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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12773

FusionGeneSummary for FAM222B_FLOT2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM222B_FLOT2
Fusion gene ID: 12773
HgeneTgene
Gene symbol

FAM222B

FLOT2

Gene ID

55731

2319

Gene namefamily with sequence similarity 222 member Bflotillin 2
SynonymsC17orf63ECS-1|ECS1|ESA|ESA1|M17S1
Cytomap

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM222Buncharacterized protein C17orf63flotillin-2Flotillin 2 (epidermal surface antigen 1)epidermal surface antigenmembrane component chromosome 17 surface marker 1membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
Modification date2018051920180522
UniProtAcc

Q8WU58

Q14254

Ensembl transtripts involved in fusion geneENST00000341217, ENST00000581407, 
ENST00000582266, ENST00000452648, 
ENST00000582059, ENST00000583953, 
ENST00000577682, ENST00000583522, 
ENST00000581381, 		ENST00000394906, 
ENST00000394908, ENST00000585169, 
ENST00000577789, 
Fusion gene scores* DoF score19 X 7 X 13=17296 X 5 X 4=120
# samples 228
** MAII scorelog2(22/1729*10)=-2.97436244011762
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM222B [Title/Abstract] AND FLOT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-XF-A9ST-01AFAM222Bchr17

27169700

-FLOT2chr17

27216044

-
TCGALDLIHCTCGA-CC-5263-01AFAM222Bchr17

27161311

-FLOT2chr17

27211333

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341217ENST00000394906FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000341217ENST00000394908FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000341217ENST00000585169FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-intronENST00000341217ENST00000577789FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000581407ENST00000394906FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000581407ENST00000394908FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000581407ENST00000585169FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-intronENST00000581407ENST00000577789FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000582266ENST00000394906FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000582266ENST00000394908FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000582266ENST00000585169FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-intronENST00000582266ENST00000577789FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000452648ENST00000394906FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000452648ENST00000394908FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000452648ENST00000585169FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-intronENST00000452648ENST00000577789FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000582059ENST00000394906FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000582059ENST00000394908FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000582059ENST00000585169FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-intronENST00000582059ENST00000577789FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000583953ENST00000394906FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000583953ENST00000394908FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000583953ENST00000585169FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-intronENST00000583953ENST00000577789FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000577682ENST00000394906FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000577682ENST00000394908FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000577682ENST00000585169FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-intronENST00000577682ENST00000577789FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000583522ENST00000394906FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000583522ENST00000394908FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000583522ENST00000585169FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-intronENST00000583522ENST00000577789FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000581381ENST00000394906FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000581381ENST00000394908FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-3CDSENST00000581381ENST00000585169FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
5UTR-intronENST00000581381ENST00000577789FAM222Bchr17

27169700

-FLOT2chr17

27216044

-
intron-3CDSENST00000341217ENST00000394906FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000341217ENST00000394908FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000341217ENST00000585169FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000341217ENST00000577789FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000581407ENST00000394906FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000581407ENST00000394908FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000581407ENST00000585169FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000581407ENST00000577789FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000582266ENST00000394906FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000582266ENST00000394908FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000582266ENST00000585169FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000582266ENST00000577789FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000452648ENST00000394906FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000452648ENST00000394908FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000452648ENST00000585169FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000452648ENST00000577789FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000582059ENST00000394906FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000582059ENST00000394908FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000582059ENST00000585169FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000582059ENST00000577789FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-3CDSENST00000583953ENST00000394906FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-3CDSENST00000583953ENST00000394908FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-intronENST00000583953ENST00000585169FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-intronENST00000583953ENST00000577789FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-3CDSENST00000577682ENST00000394906FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-3CDSENST00000577682ENST00000394908FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-intronENST00000577682ENST00000585169FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-intronENST00000577682ENST00000577789FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-3CDSENST00000583522ENST00000394906FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-3CDSENST00000583522ENST00000394908FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-intronENST00000583522ENST00000585169FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
5UTR-intronENST00000583522ENST00000577789FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000581381ENST00000394906FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-3CDSENST00000581381ENST00000394908FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000581381ENST00000585169FAM222Bchr17

27161311

-FLOT2chr17

27211333

-
intron-intronENST00000581381ENST00000577789FAM222Bchr17

27161311

-FLOT2chr17

27211333

-

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FusionProtFeatures for FAM222B_FLOT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM222B

Q8WU58

FLOT2

Q14254

May act as a scaffolding protein within caveolarmembranes, functionally participating in formation of caveolae orcaveolae-like vesicles. May be involved in epidermal cell adhesionand epidermal structure and function.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM222B_FLOT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM222B_FLOT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM222BNLKFLOT2CAV1, MME, CD44, KIAA0368, CCP110, F2R, ATP6V1B1, APP, FLOT1, MRPS14, VDAC2, PTRF, HNRNPUL2, RAB2A, MMGT1, SSR1, UQCRFS1P1, UQCC3, EEF2, TOMM40, GNG12, ERLIN2, VAMP2, PTRH2, MAVS, VDAC1, UBC, FN1, CFTR, SVIL, NMNAT1, SPATA24, CUL7, OBSL1, CCDC8, EED, EGFR, ABCE1, TMEM185A, TMEM79, ABCB6, TBC1D15, MPZL3, DEGS1, MPC2, SLC26A6, TMEM17, DBN1, FLNA, PTPN1, RAB5C, RAB7A, VAPA, ATP6AP2, TFG, SYNPO, MYEF2, GOLT1B, LIMA1, SGTB, TMEM63B, MYO19, CHMP4B, U2AF2, GORASP2, COX15, DLST, SOAT1, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM222B_FLOT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM222B_FLOT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource