|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 12904 |
FusionGeneSummary for FAM98C_SPINT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM98C_SPINT2 | Fusion gene ID: 12904 | Hgene | Tgene | Gene symbol | FAM98C | SPINT2 | Gene ID | 147965 | 10653 |
| Gene name | family with sequence similarity 98 member C | serine peptidase inhibitor, Kunitz type 2 | |
| Synonyms | - | DIAR3|HAI-2|HAI2|Kop|PB | |
| Cytomap | 19q13.2 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM98C | kunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q17RN3 | O43291 | |
| Ensembl transtripts involved in fusion gene | ENST00000588262, ENST00000252530, ENST00000343358, ENST00000585954, | ENST00000301244, ENST00000587090, ENST00000454580, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 8 X 2 X 7=112 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM98C [Title/Abstract] AND SPINT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SPINT2 | GO:0022408 | negative regulation of cell-cell adhesion | 19592578 |
| Tgene | SPINT2 | GO:2000146 | negative regulation of cell motility | 19592578 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-61-2094-01A | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000588262 | ENST00000301244 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| 5CDS-5UTR | ENST00000588262 | ENST00000587090 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| 5CDS-intron | ENST00000588262 | ENST00000454580 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| In-frame | ENST00000252530 | ENST00000301244 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| 5CDS-5UTR | ENST00000252530 | ENST00000587090 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| 5CDS-intron | ENST00000252530 | ENST00000454580 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| In-frame | ENST00000343358 | ENST00000301244 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| 5CDS-5UTR | ENST00000343358 | ENST00000587090 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| 5CDS-intron | ENST00000343358 | ENST00000454580 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| 3UTR-3CDS | ENST00000585954 | ENST00000301244 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| 3UTR-5UTR | ENST00000585954 | ENST00000587090 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
| 3UTR-intron | ENST00000585954 | ENST00000454580 | FAM98C | chr19 | 38894334 | + | SPINT2 | chr19 | 38774267 | + |
Top |
FusionProtFeatures for FAM98C_SPINT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM98C | SPINT2 |
| Inhibitor of HGF activator. Also inhibits plasmin,plasma and tissue kallikrein, and factor XIa. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SPINT2 | chr19:38894334 | chr19:38774267 | ENST00000301244 | + | 0 | 7 | 219_252 | 35 | 253 | Topological domain | Cytoplasmic |
| Tgene | >SPINT2 | chr19:38894334 | chr19:38774267 | ENST00000454580 | + | 0 | 6 | 219_252 | -106 | 196 | Topological domain | Cytoplasmic |
| Tgene | >SPINT2 | chr19:38894334 | chr19:38774267 | ENST00000454580 | + | 0 | 6 | 28_197 | -106 | 196 | Topological domain | Extracellular |
| Tgene | >SPINT2 | chr19:38894334 | chr19:38774267 | ENST00000301244 | + | 0 | 7 | 198_218 | 35 | 253 | Transmembrane | Helical |
| Tgene | >SPINT2 | chr19:38894334 | chr19:38774267 | ENST00000454580 | + | 0 | 6 | 198_218 | -106 | 196 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SPINT2 | chr19:38894334 | chr19:38774267 | ENST00000301244 | + | 0 | 7 | 28_197 | 35 | 253 | Topological domain | Extracellular |
Top |
FusionGeneSequence for FAM98C_SPINT2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FAM98C_ENST00000588262_chr19_38894334_+_SPINT2_ENST00000301244_chr19_38774267_+_334aa MEAVKAEAWEGAAVAQDLLALGYGGVPGAASRGASCPDFRGLCVRLAAELATLGALEQQREAGAEVLSAGDGPGAEEDFLRQLGSLLREL HCPDRALCGGDGAAALREPGAGLRLLHFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDL ATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQEN >In-frame_FAM98C_ENST00000252530_chr19_38894334_+_SPINT2_ENST00000301244_chr19_38774267_+_334aa MEAVKAEAWEGAAVAQDLLALGYGGVPGAASRGASCPDFRGLCVRLAAELATLGALEQQREAGAEVLSAGDGPGAEEDFLRQLGSLLREL HCPDRALCGGDGAAALREPGAGLRLLHFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDL ATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQEN >In-frame_FAM98C_ENST00000343358_chr19_38894334_+_SPINT2_ENST00000301244_chr19_38774267_+_334aa MEAVKAEAWEGAAVAQDLLALGYGGVPGAASRGASCPDFRGLCVRLAAELATLGALEQQREAGAEVLSAGDGPGAEEDFLRQLGSLLREL HCPDRALCGGDGAAALREPGAGLRLLHFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDL ATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQEN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FAM98C_ENST00000588262_chr19_38894334_+_SPINT2_ENST00000301244_chr19_38774267_+_1002nt ATGGAGGCGGTGAAGGCGGAAGCGTGGGAGGGGGCCGCGGTGGCCCAGGACCTGCTGGCTCTGGGGTATGGAGGTGTCCCGGGGGCGGCG TCGCGGGGCGCCTCATGCCCAGACTTCAGGGGGCTGTGCGTGCGGCTGGCGGCGGAGCTGGCGACGCTGGGCGCCCTCGAGCAGCAGCGA GAGGCGGGCGCGGAGGTGCTGAGCGCCGGCGACGGCCCTGGCGCGGAGGAGGACTTTCTGCGGCAGCTCGGCAGCCTGCTGCGGGAGCTG CACTGCCCGGATCGCGCGCTCTGCGGCGGGGATGGCGCGGCTGCGCTTCGGGAACCCGGTGCCGGACTGCGCCTGCTGCACTTCTGCCTG GTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTGTTTGTGTATGGG GGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTG GCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTAT GAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAAT AACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAAT CCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCTGGGAGCCTCCATGGTCTAC CTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGAGCAGCTGGTGAAGAACACA >In-frame_FAM98C_ENST00000252530_chr19_38894334_+_SPINT2_ENST00000301244_chr19_38774267_+_1002nt ATGGAGGCGGTGAAGGCGGAAGCGTGGGAGGGGGCCGCGGTGGCCCAGGACCTGCTGGCTCTGGGGTATGGAGGTGTCCCGGGGGCGGCG TCGCGGGGCGCCTCATGCCCAGACTTCAGGGGGCTGTGCGTGCGGCTGGCGGCGGAGCTGGCGACGCTGGGCGCCCTCGAGCAGCAGCGA GAGGCGGGCGCGGAGGTGCTGAGCGCCGGCGACGGCCCTGGCGCGGAGGAGGACTTTCTGCGGCAGCTCGGCAGCCTGCTGCGGGAGCTG CACTGCCCGGATCGCGCGCTCTGCGGCGGGGATGGCGCGGCTGCGCTTCGGGAACCCGGTGCCGGACTGCGCCTGCTGCACTTCTGCCTG GTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTGTTTGTGTATGGG GGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTG GCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTAT GAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAAT AACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAAT CCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCTGGGAGCCTCCATGGTCTAC CTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGAGCAGCTGGTGAAGAACACA >In-frame_FAM98C_ENST00000343358_chr19_38894334_+_SPINT2_ENST00000301244_chr19_38774267_+_1002nt ATGGAGGCGGTGAAGGCGGAAGCGTGGGAGGGGGCCGCGGTGGCCCAGGACCTGCTGGCTCTGGGGTATGGAGGTGTCCCGGGGGCGGCG TCGCGGGGCGCCTCATGCCCAGACTTCAGGGGGCTGTGCGTGCGGCTGGCGGCGGAGCTGGCGACGCTGGGCGCCCTCGAGCAGCAGCGA GAGGCGGGCGCGGAGGTGCTGAGCGCCGGCGACGGCCCTGGCGCGGAGGAGGACTTTCTGCGGCAGCTCGGCAGCCTGCTGCGGGAGCTG CACTGCCCGGATCGCGCGCTCTGCGGCGGGGATGGCGCGGCTGCGCTTCGGGAACCCGGTGCCGGACTGCGCCTGCTGCACTTCTGCCTG GTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTGTTTGTGTATGGG GGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTG GCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTAT GAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAAT AACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAAT CCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCTGGGAGCCTCCATGGTCTAC CTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGAGCAGCTGGTGAAGAACACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FAM98C_ENST00000588262_chr19_38894334_+_SPINT2_ENST00000301244_chr19_38774267_+_1629nt GCGCCGAGACCACACTTTCATGGAGGCGGTGAAGGCGGAAGCGTGGGAGGGGGCCGCGGTGGCCCAGGACCTGCTGGCTCTGGGGTATGG AGGTGTCCCGGGGGCGGCGTCGCGGGGCGCCTCATGCCCAGACTTCAGGGGGCTGTGCGTGCGGCTGGCGGCGGAGCTGGCGACGCTGGG CGCCCTCGAGCAGCAGCGAGAGGCGGGCGCGGAGGTGCTGAGCGCCGGCGACGGCCCTGGCGCGGAGGAGGACTTTCTGCGGCAGCTCGG CAGCCTGCTGCGGGAGCTGCACTGCCCGGATCGCGCGCTCTGCGGCGGGGATGGCGCGGCTGCGCTTCGGGAACCCGGTGCCGGACTGCG CCTGCTGCACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTG CCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGA GAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTC CAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGT GGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTG CTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCT GGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGA GCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTTTA AATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAGGG ATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGAT TTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTTTT GTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAATAA AAAGGGGCCTTCCCCTTTAGAATAAATTTCAGCATGTGCTTTCTTTATGGGAGTCCTAATTTCAACCCTACCAAAATGATCACAAGACAC TATCTGAGGTGTCCCATTCTAGAAATAGACCCCTCAAAATAGCGTCTTTCAGATCTTTTTGAATGAATCCACAAGATGAAATAAATGTCC >In-frame_FAM98C_ENST00000252530_chr19_38894334_+_SPINT2_ENST00000301244_chr19_38774267_+_1629nt GCGCCGAGACCACACTTTCATGGAGGCGGTGAAGGCGGAAGCGTGGGAGGGGGCCGCGGTGGCCCAGGACCTGCTGGCTCTGGGGTATGG AGGTGTCCCGGGGGCGGCGTCGCGGGGCGCCTCATGCCCAGACTTCAGGGGGCTGTGCGTGCGGCTGGCGGCGGAGCTGGCGACGCTGGG CGCCCTCGAGCAGCAGCGAGAGGCGGGCGCGGAGGTGCTGAGCGCCGGCGACGGCCCTGGCGCGGAGGAGGACTTTCTGCGGCAGCTCGG CAGCCTGCTGCGGGAGCTGCACTGCCCGGATCGCGCGCTCTGCGGCGGGGATGGCGCGGCTGCGCTTCGGGAACCCGGTGCCGGACTGCG CCTGCTGCACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTG CCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGA GAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTC CAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGT GGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTG CTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCT GGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGA GCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTTTA AATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAGGG ATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGAT TTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTTTT GTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAATAA AAAGGGGCCTTCCCCTTTAGAATAAATTTCAGCATGTGCTTTCTTTATGGGAGTCCTAATTTCAACCCTACCAAAATGATCACAAGACAC TATCTGAGGTGTCCCATTCTAGAAATAGACCCCTCAAAATAGCGTCTTTCAGATCTTTTTGAATGAATCCACAAGATGAAATAAATGTCC >In-frame_FAM98C_ENST00000343358_chr19_38894334_+_SPINT2_ENST00000301244_chr19_38774267_+_1610nt ATGGAGGCGGTGAAGGCGGAAGCGTGGGAGGGGGCCGCGGTGGCCCAGGACCTGCTGGCTCTGGGGTATGGAGGTGTCCCGGGGGCGGCG TCGCGGGGCGCCTCATGCCCAGACTTCAGGGGGCTGTGCGTGCGGCTGGCGGCGGAGCTGGCGACGCTGGGCGCCCTCGAGCAGCAGCGA GAGGCGGGCGCGGAGGTGCTGAGCGCCGGCGACGGCCCTGGCGCGGAGGAGGACTTTCTGCGGCAGCTCGGCAGCCTGCTGCGGGAGCTG CACTGCCCGGATCGCGCGCTCTGCGGCGGGGATGGCGCGGCTGCGCTTCGGGAACCCGGTGCCGGACTGCGCCTGCTGCACTTCTGCCTG GTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTGTTTGTGTATGGG GGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTG GCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTAT GAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAAT AACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAAT CCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCTGGGAGCCTCCATGGTCTAC CTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGAGCAGCTGGTGAAGAACACA TATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTTTAAATAGAGGGATTGACTCGG ATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAGGGATGGGTTTGCTTTGGAAAT CCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGATTTCTTTCCTCCAGGTAGAG TTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTTTTGTTTGTCTGATTTATGGTT TTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAATAAAAAGGGGCCTTCCCCTTTA GAATAAATTTCAGCATGTGCTTTCTTTATGGGAGTCCTAATTTCAACCCTACCAAAATGATCACAAGACACTATCTGAGGTGTCCCATTC |
Top |
FusionGenePPI for FAM98C_SPINT2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FAM98C | SPINT2 | ITIH2, APP, TUBG1, MOV10, CUL7, ILK, TUBGCP2, LSR, ATP12A, LIN54, TBC1D9B, TBC1D15, ATP2A3, ITPRIPL1, FNDC3A, ZNF696, OCRL, ABCA3, RPS7, TMEM214, NCAPD3, SREBF2, THAP11, IQCB1, TSC2, WDR44, LEMD3, POM121, UBR3, TBL2, ATP8B2, DIP2A, NFRKB, SACM1L, ZDHHC13, RETSAT, DHRS7, SPTLC2, ARFGEF1, CCZ1, ACVR1B, CYP51A1, PRR14, LRIF1, MAP7D3, CDC20, TYW1, C20orf24, SMC2, DNAJC16, MOSPD2, BAG3, KIF14, EPHX1, TAF6L, ALG5, NOP9, OSBPL8, NUS1, SLC35F5, TEX264, CKAP5, TMUB1, POLE2, HMGCR, UPK3BL, FNDC3B, VRK2, MZT2B, SLC39A10, SEC22A, ELF2, SLC39A6, C1orf112, USP33, NDC1, SLC30A7, LMF1, GOLGA5, GTPBP3, DAGLB, VANGL2, FAM189B, DPH1, FRMD5, CHD8, PI4K2B, SLC27A3, CMTM6, EGFL7, PKMYT1, LRP10, CNTNAP1, ZDHHC18, CTU1, TIGD5, KLHL26, LRP12, ASPHD2, SCARF2, HGFAC, RNF13, MARC1, GPN3, ARL6IP6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FAM98C_SPINT2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FAM98C_SPINT2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SPINT2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | SPINT2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | SPINT2 | C0027794 | Neural Tube Defects | 1 | CTD_human |
| Tgene | SPINT2 | C0032045 | Placenta Disorders | 1 | CTD_human |
| Tgene | SPINT2 | C0267663 | Congenital secretory diarrhea, sodium type (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|