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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 12876

FusionGeneSummary for FAM83G_TTC19

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM83G_TTC19
Fusion gene ID: 12876
HgeneTgene
Gene symbol

FAM83G

TTC19

Gene ID

644815

54902

Gene namefamily with sequence similarity 83 member Gtetratricopeptide repeat domain 19
SynonymsPAWS12010204O13Rik|MC3DN2
Cytomap

17p11.2

17p12

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM83Gprotein associated with SMAD1tetratricopeptide repeat protein 19, mitochondrialTPR repeat protein 19
Modification date2018051920180523
UniProtAcc

A6ND36

Q6DKK2

Ensembl transtripts involved in fusion geneENST00000388995, ENST00000585154, 
ENST00000345041, 		ENST00000261647, 
ENST00000486880, ENST00000497842, 
Fusion gene scores* DoF score5 X 2 X 5=504 X 4 X 2=32
# samples 55
** MAII scorelog2(5/50*10)=0log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM83G [Title/Abstract] AND TTC19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM83G

GO:0030509

BMP signaling pathway

24554596


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-D8-A1JA-01AFAM83Gchr17

18891560

-TTC19chr17

15928331

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000388995ENST00000261647FAM83Gchr17

18891560

-TTC19chr17

15928331

+
In-frameENST00000388995ENST00000486880FAM83Gchr17

18891560

-TTC19chr17

15928331

+
5CDS-3UTRENST00000388995ENST00000497842FAM83Gchr17

18891560

-TTC19chr17

15928331

+
Frame-shiftENST00000585154ENST00000261647FAM83Gchr17

18891560

-TTC19chr17

15928331

+
Frame-shiftENST00000585154ENST00000486880FAM83Gchr17

18891560

-TTC19chr17

15928331

+
5CDS-3UTRENST00000585154ENST00000497842FAM83Gchr17

18891560

-TTC19chr17

15928331

+
Frame-shiftENST00000345041ENST00000261647FAM83Gchr17

18891560

-TTC19chr17

15928331

+
Frame-shiftENST00000345041ENST00000486880FAM83Gchr17

18891560

-TTC19chr17

15928331

+
5CDS-3UTRENST00000345041ENST00000497842FAM83Gchr17

18891560

-TTC19chr17

15928331

+

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FusionProtFeatures for FAM83G_TTC19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM83G

A6ND36

TTC19

Q6DKK2

May regulate the bone morphogenetic proteins (BMP)pathway. {ECO:0000269|PubMed:24554596}. Required for the preservation of the structural andfunctional integrity of mitochondrial respiratory complex III byallowing the physiological turnover of the Rieske protein UQCRFS1(PubMed:21278747, PubMed:28673544). Involved in the clearance ofUQCRFS1 N-terminal fragments, which are produced uponincorporation of UQCRFS1 into the complex III and whose presenceis detrimental for its catalytic activity (PubMed:28673544).{ECO:0000269|PubMed:21278747, ECO:0000269|PubMed:28673544}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTTC19chr17:18891560chr17:15928331ENST00000261647+610237_270225381RepeatNote=TPR 3
TgeneTTC19chr17:18891560chr17:15928331ENST00000261647+610279_312225381RepeatNote=TPR 4
TgeneTTC19chr17:18891560chr17:15928331ENST00000261647+610318_351225381RepeatNote=TPR 5

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM83Gchr17:18891560chr17:15928331ENST00000345041-36470_511230824Compositional biasNote=Pro-rich
HgeneFAM83Gchr17:18891560chr17:15928331ENST00000345041-36583_586230824Compositional biasNote=Poly-Asp
HgeneFAM83Gchr17:18891560chr17:15928331ENST00000388995-36470_511230824Compositional biasNote=Pro-rich
HgeneFAM83Gchr17:18891560chr17:15928331ENST00000388995-36583_586230824Compositional biasNote=Poly-Asp
HgeneFAM83Gchr17:18891560chr17:15928331ENST00000585154-25470_511230824Compositional biasNote=Pro-rich
HgeneFAM83Gchr17:18891560chr17:15928331ENST00000585154-25583_586230824Compositional biasNote=Poly-Asp
TgeneTTC19chr17:18891560chr17:15928331ENST00000261647+61073_76225381Compositional biasNote=Poly-Glu
TgeneTTC19chr17:18891560chr17:15928331ENST00000486880+61073_76346502Compositional biasNote=Poly-Glu
TgeneTTC19chr17:18891560chr17:15928331ENST00000261647+610136_169225381RepeatNote=TPR 1
TgeneTTC19chr17:18891560chr17:15928331ENST00000261647+610179_212225381RepeatNote=TPR 2
TgeneTTC19chr17:18891560chr17:15928331ENST00000486880+610136_169346502RepeatNote=TPR 1
TgeneTTC19chr17:18891560chr17:15928331ENST00000486880+610179_212346502RepeatNote=TPR 2
TgeneTTC19chr17:18891560chr17:15928331ENST00000486880+610237_270346502RepeatNote=TPR 3
TgeneTTC19chr17:18891560chr17:15928331ENST00000486880+610279_312346502RepeatNote=TPR 4
TgeneTTC19chr17:18891560chr17:15928331ENST00000486880+610318_351346502RepeatNote=TPR 5


