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Fusion gene ID: 12753 |
FusionGeneSummary for FAM216A_IGF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM216A_IGF1 | Fusion gene ID: 12753 | Hgene | Tgene | Gene symbol | FAM216A | IGF1 | Gene ID | 29902 | 3479 |
| Gene name | family with sequence similarity 216 member A | insulin like growth factor 1 | |
| Synonyms | C12orf24|HSU79274 | IGF-I|IGFI|MGF | |
| Cytomap | 12q24.11 | 12q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM216Aprotein predicted by clone 23733uncharacterized protein C12orf24 | insulin-like growth factor Iinsulin-like growth factor 1 (somatomedin C)insulin-like growth factor IBmechano growth factorsomatomedin-C | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q8WUB2 | P05019 | |
| Ensembl transtripts involved in fusion gene | ENST00000377673, | ENST00000456098, ENST00000337514, ENST00000481539, ENST00000392904, ENST00000424202, ENST00000307046, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 4=48 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM216A [Title/Abstract] AND IGF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IGF1 | GO:0001775 | cell activation | 22797923 |
| Tgene | IGF1 | GO:0008284 | positive regulation of cell proliferation | 7688386|9722506|12746903 |
| Tgene | IGF1 | GO:0009408 | response to heat | 11404306 |
| Tgene | IGF1 | GO:0010613 | positive regulation of cardiac muscle hypertrophy | 19654000 |
| Tgene | IGF1 | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 7688386 |
| Tgene | IGF1 | GO:0014834 | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration | 17531227 |
| Tgene | IGF1 | GO:0014904 | myotube cell development | 17531227 |
| Tgene | IGF1 | GO:0014911 | positive regulation of smooth muscle cell migration | 10766744 |
| Tgene | IGF1 | GO:0030166 | proteoglycan biosynthetic process | 12746903 |
| Tgene | IGF1 | GO:0033160 | positive regulation of protein import into nucleus, translocation | 19654000 |
| Tgene | IGF1 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process | 16942485 |
| Tgene | IGF1 | GO:0035630 | bone mineralization involved in bone maturation | 16433617 |
| Tgene | IGF1 | GO:0042104 | positive regulation of activated T cell proliferation | 15694994 |
| Tgene | IGF1 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 9722506 |
| Tgene | IGF1 | GO:0043388 | positive regulation of DNA binding | 19654000 |
| Tgene | IGF1 | GO:0043410 | positive regulation of MAPK cascade | 19654000 |
| Tgene | IGF1 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway | 7688386|10766744 |
| Tgene | IGF1 | GO:0045445 | myoblast differentiation | 17531227 |
| Tgene | IGF1 | GO:0045669 | positive regulation of osteoblast differentiation | 16433617 |
| Tgene | IGF1 | GO:0045725 | positive regulation of glycogen biosynthetic process | 21076856 |
| Tgene | IGF1 | GO:0045821 | positive regulation of glycolytic process | 7688386 |
| Tgene | IGF1 | GO:0045840 | positive regulation of mitotic nuclear division | 7188854|10644978 |
| Tgene | IGF1 | GO:0045893 | positive regulation of transcription, DNA-templated | 9722506|19654000 |
| Tgene | IGF1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16433617 |
| Tgene | IGF1 | GO:0046326 | positive regulation of glucose import | 21076856 |
| Tgene | IGF1 | GO:0046579 | positive regulation of Ras protein signal transduction | 9722506 |
| Tgene | IGF1 | GO:0048015 | phosphatidylinositol-mediated signaling | 7692086 |
| Tgene | IGF1 | GO:0048146 | positive regulation of fibroblast proliferation | 7188854 |
| Tgene | IGF1 | GO:0048661 | positive regulation of smooth muscle cell proliferation | 10766744|16942485 |
| Tgene | IGF1 | GO:0050679 | positive regulation of epithelial cell proliferation | 7188854 |
| Tgene | IGF1 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 7782332|22635104 |
| Tgene | IGF1 | GO:0051450 | myoblast proliferation | 17531227 |
| Tgene | IGF1 | GO:0061051 | positive regulation of cell growth involved in cardiac muscle cell development | 24117217 |
| Tgene | IGF1 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade | 19654000 |
| Tgene | IGF1 | GO:2000679 | positive regulation of transcription regulatory region DNA binding | 15059951 |
| Tgene | IGF1 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 16942485 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | MESO | TCGA-TS-A8AY-01A | FAM216A | chr12 | 110910923 | + | IGF1 | chr12 | 102813468 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000377673 | ENST00000456098 | FAM216A | chr12 | 110910923 | + | IGF1 | chr12 | 102813468 | - |
| In-frame | ENST00000377673 | ENST00000337514 | FAM216A | chr12 | 110910923 | + | IGF1 | chr12 | 102813468 | - |
| 5CDS-intron | ENST00000377673 | ENST00000481539 | FAM216A | chr12 | 110910923 | + | IGF1 | chr12 | 102813468 | - |
| 5CDS-intron | ENST00000377673 | ENST00000392904 | FAM216A | chr12 | 110910923 | + | IGF1 | chr12 | 102813468 | - |
| 5CDS-intron | ENST00000377673 | ENST00000424202 | FAM216A | chr12 | 110910923 | + | IGF1 | chr12 | 102813468 | - |
| 5CDS-intron | ENST00000377673 | ENST00000307046 | FAM216A | chr12 | 110910923 | + | IGF1 | chr12 | 102813468 | - |
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FusionProtFeatures for FAM216A_IGF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM216A | IGF1 |
| The insulin-like growth factors, isolated from plasma,are structurally and functionally related to insulin but have amuch higher growth-promoting activity. May be a physiologicalregulator of [1-14C]-2-deoxy-D-glucose (2DG) transport andglycogen synthesis in osteoblasts. Stimulates glucose transport inbone-derived osteoblastic (PyMS) cells and is effective at muchlower concentrations than insulin, not only regarding glycogen andDNA synthesis but also with regard to enhancing glucose uptake.May play a role in synapse maturation (PubMed:21076856,PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is requiredfor sensory perception of smell in the olfactory bulb (Bysimilarity). Acts as a ligand for IGF1R. Binds to the alphasubunit of IGF1R, leading to the activation of the intrinsictyrosine kinase activity which autophosphorylates tyrosineresidues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKBand the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 andITGA6:ITGB4. Its binding to integrins and subsequent ternarycomplex formation with integrins and IGFR1 are essential for IGF1signaling. Induces the phosphorylation and activation of IGFR1,MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760,PubMed:23696648, PubMed:23243309). {ECO:0000250|UniProtKB:P05017,ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:21076856,ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:23243309,ECO:0000269|PubMed:23696648, ECO:0000269|PubMed:24132240}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000307046 | - | 1 | 4 | 111_118 | 73 | 196 | Region | Note=D |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000307046 | - | 1 | 4 | 78_89 | 73 | 196 | Region | Note=C |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000307046 | - | 1 | 4 | 90_110 | 73 | 196 | Region | Note=A |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000337514 | - | 1 | 4 | 111_118 | 73 | 154 | Region | Note=D |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000337514 | - | 1 | 4 | 78_89 | 73 | 154 | Region | Note=C |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000337514 | - | 