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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12917

FusionGeneSummary for FANCC_SLC28A3

check button Fusion gene summary
Fusion gene informationFusion gene name: FANCC_SLC28A3
Fusion gene ID: 12917
HgeneTgene
Gene symbol

FANCC

SLC28A3

Gene ID

2176

64078

Gene nameFA complementation group Csolute carrier family 28 member 3
SynonymsFA3|FAC|FACCCNT3
Cytomap

9q22.32

9q21.32-q21.33

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia group C proteinFanconi anemia complementation group Csolute carrier family 28 member 3concentrative Na(+)-nucleoside cotransporter 3concentrative Na+-nucleoside cotransportersolute carrier family 28 (concentrative nucleoside transporter), member 3solute carrier family 28 (sodium-coupled nucleoside trans
Modification date2018052320180523
UniProtAcc

Q00597

Q9HAS3

Ensembl transtripts involved in fusion geneENST00000289081, ENST00000375305, 
ENST00000464653, 
ENST00000376238, 
ENST00000537648, ENST00000495823, 
Fusion gene scores* DoF score7 X 5 X 6=2106 X 4 X 4=96
# samples 76
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FANCC [Title/Abstract] AND SLC28A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1JP-01AFANCCchr9

98079808

-SLC28A3chr9

86903093

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000289081ENST00000376238FANCCchr9

98079808

-SLC28A3chr9

86903093

-
5UTR-3CDSENST00000289081ENST00000537648FANCCchr9

98079808

-SLC28A3chr9

86903093

-
5UTR-intronENST00000289081ENST00000495823FANCCchr9

98079808

-SLC28A3chr9

86903093

-
intron-3CDSENST00000375305ENST00000376238FANCCchr9

98079808

-SLC28A3chr9

86903093

-
intron-3CDSENST00000375305ENST00000537648FANCCchr9

98079808

-SLC28A3chr9

86903093

-
intron-intronENST00000375305ENST00000495823FANCCchr9

98079808

-SLC28A3chr9

86903093

-
intron-3CDSENST00000464653ENST00000376238FANCCchr9

98079808

-SLC28A3chr9

86903093

-
intron-3CDSENST00000464653ENST00000537648FANCCchr9

98079808

-SLC28A3chr9

86903093

-
intron-intronENST00000464653ENST00000495823FANCCchr9

98079808

-SLC28A3chr9

86903093

-

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FusionProtFeatures for FANCC_SLC28A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FANCC

Q00597

SLC28A3

Q9HAS3

DNA repair protein that may operate in a postreplicationrepair or a cell cycle checkpoint function. May be implicated ininterstrand DNA cross-link repair and in the maintenance of normalchromosome stability. Upon IFNG induction, may facilitate STAT1activation by recruiting STAT1 to IFNGR1.{ECO:0000269|PubMed:11520787}. Sodium-dependent, pyrimidine- and purine-selective.Involved in the homeostasis of endogenous nucleosides. Exhibitsthe transport characteristics of the nucleoside transport systemcib or N3 subtype (N3/cib) (with marked transport of boththymidine and inosine). Employs a 2:1 sodium/nucleoside ratio.Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine(AZT), ribavirin and 3-deazauridine. {ECO:0000269|PubMed:11032837,ECO:0000269|PubMed:16446384, ECO:0000269|PubMed:17140564}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FANCC_SLC28A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FANCC_SLC28A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FANCCEBLN2, HSPA1A, EIF2AK2, FANCE, FANCF, STAT1, GSTP1, FANCA, SPTAN1, AZIN1, TCERG1, CDK1, FANCG, ZBTB32, RPS3A, HSP90B1, HSP90AA1, HSPA8, ATP6, KRT1, IK, RPL18, USP14, FANCM, NPM1, CAPN1, FANCL, HES1, FANCD2, HSPA4, DNAJB1, POR, CTNNB1, C1orf86, CAPN10, APITD1, STRA13, C17orf70, NOTCH1, STMN2, STMN1, CTBP1, RECQL5, UNC5A, FANCC, PRDX3, PRPF31, CCNA2, SPTA1SLC28A3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FANCC_SLC28A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FANCC_SLC28A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFANCCC3468041FANCONI ANEMIA, COMPLEMENTATION GROUP C2CTD_human;UNIPROT