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Fusion gene ID: 12736 |
FusionGeneSummary for FAM20B_RALGPS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM20B_RALGPS2 | Fusion gene ID: 12736 | Hgene | Tgene | Gene symbol | FAM20B | RALGPS2 | Gene ID | 9917 | 55103 |
| Gene name | FAM20B, glycosaminoglycan xylosylkinase | Ral GEF with PH domain and SH3 binding motif 2 | |
| Synonyms | gxk1 | dJ595C2.1 | |
| Cytomap | 1q25.2 | 1q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycosaminoglycan xylosylkinasefamily with sequence similarity 20, member Bxylose kinase | ras-specific guanine nucleotide-releasing factor RalGPS2Ral-A exchange factor RalGPS2ral GEF with PH domain and SH3-binding motif 2ralA exchange factor RalGPS2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O75063 | Q86X27 | |
| Ensembl transtripts involved in fusion gene | ENST00000263733, | ENST00000367635, ENST00000367634, ENST00000477383, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 3 X 4 X 3=36 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FAM20B [Title/Abstract] AND RALGPS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-3B-A9HY-01A | FAM20B | chr1 | 178995233 | + | RALGPS2 | chr1 | 178858777 | + |
| TCGA | LD | STAD | TCGA-BR-8678-01A | FAM20B | chr1 | 179023773 | + | RALGPS2 | chr1 | 178846633 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000263733 | ENST00000367635 | FAM20B | chr1 | 178995233 | + | RALGPS2 | chr1 | 178858777 | + |
| 5UTR-3CDS | ENST00000263733 | ENST00000367634 | FAM20B | chr1 | 178995233 | + | RALGPS2 | chr1 | 178858777 | + |
| 5UTR-3UTR | ENST00000263733 | ENST00000477383 | FAM20B | chr1 | 178995233 | + | RALGPS2 | chr1 | 178858777 | + |
| In-frame | ENST00000263733 | ENST00000367635 | FAM20B | chr1 | 179023773 | + | RALGPS2 | chr1 | 178846633 | + |
| In-frame | ENST00000263733 | ENST00000367634 | FAM20B | chr1 | 179023773 | + | RALGPS2 | chr1 | 178846633 | + |
| 5CDS-intron | ENST00000263733 | ENST00000477383 | FAM20B | chr1 | 179023773 | + | RALGPS2 | chr1 | 178846633 | + |
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FusionProtFeatures for FAM20B_RALGPS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM20B | RALGPS2 |
