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Fusion gene ID: 12900 |
FusionGeneSummary for FAM98B_RASGRP1 |
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Fusion gene information | Fusion gene name: FAM98B_RASGRP1 | Fusion gene ID: 12900 | Hgene | Tgene | Gene symbol | FAM98B | RASGRP1 | Gene ID | 283742 | 10125 |
Gene name | family with sequence similarity 98 member B | RAS guanyl releasing protein 1 | |
Synonyms | - | CALDAG-GEFI|CALDAG-GEFII|RASGRP|V|hRasGRP1 | |
Cytomap | 15q14 | 15q14 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM98B | RAS guanyl-releasing protein 1RAS guanyl nucleotide-releasing protein 1RAS guanyl releasing protein 1 (calcium and DAG-regulated)calcium and DAG-regulated guanine nucleotide exchange factor IIcalcium- and diacylglycerol-regulated guanine nucleotide ex | |
Modification date | 20180523 | 20180520 | |
UniProtAcc | Q52LJ0 | O95267 | |
Ensembl transtripts involved in fusion gene | ENST00000397609, ENST00000491535, | ENST00000310803, ENST00000539159, ENST00000561180, ENST00000450598, ENST00000558164, ENST00000559830, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: FAM98B [Title/Abstract] AND RASGRP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RASGRP1 | GO:0001934 | positive regulation of protein phosphorylation | 21968647 |
Tgene | RASGRP1 | GO:0090630 | activation of GTPase activity | 10807788 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-OL-A5RW-01A | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000397609 | ENST00000310803 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
In-frame | ENST00000397609 | ENST00000539159 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
In-frame | ENST00000397609 | ENST00000561180 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
In-frame | ENST00000397609 | ENST00000450598 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
In-frame | ENST00000397609 | ENST00000558164 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
In-frame | ENST00000397609 | ENST00000559830 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
Frame-shift | ENST00000491535 | ENST00000310803 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
Frame-shift | ENST00000491535 | ENST00000539159 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
Frame-shift | ENST00000491535 | ENST00000561180 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
Frame-shift | ENST00000491535 | ENST00000450598 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
Frame-shift | ENST00000491535 | ENST00000558164 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
Frame-shift | ENST00000491535 | ENST00000559830 | FAM98B | chr15 | 38773660 | + | RASGRP1 | chr15 | 38798121 | - |
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FusionProtFeatures for FAM98B_RASGRP1 |
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Hgene | Tgene |
FAM98B | RASGRP1 |
Positively stimulates PRMT1-induced protein argininedimethylated arginine methylation (PubMed:28040436). Promotescolorectal cancer cell malignancy (PubMed:28040436).{ECO:0000269|PubMed:28040436}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 483_494 | 414 | 798 | Calcium binding | Ontology_term=ECO:0000255 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 483_494 | 414 | 763 | Calcium binding | Ontology_term=ECO:0000255 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 483_494 | 414 | 547 | Calcium binding | Ontology_term=ECO:0000255 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 483_494 | 414 | 598 | Calcium binding | Ontology_term=ECO:0000255 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 746_786 | 414 | 798 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 746_786 | 414 | 763 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 746_786 | 414 | 547 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 746_786 | 414 | 598 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 470_505 | 414 | 798 | Domain | EF-hand 1 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 497_532 | 414 | 798 | Domain | EF-hand 2 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 470_505 | 414 | 763 | Domain | EF-hand 1 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 497_532 | 414 | 763 | Domain | EF-hand 2 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 470_505 | 414 | 547 | Domain | EF-hand 1 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 497_532 | 414 | 547 | Domain | EF-hand 2 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 470_505 | 414 | 598 | Domain | EF-hand 1 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 497_532 | 414 | 598 | Domain | EF-hand 2 |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 686_694 | 414 | 798 | Region | Suppress the PT region-mediated translocation to plasma membrane |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 718_797 | 414 | 798 | Region | PT region%3B mediates the BCR-dependent translocation to plasma membrane |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 686_694 | 414 | 763 | Region | Suppress the PT region-mediated translocation to plasma membrane |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 718_797 | 414 | 763 | Region | PT region%3B mediates the BCR-dependent translocation to plasma membrane |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 686_694 | 414 | 547 | Region | Suppress the PT region-mediated translocation to plasma membrane |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 718_797 | 414 | 547 | Region | PT region%3B mediates the BCR-dependent translocation to plasma membrane |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 686_694 | 414 | 598 | Region | Suppress the PT region-mediated translocation to plasma membrane |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 718_797 | 414 | 598 | Region | PT region%3B mediates the BCR-dependent translocation to plasma membrane |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 541_591 | 414 | 798 | Zinc finger | Phorbol-ester/DAG-type |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 541_591 | 414 | 763 | Zinc finger | Phorbol-ester/DAG-type |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 541_591 | 414 | 547 | Zinc finger | Phorbol-ester/DAG-type |
Tgene | >RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 541_591 | 414 | 598 | Zinc finger | Phorbol-ester/DAG-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 205_436 | 414 | 798 | Domain | Ras-GEF |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 53_176 | 414 | 798 | Domain | N-terminal Ras-GEF |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 205_436 | 414 | 763 | Domain | Ras-GEF |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 53_176 | 414 | 763 | Domain | N-terminal Ras-GEF |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 205_436 | 414 | 547 | Domain | Ras-GEF |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 53_176 | 414 | 547 | Domain | N-terminal Ras-GEF |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 205_436 | 414 | 598 | Domain | Ras-GEF |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 53_176 | 414 | 598 | Domain | N-terminal Ras-GEF |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000310803 | - | 8 | 17 | 57_110 | 414 | 798 | Region | Ras exchanger motif region%3B required for transforming activity |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000450598 | - | 8 | 16 | 57_110 | 414 | 763 | Region | Ras exchanger motif region%3B required for transforming activity |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000558164 | - | 8 | 14 | 57_110 | 414 | 547 | Region | Ras exchanger motif region%3B required for transforming activity |
Tgene | RASGRP1 | chr15:38773660 | chr15:38798121 | ENST00000559830 | - | 8 | 15 | 57_110 | 414 | 598 | Region | Ras exchanger motif region%3B required for transforming activity |
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FusionGeneSequence for FAM98B_RASGRP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM98B_RASGRP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM98B | BCKDK, CUL3, COPS5, CAND1, DDX1, RTCB, C14orf166, C2orf49, CD81, MOV10, NXF1, BMI1, HNRNPA1, ACTR2, ARHGDIA, EEF1A1, EHD1, EIF4H, GORASP2, IDE, PAFAH1B2, PPP1R8, TRIM25, TXN2, VARS, YOD1, RNPEP, NTRK1, XPO1, MCM2, CYLD, DLD | RASGRP1 | PPM1B, VHL, DGKZ, ABCB8 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM98B_RASGRP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM98B_RASGRP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RASGRP1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | RASGRP1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | RASGRP1 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | RASGRP1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | RASGRP1 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |