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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12916

FusionGeneSummary for FANCC_ROR2

check button Fusion gene summary
Fusion gene informationFusion gene name: FANCC_ROR2
Fusion gene ID: 12916
HgeneTgene
Gene symbol

FANCC

ROR2

Gene ID

2176

6095

Gene nameFA complementation group CRAR related orphan receptor A
SynonymsFA3|FAC|FACCNR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRA
Cytomap

9q22.32

15q22.2

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia group C proteinFanconi anemia complementation group Cnuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4tran
Modification date2018052320180523
UniProtAcc

Q00597

Q01974

Ensembl transtripts involved in fusion geneENST00000289081, ENST00000375305, 
ENST00000464653, 
ENST00000375715, 
ENST00000375708, ENST00000550066, 
Fusion gene scores* DoF score7 X 5 X 6=2102 X 2 X 2=8
# samples 72
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: FANCC [Title/Abstract] AND ROR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneROR2

GO:0006355

regulation of transcription, DNA-templated

9328355

TgeneROR2

GO:0030522

intracellular receptor signaling pathway

19965867

TgeneROR2

GO:0036315

cellular response to sterol

19965867

TgeneROR2

GO:0045893

positive regulation of transcription, DNA-templated

7926749

TgeneROR2

GO:0045944

positive regulation of transcription by RNA polymerase II

17545671|19955433


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-XQ-A8TA-01AFANCCchr9

98002931

-ROR2chr9

94538100

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000289081ENST00000375715FANCCchr9

98002931

-ROR2chr9

94538100

-
5CDS-5UTRENST00000289081ENST00000375708FANCCchr9

98002931

-ROR2chr9

94538100

-
5CDS-5UTRENST00000289081ENST00000550066FANCCchr9

98002931

-ROR2chr9

94538100

-
5CDS-5UTRENST00000375305ENST00000375715FANCCchr9

98002931

-ROR2chr9

94538100

-
5CDS-5UTRENST00000375305ENST00000375708FANCCchr9

98002931

-ROR2chr9

94538100

-
5CDS-5UTRENST00000375305ENST00000550066FANCCchr9

98002931

-ROR2chr9

94538100

-
intron-5UTRENST00000464653ENST00000375715FANCCchr9

98002931

-ROR2chr9

94538100

-
intron-5UTRENST00000464653ENST00000375708FANCCchr9

98002931

-ROR2chr9

94538100

-
intron-5UTRENST00000464653ENST00000550066FANCCchr9

98002931

-ROR2chr9

94538100

-

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FusionProtFeatures for FANCC_ROR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FANCC

Q00597

ROR2

Q01974

DNA repair protein that may operate in a postreplicationrepair or a cell cycle checkpoint function. May be implicated ininterstrand DNA cross-link repair and in the maintenance of normalchromosome stability. Upon IFNG induction, may facilitate STAT1activation by recruiting STAT1 to IFNGR1.{ECO:0000269|PubMed:11520787}. Tyrosine-protein kinase receptor which may be involvedin the early formation of the chondrocytes. It seems to berequired for cartilage and growth plate development (Bysimilarity). Phosphorylates YWHAB, leading to induction ofosteogenesis and bone formation (PubMed:17717073). In contrast,has also been shown to have very little tyrosine kinase activityin vitro. May act as a receptor for wnt ligand WNT5A which mayresult in the inhibition of WNT3A-mediated signaling(PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138,ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FANCC_ROR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FANCC_ROR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FANCCEBLN2, HSPA1A, EIF2AK2, FANCE, FANCF, STAT1, GSTP1, FANCA, SPTAN1, AZIN1, TCERG1, CDK1, FANCG, ZBTB32, RPS3A, HSP90B1, HSP90AA1, HSPA8, ATP6, KRT1, IK, RPL18, USP14, FANCM, NPM1, CAPN1, FANCL, HES1, FANCD2, HSPA4, DNAJB1, POR, CTNNB1, C1orf86, CAPN10, APITD1, STRA13, C17orf70, NOTCH1, STMN2, STMN1, CTBP1, RECQL5, UNC5A, FANCC, PRDX3, PRPF31, CCNA2, SPTA1ROR2MAGED1, IKBKG, MAP3K7, DAZAP2, WNT1, HSP90AA1, CRX, DAB1, ROR2, ZMYM4, RBPMS, C1orf94, PRR20A, MOV10, NXF1, NTRK1, TMEM17, TMEM216, PPP3CB, PPM1A, PPM1B, PPM1F, ILKAP, TAB1, PTPRR, PTPN6, PTPN7, PTPN11, PTPN12, PTPN20B, DUSP1, DUSP6, DUSP10, DUSP14, DUSP18, DUSP19, DUSP21, DUPD1, STYX, CDC14A, TPTE, MTMR1, MTMR2, MTMR6, MTMR9, CDC25C, EYA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FANCC_ROR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FANCC_ROR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFANCCC3468041FANCONI ANEMIA, COMPLEMENTATION GROUP C2CTD_human;UNIPROT
TgeneROR2C1849334Robinow syndrome, autosomal recessive4CTD_human;ORPHANET;UNIPROT