| Responsible for the 2-O-phosphorylation of xylose in theglycosaminoglycan-protein linkage region of proteoglycans therebyregulating the amount of mature GAG chains. Sulfatedglycosaminoglycans (GAGs), including heparan sulfate andchondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise additionof monosaccharide residues by the respective specificglycosyltransferases. Xylose 2-O-phosphorylation may influence thecatalytic activity of B3GAT3 (GlcAT-I) which completes theprecursor tetrasaccharide of GAG-protein linkage regions on whichthe repeating disaccharide region is synthesized.{ECO:0000269|PubMed:19473117, ECO:0000269|PubMed:24425863}. | Guanine nucleotide exchange factor for the small GTPaseRALA. May be involved in cytoskeletal organization. May also beinvolved in the stimulation of transcription in a Ras-independentfashion (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FAM20B | chr1:179023773 | chr1:178846633 | ENST00000263733 | + | 4 | 8 | 1_6 | 191 | 410 | Topological domain | Cytoplasmic |
| Hgene | FAM20B | chr1:179023773 | chr1:178846633 | ENST00000263733 | + | 4 | 8 | 7_25 | 191 | 410 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >RALGPS2 | chr1:179023773 | chr1:178846633 | ENST00000367635 | + | 7 | 20 | 457_569 | 202 | 584 | Domain | PH |
| Tgene | >RALGPS2 | chr1:179023773 | chr1:178846633 | ENST00000367635 | + | 7 | 20 | 324_327 | 202 | 584 | Motif | Note=PXXP |
| Tgene | >RALGPS2 | chr1:179023773 | chr1:178846633 | ENST00000367635 | + | 7 | 20 | 459_583 | 202 | 584 | Region | Required for stimulation of nucleotide exchange by RALA |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FAM20B | chr1:179023773 | chr1:178846633 | ENST00000263733 | + | 4 | 8 | 222_225 | 191 | 410 | Nucleotide binding | ATP |
| Hgene | >FAM20B | chr1:179023773 | chr1:178846633 | ENST00000263733 | + | 4 | 8 | 26_409 | 191 | 410 | Topological domain | Lumenal |
| Tgene | RALGPS2 | chr1:179023773 | chr1:178846633 | ENST00000367635 | + | 7 | 20 | 49_287 | 202 | 584 | Domain | Ras-GEF |
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FusionGeneSequence for FAM20B_RALGPS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FAM20B_ENST00000263733_chr1_179023773_+_RALGPS2_ENST00000367635_chr1_178846633_+_573aa MKLKQRVVLLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRMMTGLRVELAPKLDHTLQSPWEIAAQWVVPREVYPEETPELGAVMHA MATKKIIKADVGYKGTQLKALLILEGGQKVVFKPKRYSRDHVVEGEPYAGYDRHNAEVAAFHLDRILGFHRAPLVVGRFVNLRTEIKPVA TEQLLSTFLTVGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLS LKIEPGTSTPRSAASREDLVGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSATFPNAGPRHLL DDSVMEPHAPSRGQAESSTLSSGISIGSSDGSELSEETSWPAFERNRLYHSLGPVTRVARNGYRSHMKASSSAESEDLAVHLYPGAVTIQ GVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVIGWMVMMADDPEHPDLFLLTDSEKGNSYKFQA >In-frame_FAM20B_ENST00000263733_chr1_179023773_+_RALGPS2_ENST00000367634_chr1_178846633_+_547aa MKLKQRVVLLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRMMTGLRVELAPKLDHTLQSPWEIAAQWVVPREVYPEETPELGAVMHA MATKKIIKADVGYKGTQLKALLILEGGQKVVFKPKRYSRDHVVEGEPYAGYDRHNAEVAAFHLDRILGFHRAPLVVGRFVNLRTEIKPVA TEQLLSTFLTVGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLS LKIEPGTSTPRSAASREDLVGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSATFPNAGPRHLL DDSVMEPHAPSRGQAESSTLSSGISIGSSDGSELSEETSWPAFESSAESEDLAVHLYPGAVTIQGVLRRKTLLKEGKKPTVASWTKYWAA LCGTQLFYYAAKSLKATERKHFKSTSNKNVSVIGWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FAM20B_ENST00000263733_chr1_179023773_+_RALGPS2_ENST00000367635_chr1_178846633_+_1719nt ATGAAGCTAAAGCAGCGAGTCGTGCTGTTAGCAATTCTCCTTGTCATTTTTATCTTCACCAAAGTTTTCCTGATTGACAACTTAGATACA TCAGCTGCCAACCGGGAGGACCAGAGGGCCTTTCACCGAATGATGACTGGCTTGCGGGTGGAGCTGGCACCCAAGCTGGACCATACCTTG CAGTCTCCCTGGGAGATTGCAGCCCAGTGGGTGGTTCCCCGGGAAGTGTACCCTGAAGAGACACCAGAGCTGGGGGCAGTCATGCATGCC ATGGCCACCAAGAAAATCATTAAAGCTGATGTGGGTTATAAAGGGACACAGCTGAAAGCCTTACTGATACTTGAAGGAGGCCAGAAAGTT GTTTTCAAACCTAAGCGGTATAGCCGAGACCATGTGGTGGAAGGGGAACCGTATGCTGGTTATGATAGACACAATGCAGAGGTAGCAGCC TTTCACTTGGACAGGATTCTGGGTTTCCACCGAGCCCCCTTGGTAGTTGGCAGATTTGTTAATCTTCGGACAGAGATCAAACCTGTCGCC ACAGAGCAGCTGTTGAGCACCTTCCTAACTGTAGGTATCTATTTGTCAGATTTAACATACATCGATTCAGCATACCCATCAACTGGCAGC ATTCTAGAAAATGAGCAAAGATCAAATTTAATGAATAATATCCTTCGAATAATTTCTGATTTACAGCAGTCTTGTGAATATGATATTCCC ATGTTGCCTCATGTCCAAAAATATCTCAACTCTGTTCAGTATATAGAAGAACTACAAAAATTTGTGGAAGACGATAATTACAAGCTTTCA TTAAAGATAGAACCAGGGACAAGCACCCCACGTTCTGCTGCTTCCAGAGAAGATTTAGTAGGTCCTGAAGTAGGAGCGTCTCCACAGAGT GGACGAAAAAGTGTGGCAGCTGAAGGAGCCTTGCTCCCACAGACACCGCCATCCCCTCGGAATCTGATTCCACATGGACATAGGAAGTGC CATAGTTTGGGTTATAATTTCATTCATAAAATGAACACAGCAGAATTTAAGAGTGCAACGTTTCCAAATGCAGGACCAAGACATCTGTTA GATGATAGCGTCATGGAGCCCCATGCGCCATCTCGAGGCCAAGCTGAAAGTTCTACTCTTTCTAGTGGAATATCAATAGGTAGCAGCGAT GGTTCTGAACTAAGTGAAGAGACCTCATGGCCTGCTTTTGAAAGGAACAGATTATACCATTCTCTCGGCCCGGTGACAAGAGTGGCACGA AATGGCTATCGAAGTCACATGAAGGCCAGCAGTTCTGCAGAATCAGAAGATTTGGCAGTACATTTATATCCAGGAGCTGTTACTATTCAA GGTGTTCTCAGGAGAAAAACTTTGTTAAAAGAAGGCAAAAAGCCTACAGTAGCATCTTGGACAAAATATTGGGCAGCTTTGTGTGGGACA