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Fusion gene ID: 12831 |
FusionGeneSummary for FAM53B_PROSER2 |
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Fusion gene information | Fusion gene name: FAM53B_PROSER2 | Fusion gene ID: 12831 | Hgene | Tgene | Gene symbol | FAM53B | PROSER2 | Gene ID | 9679 | 254427 |
Gene name | family with sequence similarity 53 member B | proline and serine rich 2 | |
Synonyms | KIAA0140|bA12J10.2|smp | C10orf47 | |
Cytomap | 10q26.13 | 10p14 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM53Bprotein simpletsimplet homolog | proline and serine-rich protein 2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q14153 | Q86WR7 | |
Ensembl transtripts involved in fusion gene | ENST00000337318, ENST00000392754, ENST00000280780, | ENST00000474155, ENST00000277570, ENST00000379200, | |
Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 2 X 2 X 4=16 |
# samples | 9 | 4 | |
** MAII score | log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FAM53B [Title/Abstract] AND PROSER2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | DLBC | TCGA-GS-A9TV-01A | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000337318 | ENST00000474155 | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
5CDS-3UTR | ENST00000337318 | ENST00000277570 | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
5CDS-intron | ENST00000337318 | ENST00000379200 | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
5CDS-3UTR | ENST00000392754 | ENST00000474155 | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
5CDS-3UTR | ENST00000392754 | ENST00000277570 | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
5CDS-intron | ENST00000392754 | ENST00000379200 | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
5CDS-3UTR | ENST00000280780 | ENST00000474155 | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
5CDS-3UTR | ENST00000280780 | ENST00000277570 | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
5CDS-intron | ENST00000280780 | ENST00000379200 | FAM53B | chr10 | 126384727 | - | PROSER2 | chr10 | 11908530 | + |
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FusionProtFeatures for FAM53B_PROSER2 |
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Hgene | Tgene |
FAM53B | PROSER2 |
Acts as a regulator of Wnt signaling pathway byregulating beta-catenin (CTNNB1) nuclear localization.{ECO:0000269|PubMed:25183871}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM53B_PROSER2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM53B_PROSER2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM53B | XPO1, CBY1, TRIM25 | PROSER2 | POT1, APP, EPS8, YTHDC1, ACTB, STK24, XPO1, PDCD10, SLC25A43, STK25, CLIC1, STK26, ITFG2, NELFA, RDH13, MTHFD2L, KPTN, PHF1, VWA8, CDKN2C, SNX27, INPP5K, GRPEL1, OBSL1, TYMS, ANK3, GTPBP2, CSNK1G3, BCAT1, DHPS, GNPAT, TYK2, CTU2, IPO4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM53B_PROSER2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM53B_PROSER2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FAM53B | C0600427 | Cocaine Dependence | 1 | PSYGENET |