1 | 4 | 90_110 | 73 | 154 | Region | Note=A |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000392904 | - | 2 | 6 | 111_118 | 73 | 159 | Region | Note=D |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000392904 | - | 2 | 6 | 78_89 | 73 | 159 | Region | Note=C |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000392904 | - | 2 | 6 | 90_110 | 73 | 159 | Region | Note=A |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000424202 | - | 1 | 4 | 111_118 | 57 | 138 | Region | Note=D |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000424202 | - | 1 | 4 | 78_89 | 57 | 138 | Region | Note=C |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000424202 | - | 1 | 4 | 90_110 | 57 | 138 | Region | Note=A |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000456098 | - | 1 | 5 | 111_118 | 73 | 159 | Region | Note=D |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000456098 | - | 1 | 5 | 78_89 | 73 | 159 | Region | Note=C |
| Tgene | >IGF1 | chr12:110910923 | chr12:102813468 | ENST00000456098 | - | 1 | 5 | 90_110 | 73 | 159 | Region | Note=A |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | IGF1 | chr12:110910923 | chr12:102813468 | ENST00000307046 | - | 1 | 4 | 49_77 | 73 | 196 | Region | Note=B |
| Tgene | IGF1 | chr12:110910923 | chr12:102813468 | ENST00000337514 | - | 1 | 4 | 49_77 | 73 | 154 | Region | Note=B |
| Tgene | IGF1 | chr12:110910923 | chr12:102813468 | ENST00000392904 | - | 2 | 6 | 49_77 | 73 | 159 | Region | Note=B |
| Tgene | IGF1 | chr12:110910923 | chr12:102813468 | ENST00000424202 | - | 1 | 4 | 49_77 | 57 | 138 | Region | Note=B |
| Tgene | IGF1 | chr12:110910923 | chr12:102813468 | ENST00000456098 | - | 1 | 5 | 49_77 | 73 | 159 | Region | Note=B |
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FusionGeneSequence for FAM216A_IGF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FAM216A_ENST00000377673_chr12_110910923_+_IGF1_ENST00000456098_chr12_102813468_-_147aa MLGQLLPHTARGLGAAEMPGQGPGSDWTERSSSAEPPAVAGTEGGGGGSAGYSCYQNSKGSDKPTGYGSSSRRAPQTGIVDECCFRSCDL >In-frame_FAM216A_ENST00000377673_chr12_110910923_+_IGF1_ENST00000337514_chr12_102813468_-_142aa MLGQLLPHTARGLGAAEMPGQGPGSDWTERSSSAEPPAVAGTEGGGGGSAGYSCYQNSKGSDKPTGYGSSSRRAPQTGIVDECCFRSCDL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FAM216A_ENST00000377673_chr12_110910923_+_IGF1_ENST00000456098_chr12_102813468_-_441nt ATGCTGGGACAGCTGCTCCCGCACACGGCTCGCGGTCTCGGCGCCGCGGAGATGCCCGGCCAGGGTCCGGGGTCCGACTGGACGGAGCGT AGCTCTTCTGCAGAGCCGCCCGCTGTGGCCGGGACCGAGGGTGGCGGCGGCGGATCAGCTGGATACTCTTGTTACCAGAATTCCAAAGGT TCTGACAAGCCCACAGGGTATGGCTCCAGCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGTGATCTA AGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCTGTCCGTGCCCAGCGCCACACCGACATGCCCAAGACC >In-frame_FAM216A_ENST00000377673_chr12_110910923_+_IGF1_ENST00000337514_chr12_102813468_-_426nt ATGCTGGGACAGCTGCTCCCGCACACGGCTCGCGGTCTCGGCGCCGCGGAGATGCCCGGCCAGGGTCCGGGGTCCGACTGGACGGAGCGT AGCTCTTCTGCAGAGCCGCCCGCTGTGGCCGGGACCGAGGGTGGCGGCGGCGGATCAGCTGGATACTCTTGTTACCAGAATTCCAAAGGT TCTGACAAGCCCACAGGGTATGGCTCCAGCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGTGATCTA AGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCTGTCCGTGCCCAGCGCCACACCGACATGCCCAAGACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FAM216A_ENST00000377673_chr12_110910923_+_IGF1_ENST00000456098_chr12_102813468_-_7627nt GAGAAACGCGTCCTGAGAAAAAAGGGGAGGGGCGAGGGAGAGGATTTGCGCGTGCGCAAAAGTAGTTGATGGAAATCGGCCGTTGGGATG CTGTCTAAGCTTGGATACCTGAGTAATAACGGACAACAGATAAAGCTCCGCATCCTTGCGCCACGTGCTTCGGTCCGTGGTTTGCGTGCA GACGTTTGACCTGTATGGTGACCCTCGCGATTTGCAAATGTGCTGAGGATCTGGAATACTGAAGTGGAAGGCACCTCTTGTTTTGGGGAG CATGTATATTTCCCTCCTGTGACGCACTGCTTCCACAGAGAGGTGCAAACGTGCAAACGCTCAGCGACCGCAGCGCTCCTGCCCCTCCCC