CAGCTTTTTTACTATGCTGCCAAATCTCTAAAGGCTACCGAAAGAAAACATTTCAAATCAACATCCAATAAGAACGTATCTGTGATAGGA TGGATGGTGATGATGGCTGATGACCCTGAACATCCTGATCTCTTCCTGCTGACTGACTCTGAGAAAGGAAATTCGTACAAGTTTCAAGCT GGCAATAGAATGAATGCAATGTTATGGTTTAAGCATTTGAGTGCAGCCTGCCAAAGTAACAAACAACAGGTTCCTACAAACTTGATGACT >In-frame_FAM20B_ENST00000263733_chr1_179023773_+_RALGPS2_ENST00000367634_chr1_178846633_+_1641nt ATGAAGCTAAAGCAGCGAGTCGTGCTGTTAGCAATTCTCCTTGTCATTTTTATCTTCACCAAAGTTTTCCTGATTGACAACTTAGATACA TCAGCTGCCAACCGGGAGGACCAGAGGGCCTTTCACCGAATGATGACTGGCTTGCGGGTGGAGCTGGCACCCAAGCTGGACCATACCTTG CAGTCTCCCTGGGAGATTGCAGCCCAGTGGGTGGTTCCCCGGGAAGTGTACCCTGAAGAGACACCAGAGCTGGGGGCAGTCATGCATGCC ATGGCCACCAAGAAAATCATTAAAGCTGATGTGGGTTATAAAGGGACACAGCTGAAAGCCTTACTGATACTTGAAGGAGGCCAGAAAGTT GTTTTCAAACCTAAGCGGTATAGCCGAGACCATGTGGTGGAAGGGGAACCGTATGCTGGTTATGATAGACACAATGCAGAGGTAGCAGCC TTTCACTTGGACAGGATTCTGGGTTTCCACCGAGCCCCCTTGGTAGTTGGCAGATTTGTTAATCTTCGGACAGAGATCAAACCTGTCGCC ACAGAGCAGCTGTTGAGCACCTTCCTAACTGTAGGTATCTATTTGTCAGATTTAACATACATCGATTCAGCATACCCATCAACTGGCAGC ATTCTAGAAAATGAGCAAAGATCAAATTTAATGAATAATATCCTTCGAATAATTTCTGATTTACAGCAGTCTTGTGAATATGATATTCCC ATGTTGCCTCATGTCCAAAAATATCTCAACTCTGTTCAGTATATAGAAGAACTACAAAAATTTGTGGAAGACGATAATTACAAGCTTTCA TTAAAGATAGAACCAGGGACAAGCACCCCACGTTCTGCTGCTTCCAGAGAAGATTTAGTAGGTCCTGAAGTAGGAGCGTCTCCACAGAGT GGACGAAAAAGTGTGGCAGCTGAAGGAGCCTTGCTCCCACAGACACCGCCATCCCCTCGGAATCTGATTCCACATGGACATAGGAAGTGC CATAGTTTGGGTTATAATTTCATTCATAAAATGAACACAGCAGAATTTAAGAGTGCAACGTTTCCAAATGCAGGACCAAGACATCTGTTA GATGATAGCGTCATGGAGCCCCATGCGCCATCTCGAGGCCAAGCTGAAAGTTCTACTCTTTCTAGTGGAATATCAATAGGTAGCAGCGAT GGTTCTGAACTAAGTGAAGAGACCTCATGGCCTGCTTTTGAAAGTTCTGCAGAATCAGAAGATTTGGCAGTACATTTATATCCAGGAGCT GTTACTATTCAAGGTGTTCTCAGGAGAAAAACTTTGTTAAAAGAAGGCAAAAAGCCTACAGTAGCATCTTGGACAAAATATTGGGCAGCT TTGTGTGGGACACAGCTTTTTTACTATGCTGCCAAATCTCTAAAGGCTACCGAAAGAAAACATTTCAAATCAACATCCAATAAGAACGTA TCTGTGATAGGATGGATGGTGATGATGGCTGATGACCCTGAACATCCTGATCTCTTCCTGCTGACTGACTCTGAGAAAGGAAATTCGTAC AAGTTTCAAGCTGGCAATAGAATGAATGCAATGTTATGGTTTAAGCATTTGAGTGCAGCCTGCCAAAGTAACAAACAACAGGTTCCTACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FAM20B_ENST00000263733_chr1_179023773_+_RALGPS2_ENST00000367635_chr1_178846633_+_5799nt GTGTGGGACTGCCGCTCTGCGCGGCGAGAGGTGGCCTGGGAATGGCCGGGCCGGGGGTGGGCCGGAGCCGCTGTGGCGGCGGCGGCGGCT GGGGGCGGTGAGCGCGGCGTGGGGCTGCCCCTCCCCGGAGGCGGCGGGGGCGGCCGGGGCCGCGCCGCACCGCACCGCGCGGGCGGCCAT GGAGCGAGCCTAGGGCCCGACAGGAACTGTGGAAGGTGCATCAGTGAAGAAATGGACCAATGTGTATAATCATGGAATCTCCTTGCTAAC CATCACCACCAGCTCTCCTTAATACATGAGCAAGAGTGGGTCAGGGGAGAAGGAAAAGAGGTCAACATGAAGCTAAAGCAGCGAGTCGTG CTGTTAGCAATTCTCCTTGTCATTTTTATCTTCACCAAAGTTTTCCTGATTGACAACTTAGATACATCAGCTGCCAACCGGGAGGACCAG AGGGCCTTTCACCGAATGATGACTGGCTTGCGGGTGGAGCTGGCACCCAAGCTGGACCATACCTTGCAGTCTCCCTGGGAGATTGCAGCC CAGTGGGTGGTTCCCCGGGAAGTGTACCCTGAAGAGACACCAGAGCTGGGGGCAGTCATGCATGCCATGGCCACCAAGAAAATCATTAAA GCTGATGTGGGTTATAAAGGGACACAGCTGAAAGCCTTACTGATACTTGAAGGAGGCCAGAAAGTTGTTTTCAAACCTAAGCGGTATAGC CGAGACCATGTGGTGGAAGGGGAACCGTATGCTGGTTATGATAGACACAATGCAGAGGTAGCAGCCTTTCACTTGGACAGGATTCTGGGT TTCCACCGAGCCCCCTTGGTAGTTGGCAGATTTGTTAATCTTCGGACAGAGATCAAACCTGTCGCCACAGAGCAGCTGTTGAGCACCTTC CTAACTGTAGGTATCTATTTGTCAGATTTAACATACATCGATTCAGCATACCCATCAACTGGCAGCATTCTAGAAAATGAGCAAAGATCA AATTTAATGAATAATATCCTTCGAATAATTTCTGATTTACAGCAGTCTTGTGAATATGATATTCCCATGTTGCCTCATGTCCAAAAATAT CTCAACTCTGTTCAGTATATAGAAGAACTACAAAAATTTGTGGAAGACGATAATTACAAGCTTTCATTAAAGATAGAACCAGGGACAAGC ACCCCACGTTCTGCTGCTTCCAGAGAAGATTTAGTAGGTCCTGAAGTAGGAGCGTCTCCACAGAGTGGACGAAAAAGTGTGGCAGCTGAA GGAGCCTTGCTCCCACAGACACCGCCATCCCCTCGGAATCTGATTCCACATGGACATAGGAAGTGCCATAGTTTGGGTTATAATTTCATT CATAAAATGAACACAGCAGAATTTAAGAGTGCAACGTTTCCAAATGCAGGACCAAGACATCTGTTAGATGATAGCGTCATGGAGCCCCAT GCGCCATCTCGAGGCCAAGCTGAAAGTTCTACTCTTTCTAGTGGAATATCAATAGGTAGCAGCGATGGTTCTGAACTAAGTGAAGAGACC TCATGGCCTGCTTTTGAAAGGAACAGATTATACCATTCTCTCGGCCCGGTGACAAGAGTGGCACGAAATGGCTATCGAAGTCACATGAAG GCCAGCAGTTCTGCAGAATCAGAAGATTTGGCAGTACATTTATATCCAGGAGCTGTTACTATTCAAGGTGTTCTCAGGAGAAAAACTTTG TTAAAAGAAGGCAAAAAGCCTACAGTAGCATCTTGGACAAAATATTGGGCAGCTTTGTGTGGGACACAGCTTTTTTACTATGCTGCCAAA TCTCTAAAGGCTACCGAAAGAAAACATTTCAAATCAACATCCAATAAGAACGTATCTGTGATAGGATGGATGGTGATGATGGCTGATGAC CCTGAACATCCTGATCTCTTCCTGCTGACTGACTCTGAGAAAGGAAATTCGTACAAGTTTCAAGCTGGCAATAGAATGAATGCAATGTTA TGGTTTAAGCATTTGAGTGCAGCCTGCCAAAGTAACAAACAACAGGTTCCTACAAACTTGATGACTTTTGAGTAGAAGCCTGAGAAAAAA AGAGAGGTGAACTGTTGCTTCTACGTGAGCATGAGGACCTGATAAAAGAGCGCCAGCTATAAACCATCCTGTGCCAGGAAGAGCCCAGAG GCTCTGTCTCAGTCGTTGGAGTTCTCAACCAAAAAAGCACTAATTTCAGGGAATGATTTGAGATATTCCCAGAGAACAAATTGGAGTTGC AAAACAAACTGCCATGAACCATGCTTCTTATCTCAGAACTGACCTGTGGAAACCACTGCCTTAAAAGAATGAAAGGAAAACCAACATGAA ACACCAAATAGTGTGTGTGAATCTTCTGGCGGTGCTGTGCTTGGAATAGATCGTAGCTAATTTGCATTTCTTTTAACTTTGTAATAATTT TAGAGGGGGGAATTGCCTTTTTTAGATATGCTTTAAAAAGGAAAAACATACTCTTGTGGATTCCATCAGGAGCTGGTTTTGAACCGAGGT GAAGAGACTTAGCAGGGATTGTACCAGCAGCCCACCTGCAAGGTTTGTTCTCCCTCTAGTAGTCTGCAACCTCACTGGCTTTCTCACAGC