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Fusion gene ID: 12972 |
FusionGeneSummary for FASN_LOXL4 |
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Fusion gene information | Fusion gene name: FASN_LOXL4 | Fusion gene ID: 12972 | Hgene | Tgene | Gene symbol | FASN | LOXL4 | Gene ID | 2194 | 84171 |
Gene name | fatty acid synthase | lysyl oxidase like 4 | |
Synonyms | FAS|OA-519|SDR27X1 | LOXC | |
Cytomap | 17q25.3 | 10q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | fatty acid synthaseshort chain dehydrogenase/reductase family 27X, member 1 | lysyl oxidase homolog 4lysyl oxidase related Clysyl oxidase-like 4 pseudogenelysyl oxidase-like protein 4lysyl oxidase-related protein C | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P49327 | Q96JB6 | |
Ensembl transtripts involved in fusion gene | ENST00000306749, ENST00000579758, | ENST00000260702, | |
Fusion gene scores | * DoF score | 6 X 7 X 6=252 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: FASN [Title/Abstract] AND LOXL4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-ER-A19H-06A | FASN | chr17 | 80040199 | - | LOXL4 | chr10 | 100022808 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000306749 | ENST00000260702 | FASN | chr17 | 80040199 | - | LOXL4 | chr10 | 100022808 | - |
5UTR-5UTR | ENST00000579758 | ENST00000260702 | FASN | chr17 | 80040199 | - | LOXL4 | chr10 | 100022808 | - |
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FusionProtFeatures for FASN_LOXL4 |
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Hgene | Tgene |
FASN | LOXL4 |
May modulate the formation of a collagenousextracellular matrix. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FASN_LOXL4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FASN_LOXL4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FASN | FASN, EWSR1, USP2, HDAC5, PCK1, RAD21, NDRG1, MAPK3, ARRB1, ARRB2, SIRT7, TSG101, ISG15, CUL3, CDK2, DCUN1D1, SHC1, AP2M1, EMD, TP53BP1, EIF4A3, MAGOH, PTPN11, SMURF1, HSP90AB1, HSP90AA1, FN1, VCAM1, NOS2, NPM1, LMNA, PRR12, YWHAQ, FBXO6, CAP1, KIAA1598, SIRT1, TPM3, TPM4, LGR4, PHKG2, ILK, STAU1, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, PTGR2, KIF3A, IMPDH1, HAUS4, TEAD3, YAP1, ABCC1, AHSA1, ASNS, CARM1, CCT6A, CCT6B, CYP27A1, HSD17B12, PC, PEF1, PIK3C2B, GFPT1, GFPT2, HSPBP1, MTCH1, TARBP1, NTRK1, AKT1, PTEN, HSPA5, KIF11, DNAJC7, IRF3, FOXI1, FOXI2, CRY1, CRY2, FOXL1, MCM2, SNW1, CDC5L, ZNF746, CDH1, USP22, CYLD, COX15, DLD, DLST, DNM1L, HSD17B10, PDHA1, SDHA, VHL, CAD, HIF1A, BRCA1, HDAC6 | LOXL4 | TRIP13, CDC37, ECSIT, EXOC6, APOE, LONP1, RAD23A, MAST1, AP1M2, RNF32, KDM1A, PRMT6, SUV39H1, CCT6B, SEPHS2, CCT6A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FASN_LOXL4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | FASN | P49327 | DB01083 | Orlistat | Fatty acid synthase | small molecule | approved|investigational |
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RelatedDiseases for FASN_LOXL4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FASN | C0025202 | melanoma | 3 | CTD_human |
Hgene | FASN | C2239176 | Liver carcinoma | 3 | CTD_human |
Hgene | FASN | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | FASN | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
Hgene | FASN | C0007194 | Hypertrophic Cardiomyopathy | 1 | CTD_human |
Hgene | FASN | C0018801 | Heart failure | 1 | CTD_human |
Hgene | FASN | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | FASN | C0023827 | liposarcoma | 1 | CTD_human |
Hgene | FASN | C0028754 | Obesity | 1 | CTD_human |
Hgene | FASN | C0086132 | Depressive Symptoms | 1 | PSYGENET |
Hgene | FASN | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | FASN | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | FASN | C3714756 | Intellectual Disability | 1 | CTD_human |
Hgene | FASN | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | LOXL4 | C0005695 | Bladder Neoplasm | 1 | CTD_human |