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Fusion gene ID: 12746 |
FusionGeneSummary for FAM213A_YTHDC1 |
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Fusion gene information | Fusion gene name: FAM213A_YTHDC1 | Fusion gene ID: 12746 | Hgene | Tgene | Gene symbol | FAM213A | YTHDC1 | Gene ID | 84293 | 91746 |
Gene name | family with sequence similarity 213 member A | YTH domain containing 1 | |
Synonyms | Adrx|C10orf58|PAMM | YT521|YT521-B | |
Cytomap | 10q23.1 | 4q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | redox-regulatory protein FAM213AAdiporedoxinUPF0765 protein C10orf58peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytesperoxiredoxin-like 2 activated in M-CSF stimulated monocytesredox-regulatory protein PAMM | YTH domain-containing protein 1putative splicing factor YT521splicing factor YT521splicing factor YT521-B | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9BRX8 | Q96MU7 | |
Ensembl transtripts involved in fusion gene | ENST00000372188, ENST00000372187, ENST00000372185, ENST00000372181, | ENST00000344157, ENST00000355665, ENST00000579690, ENST00000552105, ENST00000550485, | |
Fusion gene scores | * DoF score | 5 X 6 X 2=60 | 5 X 5 X 2=50 |
# samples | 6 | 5 | |
** MAII score | log2(6/60*10)=0 | log2(5/50*10)=0 | |
Context | PubMed: FAM213A [Title/Abstract] AND YTHDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FAM213A | GO:0045670 | regulation of osteoclast differentiation | 19951071 |
Hgene | FAM213A | GO:0055114 | oxidation-reduction process | 19951071 |
Tgene | YTHDC1 | GO:0006376 | mRNA splice site selection | 20167602 |
Tgene | YTHDC1 | GO:0048024 | regulation of mRNA splicing, via spliceosome | 26876937 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AQ-A04L-01B | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000372188 | ENST00000344157 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372188 | ENST00000355665 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372188 | ENST00000579690 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
5CDS-intron | ENST00000372188 | ENST00000552105 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
5CDS-intron | ENST00000372188 | ENST00000550485 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372187 | ENST00000344157 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372187 | ENST00000355665 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372187 | ENST00000579690 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
5CDS-intron | ENST00000372187 | ENST00000552105 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
5CDS-intron | ENST00000372187 | ENST00000550485 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372185 | ENST00000344157 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372185 | ENST00000355665 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372185 | ENST00000579690 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
5CDS-intron | ENST00000372185 | ENST00000552105 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
5CDS-intron | ENST00000372185 | ENST00000550485 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372181 | ENST00000344157 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372181 | ENST00000355665 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
Frame-shift | ENST00000372181 | ENST00000579690 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
5CDS-intron | ENST00000372181 | ENST00000552105 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
5CDS-intron | ENST00000372181 | ENST00000550485 | FAM213A | chr10 | 82180401 | + | YTHDC1 | chr4 | 69180041 | - |
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FusionProtFeatures for FAM213A_YTHDC1 |
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Hgene | Tgene |
FAM213A | YTHDC1 |
Involved in redox regulation of the cell(PubMed:26438880, PubMed:19951071). Acts as an antioxidant(PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1and JUN activation and osteoclast differentiation(PubMed:19951071). May affect bone resorption and help to maintainbone mass (PubMed:19951071). Acts as a negative regulator ofmacrophage-mediated inflammation by inhibiting macrophageproduction of inflammatory cytokines, probably through suppressionof the MAPK signaling pathway (PubMed:26438880).{ECO:0000269|PubMed:19951071, ECO:0000269|PubMed:26438880}. | Regulator of alternative splicing that specificallyrecognizes and binds N6-methyladenosine (m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552,PubMed:28984244). M6A is a modification present at internal sitesof mRNAs and some non-coding RNAs and plays a role in theefficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator ofexon-inclusion or exon-skipping during alternative splicing viainteraction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs andpromotes recruitment of SRSF3 to its mRNA-binding elementsadjacent to m6A sites, leading to exon-inclusion duringalternative splicing (PubMed:26876937). In contrast, interactionwith SRSF3 prevents interaction with SRSF10, a splicing factorthat promotes exon skipping: this prevents SRSF10 from binding toits mRNA-binding sites close to m6A-containing regions, leading toinhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice siteselection (PubMed:20167602). Also involved in nuclear export ofm6A-containing mRNAs via interaction with SRSF3: interaction withSRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 andNXF1, promoting mRNA nuclear export (PubMed:28984244). Alsorecognizes and binds m6A on other RNA molecules (PubMed:27602518).Involved in random X inactivation mediated by Xist RNA: recognizesand binds m6A-containing Xist and promotes transcriptionrepression activity of Xist (PubMed:27602518). Involved in S-adenosyl-L-methionine homeostasis by regulating expression ofMAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs(By similarity). {ECO:0000250|UniProtKB:E9Q5K9,ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552,ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937,ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM213A_YTHDC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM213A_YTHDC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM213A | APP, ST3GAL4, HLA-C, A4GNT, COQ9, YIPF3, CSGALNACT2, SLC18A1, GRPR, TLR5, SLC39A12, ADPGK, TMEM30A, HLA-G, TACR1, GPR114, RTN1, TSPAN5, CHRND, GDPD5, FAM131B, MME | YTHDC1 | ABL1, EMD, KHDRBS1, ISG15, MAGOH, EIF4A3, KIAA0101, ADAMTS4, SOX13, GOLGA2, LAMC3, LZTS2, PLG, CFH, VPS51, KRT18, TRA2B, LAMTOR5, CORO1A, MPRIP, EDC4, TRA2A, SEPT10, PROSER2, SRPK1, SRPK2, CLK2, DVL3, HNRNPK, KHDRBS3, SDCBP2, RBMY1F, KHDRBS2, BMI1, RALYL, HNRNPA1, ILF2, RBMX, SNIP1, SRC, IFI16, CLK1, KPNB1, SLAIN2, FOXK2, ZC3H18, APOBEC3D, ELAVL2, CLK3, FBXW11, C11orf57, CDX1, SNRNP70, GSPT2, NXF2, HIST1H1T, DLST |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM213A_YTHDC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM213A_YTHDC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |