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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12900

FusionGeneSummary for FAM98B_RASGRP1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM98B_RASGRP1
Fusion gene ID: 12900
HgeneTgene
Gene symbol

FAM98B

RASGRP1

Gene ID

283742

10125

Gene namefamily with sequence similarity 98 member BRAS guanyl releasing protein 1
Synonyms-CALDAG-GEFI|CALDAG-GEFII|RASGRP|V|hRasGRP1
Cytomap

15q14

15q14

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM98BRAS guanyl-releasing protein 1RAS guanyl nucleotide-releasing protein 1RAS guanyl releasing protein 1 (calcium and DAG-regulated)calcium and DAG-regulated guanine nucleotide exchange factor IIcalcium- and diacylglycerol-regulated guanine nucleotide ex
Modification date2018052320180520
UniProtAcc

Q52LJ0

O95267

Ensembl transtripts involved in fusion geneENST00000397609, ENST00000491535, 
ENST00000310803, ENST00000539159, 
ENST00000561180, ENST00000450598, 
ENST00000558164, ENST00000559830, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: FAM98B [Title/Abstract] AND RASGRP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRASGRP1

GO:0001934

positive regulation of protein phosphorylation

21968647

TgeneRASGRP1

GO:0090630

activation of GTPase activity

10807788


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-OL-A5RW-01AFAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397609ENST00000310803FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
In-frameENST00000397609ENST00000539159FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
In-frameENST00000397609ENST00000561180FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
In-frameENST00000397609ENST00000450598FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
In-frameENST00000397609ENST00000558164FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
In-frameENST00000397609ENST00000559830FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
Frame-shiftENST00000491535ENST00000310803FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
Frame-shiftENST00000491535ENST00000539159FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
Frame-shiftENST00000491535ENST00000561180FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
Frame-shiftENST00000491535ENST00000450598FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
Frame-shiftENST00000491535ENST00000558164FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-
Frame-shiftENST00000491535ENST00000559830FAM98Bchr15

38773660

+RASGRP1chr15

38798121

-

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FusionProtFeatures for FAM98B_RASGRP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM98B

Q52LJ0

RASGRP1

O95267

Positively stimulates PRMT1-induced protein argininedimethylated arginine methylation (PubMed:28040436). Promotescolorectal cancer cell malignancy (PubMed:28040436).{ECO:0000269|PubMed:28040436}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-817483_494414798Calcium bindingOntology_term=ECO:0000255
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-816483_494414763Calcium bindingOntology_term=ECO:0000255
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-814483_494414547Calcium bindingOntology_term=ECO:0000255
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-815483_494414598Calcium bindingOntology_term=ECO:0000255
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-817746_786414798Coiled coilOntology_term=ECO:0000255
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-816746_786414763Coiled coilOntology_term=ECO:0000255
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-814746_786414547Coiled coilOntology_term=ECO:0000255
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-815746_786414598Coiled coilOntology_term=ECO:0000255
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-817470_505414798DomainEF-hand 1
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-817497_532414798DomainEF-hand 2
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-816470_505414763DomainEF-hand 1
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-816497_532414763DomainEF-hand 2
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-814470_505414547DomainEF-hand 1
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-814497_532414547DomainEF-hand 2
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-815470_505414598DomainEF-hand 1
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-815497_532414598DomainEF-hand 2
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-817686_694414798RegionSuppress the PT region-mediated translocation to plasma membrane
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-817718_797414798RegionPT region%3B mediates the BCR-dependent translocation to plasma membrane
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-816686_694414763RegionSuppress the PT region-mediated translocation to plasma membrane
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-816718_797414763RegionPT region%3B mediates the BCR-dependent translocation to plasma membrane
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-814686_694414547RegionSuppress the PT region-mediated translocation to plasma membrane
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-814718_797414547RegionPT region%3B mediates the BCR-dependent translocation to plasma membrane
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-815686_694414598RegionSuppress the PT region-mediated translocation to plasma membrane
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-815718_797414598RegionPT region%3B mediates the BCR-dependent translocation to plasma membrane
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-817541_591414798Zinc fingerPhorbol-ester/DAG-type
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-816541_591414763Zinc fingerPhorbol-ester/DAG-type
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-814541_591414547Zinc fingerPhorbol-ester/DAG-type
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-815541_591414598Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-817205_436414798DomainRas-GEF
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-81753_176414798DomainN-terminal Ras-GEF
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-816205_436414763DomainRas-GEF
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-81653_176414763DomainN-terminal Ras-GEF
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-814205_436414547DomainRas-GEF
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-81453_176414547DomainN-terminal Ras-GEF
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-815205_436414598DomainRas-GEF
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-81553_176414598DomainN-terminal Ras-GEF
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000310803-81757_110414798RegionRas exchanger motif region%3B required for transforming activity
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000450598-81657_110414763RegionRas exchanger motif region%3B required for transforming activity
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000558164-81457_110414547RegionRas exchanger motif region%3B required for transforming activity
TgeneRASGRP1chr15:38773660chr15:38798121ENST00000559830-81557_110414598RegionRas exchanger motif region%3B required for transforming activity


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FusionGeneSequence for FAM98B_RASGRP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM98B_RASGRP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM98BBCKDK, CUL3, COPS5, CAND1, DDX1, RTCB, C14orf166, C2orf49, CD81, MOV10, NXF1, BMI1, HNRNPA1, ACTR2, ARHGDIA, EEF1A1, EHD1, EIF4H, GORASP2, IDE, PAFAH1B2, PPP1R8, TRIM25, TXN2, VARS, YOD1, RNPEP, NTRK1, XPO1, MCM2, CYLD, DLDRASGRP1PPM1B, VHL, DGKZ, ABCB8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM98B_RASGRP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM98B_RASGRP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRASGRP1C0003873Rheumatoid Arthritis1CTD_human
TgeneRASGRP1C0005586Bipolar Disorder1PSYGENET
TgeneRASGRP1C0014175Endometriosis1CTD_human
TgeneRASGRP1C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneRASGRP1C0024141Lupus Erythematosus, Systemic1CTD_human