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Fusion gene ID: 12916 |
FusionGeneSummary for FANCC_ROR2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FANCC_ROR2 | Fusion gene ID: 12916 | Hgene | Tgene | Gene symbol | FANCC | ROR2 | Gene ID | 2176 | 6095 |
| Gene name | FA complementation group C | RAR related orphan receptor A | |
| Synonyms | FA3|FAC|FACC | NR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRA | |
| Cytomap | 9q22.32 | 15q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Fanconi anemia group C proteinFanconi anemia complementation group C | nuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4tran | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q00597 | Q01974 | |
| Ensembl transtripts involved in fusion gene | ENST00000289081, ENST00000375305, ENST00000464653, | ENST00000375715, ENST00000375708, ENST00000550066, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 2 X 2 X 2=8 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: FANCC [Title/Abstract] AND ROR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ROR2 | GO:0006355 | regulation of transcription, DNA-templated | 9328355 |
| Tgene | ROR2 | GO:0030522 | intracellular receptor signaling pathway | 19965867 |
| Tgene | ROR2 | GO:0036315 | cellular response to sterol | 19965867 |
| Tgene | ROR2 | GO:0045893 | positive regulation of transcription, DNA-templated | 7926749 |
| Tgene | ROR2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17545671|19955433 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-XQ-A8TA-01A | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000289081 | ENST00000375715 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000289081 | ENST00000375708 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000289081 | ENST00000550066 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000375305 | ENST00000375715 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000375305 | ENST00000375708 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000375305 | ENST00000550066 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| intron-5UTR | ENST00000464653 | ENST00000375715 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| intron-5UTR | ENST00000464653 | ENST00000375708 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| intron-5UTR | ENST00000464653 | ENST00000550066 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
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FusionProtFeatures for FANCC_ROR2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FANCC | ROR2 |
| DNA repair protein that may operate in a postreplicationrepair or a cell cycle checkpoint function. May be implicated ininterstrand DNA cross-link repair and in the maintenance of normalchromosome stability. Upon IFNG induction, may facilitate STAT1activation by recruiting STAT1 to IFNGR1.{ECO:0000269|PubMed:11520787}. | Tyrosine-protein kinase receptor which may be involvedin the early formation of the chondrocytes. It seems to berequired for cartilage and growth plate development (Bysimilarity). Phosphorylates YWHAB, leading to induction ofosteogenesis and bone formation (PubMed:17717073). In contrast,has also been shown to have very little tyrosine kinase activityin vitro. May act as a receptor for wnt ligand WNT5A which mayresult in the inhibition of WNT3A-mediated signaling(PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138,ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FANCC_ROR2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FANCC_ROR2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FANCC | EBLN2, HSPA1A, EIF2AK2, FANCE, FANCF, STAT1, GSTP1, FANCA, SPTAN1, AZIN1, TCERG1, CDK1, FANCG, ZBTB32, RPS3A, HSP90B1, HSP90AA1, HSPA8, ATP6, KRT1, IK, RPL18, USP14, FANCM, NPM1, CAPN1, FANCL, HES1, FANCD2, HSPA4, DNAJB1, POR, CTNNB1, C1orf86, CAPN10, APITD1, STRA13, C17orf70, NOTCH1, STMN2, STMN1, CTBP1, RECQL5, UNC5A, FANCC, PRDX3, PRPF31, CCNA2, SPTA1 | ROR2 | MAGED1, IKBKG, MAP3K7, DAZAP2, WNT1, HSP90AA1, CRX, DAB1, ROR2, ZMYM4, RBPMS, C1orf94, PRR20A, MOV10, NXF1, NTRK1, TMEM17, TMEM216, PPP3CB, PPM1A, PPM1B, PPM1F, ILKAP, TAB1, PTPRR, PTPN6, PTPN7, PTPN11, PTPN12, PTPN20B, DUSP1, DUSP6, DUSP10, DUSP14, DUSP18, DUSP19, DUSP21, DUPD1, STYX, CDC14A, TPTE, MTMR1, MTMR2, MTMR6, MTMR9, CDC25C, EYA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FANCC_ROR2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FANCC_ROR2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FANCC | C3468041 | FANCONI ANEMIA, COMPLEMENTATION GROUP C | 2 | CTD_human;UNIPROT |
| Tgene | ROR2 | C1849334 | Robinow syndrome, autosomal recessive | 4 | CTD_human;ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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