CACCGTAACTCCGGGGTCGCGGATCTGCCCGCCCCGCTCTCCCGAAGCTGTTCGGGCAGTGTCCGAACGGCTTCGGAGGGGCGAGAAGCC AGCATCCGAGCCGCCTCTCCGGAATACCAGCAGCCTGACGCACGCGTGCTGTCGGGGGAGGGATGCTGGGACAGCTGCTCCCGCACACGG CTCGCGGTCTCGGCGCCGCGGAGATGCCCGGCCAGGGTCCGGGGTCCGACTGGACGGAGCGTAGCTCTTCTGCAGAGCCGCCCGCTGTGG CCGGGACCGAGGGTGGCGGCGGCGGATCAGCTGGATACTCTTGTTACCAGAATTCCAAAGGTTCTGACAAGCCCACAGGGTATGGCTCCA GCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGTGATCTAAGGAGGCTGGAGATGTATTGCGCACCCC TCAAGCCTGCCAAGTCAGCTCGCTCTGTCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGTATCAGCCCCCATCTACCAACA AGAACACGAAGTCTCAGAGAAGGAAAGGAAGTACATTTGAAGAACGCAAGTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAGGAA GACCCTCCTGAGGAGTGAAGAGTGACATGCCACCGCAGGATCCTTTGCTCTGCACGAGTTACCTGTTAAACTTTGGAACACCTACCAAAA AATAAGTTTGATAACATTTAAAAGATGGGCGTTTCCCCCAATGAAATACACAAGTAAACATTCCAACATTGTCTTTAGGAGTGATTTGCA CCTTGCAAAAATGGTCCTGGAGTTGGTAGATTGCTGTTGATCTTTTATCAATAATGTTCTATAGAAAAGAAAAAAAAAATATATATATAT ATATATCTTAGTCCCTGCCTCTCAAGAGCCACAAATGCATGGGTGTTGTATAGATCCAGTTGCACTAAATTCCTCTCTGAATCTTGGCTG CTGGAGCCATTCATTCAGCAACCTTGTCTAAGTGGTTTATGAATTGTTTCCTTATTTGCACTTCTTTCTACACAACTCGGGCTGTTTGTT TTACAGTGTCTGATAATCTTGTTAGTCTATACCCACCACCTCCCTTCATAACCTTTATATTTGCCGAATTTGGCCTCCTCAAAAGCAGCA GCAAGTCGTCAAGAAGCACACCAATTCTAACCCACAAGATTCCATCTGTGGCATTTGTACCAAATATAAGTTGGATGCATTTTATTTTAG ACACAAAGCTTTATTTTTCCACATCATGCTTACAAAAAAGAATAATGCAAATAGTTGCAACTTTGAGGCCAATCATTTTTAGGCATATGT TTTAAACATAGAAAGTTTCTTCAACTCAAAAGAGTTCCTTCAAATGATGAGTTAATGTGCAACCTAATTAGTAACTTTCCTCTTTTTATT TTTTCCATATAGAGCACTATGTAAATTTAGCATATCAATTATACAGGATATATCAAACAGTATGTAAAACTCTGTTTTTTAGTATAATGG TGCTATTTTGTAGTTTGTTATATGAAAGAGTCTGGCCAAAACGGTAATACGTGAAAGCAAAACAATAGGGGAAGCCTGGAGCCAAAGATG ACACAAGGGGAAGGGTACTGAAAACACCATCCATTTGGGAAAGAAGGCAAAGTCCCCCCAGTTATGCCTTCCAAGAGGAACTTCAGACAC AAAAGTCCACTGATGCAAATTGGACTGGCGAGTCCAGAGAGGAAACTGTGGAATGGAAAAAGCAGAAGGCTAGGAATTTTAGCAGTCCTG GTTTCTTTTTCTCATGGAAGAAATGAACATCTGCCAGCTGTGTCATGGACTCACCACTGTGTGACCTTGGGCAAGTCACTTCACCTCTCT GTGCCTCAGTTTCCTCATCTGCAAAATGGGGGCAATATGTCATCTACCTACCTCAAAGGGGTGGTATAAGGTTTAAAAAGATAAAGATTC AGATTTTTTTTACCCTGGGTTGCTGTAAGGGTGCAACATCAGGGCGCTTGAGTTGCTGAGATGCAAGGAATTCTATAAATAACCCATTCA TAGCATAGCTAGAGATTGGTGAATTGAATGCTCCTGACATCTCAGTTCTTGTCAGTGAAGCTATCCAAATAACTGGCCAACTAGTTGTTA AAAGCTAACAGCTCAATCTCTTAAAACACTTTTCAAAATATGTGGGAAGCATTTGATTTTCAATTTGATTTTGAATTCTGCATTTGGTTT TATGAATACAAAGATAAGTGAAAAGAGAGAAAGGAAAAGAAAAAGGAGAAAAACAAAGAGATTTCTACCAGTGAAAGGGGAATTAATTAC TCTTTGTTAGCACTCACTGACTCTTCTATGCAGTTACTACATATCTAGTAAAACCTCGTTTAATACTATAAATAATATTCTATTCATTTT GAAAAACACAATGATTCCTTCTTTTCTAGGCAATATAAGGAAAGTGATCCAAAATTTGAAATATTAAAATAATATCTAATAAAAAGTCAC AAAGTTATCTTCTTTAACAAACTTTACTCTTATTCTTAGCTGTATATACATTTTTTTAAAAGTTTGTTAAAATATGCTTGACTAGAGTTT CCAGTTGAAAGGCAAAAACTTCCATCACAACAAGAAATTTCCCATGCCTGCTCAGAAGGGTAGCCCCTAGCTCTCTGTGAATGTGTTTTA TCCATTCAACTGAAAATTGGTATCAAGAAAGTCCACTGGTTAGTGTACTAGTCCATCATAGCCTAGAAAATGATCCCTATCTGCAGATCA AGATTTTCTCATTAGAACAATGAATTATCCAGCATTCAGATCTTTCTAGTCACCTTAGAACTTTTTGGTTAAAAGTACCCAGGCTTGATT ATTTCATGCAAATTCTATATTTTACATTCTTGGAAAGTCTATATGAAAAACAAAAATAACATCTTCAGTTTTTCTCCCACTGGGTCACCT CAAGGATCAGAGGCCAGGAAAAAAAAAAAAAAGACTCCCTGGATCTCTGAATATATGCAAAAAGAAGGCCCCATTTAGTGGAGCCAGCAA TCCTGTTCAGTCAACAAGTATTTTAACTCTCAGTCCAACATTATTTGAATTGAGCACCTCAAGCATGCTTAGCAATGTTCTAATCACTAT GGACAGATGTAAAAGAAACTATACATCATTTTTGCCCTCTGCCTGTTTTCCAGACATACAGGTTCTGTGGAATAAGATACTGGACTCCTC TTCCCAAGATGGCACTTCTTTTTATTTCTTGTCCCCAGTGTGTACCTTTTAAAATTATTCCCTCTCAACAAAACTTTATAGGCAGTCTTC TGCAGACTTAACGTGTTTTCTGTCATAGTTAGATGTGATAATTCTAAGAGTGTCTATGACTTATTTCCTTCACTTAATTCTATCCACAGT CAAAAATCCCCCAAGGAGGAAAGCTGAAAGATGCACTGCCATATTATCTTTCTTAACTTTTTCCAACACATAATCCTCTCCAACTGGATT ATAAATAAATTGAAAATAACTCATTATACCAATTCACTATTTTATTTTTTAATGAATTAAAACTAGAAAACAAATTGATGCAAACCCTGG AAGTCAGTTGATTACTATATACTACAGCAGAATGACTCAGATTTCATAGAAAGGAGCAACCAAAATGTCACAACCCAAAACTTTACAAGC TTTGCTTCAGAATTAGATTGCTTTATAATTCTTGAATGAGGCAATTTCAAGATATTTGTAAAAGAACAGTAAACATTGGTAAGAATGAGC TTTCAACTCATAGGCTTATTTCCAATTTAATTGACCATACTGGATACTTAGGTCAAATTTCTGTTCTCTCTTCCCCAAATAATATTAAAG TATTATTTGAACTTTTTAAGATGAGGCAGTTCCCCTGAAAAAGTTAATGCAGCTCTCCATCAGAATCCACTCTTCTAGGGATATGAAAAT CTCTTAACACCCACCCTACATACACAGACACACACACACACACACACACACACACACACACACACATTCACCCTAAGGATCCAATGGAAT ACTGAAAAGAAATCACTTCCTTGAAAATTTTATTAAAAAACAAACAAACAAACAAAAAGCCTGTCCACCCTTGAGAATCCTTCCTCTCCT TGGAACGTCAATGTTTGTGTAGATGAAACCATCTCATGCTCTGTGGCTCCAGGGTTTCTGTTACTATTTTATGCACTTGGGAGAAGGCTT AGAATAAAAGATGTAGCACATTTTGCTTTCCCATTTATTGTTTGGCCAGCTATGCCAATGTGGTGCTATTGTTTCTTTAAGAAAGTACTT GACTAAAAAAAAAAGAAAAAAAGAAAAAAAAGAAAGCATAGACATATTTTTTTAAAGTATAAAAACAACAATTCTATAGATAGATGGCTT AATAAAATAGCATTAGGTCTATCTAGCCACCACCACCTTTCAACTTTTTATCACTCACAAGTAGTGTACTGTTCACCAAATTGTGAATTT GGGGGTGCAGGGGCAGGAGTTGGAAATTTTTTAAAGTTAGAAGGCTCCATTGTTTTGTTGGCTCTCAAACTTAGCAAAATTAGCAATATA TTATCCAATCTTCTGAACTTGATCAAGAGCATGGAGAATAAACGCGGGAAAAAAGATCTTATAGGCAAATAGAAGAATTTAAAAGATAAG TAAGTTCCTTATTGATTTTTGTGCACTCTGCTCTAAAACAGATATTCAGCAAGTGGAGAAAATAAGAACAAAGAGAAAAAATACATAGAT TTACCTGCAAAAAATAGCTTCTGCCAAATCCCCCTTGGGTATTCTTTGGCATTTACTGGTTTATAGAAGACATTCTCCCTTCACCCAGAC ATCTCAAAGAGCAGTAGCTCTCATGAAAAGCAATCACTGATCTCATTTGGGAAATGTTGGAAAGTATTTCCTTATGAGATGGGGGTTATC TACTGATAAAGAAAGAATTTATGAGAAATTGTTGAAAGAGATGGCTAACAATCTGTGAAGATTTTTTGTTTCTTGTTTTTGTTTTTTTTT TTTTTTTACTTTATACAGTCTTTATGAATTTCTTAATGTTCAAAATGACTTGGTTCTTTTCTTCTTTTTTTATATCAGAATGAGGAATAA TAAGTTAAACCCACATAGACTCTTTAAAACTATAGGCTAGATAGAAATGTATGTTTGACTTGTTGAAGCTATAATCAGACTATTTAAAAT GTTTTGCTATTTTTAATCTTAAAAGATTGTGCTAATTTATTAGAGCAGAACCTGTTTGGCTCTCCTCAGAAGAAAGAATCTTTCCATTCA AATCACATGGCTTTCCACCAATATTTTCAAAAGATAAATCTGATTTATGCAATGGCATCATTTATTTTAAAACAGAAGAATTGTGAAAGT TTATGCCCCTCCCTTGCAAAGACCATAAAGTCCAGATCTGGTAGGGGGGCAACAACAAAAGGAAAATGTTGTTGATTCTTGGTTTTGGAT TTTGTTTTGTTTTCAATGCTAGTGTTTAATCCTGTAGTACATATTTGCTTATTGCTATTTTAATATTTTATAAGACCTTCCTGTTAGGTA TTAGAAAGTGATACATAGATATCTTTTTTGTGTAATTTCTATTTAAAAAAGAGAGAAGACTGTCAGAAGCTTTAAGTGCATATGGTACAG GATAAAGATATCAATTTAAATAACCAATTCCTATCTGGAACAATGCTTTTGTTTTTTAAAGAAACCTCTCACAGATAAGACAGAGGCCCA GGGGATTTTTGAAGCTGTCTTTATTCTGCCCCCATCCCAACCCAGCCCTTATTATTTTAGTATCTGCCTCAGAATTTTATAGAGGGCTGA CCAAGCTGAAACTCTAGAATTAAAGGAACCTCACTGAAAACATATATTTCACGTGTTCCCTCTTTTTTTTTTTCCTTTTTGTGAGATGGG GTCTCGCACTGTCCCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTTAAGCGATTCTCCTGCCT CAGCCTCCTGAGTAGCTGGGATTACAGGCACCCACCACTATGCCCGGCTAATTTTTTGGATTTTTAATAGAGACGGGGTTTTACCATGTT GGCCAGGTTGGTCTCAAACTCCTGACCTTGTGATTTGCCCGCCTCAGCCTCCCAAATTGCTGGGATTACAGGCATGAGCCACCACACCCT GCCCATGTGTTCCCTCTTAATGTATGATTACATGGATCTTAAACATGATCCTTCTCTCCTCATTCTTCAACTATCTTTGATGGGGTCTTT CAAGGGGAAAAAAATCCAAGCTTTTTTAAAGTAAAAAAAAAAAAAGAGAGGACACAAAACCAAATGTTACTGCTCAACTGAAATATGAGT TAAGATGGAGACAGAGTTTCTCCTAATAACCGGAGCTGAATTACCTTTCACTTTCAAAAACATGACCTTCCACAATCCTTAGAATCTGCC TTTTTTTATATTACTGAGGCCTAAAAGTAAACATTACTCATTTTATTTTGCCCAAAATGCACTGATGTAAAGTAGGAAAAATAAAAACAG AGCTCTAAAATCCCTTTCAAGCCACCCATTGACCCCACTCACCAACTCATAGCAAAGTCACTTCTGTTAATCCCTTAATCTGATTTTGTT TGGATATTTATCTTGTACCCGCTGCTAAACACACTGCAGGAGGGACTCTGAAACCTCAAGCTGTCTACTTACATCTTTTATCTGTGTCTG TGTATCATGAAAATGTCTATTCAAAATATCAAAACCTTTCAAATATCACGCAGCTTATATTCAGTTTACATAAAGGCCCCAAATACCATG TCAGATCTTTTTGGTAAAAGAGTTAATGAACTATGAGAATTGGGATTACATCATGTATTTTGCCTCATGTATTTTTATCACACTTATAGG CCAAGTGTGATAAATAAACTTACAGACACTGAATTAATTTCCCCTGCTACTTTGAAACCAGAAAATAATGACTGGCCATTCGTTACATCT GTCTTAGTTGAAAAGCATATTTTTTATTAAATTAATTCTGATTGTATTTGAAATTATTATTCAATTCACTTATGGCAGAGGAATATCAAT CCTAATGACTTCTAAAAATGTAACTAATTGAATCATTATCTTACATTTACTGTTTAATAAGCATATTTTGAAAATGTATGGCTAGAGTGT >In-frame_FAM216A_ENST00000377673_chr12_110910923_+_IGF1_ENST00000337514_chr12_102813468_-_7571nt