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FusionGeneSequence for FAM83G_TTC19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FAM83G_ENST00000388995_chr17_18891560_-_TTC19_ENST00000261647_chr17_15928331_+_385aa
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGP
EDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVYMQPPIDGQAHIKEVVRKMISQAQKVIAVVM
DMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACAXTPVLATFCSPSSRHRHKGCMKKLCR
FLKKYKEKDTHRPLCXXVTWLLPWMHRAALMRPIFICKGHQIWQDRXIILSYTWYSVIXLQFXCTENDIHKQKRSTRKHXSKQSXKKMKF

>In-frame_FAM83G_ENST00000388995_chr17_18891560_-_TTC19_ENST00000486880_chr17_15928331_+_385aa
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGP
EDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVYMQPPIDGQAHIKEVVRKMISQAQKVIAVVM
DMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKWKRKPIPTSSWACAXTPVLATFCSPSSRHRHKGCMKKLCR
FLKKYKEKDTHRPLCXXVTWLLPWMHRAALMRPIFICKGHQIWQDRXIILSYTWYSVIXLQFXCTENDIHKQKRSTRKHXSKQSXKKMKF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FAM83G_ENST00000388995_chr17_18891560_-_TTC19_ENST00000261647_chr17_15928331_+_1157nt
ATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACTGGCGCTCCAGCGAGTCCAAGCCTGAGTTCTTCTACAGCGAGGAG
CAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCTTCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCG
GAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACCCGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCC
GAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGATGGGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGG
CCCCAGAAGTCGGACCGCTCCATCCCGCAGCTGGACCTGGGCTGGCCCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTAC
ATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGCGGAAGATGATCAGCCAGGCACAGAAGGTGATAGCTGTGGTCATG
GACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCGGCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGT
AACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACCTGGGGCACCTCAAGTGGAAGAGAAAGCCAATACCCACCTCCTCT
TGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGA
TTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTG
ATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCTACACATGGTACTCAGTAATCTAGCTG
CAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTT

>In-frame_FAM83G_ENST00000388995_chr17_18891560_-_TTC19_ENST00000486880_chr17_15928331_+_1157nt
ATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACTGGCGCTCCAGCGAGTCCAAGCCTGAGTTCTTCTACAGCGAGGAG
CAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCTTCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCG
GAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACCCGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCC
GAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGATGGGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGG
CCCCAGAAGTCGGACCGCTCCATCCCGCAGCTGGACCTGGGCTGGCCCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTAC
ATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGCGGAAGATGATCAGCCAGGCACAGAAGGTGATAGCTGTGGTCATG
GACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCGGCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGT
AACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACCTGGGGCACCTCAAGTGGAAGAGAAAGCCAATACCCACCTCCTCT
TGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAAGCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGA
TTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCTGATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTG
ATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACAGATAAATCATCCTGAGCTACACATGGTACTCAGTAATCTAGCTG
CAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTACCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_FAM83G_ENST00000388995_chr17_18891560_-_TTC19_ENST00000261647_chr17_15928331_+_2771nt
AGCGGGGCGGCCCTGAGTCACCGGCGCGCCCCCGCCCAGCCTCGCGCCGCCGCCGCAGCCGCCGCGTGTGCGCCCCGCTCCGCCAGCGCC
CGCTCGATTGCTCATGGGCAGAGAAGCAGAGGCCGCGGAGAGGCCCCCGAGCGCGCGGTGCCCCAGCTGGGCCGGAGCTAGGAGCTGGAC
CTTGCCCACCCACCCCCGGCAGCAGTGCCCGGGCAGGCGGCGCCATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACT
GGCGCTCCAGCGAGTCCAAGCCTGAGTTCTTCTACAGCGAGGAGCAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCT
TCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCGGAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACC
CGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCCGAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGATG
GGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGGCCCCAGAAGTCGGACCGCTCCATCCCGCAGCTGGACCTGGGCTGGC
CCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTACATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGC
GGAAGATGATCAGCCAGGCACAGAAGGTGATAGCTGTGGTCATGGACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCG
GCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGTAACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACC
TGGGGCACCTCAAGTGGAAGAGAAAGCCAATACCCACCTCCTCTTGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAA
GCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGATTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCT
GATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTGATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACA
GATAAATCATCCTGAGCTACACATGGTACTCAGTAATCTAGCTGCAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTA
CCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTTCTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAG
TAGACCTTTGACAAATTCTGTCAAGCTCTAAATCCATTTTTGTGTAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCT
GTCTCTGTGGCACCCGATCAATGGCTTAAATCTGTCGTTTTTGATATTCAGGTTTCCTCAATTTAGCCTTAGTGAAGGAGGGGTTGTACA
CACTGCCATTTTTGTATTTTAAAGGAAAAATGACTTTCATTCCCAACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTT
GTAACACGTGACTTGGTGCTGTCCCTGCTGGTCTAAGTAGAACTGTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGA
TTCAGCCTGGCATTTCTACCATAAGTTTTTGGTCTGCTGATTTGCTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTG
ACCAGAATTACCTTCCTCATGGCAAAGGGGGATTATGGTGAATTGTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATAC
ATAAAAGAGAAAAATATCTTAGTTTGCTACCAGCATCCAGCATGAAGTTGTAAAGTGGGGATTAGGCACGTGACAGTATAGCACCCATTT
GAATTTAAATAAAAGTGAACCATATTTATCTGGTTATATAAAACTAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTA
ACCTTTTGTCTGTGTTATCTGAACACTCTACTTCCTTTGCAGCCTTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACA
GCCCAGGCTGTTCTGAGTCAGAATAGGCCCCTACAGGTATATTTTAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACT
ACTGACCTGGATCTTAGTCCTAGCCTTTTTGCTTTTGCAATTTCAGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAG
CTGTGGGGGAAGGTATTTGGTTAGATGACTTTGAATGAATAGACTGCTGTGCTGAAAGAGCTTTATCACACTGTCTCAAAGTATGTAAAG
ATACATAGGTGGATGCTCTTACTGCAGCAGTCATGAATACATTTTTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGA
AGGAAGATTGACCCTGTTGGTATGCCTGTGGGGGTGGGATGTGAGTGGGACTGATAAACTGATACTTTTGGTTCGTATGTACATACTGGA
AGAATCTTCATAATAAATGAGACTACACAACAATATTGTATGTATCCCAGTAATCTTTGCATTTCTCAAAAAAAAAAAAAAAAAAAAAAA

>In-frame_FAM83G_ENST00000388995_chr17_18891560_-_TTC19_ENST00000486880_chr17_15928331_+_2641nt
AGCGGGGCGGCCCTGAGTCACCGGCGCGCCCCCGCCCAGCCTCGCGCCGCCGCCGCAGCCGCCGCGTGTGCGCCCCGCTCCGCCAGCGCC
CGCTCGATTGCTCATGGGCAGAGAAGCAGAGGCCGCGGAGAGGCCCCCGAGCGCGCGGTGCCCCAGCTGGGCCGGAGCTAGGAGCTGGAC
CTTGCCCACCCACCCCCGGCAGCAGTGCCCGGGCAGGCGGCGCCATGGCCTTCTCTCAGGTGCAGTGTCTGGACGACAACCATGTGAACT
GGCGCTCCAGCGAGTCCAAGCCTGAGTTCTTCTACAGCGAGGAGCAGCGGCTGGCGCTGGAGGCCCTGGTGGCCCGCGGCCGGGACGCCT
TCTACGAGGTGCTCAAGCGGGAGAACATCCGAGACTTCCTCTCGGAGCTGGAGCTCAAGCGCATCCTGGAGACCATCGAGGTGTACGACC
CGGGCTCTGAGGACCCTCGGGGCACGGGCCCCTCTCAGGGGCCCGAGGACAATGGGGTCGGCGACGGCGAGGAAGCCAGCGGGGCGGATG
GGGTCCCCATCGAGGCCGAGCCGCTGCCCTCCCTGGAGTACTGGCCCCAGAAGTCGGACCGCTCCATCCCGCAGCTGGACCTGGGCTGGC
CCGACACCATCGCCTACCGCGGCGTGACCCGGGCTAGCGTCTACATGCAGCCCCCCATAGACGGGCAGGCCCACATCAAAGAGGTGGTGC
GGAAGATGATCAGCCAGGCACAGAAGGTGATAGCTGTGGTCATGGACATGTTCACCGACGTGGACATCTTCAAGGACCTGCTGGACGCCG
GCTTCAAGAGGAAAGTGGCCGTGTACATCATCGTGGATGAGAGTAACGTCAAGTACTTCCTGCACATGTGTGAGCGGGCCTGCATGCACC
TGGGGCACCTCAAGTGGAAGAGAAAGCCAATACCCACCTCCTCTTGGGCATGTGCTTAGACGCCTGTGCTCGCTACCTTCTGTTCTCCAA
GCAGCCGTCACAGGCACAAAGGATGTATGAAAAAGCTCTGCAGATTTCTGAAGAAATACAAGGAGAAAGACACCCACAGACCATTGTGCT
GATGAGTGACCTGGCTACTACCCTGGATGCACAGGGCCGCTTTGATGAGGCCTATATTTATATGCAAAGGGCATCAGATCTGGCAAGACA
GATAAATCATCCTGAGCTACACATGGTACTCAGTAATCTAGCTGCAGTTTTGATGCACAGAGAACGATATACACAAGCAAAAGAGATCTA
CCAGGAAGCACTGAAGCAAGCAAAGCTGAAAAAAGATGAAATTTCTGTACAACACATCAGGGAAGAGTTGGCTGAGCTGTCAAAGAAAAG
TAGACCTTTGACAAATTCTGTCAAGCTCTAAATCCATTTTTGTGTAGGGAGAATAATGTCTAGTAATGTGGAAGAATAGCTATCATTCCT
GTCTCTGTGGCACCCGATCAATGGCTTAAATCTGTCGTTTTTGATATTCAGGTTTCCTCAATTTAGCCTTAGTGAAGGAGGGGTTGTACA
CACTGCCATTTTTGTATTTTAAAGGAAAAATGACTTTCATTCCCAACTGATTATGACCTTTCAGGATGTCGTCAAGTGATGCTTTCAGTT
GTAACACGTGACTTGGTGCTGTCCCTGCTGGTCTAAGTAGAACTGTAGATTCATATGGGCTGGTGTTCCTGTGCGCTGTGGGTGTGGTGA
TTCAGCCTGGCATTTCTACCATAAGTTTTTGGTCTGCTGATTTGCTGCCCTGTCTTCTCTTACTTTACTTTATCAATACCTGGCAAACTG
ACCAGAATTACCTTCCTCATGGCAAAGGGGGATTATGGTGAATTGTTGTTCTTATAGTCTGTTTCATGAAGCACAAGTGGAATTTAATAC
ATAAAAGAGAAAAATATCTTAGTTTGCTACCAGCATCCAGCATGAAGTTGTAAAGTGGGGATTAGGCACGTGACAGTATAGCACCCATTT
GAATTTAAATAAAAGTGAACCATATTTATCTGGTTATATAAAACTAAAAATGGGGGTGTTTATATAAAACTAAAAACTAAGAATGATGTA
ACCTTTTGTCTGTGTTATCTGAACACTCTACTTCCTTTGCAGCCTTAGTCACACAACTGAGTCATCTCAAGTACTCTTTAAGGACACACA
GCCCAGGCTGTTCTGAGTCAGAATAGGCCCCTACAGGTATATTTTAAAACTCTTCGTAATTCTAATGTGTACTGCTGGTATAGCTGAACT
ACTGACCTGGATCTTAGTCCTAGCCTTTTTGCTTTTGCAATTTCAGTATCTTCATCTCTAAACTAGGGAAACACTGGGATTCTTTCTTAG
CTGTGGGGGAAGGTATTTGGTTAGATGACTTTGAATGAATAGACTGCTGTGCTGAAAGAGCTTTATCACACTGTCTCAAAGTATGTAAAG
ATACATAGGTGGATGCTCTTACTGCAGCAGTCATGAATACATTTTTAGCCATTTACCTAAGGAAAAAGACAGTTTTTCTAGGTACCATGA
AGGAAGATTGACCCTGTTGGTATGCCTGTGGGGGTGGGATGTGAGTGGGACTGATAAACTGATACTTTTGGTTCGTATGTACATACTGGA


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FusionGenePPI for FAM83G_TTC19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM83GYWHAQ, SH3KBP1, SMAD2, SMAD3, CSNK1A1, MOV10, NXF1, VAPB, YWHAH, VAPATTC19UPF3B, SPRED1, HPS6, UBA1, CHMP4A, ATXN1, NAB2, REL, EIF4ENIF1, CCDC33, L3MBTL3, CCDC36, RHOD, CMPK1, RTBDN, GPANK1, KIAA1456, MYBPHL, ELMO1, FAM64A, GUK1, BPHL, C2orf48, SMC6, PAK7, EXT2, RHPN1, GCNT1, ARHGAP36, C17orf89, FOXD4, RPL18, SLAIN2, FDPS, DYNC2LI1, C12orf74, SCAMP1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM83G_TTC19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM83G_TTC19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTTC19C0021359Infertility1CTD_human
TgeneTTC19C0027765nervous system disorder1CTD_human
TgeneTTC19C0524851Neurodegenerative Disorders1CTD_human;HPO
TgeneTTC19C0751830Gait Disorders, Neurologic1CTD_human