, AIFM3, FIP1L1, ATF2, DPY19L2P1, NEDD9, PHYH, LUC7L2, CSNK1D, RAB40B, MRPL35, CCSER2, TFPT, CCDC59, MRPL11, ZNF2, IFIH1, TRIM40, SETBP1, DMD, ZNF410, ATP5H, ERG, RSRP1, HBG1, GJB1, ATG16L1, UBE2E2, HIST2H2AA3, POLE3, DENND6B, PPP1R8, FAM133B, TK1, GYS1, SIVA1, LMNTD1, BMX, HNRNPA1, UBE2S, COL14A1, COX6A2, HOMER3, HBS1L, ZNF574, MND1, GABPA, SDC1, KLF12, ALDH4A1, LARP6, DDHD2, ULK4, MOB1A, BMPR1B, ATF6, PHF20L1, TIPIN, ENTHD2, GNL2, CHGB, TBPL1, PRSS23, EIF2B5, ECHDC2, ARPC1B, WASH2P, DUS3L, SLC4A1AP, SPX, ZSCAN1, CCDC60, ACBD6, KCNN3, NUSAP1, PDE4D, NECAP1, PIP4K2C, DCDC2, NOL7, ADAT2, TWF1, BCAT2, SIRT7, OLFML2A, TBC1D7, RNF41, MAP1LC3A, ANKS6, SMAD1, CAPNS2, PHGDH, ECHDC1, HDAC4, VPS37C, PPAN, PSMA1, PCK1, ENKD1, ARNT2, CACNB1, PSMD11, MAPK7, ZMAT4, CSNK1E, HSPB7, GPKOW, ELK3, DCTN6, POLR2K, XAF1, CDC20, OCEL1, MX1, MORF4L1, GFAP, MYBBP1A, IL15, CTNND1, VCY1B, PTPN12, CCDC115, SRRT, RNMTL1, RUSC1, TSPY2, ACAD10, FGF16, CCDC15, SYCP2L, ACLY, ENO3, ATP5C1, FKBP1A, OTX2, SAMHD1, PNKP, HEYL, RPS6KB1, CCNL1, HDDC3, PLA2G4D, RPS11, MTURN, CHKA, FCHO1, PACRG, TTK, DNAJB1, C3orf36, STK17B, AAMDC, DPY19L2P4, STAU1, RRP15, BRD3, SIRT5, DDX1, CAAP1, RBM8A, CSNK2A1, LARP7, HIST1H2BA, NME3, ZNF740, SYK, TCP11L1, EMG1, PPHLN1, PLEKHJ1, KRTCAP2, AK4, BEND5, CMAS, ZMYM3, PRR14, CARF, PLSCR1, RPL34, KIAA1191, ITGB1BP1, TSSK2, FGFR2, LOC254896, MMGT1, SYT6, LINC00982, ATP5A1, SPG20, FSD1L, DRAP1, ZRSR2, HRASLS5, SRSF3, SKA3, GAS2, KCNK5, NELFA, USP2, YWHAB, HMBS, C14orf93, RCAN1, LETM2, BLOC1S6, LMX1B, TSSK6, CMTM2, CAMKK2, DIDO1, NAA25, SGK2, SRSF8, HIC2, SPATA4, ZFC3H1, PHYHD1, SYNCRIP, ABR, NECAB3, CDCA7, PSMA5, SND1, ASS1, THAP4, CAMK1D, PHACTR4, FBXO38, ARAP1, LOC401068, SIK2, SETD3, ZNF343, MARCH10, HBZ, CDK5R1, RGS1, SRR, LAD1, MURC, ADARB1, MYOZ1, KANSL2, SUPT4H1, ZSCAN5A, CHRAC1, PAIP2, PAGR1, UPF3A, EXOC3, HMGCS2, SNX1, LOC554207, TBC1D9B, PDPK1, ZCCHC17, FKBPL, TOM1, CLDN16, ABHD11, URI1, SP140L, RLBP1, TARP, WARS, EXOSC3, DKFZP434K028, MAT2B, SAE1, DYRK1A, ELF2, PRKCD, MB, TBCD, FAM90A1, HELLS, NUMB, DNAJC4, STIP1, CENPI, CSNK1G1, TICRR, CINP, ZNF35, TPI1, GNAZ, STK33, E2F6, TMOD2, NOL12, ICK, TTC23, PAK1, DECR1, HAGH, RPL37A, SULF1, GPAM, DDX10, YWHAZ, CCZ1B, DPCR1, ANKS4B, MAK, DZIP1L, ABCB7, UBAC1, NIM1K, TFPI, SLC7A1, AGFG1, VAC14, NNMT, PPP3CC, NR1H3, ZSCAN16, NEIL1, CFDP1, RAB39A, DECR2, CPEB1, PRSS33, FILIP1, PRPSAP2, ACO1, OARD1, WASL, PPIL2, KIFC1, CCDC88C, SLFNL1, SSTR2, FAM184A, C18orf21, SF3B2, CFAP58, H1F0, PHF8, DUSP12, UBL4A, GIMAP5, POMZP3, BEGAIN, AKT1, SOX7, BEND2, SPSB2, GPN2, FIBP, TNIP2, SPATS2, KLHL32, ZCCHC8, C2orf57, ING3, WWC3, METTL2B, RPL37, IFI16, LETMD1, NUDT16L1, SSBP3, EFS, TSKS, ATPAF2, TRAIP, MAPRE2, MAPK11, EIF2B2, C22orf46, ANKRD36BP1, ETNPPL, DUSP4, SAR1A, LIN7A, PSMD4, VPS41, BCL2L13, MRPL24, FAM212B, ARL6IP6, TMEM53, SLCO2B1, DLGAP5, CENPQ, RPS26, MEF2D, USP39, KLF8, DYNC1LI2, ERH, INIP, MLLT3, CHEK1, CCL26, PCDHGA12, RCOR3, ACSL3, ODF2L, COPZ1, METAP2, MARS2, PLBD1, PCK2, YTHDF2, C4orf46, RBX1, SUSD3, METTL16, LIMD1, MRPL27, POLH, POMC, C19orf33, BCL2L11, BHLHB9, ACY1, PPP2R5C, NEK11, PLEKHF2, IL26, IGSF10, HOXC6, CDC7, PPP1R17, STK26, TARDBP, OLFM1, SRPK2, SIGIRR, KLF6, PWP1, LENG1, RASGRP2, VWA5A, FAAH2, RIOK2, CAPRIN1, RSU1, ZMAT3, GNAT2, TP53TG1, MCC, FAM50A, RASA3, ARHGAP9, BHMT2, RIT2, CHTOP, CCNG1, IFT81, MRPS6, TXNDC5, OR7A5, PRKRIP1, LOC142937, DGCR6, SLX4, LRRC42, FBF1, NDUFB1, PARD6B, FRMD8, CDC25A, RAB14, TAF9, C3orf33, TRIM44, GIMAP8, AHDC1, ECI1, NPL, MRPL53, C11orf71, IK, QARS, FAM19A4, C11orf53, DTWD1, NDUFB6, CDK2AP2, GSTA3, AGO4, ZFAND5, FTSJ1, SMURF1, SNRNP35, MTMR14, ZXDC, SCD, PTK2, CDC42EP4, NXT2, FRG1B, MBD1, DSN1, RUFY3, PUSL1, VAMP3, ORC3, KLF4, C11orf45, FBXL7, ZCCHC12, IL18RAP, NDP, MROH8, AGAP1, CDKN2B, SERPINB2, TEX2, PROSER2, CLP1, FHL2, MOBP, NOVA1, TET3, PKM, ZC3HAV1, PRPF4, RPS6KA6, OR4D6, LOC403312, TCL1B, TOMM5, IRF2, CCT7, ZNF720, MEOX1, HBD, IGSF6, NMNAT1, TBC1D3P2, CDK5, LURAP1L, AIMP2, ZNF839, HIST1H4I, RBM4B, ARHGAP17, DNAJB6, TRAP1, PSME1, MRPL3, ATG12, GPR78, VPS29, S100A16, CHURC1, EIF6, LIPT1, LGALS2, HIGD2A, HOXB7, C15orf43, ASB6, MVB12A, LIMS2, DNALI1, CCDC33, EOGT, HIST2H2AB, EPB41L1, LMAN1, FAM212A, EAF1, OSM, IGHM, MEIS2, MICU1, SENP1, LAMC1, GPATCH1, RPL3L, PCYT1B, ATP6V1E1, ZNF23, CHCHD6, SLC35B1, SRSF1, ESRRG, PRICKLE2, CXCL16, RTKN, TRAM1, DPCD, RAI2, POLI, DENND1C, PTBP3, CLUAP1, HINT3, FAM47B, OXSR1, ARMC9, HMBOX1, PHLDA1, C8orf33, EP400NL, TAF7L, HMG20B, VHL, NARF, MCFD2, CTSB, SCAMP3, STRIP2, MCM5, QPCTL, USP6, TP53TG5, AGR2, SLC41A3, CELF4, OLFM3, CD36, ICT1, C3orf20, PIBF1, COPB1, GSPT2, CENPT, TAGLN2, RAB43, CCNE2, MRPS2, TGIF1, USP12, CD58, USP6NL, TCN2, GABRA4, PDSS2, APOA1, COPS5, IARS2, AHSA1, OPA1, SGK3, LPL, MED19, TNNT2, RPS14, UBE2G1, PSME2, CDIPT, KIAA1143, RNF183, CD300LF, TMEM126B, DGCR8, ALKBH7, AAK1, FOXI1, FMNL2, GALE, PARVG, FERMT3, WARS2, ZWINT, C21orf33, LFNG, TRDMT1, COL4A6, SOD2, CCDC144NL, DERL1, SRPK1, AK1, KCNMB2, TCEANC2, NECAP2, KLF7, DCTPP1, RAB11B, ARMC7, IDO1, POLL, SDCCAG3, MRPL20, MSMB, CCDC40, LY86, VAPA, WDR45B, CRACR2B, RAB10, COMMD2, RNF115, SYF2, ACTL7B, IL7, SULT1A3, GSTA1, ANKRD39, CIART, DDX20, MCM2, GPR61, H2AFV, WDR88, PTGDR, CGB, TIMM17B, CMTM3, DGUOK, TPRA1, ERVFRD-1, LINC00341, PSAT1, ORC4, NDEL1, ORMDL1, BAALC-AS2, PPP5C, TRAPPC3, MTFMT, S100A8, VTA1, USF1, PPP1R3C, GAL3ST1, SMARCB1, BNIP1, TBX22, PLRG1, NME8, MDM4, IPO4, EXOSC1, RALGPS1, DIMT1, GTDC1, COX4I2, RETSAT, RXFP3, MPV17L, NDUFA2, POLR2F, SEPT1, SKAP2, RUVBL2, AFG3L1P, ALDH8A1, ARHGDIB, RAB1B, C21orf59, KIAA0825, NRIP1, MRAP2, HAPLN1, CAMKK1, TGM2, CELF1, TNFSF14, DSCR9, RAB8B, ANXA8, CDK18, PIP5K1A, SRSF9, RIMS4, THAP7, C15orf39, GAGE1, POMGNT2, DEFA6, IREB2, PCDHGC3, CERK, WASH3P, PARP3, SH3BP5, HSPA9, UGCG, CLASRP, CCDC28B, MITF, RAB7B, SNX21, GNLY, PCDHA7, MAP2K3, SERAC1, DNAJB14, WDR45, SHMT2, KRT36, TRMT1L, TPMT, DIEXF, GEMIN8, RAB5C, GTF2E1, NAPA, CDK4, STOML1, FAM131C, ANKRA2, GUCD1, AGER, SUB1, C19orf18, DNAJC12, RPA4, GRAMD4, ALDH2, PGM3, ETFB, COLEC12, PPP6R2, ACKR2, PCDHGC5, MAPK10, RAB38, KIAA1841, PPAP2B, ETHE1, NMNAT2, PIKFYVE, GUCY1B3, OPA3, PLA2G4C, CD300LB, ZDHHC23, PFKL, NXF2, SPINT2, PUS7L, TRIM69, ZNF483, CUL4B, RNF34, EIF4E, SNAI2, ASCL3, C7orf31, HMGB4, NECAB1, REG1A, PIK3R5, ADAD2, CAPSL, MYOT, BIN3-IT1, ASGR1, C1D, APOBEC3G, GSTO1, RPS27A, ARF6, SEC24C, PPP2R4, CRHR2, SPAG6, RAB26, HCFC1R1, RBM39, CCL13, NAT2, NDUFS4, RPS18, ZC3HC1, FMNL3, KIF4A, VIPR2, KLK7, ZKSCAN1, NUDT9, CBFA2T2, PPIA, SYNJ2BP, IFNW1, TRAF6, MIER1, C3orf62, UBE3A, WDR89, MXD1, EBF4, SPIC, KCNE1L, SRSF6, ZCCHC6, L3MBTL4, YAE1D1, ANXA2, PLK2, ANKS1B, ZSCAN18, GGA2, DCUN1D2, SH2D1B, CDPF1, GSDMB, SLC1A1, FERMT2, VPS37A, TSNAXIP1, P2RX6, MRRF, GAPDHS, INTS12, C1orf64, EIF3M, OBFC1, ASPH, KAT7, ETV5, HYPK, EPHA2, LGALS3, SPC24, SLC48A1, VASH2, KPNA2, CLDN3, TMEM97, ARRDC1, ACAA2, ANKRD13D, CDK7, LANCL2, YPEL3, DYNLT1, C12orf5, RWDD2B, PDE1A, C6orf118, ADH4, ALB, GNB5, EIF2A, PSMD5, CFAP53, PGM1, SERF1A, AEBP2, TBC1D20, ARCN1, USP5, RSPH3, CDKL2, CCDC107, RD3, UGGT2, TSPAN5, TMX3, FUCA1, AP2A2, ARPP19, C19orf12, MPI, GRHL2, CCIN, RSPH10B2, SUN5, EEF1B2, C16orf70, PYROXD1, TNFAIP8L1, CLDN20, PIK3R2, POLDIP2, TCEA2, NLRP2, LRRC1, NOL11, RAB35, FGFBP2, CHEK2, NARFL, ISOC2, UBE3C, BRMS1, TANK, BET1L, SRRM2, PLCD4, C17orf70, CSTF2, IFI6, R3HDML, FKBP5, NGLY1, OXSM, MKKS, FOXJ2, MCTP2, MAD2L1, RBPJ, ARL5A, FAM151A, CAMKV, AFG3L2, TEX37, MEST, PARVA, GLOD4, PTMS, MCEE, MED11, BDH1, FAM127B, FAM127A, INPP5B, LLPH, DNAH14, SDF4, GNRH2, CSRP1, NAV1, DEPTOR, CTBP2, NDUFA4, EMC8, ASMTL, HBG2, BCL11A, TSPAN13, CYB561D2, PEX2, MMP12, OSTF1, CHMP3, MTERF4, RRAGB, UBL3, DHRS7B, PDS5B, CDCA3, RBPJL, HAVCR2, TUBB, TAF11, UBXN7, C11orf54, CISD2, HIST1H2BB, STK11, STX11, LINGO2, HIRIP3, CXXC4, MARCH3, NOC2L, SMYD3, AKT2, RAB28, UXT, ACSBG1, RGS18, NNAT, DUSP21, ST3GAL6, SKAP1, C1orf112, FITM1, NAGA, FAM122A, CLIC3, ZDHHC7, MAP2K4, IRGC, STAT5B, FAM160B2, KIAA0513, TMEM175, ATL3, MOB1B, SSH3, DAPK2, ERC1, COA5, IL1B, PELI3, PRPF38A, GORASP2, FAM214B, BRF1, PDZK1, RING1, GTF3C6, RASSF8, RPA2, TEK, LOC90768, PFKFB1, POLR3C, HCK, ARL8B, SYT17, FN3KRP, MAGEA4, FAM213A, ROR1, KLK9, HSPA2, JAGN1, H2AFY, IGF1R, WAC, ETS1, BDNF, STARD10, TMCC2, CIAO1, CNPY2, TRIM16, MAB21L2, LAIR1, EFHD2, SPATA7, DNAAF2, KISS1, PRKAB1, GLB1L, TLL1, ART4, GNA12, CCDC14, METTL8, NUP50, KPNA4, FAM3B, RPS6KA5, RFWD3, SNURF, CAMK1, SMG5, FYCO1, TIMMDC1, SIX2, OTUB2, CHID1, GGCT, CCND3, ARID3B, EXOSC7, MRPL52, UBE2DNL, ODAM, NME6, PHLDA3, VPS35, NDUFA5, SNAP25, DCXR, INTS3, CALCOCO1, TBCK, PAEP, RNASE11, MYL10, TNFRSF14, PABPC3, CNOT7, ALOX5, TMEM35, TTLL6, GNA15, RABL3, METTL25, LYPLA2, LOC554223, ORMDL3, INS, TMOD4, GALNT12, CFHR2, TCP11L2, ZNF75A, PPP2R5E, SNRNP40, FCGR3A, NTM, AP4S1, SH3BGRL3, PRKCG, NOS1AP, ZNF581, KPTN, SLC17A5, MAST2, ALDH7A1, VAT1L, MTERF3, ANXA5, CASP4, PARP15, EPS8L2, WNT4, GADD45G, BTK, PCBP1, CASC4, HAUS6, ZFP36, RNF11, PTK6, CARS, TAP2, C1orf111, ZEB2, FLCN, MINA, MSTN, GPR12, TBC1D21, NUDT16P1, DPP3, TCEAL8, PIGG, UGT1A10, RNF138, CXCL14, DTD2, PTGIS, GTPBP8, PTPRO, NDUFAF7, MED9, CIRBP, AGFG2, SPINK6, RNF185, ARHGEF5, TMEM255A, SCO2, MS4A2, IFNA16, RPS21, TIPRL, PQBP1, RIOK1, CACNG2, EIF3F, MSI1, C6orf106, RBCK1, CYP20A1, ANKRD45, NMRK1, RAD51C, CACNG3, NXPE3, APITD1, HCP5, CYB5B, OSBPL5, ACAD11, MBNL1, RASSF3, SLC2A2, ABHD10, ANP32B, DHRSX, ACYP1, C14orf159, MAG, TNFSF13B, MOGAT3, OSTCP1, KRTAP10-7, RCBTB1, DIO3, TRIB3, PNPO, BCL2A1, RAB27A, RAPGEFL1, ZFYVE16, KLK2, PLS3, DRAM1, SF3A3, CAMKMT, ACTL7A, HPGD, ARFGAP3, RAB2B, PDK3, CCBL1, P2RY2, CATIP, TRIM47, DCAF7, C9orf72, SEPT12, SGCG, GIMAP6, MTCP1, OCIAD2, APEX1, POU2F1, CHAC2, NDUFB3, AIDA, CNDP1, ACTL6B, TRIM39, DIXDC1, EBP, LIMK1, RNF151, SLC38A2, ITGA6, C9orf142, OLFM4, NLN, AREG, DUSP3, PDCD7, VTN, NTRK3, C6orf203, ICAM3, FAM200A, FOXS1, ACBD4, AKAP1, SPEG, PSMB4, SLC22A6, IPO9, ATG13, CCT8, HAUS8, TRIB2, ODF4, ADI1, LSMEM2, MRPL48, HRASLS, IFNA5, MAPK8, DMKN, CDKN2D, PRDX2, C10orf88, RAB3D, C5orf28, FSIP1, MYL1, VSIG4, ATXN3, CEACAM6, IL1RL1, ATRAID, MED30, ETV4, TRIML1, PPARG, IFNA8, KCNIP4, TMEM261, NAAA, CEP250, ATG7, C11orf73, NMRK2, NUP62CL, PASD1, ZNF322, RPS25, ARMCX3, POLA2, ATF4, CHAF1B, PDZD9, KCNJ10, BSND, KIR2DL3, SERTM1, FAM134B, LSMEM1, C4orf22, PIGO, CLEC2B, C5orf15, TMEM183A, SCAND2P, LPAR3, LINC00663, CST2, PLCD1, COX4I1, CTNNB1, JTB, C1orf105, GOSR1, VDAC2, BOLA1, C2orf47, IARS, EVI2A, USP48, PDIA3, EPHB4, ATCAY, TBK1, PBRM1, COQ6, PDYN, TRAPPC4, FBXW9, SPRR4, TMUB1, DNAJC19, TMEM180, RMND5A, PLA1A, HERC2P9, PPP1CC, DHX16, PIM1, PKNOX1, NDUFS2, STOML3, GNPTAB, FAM3A, PDDC1, ANGPTL7, NAALADL2, DLK2, PSMA7, A2M, PSEN1, IFIT3, AP1M2, PRAM1, CDC37, EXOC6, MAST1, PAXIP1, PI4K2A, PSEN2, RAB3A, ECSIT, CFL1, APP, TM2D1, MAP3K11, MAPK8IP2, KIF1B, TPD52L2, TIRAP