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Fusion gene ID: 12764 |
FusionGeneSummary for FAM221A_KLHL7 |
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Fusion gene information | Fusion gene name: FAM221A_KLHL7 | Fusion gene ID: 12764 | Hgene | Tgene | Gene symbol | FAM221A | KLHL7 | Gene ID | 340277 | 55975 |
Gene name | family with sequence similarity 221 member A | kelch like family member 7 | |
Synonyms | C7orf46 | CISS3|KLHL6|SBBI26 | |
Cytomap | 7p15.3 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM221Auncharacterized protein C7orf46 | kelch-like protein 7kelch-like 6kelch-like 7kelch/BTB | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | A4D161 | Q8IXQ5 | |
Ensembl transtripts involved in fusion gene | ENST00000409192, ENST00000344962, ENST00000409653, ENST00000409994, ENST00000483090, | ENST00000322231, ENST00000339077, ENST00000539124, ENST00000542558, ENST00000409689, ENST00000545443, ENST00000479288, ENST00000322275, ENST00000410047, ENST00000545771, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FAM221A [Title/Abstract] AND KLHL7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KLHL7 | GO:0016567 | protein ubiquitination | 21828050 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | DLBC | TCGA-GS-A9TY-01A | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000409192 | ENST00000322231 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409192 | ENST00000339077 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409192 | ENST00000539124 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409192 | ENST00000542558 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409192 | ENST00000409689 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409192 | ENST00000545443 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409192 | ENST00000479288 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409192 | ENST00000322275 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000409192 | ENST00000410047 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000409192 | ENST00000545771 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000344962 | ENST00000322231 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000344962 | ENST00000339077 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000344962 | ENST00000539124 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000344962 | ENST00000542558 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000344962 | ENST00000409689 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000344962 | ENST00000545443 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000344962 | ENST00000479288 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000344962 | ENST00000322275 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000344962 | ENST00000410047 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000344962 | ENST00000545771 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000409653 | ENST00000322231 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409653 | ENST00000339077 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409653 | ENST00000539124 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409653 | ENST00000542558 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409653 | ENST00000409689 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409653 | ENST00000545443 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409653 | ENST00000479288 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409653 | ENST00000322275 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000409653 | ENST00000410047 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000409653 | ENST00000545771 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000409994 | ENST00000322231 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409994 | ENST00000339077 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409994 | ENST00000539124 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409994 | ENST00000542558 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409994 | ENST00000409689 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409994 | ENST00000545443 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409994 | ENST00000479288 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-intron | ENST00000409994 | ENST00000322275 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000409994 | ENST00000410047 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
5CDS-5UTR | ENST00000409994 | ENST00000545771 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-5UTR | ENST00000483090 | ENST00000322231 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-intron | ENST00000483090 | ENST00000339077 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-intron | ENST00000483090 | ENST00000539124 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-intron | ENST00000483090 | ENST00000542558 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-intron | ENST00000483090 | ENST00000409689 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-intron | ENST00000483090 | ENST00000545443 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-intron | ENST00000483090 | ENST00000479288 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-intron | ENST00000483090 | ENST00000322275 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-5UTR | ENST00000483090 | ENST00000410047 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
intron-5UTR | ENST00000483090 | ENST00000545771 | FAM221A | chr7 | 23731215 | + | KLHL7 | chr7 | 23157453 | + |
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FusionProtFeatures for FAM221A_KLHL7 |
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Hgene | Tgene |
FAM221A | KLHL7 |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediatingubiquitination and subsequent degradation of substrate proteins.Probably mediates 'Lys-48'-linked ubiquitination.{ECO:0000269|PubMed:21828050}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM221A_KLHL7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM221A_KLHL7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM221A | SNX5, SNX2, SNX6 | KLHL7 | CUL3, RBX1, KLHL7, UBC, MOV10, NXF1, NUP50, C9orf41, NR2C2, YWHAZ, CKAP5, NUP153, FERMT3, BOD1L1, MSRB3, KLHL6, ARIH1, SDC2, STAT5A, CEP44, GLI3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM221A_KLHL7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM221A_KLHL7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | KLHL7 | C2751986 | RETINITIS PIGMENTOSA 42 | 1 | CTD_human;UNIPROT |