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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12831

FusionGeneSummary for FAM53B_PROSER2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM53B_PROSER2
Fusion gene ID: 12831
HgeneTgene
Gene symbol

FAM53B

PROSER2

Gene ID

9679

254427

Gene namefamily with sequence similarity 53 member Bproline and serine rich 2
SynonymsKIAA0140|bA12J10.2|smpC10orf47
Cytomap

10q26.13

10p14

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM53Bprotein simpletsimplet homologproline and serine-rich protein 2
Modification date2018051920180519
UniProtAcc

Q14153

Q86WR7

Ensembl transtripts involved in fusion geneENST00000337318, ENST00000392754, 
ENST00000280780, 
ENST00000474155, 
ENST00000277570, ENST00000379200, 
Fusion gene scores* DoF score8 X 4 X 6=1922 X 2 X 4=16
# samples 94
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM53B [Title/Abstract] AND PROSER2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDDLBCTCGA-GS-A9TV-01AFAM53Bchr10

126384727

-PROSER2chr10

11908530

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000337318ENST00000474155FAM53Bchr10

126384727

-PROSER2chr10

11908530

+
5CDS-3UTRENST00000337318ENST00000277570FAM53Bchr10

126384727

-PROSER2chr10

11908530

+
5CDS-intronENST00000337318ENST00000379200FAM53Bchr10

126384727

-PROSER2chr10

11908530

+
5CDS-3UTRENST00000392754ENST00000474155FAM53Bchr10

126384727

-PROSER2chr10

11908530

+
5CDS-3UTRENST00000392754ENST00000277570FAM53Bchr10

126384727

-PROSER2chr10

11908530

+
5CDS-intronENST00000392754ENST00000379200FAM53Bchr10

126384727

-PROSER2chr10

11908530

+
5CDS-3UTRENST00000280780ENST00000474155FAM53Bchr10

126384727

-PROSER2chr10

11908530

+
5CDS-3UTRENST00000280780ENST00000277570FAM53Bchr10

126384727

-PROSER2chr10

11908530

+
5CDS-intronENST00000280780ENST00000379200FAM53Bchr10

126384727

-PROSER2chr10

11908530

+

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FusionProtFeatures for FAM53B_PROSER2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM53B

Q14153

PROSER2

Q86WR7

Acts as a regulator of Wnt signaling pathway byregulating beta-catenin (CTNNB1) nuclear localization.{ECO:0000269|PubMed:25183871}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM53B_PROSER2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM53B_PROSER2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM53BXPO1, CBY1, TRIM25PROSER2POT1, APP, EPS8, YTHDC1, ACTB, STK24, XPO1, PDCD10, SLC25A43, STK25, CLIC1, STK26, ITFG2, NELFA, RDH13, MTHFD2L, KPTN, PHF1, VWA8, CDKN2C, SNX27, INPP5K, GRPEL1, OBSL1, TYMS, ANK3, GTPBP2, CSNK1G3, BCAT1, DHPS, GNPAT, TYK2, CTU2, IPO4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM53B_PROSER2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM53B_PROSER2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAM53BC0600427Cocaine Dependence1PSYGENET