, FOS, PCBD1, JUN, MDM2, RANBP9, LRP1, BACE1, SNX17, SNX27, CUL7, MAPT, QRICH1, RNF2, EGFR, UBE2I, GSAP, SORL1, TMEM30A, USP25, FBXW11, SRP19, FAM27E3, RBM11, VCY, KIAA0020, LTV1, OR6B3, TUBG1, PINX1, ABT1, AGO1, TYMSOS, ZNF747, FGF13, UTP14A, MYC, RBM34, ZC3H3, HIST2H2AC, ADAM22, ERCC1, PES1, ATXN7L3, APOBEC3H, DDX49, RPL11, ZNF486, TBC1D26, ZNF385B, AKAP13, DNAJB7, PARD6A, RSL1D1, C1orf116, C16orf78, PURG, ALKBH8, FCF1, PNRC2, EHF, GLRB, CPED1, GPATCH2L, RAG1, ROBO3, FES, NCR1, THAP1, GRAMD1C, ST6GALNAC6, ZSCAN21, DNAJC30, ZNF449, PPP1R10, HDGF, ATP5O, S1PR1, GPR15, EEF1D, ZKSCAN8, TRAPPC9, TRIM46, HMGA1, THBS4, RFX5, HOXC4, ARHGAP15, TMCC1, ZNF641, LMF2, KATNA1, SGIP1, TMEM216, XRCC3, CASP3, CASP6, MAP3K5, NEFL, TGFB1, TGFB2, UCHL1, PTGS2, SRC, NF1, KDR, PTPN2, CES2, FRMD6, UTP11L, ZNF107, INHBE, ZNF431, SULF2, ZNF92, ZNF724P, ACADL, NME2, GSG2, CES3, GDF11, DNAJB9, TMEM30B, MAP7, OBSL1, F11, IL20RB, TIMP3, KEAP1, MAP7D1, ZNF445, AARS2, CBX6, COL18A1, CKAP2, C3orf17, CLEC12A, HS2ST1, PTCD2, QTRT1, TRIM25, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAPPchr4:187627717chr21:27372497ENST00000346798-518732_751288771G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000348990-016732_751-49696G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000354192-015732_751-43640G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000357903-517732_751288752G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000358918-517732_751288753G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000359726-017732_751-67715G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000440126-517732_751283747G(o)-alpha


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAT1_APP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneAPPP05067DB06782DimercaprolAmyloid-beta A4 proteinsmall moleculeapproved
TgeneAPPP05067DB09148Florbetaben (18F)Amyloid-beta A4 proteinsmall moleculeapproved
TgeneAPPP05067DB00746DeferoxamineAmyloid-beta A4 proteinsmall moleculeapproved|investigational
TgeneAPPP05067DB01370AluminiumAmyloid-beta A4 proteinsmall moleculeapproved|investigational
TgeneAPPP05067DB01593ZincAmyloid-beta A4 proteinsmall moleculeapproved|investigational
TgeneAPPP05067DB09149Florbetapir (18F)Amyloid-beta A4 proteinsmall moleculeapproved|investigational
TgeneAPPP05067DB09151Flutemetamol (18F)Amyloid-beta A4 proteinsmall moleculeapproved|investigational

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RelatedDiseases for FAT1_APP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAT1C0009404Colorectal Neoplasms1CTD_human
HgeneFAT1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneFAT1C0017636Glioblastoma1CTD_human
HgeneFAT1C0018671Head and Neck Neoplasms1CTD_human
HgeneFAT1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFAT1C0036095Salivary Gland Neoplasms1CTD_human
HgeneFAT1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneAPPC0002395Alzheimer's Disease55CTD_human;HPO;ORPHANET;UNIPROT
TgeneAPPC0025261Memory Disorders12CTD_human
TgeneAPPC0027746Nerve Degeneration11CTD_human
TgeneAPPC0023186Learning Disorders6CTD_human
TgeneAPPC0011570Mental Depression5PSYGENET
TgeneAPPC0011581Depressive disorder5PSYGENET
TgeneAPPC2751536CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED5ORPHANET;UNIPROT
TgeneAPPC0009241Cognition Disorders4CTD_human
TgeneAPPC0522224Paralysed4CTD_human
TgeneAPPC0524851Neurodegenerative Disorders2CTD_human
TgeneAPPC0600467Neurogenic Inflammation2CTD_human
TgeneAPPC2931672Cerebral hemorrhage with amyloidosis, hereditary, Dutch type2CTD_human;ORPHANET
TgeneAPPC0002622Amnesia1CTD_human
TgeneAPPC0002726Amyloidosis1CTD_human
TgeneAPPC0003469Anxiety Disorders1CTD_human
TgeneAPPC0005586Bipolar Disorder1PSYGENET
TgeneAPPC0006111Brain Diseases1CTD_human
TgeneAPPC0011573Endogenous depression1PSYGENET
TgeneAPPC0016667Fragile X Syndrome1CTD_human
TgeneAPPC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneAPPC0027540Necrosis1CTD_human
TgeneAPPC0037928Spinal Cord Diseases1CTD_human
TgeneAPPC0038002Splenomegaly1CTD_human
TgeneAPPC0043094Weight Gain1CTD_human
TgeneAPPC0085220Cerebral Amyloid Angiopathy1CTD_human;HPO
TgeneAPPC0231341Premature aging syndrome1CTD_human
TgeneAPPC0338656Impaired cognition1CTD_human
TgeneAPPC0497327Dementia1CTD_human;HPO
TgeneAPPC2936349Plaque, Amyloid1CTD_human