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Fusion gene ID: 12875 |
FusionGeneSummary for FAM83G_TRIM16 |
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Fusion gene information | Fusion gene name: FAM83G_TRIM16 | Fusion gene ID: 12875 | Hgene | Tgene | Gene symbol | FAM83G | TRIM16 | Gene ID | 644815 | 10626 |
Gene name | family with sequence similarity 83 member G | tripartite motif containing 16 | |
Synonyms | PAWS1 | EBBP | |
Cytomap | 17p11.2 | 17p12 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM83Gprotein associated with SMAD1 | tripartite motif-containing protein 16estrogen-responsive B box protein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | A6ND36 | O95361 | |
Ensembl transtripts involved in fusion gene | ENST00000388995, ENST00000585154, ENST00000345041, | ENST00000577886, ENST00000416464, ENST00000578237, ENST00000336708, ENST00000579219, ENST00000581224, | |
Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/50*10)=0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: FAM83G [Title/Abstract] AND TRIM16 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FAM83G | GO:0030509 | BMP signaling pathway | 24554596 |
Tgene | TRIM16 | GO:0043966 | histone H3 acetylation | 19147277 |
Tgene | TRIM16 | GO:0043967 | histone H4 acetylation | 16636064 |
Tgene | TRIM16 | GO:0045618 | positive regulation of keratinocyte differentiation | 11919186 |
Tgene | TRIM16 | GO:0045893 | positive regulation of transcription, DNA-templated | 16636064|19147277 |
Tgene | TRIM16 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway | 16636064 |
Tgene | TRIM16 | GO:0060416 | response to growth hormone | 11919186 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-62-8394-01A | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000388995 | ENST00000577886 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000388995 | ENST00000416464 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000388995 | ENST00000578237 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000388995 | ENST00000336708 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000388995 | ENST00000579219 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000388995 | ENST00000581224 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000585154 | ENST00000577886 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000585154 | ENST00000416464 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000585154 | ENST00000578237 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000585154 | ENST00000336708 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000585154 | ENST00000579219 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000585154 | ENST00000581224 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000345041 | ENST00000577886 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000345041 | ENST00000416464 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000345041 | ENST00000578237 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000345041 | ENST00000336708 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000345041 | ENST00000579219 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
5CDS-5UTR | ENST00000345041 | ENST00000581224 | FAM83G | chr17 | 18891560 | - | TRIM16 | chr17 | 15546130 | - |
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FusionProtFeatures for FAM83G_TRIM16 |
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Hgene | Tgene |
FAM83G | TRIM16 |
May regulate the bone morphogenetic proteins (BMP)pathway. {ECO:0000269|PubMed:24554596}. | May play a role in the regulation of keratinocytedifferentiation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM83G_TRIM16 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM83G_TRIM16 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM83G | YWHAQ, SH3KBP1, SMAD2, SMAD3, CSNK1A1, MOV10, NXF1, VAPB, YWHAH, VAPA | TRIM16 | VIM, E2F1, TERF1, TINF2, ACD, POT1, APP, HSP90AB2P, CLUH, MCM7, TOMM34, MOV10, NXF1, TRIM16L, OPTN, LGALS2, LGALS3, ULK1, CUL4A, BECN1, ATG16L1, CUL5, DEPTOR, RRAGB, RRAGD, TFEB, PPP3CB |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM83G_TRIM16 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM83G_TRIM16 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |