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Fusion gene ID: 12858 |
FusionGeneSummary for FAM76A_GPR3 |
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Fusion gene information | Fusion gene name: FAM76A_GPR3 | Fusion gene ID: 12858 | Hgene | Tgene | Gene symbol | FAM76A | GPR3 | Gene ID | 199870 | 2827 |
Gene name | family with sequence similarity 76 member A | G protein-coupled receptor 3 | |
Synonyms | - | ACCA | |
Cytomap | 1p35.3 | 1p36.11 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM76A | G-protein coupled receptor 3ACCA orphan receptoradenylate cyclase constitutive activator | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8TAV0 | P46089 | |
Ensembl transtripts involved in fusion gene | ENST00000373954, ENST00000419687, ENST00000530324, ENST00000234549, ENST00000373949, ENST00000010299, | ENST00000374024, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: FAM76A [Title/Abstract] AND GPR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-BR-8289-01A | FAM76A | chr1 | 28075665 | + | GPR3 | chr1 | 27720298 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000373954 | ENST00000374024 | FAM76A | chr1 | 28075665 | + | GPR3 | chr1 | 27720298 | + |
intron-5UTR | ENST00000419687 | ENST00000374024 | FAM76A | chr1 | 28075665 | + | GPR3 | chr1 | 27720298 | + |
5CDS-5UTR | ENST00000530324 | ENST00000374024 | FAM76A | chr1 | 28075665 | + | GPR3 | chr1 | 27720298 | + |
intron-5UTR | ENST00000234549 | ENST00000374024 | FAM76A | chr1 | 28075665 | + | GPR3 | chr1 | 27720298 | + |
intron-5UTR | ENST00000373949 | ENST00000374024 | FAM76A | chr1 | 28075665 | + | GPR3 | chr1 | 27720298 | + |
5CDS-5UTR | ENST00000010299 | ENST00000374024 | FAM76A | chr1 | 28075665 | + | GPR3 | chr1 | 27720298 | + |
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FusionProtFeatures for FAM76A_GPR3 |
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Hgene | Tgene |
FAM76A | GPR3 |
Orphan receptor with constitutive G(s) signalingactivity that activate cyclic AMP. Has a potential role inmodulating a number of brain functions, including behavioralresponses to stress (By similarity), amyloid-beta peptidegeneration in neurons and neurite outgrowth (By similarity).Maintains also meiotic arrest in oocytes (By similarity).{ECO:0000250, ECO:0000269|PubMed:19213921}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM76A_GPR3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM76A_GPR3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM76A | ELAVL1 | GPR3 | ELAVL1, GNPAT, TMEM5, ZNF593, DMWD, APOD |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM76A_GPR3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM76A_GPR3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |