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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1274

FusionGeneSummary for AIM1_MYB

check button Fusion gene summary
Fusion gene informationFusion gene name: AIM1_MYB
Fusion gene ID: 1274
HgeneTgene
Gene symbol

AIM1

MYB

Gene ID

51151

4602

Gene namesolute carrier family 45 member 2MYB proto-oncogene, transcription factor
Synonyms1A1|AIM1|MATP|OCA4|SHEP5Cmyb|c-myb|c-myb_CDS|efg
Cytomap

5p13.2

6q23.3

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated transporter proteinmelanoma antigen AIM1protein AIM-1underwhitetranscriptional activator Myboncogene AMVproto-oncogene c-Mybv-myb avian myeloblastosis viral oncogene homolog
Modification date2018051920180527
UniProtAcc

P10242

Ensembl transtripts involved in fusion geneENST00000369066, ENST00000535438, 
ENST00000487681, 		ENST00000341911, 
ENST00000316528, ENST00000442647, 
ENST00000367814, ENST00000525369, 
ENST00000534121, ENST00000533624, 
ENST00000534044, ENST00000528774, 
ENST00000531845, ENST00000527615, 
ENST00000420123, 
Fusion gene scores* DoF score7 X 5 X 3=1057 X 5 X 3=105
# samples 79
** MAII scorelog2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/105*10)=-0.222392421336448
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AIM1 [Title/Abstract] AND MYB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMYB

GO:0045944

positive regulation of transcription by RNA polymerase II

10233885|20484083


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-EW-A1P3-01AAIM1chr6

106808956

+MYBchr6

135513462

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000369066ENST00000341911AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000369066ENST00000316528AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000369066ENST00000442647AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000369066ENST00000367814AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000369066ENST00000525369AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000369066ENST00000534121AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000369066ENST00000533624AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000369066ENST00000534044AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000369066ENST00000528774AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3UTRENST00000369066ENST00000531845AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3UTRENST00000369066ENST00000527615AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3UTRENST00000369066ENST00000420123AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000535438ENST00000341911AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000535438ENST00000316528AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000535438ENST00000442647AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000535438ENST00000367814AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000535438ENST00000525369AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000535438ENST00000534121AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000535438ENST00000533624AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000535438ENST00000534044AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000535438ENST00000528774AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3UTRENST00000535438ENST00000531845AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3UTRENST00000535438ENST00000527615AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3UTRENST00000535438ENST00000420123AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000487681ENST00000341911AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000487681ENST00000316528AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000487681ENST00000442647AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000487681ENST00000367814AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000487681ENST00000525369AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000487681ENST00000534121AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000487681ENST00000533624AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000487681ENST00000534044AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3CDSENST00000487681ENST00000528774AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3UTRENST00000487681ENST00000531845AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3UTRENST00000487681ENST00000527615AIM1chr6

106808956

+MYBchr6

135513462

+
intron-3UTRENST00000487681ENST00000420123AIM1chr6

106808956

+MYBchr6

135513462

+

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FusionProtFeatures for AIM1_MYB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AIM1

MYB

P10242

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AIM1_MYB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AIM1_MYB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AIM1CUL3, ZNF829, PYHIN1, XPO1, CD44, GSK3A, KIFAP3, CDH1, FBXL4, IL31RA, MRPL38, TBC1D22B, CDK15MYBPML, SMARCA2, CREBBP, NCL, CEBPB, CEBPE, MAF, SND1, PAX5, FBXW7, ZMYND11, KMT2A, WDR5, RBBP5, ASH2L, MEN1, NLK, HIPK2, HLF, SP100, PARP1, EP300, TRIM28, SKI, SIN3A, NCOR1, UBE2I, CHD3, KAT2B, RPL4, LEF1, KAT5, GATA3, STAT5A, TRAF6, FBXW5, DDB1, CUL4A, PIAS1, RBX1, SUMO1, SUMO2, CCND3, MYOZ2, PPM1K, ERC2, UPF2, KAT2A, HSPA8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AIM1_MYB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AIM1_MYB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYBC0010606Adenoid Cystic Carcinoma2CTD_human
TgeneMYBC0017638Glioma2CTD_human
TgeneMYBC0004096Asthma1CTD_human
TgeneMYBC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human