FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12858

FusionGeneSummary for FAM76A_GPR3

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM76A_GPR3
Fusion gene ID: 12858
HgeneTgene
Gene symbol

FAM76A

GPR3

Gene ID

199870

2827

Gene namefamily with sequence similarity 76 member AG protein-coupled receptor 3
Synonyms-ACCA
Cytomap

1p35.3

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM76AG-protein coupled receptor 3ACCA orphan receptoradenylate cyclase constitutive activator
Modification date2018051920180519
UniProtAcc

Q8TAV0

P46089

Ensembl transtripts involved in fusion geneENST00000373954, ENST00000419687, 
ENST00000530324, ENST00000234549, 
ENST00000373949, ENST00000010299, 
ENST00000374024, 
Fusion gene scores* DoF score2 X 1 X 2=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: FAM76A [Title/Abstract] AND GPR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-8289-01AFAM76Achr1

28075665

+GPR3chr1

27720298

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000373954ENST00000374024FAM76Achr1

28075665

+GPR3chr1

27720298

+
intron-5UTRENST00000419687ENST00000374024FAM76Achr1

28075665

+GPR3chr1

27720298

+
5CDS-5UTRENST00000530324ENST00000374024FAM76Achr1

28075665

+GPR3chr1

27720298

+
intron-5UTRENST00000234549ENST00000374024FAM76Achr1

28075665

+GPR3chr1

27720298

+
intron-5UTRENST00000373949ENST00000374024FAM76Achr1

28075665

+GPR3chr1

27720298

+
5CDS-5UTRENST00000010299ENST00000374024FAM76Achr1

28075665

+GPR3chr1

27720298

+

Top

FusionProtFeatures for FAM76A_GPR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM76A

Q8TAV0

GPR3

P46089

Orphan receptor with constitutive G(s) signalingactivity that activate cyclic AMP. Has a potential role inmodulating a number of brain functions, including behavioralresponses to stress (By similarity), amyloid-beta peptidegeneration in neurons and neurite outgrowth (By similarity).Maintains also meiotic arrest in oocytes (By similarity).{ECO:0000250, ECO:0000269|PubMed:19213921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAM76A_GPR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAM76A_GPR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM76AELAVL1GPR3ELAVL1, GNPAT, TMEM5, ZNF593, DMWD, APOD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM76A_GPR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM76A_GPR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource