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Fusion gene ID: 12948 |
FusionGeneSummary for FARP2_GTDC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FARP2_GTDC1 | Fusion gene ID: 12948 | Hgene | Tgene | Gene symbol | FARP2 | GTDC1 | Gene ID | 9855 | 79712 |
| Gene name | FERM, ARH/RhoGEF and pleckstrin domain protein 2 | glycosyltransferase like domain containing 1 | |
| Synonyms | FIR|FRG|PLEKHC3 | Hmat-Xa|mat-Xa | |
| Cytomap | 2q37.3 | 2q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FERM, ARHGEF and pleckstrin domain-containing protein 2FERM domain including RhoGEFFERM, RhoGEF and pleckstrin domain protein 2FERM, RhoGEF and pleckstrin domain-containing protein 2FGD1-related Cdc42-GEFPH domain-containing family C member 3pleckst | glycosyltransferase-like domain-containing protein 1glycosyltransferase-like 1mannosyltransferase candidatemannosyltransferase-like protein Xa | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O94887 | Q4AE62 | |
| Ensembl transtripts involved in fusion gene | ENST00000264042, ENST00000545004, ENST00000373287, ENST00000479427, | ENST00000392869, ENST00000409214, ENST00000392867, ENST00000409298, ENST00000344850, ENST00000542155, ENST00000241391, ENST00000463875, ENST00000467352, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 3 X 1=9 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FARP2 [Title/Abstract] AND GTDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FARP2 | GO:0016322 | neuron remodeling | 12351724 |
| Hgene | FARP2 | GO:0016601 | Rac protein signal transduction | 12351724 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CV337072 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000264042 | ENST00000392869 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000264042 | ENST00000409214 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000264042 | ENST00000392867 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000264042 | ENST00000409298 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000264042 | ENST00000344850 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000264042 | ENST00000542155 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000264042 | ENST00000241391 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000264042 | ENST00000463875 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000264042 | ENST00000467352 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000545004 | ENST00000392869 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000545004 | ENST00000409214 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000545004 | ENST00000392867 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000545004 | ENST00000409298 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000545004 | ENST00000344850 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000545004 | ENST00000542155 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000545004 | ENST00000241391 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000545004 | ENST00000463875 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000545004 | ENST00000467352 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000373287 | ENST00000392869 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000373287 | ENST00000409214 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000373287 | ENST00000392867 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000373287 | ENST00000409298 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000373287 | ENST00000344850 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000373287 | ENST00000542155 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000373287 | ENST00000241391 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000373287 | ENST00000463875 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000373287 | ENST00000467352 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000479427 | ENST00000392869 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000479427 | ENST00000409214 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000479427 | ENST00000392867 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000479427 | ENST00000409298 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000479427 | ENST00000344850 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000479427 | ENST00000542155 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000479427 | ENST00000241391 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000479427 | ENST00000463875 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
| intron-intron | ENST00000479427 | ENST00000467352 | FARP2 | chr2 | 242382329 | - | GTDC1 | chr2 | 144725369 | + |
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FusionProtFeatures for FARP2_GTDC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FARP2 | GTDC1 |
| Functions as guanine nucleotide exchange factor thatactivates RAC1. May have relatively low activity. Plays a role inthe response to class 3 semaphorins and remodeling of the actincytoskeleton. Plays a role in TNFSF11-mediated osteoclastdifferentiation, especially in podosome rearrangement andreorganization of the actin cytoskeleton. Regulates the activationof ITGB3, integrin signaling and cell adhesion (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FARP2_GTDC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FARP2_GTDC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FARP2_GTDC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FARP2_GTDC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FARP2 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | FARP2 | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
| Hgene | FARP2 | C2931817 | Chromosome 2q37 deletion syndrome | 1 | CTD_human |
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