GAGAAACGCGTCCTGAGAAAAAAGGGGAGGGGCGAGGGAGAGGATTTGCGCGTGCGCAAAAGTAGTTGATGGAAATCGGCCGTTGGGATG CTGTCTAAGCTTGGATACCTGAGTAATAACGGACAACAGATAAAGCTCCGCATCCTTGCGCCACGTGCTTCGGTCCGTGGTTTGCGTGCA GACGTTTGACCTGTATGGTGACCCTCGCGATTTGCAAATGTGCTGAGGATCTGGAATACTGAAGTGGAAGGCACCTCTTGTTTTGGGGAG CATGTATATTTCCCTCCTGTGACGCACTGCTTCCACAGAGAGGTGCAAACGTGCAAACGCTCAGCGACCGCAGCGCTCCTGCCCCTCCCC CACCGTAACTCCGGGGTCGCGGATCTGCCCGCCCCGCTCTCCCGAAGCTGTTCGGGCAGTGTCCGAACGGCTTCGGAGGGGCGAGAAGCC AGCATCCGAGCCGCCTCTCCGGAATACCAGCAGCCTGACGCACGCGTGCTGTCGGGGGAGGGATGCTGGGACAGCTGCTCCCGCACACGG CTCGCGGTCTCGGCGCCGCGGAGATGCCCGGCCAGGGTCCGGGGTCCGACTGGACGGAGCGTAGCTCTTCTGCAGAGCCGCCCGCTGTGG CCGGGACCGAGGGTGGCGGCGGCGGATCAGCTGGATACTCTTGTTACCAGAATTCCAAAGGTTCTGACAAGCCCACAGGGTATGGCTCCA GCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGTGATCTAAGGAGGCTGGAGATGTATTGCGCACCCC TCAAGCCTGCCAAGTCAGCTCGCTCTGTCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGGAAGTACATTTGAAGAACGCAA GTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAGGAAGACCCTCCTGAGGAGTGAAGAGTGACATGCCACCGCAGGATCCTTTGCT CTGCACGAGTTACCTGTTAAACTTTGGAACACCTACCAAAAAATAAGTTTGATAACATTTAAAAGATGGGCGTTTCCCCCAATGAAATAC ACAAGTAAACATTCCAACATTGTCTTTAGGAGTGATTTGCACCTTGCAAAAATGGTCCTGGAGTTGGTAGATTGCTGTTGATCTTTTATC AATAATGTTCTATAGAAAAGAAAAAAAAAATATATATATATATATATCTTAGTCCCTGCCTCTCAAGAGCCACAAATGCATGGGTGTTGT ATAGATCCAGTTGCACTAAATTCCTCTCTGAATCTTGGCTGCTGGAGCCATTCATTCAGCAACCTTGTCTAAGTGGTTTATGAATTGTTT CCTTATTTGCACTTCTTTCTACACAACTCGGGCTGTTTGTTTTACAGTGTCTGATAATCTTGTTAGTCTATACCCACCACCTCCCTTCAT AACCTTTATATTTGCCGAATTTGGCCTCCTCAAAAGCAGCAGCAAGTCGTCAAGAAGCACACCAATTCTAACCCACAAGATTCCATCTGT GGCATTTGTACCAAATATAAGTTGGATGCATTTTATTTTAGACACAAAGCTTTATTTTTCCACATCATGCTTACAAAAAAGAATAATGCA AATAGTTGCAACTTTGAGGCCAATCATTTTTAGGCATATGTTTTAAACATAGAAAGTTTCTTCAACTCAAAAGAGTTCCTTCAAATGATG AGTTAATGTGCAACCTAATTAGTAACTTTCCTCTTTTTATTTTTTCCATATAGAGCACTATGTAAATTTAGCATATCAATTATACAGGAT ATATCAAACAGTATGTAAAACTCTGTTTTTTAGTATAATGGTGCTATTTTGTAGTTTGTTATATGAAAGAGTCTGGCCAAAACGGTAATA CGTGAAAGCAAAACAATAGGGGAAGCCTGGAGCCAAAGATGACACAAGGGGAAGGGTACTGAAAACACCATCCATTTGGGAAAGAAGGCA AAGTCCCCCCAGTTATGCCTTCCAAGAGGAACTTCAGACACAAAAGTCCACTGATGCAAATTGGACTGGCGAGTCCAGAGAGGAAACTGT GGAATGGAAAAAGCAGAAGGCTAGGAATTTTAGCAGTCCTGGTTTCTTTTTCTCATGGAAGAAATGAACATCTGCCAGCTGTGTCATGGA CTCACCACTGTGTGACCTTGGGCAAGTCACTTCACCTCTCTGTGCCTCAGTTTCCTCATCTGCAAAATGGGGGCAATATGTCATCTACCT ACCTCAAAGGGGTGGTATAAGGTTTAAAAAGATAAAGATTCAGATTTTTTTTACCCTGGGTTGCTGTAAGGGTGCAACATCAGGGCGCTT GAGTTGCTGAGATGCAAGGAATTCTATAAATAACCCATTCATAGCATAGCTAGAGATTGGTGAATTGAATGCTCCTGACATCTCAGTTCT TGTCAGTGAAGCTATCCAAATAACTGGCCAACTAGTTGTTAAAAGCTAACAGCTCAATCTCTTAAAACACTTTTCAAAATATGTGGGAAG CATTTGATTTTCAATTTGATTTTGAATTCTGCATTTGGTTTTATGAATACAAAGATAAGTGAAAAGAGAGAAAGGAAAAGAAAAAGGAGA AAAACAAAGAGATTTCTACCAGTGAAAGGGGAATTAATTACTCTTTGTTAGCACTCACTGACTCTTCTATGCAGTTACTACATATCTAGT AAAACCTCGTTTAATACTATAAATAATATTCTATTCATTTTGAAAAACACAATGATTCCTTCTTTTCTAGGCAATATAAGGAAAGTGATC CAAAATTTGAAATATTAAAATAATATCTAATAAAAAGTCACAAAGTTATCTTCTTTAACAAACTTTACTCTTATTCTTAGCTGTATATAC ATTTTTTTAAAAGTTTGTTAAAATATGCTTGACTAGAGTTTCCAGTTGAAAGGCAAAAACTTCCATCACAACAAGAAATTTCCCATGCCT GCTCAGAAGGGTAGCCCCTAGCTCTCTGTGAATGTGTTTTATCCATTCAACTGAAAATTGGTATCAAGAAAGTCCACTGGTTAGTGTACT AGTCCATCATAGCCTAGAAAATGATCCCTATCTGCAGATCAAGATTTTCTCATTAGAACAATGAATTATCCAGCATTCAGATCTTTCTAG TCACCTTAGAACTTTTTGGTTAAAAGTACCCAGGCTTGATTATTTCATGCAAATTCTATATTTTACATTCTTGGAAAGTCTATATGAAAA ACAAAAATAACATCTTCAGTTTTTCTCCCACTGGGTCACCTCAAGGATCAGAGGCCAGGAAAAAAAAAAAAAAGACTCCCTGGATCTCTG AATATATGCAAAAAGAAGGCCCCATTTAGTGGAGCCAGCAATCCTGTTCAGTCAACAAGTATTTTAACTCTCAGTCCAACATTATTTGAA TTGAGCACCTCAAGCATGCTTAGCAATGTTCTAATCACTATGGACAGATGTAAAAGAAACTATACATCATTTTTGCCCTCTGCCTGTTTT CCAGACATACAGGTTCTGTGGAATAAGATACTGGACTCCTCTTCCCAAGATGGCACTTCTTTTTATTTCTTGTCCCCAGTGTGTACCTTT TAAAATTATTCCCTCTCAACAAAACTTTATAGGCAGTCTTCTGCAGACTTAACGTGTTTTCTGTCATAGTTAGATGTGATAATTCTAAGA GTGTCTATGACTTATTTCCTTCACTTAATTCTATCCACAGTCAAAAATCCCCCAAGGAGGAAAGCTGAAAGATGCACTGCCATATTATCT TTCTTAACTTTTTCCAACACATAATCCTCTCCAACTGGATTATAAATAAATTGAAAATAACTCATTATACCAATTCACTATTTTATTTTT TAATGAATTAAAACTAGAAAACAAATTGATGCAAACCCTGGAAGTCAGTTGATTACTATATACTACAGCAGAATGACTCAGATTTCATAG AAAGGAGCAACCAAAATGTCACAACCCAAAACTTTACAAGCTTTGCTTCAGAATTAGATTGCTTTATAATTCTTGAATGAGGCAATTTCA AGATATTTGTAAAAGAACAGTAAACATTGGTAAGAATGAGCTTTCAACTCATAGGCTTATTTCCAATTTAATTGACCATACTGGATACTT AGGTCAAATTTCTGTTCTCTCTTCCCCAAATAATATTAAAGTATTATTTGAACTTTTTAAGATGAGGCAGTTCCCCTGAAAAAGTTAATG CAGCTCTCCATCAGAATCCACTCTTCTAGGGATATGAAAATCTCTTAACACCCACCCTACATACACAGACACACACACACACACACACAC ACACACACACACACACATTCACCCTAAGGATCCAATGGAATACTGAAAAGAAATCACTTCCTTGAAAATTTTATTAAAAAACAAACAAAC AAACAAAAAGCCTGTCCACCCTTGAGAATCCTTCCTCTCCTTGGAACGTCAATGTTTGTGTAGATGAAACCATCTCATGCTCTGTGGCTC CAGGGTTTCTGTTACTATTTTATGCACTTGGGAGAAGGCTTAGAATAAAAGATGTAGCACATTTTGCTTTCCCATTTATTGTTTGGCCAG CTATGCCAATGTGGTGCTATTGTTTCTTTAAGAAAGTACTTGACTAAAAAAAAAAGAAAAAAAGAAAAAAAAGAAAGCATAGACATATTT TTTTAAAGTATAAAAACAACAATTCTATAGATAGATGGCTTAATAAAATAGCATTAGGTCTATCTAGCCACCACCACCTTTCAACTTTTT ATCACTCACAAGTAGTGTACTGTTCACCAAATTGTGAATTTGGGGGTGCAGGGGCAGGAGTTGGAAATTTTTTAAAGTTAGAAGGCTCCA TTGTTTTGTTGGCTCTCAAACTTAGCAAAATTAGCAATATATTATCCAATCTTCTGAACTTGATCAAGAGCATGGAGAATAAACGCGGGA AAAAAGATCTTATAGGCAAATAGAAGAATTTAAAAGATAAGTAAGTTCCTTATTGATTTTTGTGCACTCTGCTCTAAAACAGATATTCAG CAAGTGGAGAAAATAAGAACAAAGAGAAAAAATACATAGATTTACCTGCAAAAAATAGCTTCTGCCAAATCCCCCTTGGGTATTCTTTGG CATTTACTGGTTTATAGAAGACATTCTCCCTTCACCCAGACATCTCAAAGAGCAGTAGCTCTCATGAAAAGCAATCACTGATCTCATTTG GGAAATGTTGGAAAGTATTTCCTTATGAGATGGGGGTTATCTACTGATAAAGAAAGAATTTATGAGAAATTGTTGAAAGAGATGGCTAAC AATCTGTGAAGATTTTTTGTTTCTTGTTTTTGTTTTTTTTTTTTTTTTACTTTATACAGTCTTTATGAATTTCTTAATGTTCAAAATGAC TTGGTTCTTTTCTTCTTTTTTTATATCAGAATGAGGAATAATAAGTTAAACCCACATAGACTCTTTAAAACTATAGGCTAGATAGAAATG TATGTTTGACTTGTTGAAGCTATAATCAGACTATTTAAAATGTTTTGCTATTTTTAATCTTAAAAGATTGTGCTAATTTATTAGAGCAGA ACCTGTTTGGCTCTCCTCAGAAGAAAGAATCTTTCCATTCAAATCACATGGCTTTCCACCAATATTTTCAAAAGATAAATCTGATTTATG CAATGGCATCATTTATTTTAAAACAGAAGAATTGTGAAAGTTTATGCCCCTCCCTTGCAAAGACCATAAAGTCCAGATCTGGTAGGGGGG CAACAACAAAAGGAAAATGTTGTTGATTCTTGGTTTTGGATTTTGTTTTGTTTTCAATGCTAGTGTTTAATCCTGTAGTACATATTTGCT TATTGCTATTTTAATATTTTATAAGACCTTCCTGTTAGGTATTAGAAAGTGATACATAGATATCTTTTTTGTGTAATTTCTATTTAAAAA AGAGAGAAGACTGTCAGAAGCTTTAAGTGCATATGGTACAGGATAAAGATATCAATTTAAATAACCAATTCCTATCTGGAACAATGCTTT TGTTTTTTAAAGAAACCTCTCACAGATAAGACAGAGGCCCAGGGGATTTTTGAAGCTGTCTTTATTCTGCCCCCATCCCAACCCAGCCCT TATTATTTTAGTATCTGCCTCAGAATTTTATAGAGGGCTGACCAAGCTGAAACTCTAGAATTAAAGGAACCTCACTGAAAACATATATTT CACGTGTTCCCTCTTTTTTTTTTTCCTTTTTGTGAGATGGGGTCTCGCACTGTCCCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCA CTGCAACCTCCACCTCCTGGGTTTAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCCACCACTATGCCCGGCT AATTTTTTGGATTTTTAATAGAGACGGGGTTTTACCATGTTGGCCAGGTTGGTCTCAAACTCCTGACCTTGTGATTTGCCCGCCTCAGCC TCCCAAATTGCTGGGATTACAGGCATGAGCCACCACACCCTGCCCATGTGTTCCCTCTTAATGTATGATTACATGGATCTTAAACATGAT CCTTCTCTCCTCATTCTTCAACTATCTTTGATGGGGTCTTTCAAGGGGAAAAAAATCCAAGCTTTTTTAAAGTAAAAAAAAAAAAAGAGA GGACACAAAACCAAATGTTACTGCTCAACTGAAATATGAGTTAAGATGGAGACAGAGTTTCTCCTAATAACCGGAGCTGAATTACCTTTC ACTTTCAAAAACATGACCTTCCACAATCCTTAGAATCTGCCTTTTTTTATATTACTGAGGCCTAAAAGTAAACATTACTCATTTTATTTT GCCCAAAATGCACTGATGTAAAGTAGGAAAAATAAAAACAGAGCTCTAAAATCCCTTTCAAGCCACCCATTGACCCCACTCACCAACTCA TAGCAAAGTCACTTCTGTTAATCCCTTAATCTGATTTTGTTTGGATATTTATCTTGTACCCGCTGCTAAACACACTGCAGGAGGGACTCT GAAACCTCAAGCTGTCTACTTACATCTTTTATCTGTGTCTGTGTATCATGAAAATGTCTATTCAAAATATCAAAACCTTTCAAATATCAC GCAGCTTATATTCAGTTTACATAAAGGCCCCAAATACCATGTCAGATCTTTTTGGTAAAAGAGTTAATGAACTATGAGAATTGGGATTAC ATCATGTATTTTGCCTCATGTATTTTTATCACACTTATAGGCCAAGTGTGATAAATAAACTTACAGACACTGAATTAATTTCCCCTGCTA CTTTGAAACCAGAAAATAATGACTGGCCATTCGTTACATCTGTCTTAGTTGAAAAGCATATTTTTTATTAAATTAATTCTGATTGTATTT GAAATTATTATTCAATTCACTTATGGCAGAGGAATATCAATCCTAATGACTTCTAAAAATGTAACTAATTGAATCATTATCTTACATTTA CTGTTTAATAAGCATATTTTGAAAATGTATGGCTAGAGTGTCATAATAAAATGGTATATCTTTCTTTAGTAATTACATTAAAATTAGTCA |
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FusionGenePPI for FAM216A_IGF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FAM216A | MAGEA10 | IGF1 | IGFBP7, IGFBP3, NOV, IGF1R, TF, IGFALS, IDE, IGFBP4, IGFBP2, IGSF1, IGFBP5, E2F1, SOX4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM216A_IGF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM216A_IGF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | IGF1 | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | IGF1 | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | IGF1 | C0001206 | Acromegaly | 4 | CTD_human |
| Tgene | IGF1 | C0011206 | Delirium | 3 | PSYGENET |
| Tgene | IGF1 | C0024668 | Mammary Neoplasms, Experimental | 3 | CTD_human |
| Tgene | IGF1 | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
| Tgene | IGF1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | IGF1 | C0020538 | Hypertensive disease | 2 | CTD_human |
| Tgene | IGF1 | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
| Tgene | IGF1 | C0027746 | Nerve Degeneration | 2 | CTD_human |
| Tgene | IGF1 | C0031117 | Peripheral Neuropathy | 2 | CTD_human |
| Tgene | IGF1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
| Tgene | IGF1 | C4277682 | Chemical and Drug Induced Liver Injury | 2 | CTD_human |
| Tgene | IGF1 | C0000786 | Spontaneous abortion | 1 | CTD_human |
| Tgene | IGF1 | C0001430 | Adenoma | 1 | CTD_human |
| Tgene | IGF1 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
| Tgene | IGF1 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Tgene | IGF1 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | IGF1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | IGF1 | C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
| Tgene | IGF1 | C0008370 | Cholestasis | 1 | CTD_human |
| Tgene | IGF1 | C0009319 | Colitis | 1 | CTD_human |
| Tgene | IGF1 | C0010034 | Corneal Diseases | 1 | CTD_human |
| Tgene | IGF1 | C0010346 | Crohn Disease | 1 | CTD_human |
| Tgene | IGF1 | C0011303 | Demyelinating Diseases | 1 | CTD_human |
| Tgene | IGF1 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Tgene | IGF1 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
| Tgene | IGF1 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | IGF1 | C0018800 | Cardiomegaly | 1 | CTD_human |
| Tgene | IGF1 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| Tgene | IGF1 | C0020429 | Hyperalgesia | 1 | CTD_human |
| Tgene | IGF1 | C0022658 | Kidney Diseases | 1 | CTD_human |
| Tgene | IGF1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
| Tgene | IGF1 | C0026846 | Muscular Atrophy | 1 | CTD_human |
| Tgene | IGF1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | IGF1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | IGF1 | C0032019 | Pituitary Neoplasms | 1 | CTD_human |
| Tgene | IGF1 | C0034013 | Precocious Puberty | 1 | CTD_human |
| Tgene | IGF1 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Tgene | IGF1 | C0037286 | Skin Neoplasms | 1 | CTD_human |
| Tgene | IGF1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Tgene | IGF1 | C0085762 | Alcohol abuse | 1 | PSYGENET |
| Tgene | IGF1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | IGF1 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
| Tgene | IGF1 | C0853897 | Diabetic Cardiomyopathies | 1 | CTD_human |
| Tgene | IGF1 | C1720887 | Female Urogenital Diseases | 1 | CTD_human |
| Tgene | IGF1 | C2609414 | Acute kidney injury | 1 | CTD_human |
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