AAGAGTGTAGGAATGAGAAATGTTAGTCATGTGAGTTCTTGGGTTTGTTTGGGATTGGGTGGGGGTGTTTGTTTTGTTTTGGATGAGGGG AGAATTTTTTTAAACACTAAACTTCTGAAATGTAGTACTGTAAGGGGAACATTATTTCCTGCAGGAGGTACAAAGGCTGTGTGTTCATTT GCCAGACGCTTTTTTTTTAAATAGGTTCCAGAAAACATGGTTGTTTCTAACTAGGGTTAAAGTTTAGCTTTCTATATGAATTCATTGTTG GACCACAGATCTGCTTAAGTAAAGAGCTATAATCCCAACCTAAACTTTTCTGAGATTTTACAATAATTAGATCTTTTTCCAAGTTAATTG GGTTTTCCCTTCTCCCAGTCATAGGTGGTTTTTATCATCAAGACAGACTGATATTTTGTCAGGATATTTTCTTTTACAGTGTTTGATGTG CATAATGCCAGAGTTATTTTTTTATTATTCATTTTCTCTCTTTTTGTTCAATATGAGATTCAGGATCATATTTGTTTAAAAGGTAACACA TAGAGATGTATGTATATATTTTGTTATAAGACATACAAAATAATTTTAAGAGGGATAAAGGTGAAAATATCAGATTCTGGAAATTTTAAG TATCTAAACTTTATACTTGTATGATTTACCATAAACATACCAAAACATTTTTCTGAAAATTTACTGTCGGTCTCTGACATGAAACCGTAT TTTGTCAGTAGTTGACCAAGCAGTTTTATGAGAACTCTTCTATGCAATGATGCATTTAATTTCTAAAGTAAATGTTGAATTATTAAAAAA AAAGTTTGAAGGTAAGATGCCTTAGAATTTTAATGAAAAATGACACTCAAACAAAGGCTATATGTCGAATGTTATAAACTCTTGAGACAT AATGAATTTTAGCAGTGGCCTAGAGTAAGGTAATGCTTTGTGACTGATATCTACTAATAGACTTCTGTTACTTTGGGCCTCACATAAAAT TTCTCACATTCGTATTCTTAGAGAATTTTATACTTTTTTATTATAAGTATTTTGCCCTTGAGTCCATGAAACTTCAATAGAAAATATTGC TTATACAATAATTAGCTTAAAATCCATCCAAAGGAAAAGAGAAGAGCTTTTTTTGAGTGTTAAGTTTTTTAATTTAGTATTCTGTTTGGA AAAGATGTTAAGAGTTCAAATATGCTTCTTATGTAACAGAAATACCATTATTTCTGGGGTTTAGTGACACAGGCTGGAGAGGACAAAAGT TTCCTGTCCTGAATGATTTTTCAATTAATGCTCTAAGCTTAACCCATGTTGGGTAATAGAAAGACATAGCCAGCAGTATTACTACGTAGA CCTTGCACATCTTACTTTTGTTTTGCATTTTTAAAAATTTCTTAATTTGTTTATTTCTCTTCAGAAATAGCGTTTTTAACAGTGTATGTG CTTTTTTAAAAAGTATTGTGAATGAGAACCCTGTGGATTTTTTTTATTTCATTTGTTTGTCATAATAAGCTAACGTAGAAATGTTGTAGG TTAACCATATCTGTGGAAATATGCAGTTGGAAGTCAGAGCCTGACATCACATAGTTTTGCCAAAGGGAGAGAGCTAAGCTGGAAGATGTT TTTGATACTTTCGGCTCTAAACATTAATGGATGTTTGCGTAGAGTAAGATAGCGTTCAAATTTGGTTAATAGTTTATAGATAGACTTGTG GCCTCTGACTGACTAAATTTCTTAACAGCACAGAAGTCGTTGTTTTTCTGTCTTTAAAATTTATTCATTCAGAAAATTAGTCATTGCTTT TTAAGATTATTTTAGCATTTGAAGCAAATTGAAAACAGAAAAGTGACTTAAAATAGTGTAGGTGAATTTTTTATCTATAATTTACCAAAT AATACCTGATAATAATTCAAAGAAAATATGTTACCAAAATATATTAAATATATAGGTAGTTCATTCGTGGGAAGATGAATCTTCTTATTA AGCCTGCCCTCAATTGTAAATAAGTGACTCAAAAACTCAAAATGTTCATCAGCATTCAGGTCATTTGTTTCACCCTTAGCCAAGAAGAAC TCATTAGAAATTCAGTTATAATTTCAATTTAAGCCTGTTTATGATAAGCATAATGATTGGCATGTTATATAGCCTGTTGAAAATAACTAC AGAATGACCTTCCAGAGCACTGTTTTTGGCCTCGTGCCCGCTCTGTTCAGGCTCTGCTTGTTTTTCAGAATATGATTTTTACCTCCAGAC AGTAAGAATTGAACAAGAACTGATCAAACACACCTTCCTATTTTGTTTTCTTCACTATGTAAATATTATTTGGGCAAACATTACAAAAAG