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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12804

FusionGeneSummary for FAM47E_TMEM184B

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM47E_TMEM184B
Fusion gene ID: 12804
HgeneTgene
Gene symbol

FAM47E

TMEM184B

Gene ID

100129583

25829

Gene namefamily with sequence similarity 47 member Etransmembrane protein 184B
Synonyms-C22orf5|FM08|HS5O6A|HSPC256
Cytomap

4q21.1

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM47Etransmembrane protein 184Bputative MAPK-activating protein FM08
Modification date2018032920180523
UniProtAcc

Q6ZV65

Q9Y519

Ensembl transtripts involved in fusion geneENST00000510197, ENST00000339906, 
ENST00000515604, ENST00000424749, 
ENST00000515589, 
ENST00000361906, 
ENST00000361684, ENST00000504337, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 5 X 7=210
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM47E [Title/Abstract] AND TMEM184B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1928-01AFAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000510197ENST00000361906FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000510197ENST00000361684FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-intronENST00000510197ENST00000504337FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000339906ENST00000361906FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000339906ENST00000361684FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-intronENST00000339906ENST00000504337FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000515604ENST00000361906FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000515604ENST00000361684FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-intronENST00000515604ENST00000504337FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000424749ENST00000361906FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-5UTRENST00000424749ENST00000361684FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
5CDS-intronENST00000424749ENST00000504337FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
intron-5UTRENST00000515589ENST00000361906FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
intron-5UTRENST00000515589ENST00000361684FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-
intron-intronENST00000515589ENST00000504337FAM47Echr4

77184996

+TMEM184Bchr22

38644025

-

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FusionProtFeatures for FAM47E_TMEM184B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM47E

Q6ZV65

TMEM184B

Q9Y519

May activate the MAP kinase signaling pathway.{ECO:0000269|PubMed:12761501}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM47E_TMEM184B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM47E_TMEM184B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM47ETMEM184BLPAR6, ERGIC3, SNIP1, REN, CLASRP, CCDC9, ACIN1, INPPL1, TIMM23, FPR2, GPR21, C17orf85, SLC22A9, CLEC2D, YTHDF1, ZFYVE27, PDCD1, ABCG8, BBS4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM47E_TMEM184B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM47E_TMEM184B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTMEM184BC0023893Liver Cirrhosis, Experimental1CTD_human