GGATCCAAACAATTTGAGTTTCAGTATTTTTTTCTCCCTAGGCATGTGCTTCAATTTCAAATATTTTTTTCTGTGTGGAAAATGCCATGT AACTATTGCACTACCTTCTGTGTGGACTGTGTTGGTATTGGTTCTTTCTGTATATCAAAAGTCAGGGTGTTTATAACTGCAAAGTTTGTA TAAGTGGCTTTATTCCTCTTCTAGAAGATTTATGAGGAGCCTAGGAAGCACTATTGGTACAGGAGGAAAAAAGAATGGAAAACATGTTTA CAGACTCTAGCTTTCCTTATTAGCTTAAACTGGGGCCCTCAAAGAGCAGCCTGTTGATCTTTTGGCCAAATGACTTGAGCATAAGTCTTT TATTTCTTTTTAAGGTTAAATCGTAAACTGTATACCTTTACTACTGAAAACAAAACTATAGGGCATCATACTAATTGAAAATCAATAGTA ATGGGTTCCATCCATTAGCTTTTTAAATGAATAGATCTGGTATTGATTTCCTTCCTGTTTTTTTGAGGCACATTCCTTTACAACCAGTGT TTAAACCACCACGTAATCATCTTCTGCAAACAAGGGGTGCCAGTGTTGCCTAACAGAAGATAATCTTTAATAAAGCAAATCCTCTGCTTC AAAGGTTTTTGAAATAATTGGATCCCTTTTTGAAAAGGAAGATGAGTTTAACTGTGTCCAGGTGGAGTAATAGTACTGCTGTTGCATGAA TAGATGATACAAAGCAAGTGATGAGGTTGGTATGACTTCTTTAGTGACCTTTTAGGGTTTGCTTTTATTTTCCTCTCTTTTTTGTATTAT >In-frame_FAM20B_ENST00000263733_chr1_179023773_+_RALGPS2_ENST00000367634_chr1_178846633_+_2267nt GTGTGGGACTGCCGCTCTGCGCGGCGAGAGGTGGCCTGGGAATGGCCGGGCCGGGGGTGGGCCGGAGCCGCTGTGGCGGCGGCGGCGGCT GGGGGCGGTGAGCGCGGCGTGGGGCTGCCCCTCCCCGGAGGCGGCGGGGGCGGCCGGGGCCGCGCCGCACCGCACCGCGCGGGCGGCCAT GGAGCGAGCCTAGGGCCCGACAGGAACTGTGGAAGGTGCATCAGTGAAGAAATGGACCAATGTGTATAATCATGGAATCTCCTTGCTAAC CATCACCACCAGCTCTCCTTAATACATGAGCAAGAGTGGGTCAGGGGAGAAGGAAAAGAGGTCAACATGAAGCTAAAGCAGCGAGTCGTG CTGTTAGCAATTCTCCTTGTCATTTTTATCTTCACCAAAGTTTTCCTGATTGACAACTTAGATACATCAGCTGCCAACCGGGAGGACCAG AGGGCCTTTCACCGAATGATGACTGGCTTGCGGGTGGAGCTGGCACCCAAGCTGGACCATACCTTGCAGTCTCCCTGGGAGATTGCAGCC CAGTGGGTGGTTCCCCGGGAAGTGTACCCTGAAGAGACACCAGAGCTGGGGGCAGTCATGCATGCCATGGCCACCAAGAAAATCATTAAA GCTGATGTGGGTTATAAAGGGACACAGCTGAAAGCCTTACTGATACTTGAAGGAGGCCAGAAAGTTGTTTTCAAACCTAAGCGGTATAGC CGAGACCATGTGGTGGAAGGGGAACCGTATGCTGGTTATGATAGACACAATGCAGAGGTAGCAGCCTTTCACTTGGACAGGATTCTGGGT TTCCACCGAGCCCCCTTGGTAGTTGGCAGATTTGTTAATCTTCGGACAGAGATCAAACCTGTCGCCACAGAGCAGCTGTTGAGCACCTTC CTAACTGTAGGTATCTATTTGTCAGATTTAACATACATCGATTCAGCATACCCATCAACTGGCAGCATTCTAGAAAATGAGCAAAGATCA AATTTAATGAATAATATCCTTCGAATAATTTCTGATTTACAGCAGTCTTGTGAATATGATATTCCCATGTTGCCTCATGTCCAAAAATAT CTCAACTCTGTTCAGTATATAGAAGAACTACAAAAATTTGTGGAAGACGATAATTACAAGCTTTCATTAAAGATAGAACCAGGGACAAGC ACCCCACGTTCTGCTGCTTCCAGAGAAGATTTAGTAGGTCCTGAAGTAGGAGCGTCTCCACAGAGTGGACGAAAAAGTGTGGCAGCTGAA GGAGCCTTGCTCCCACAGACACCGCCATCCCCTCGGAATCTGATTCCACATGGACATAGGAAGTGCCATAGTTTGGGTTATAATTTCATT CATAAAATGAACACAGCAGAATTTAAGAGTGCAACGTTTCCAAATGCAGGACCAAGACATCTGTTAGATGATAGCGTCATGGAGCCCCAT GCGCCATCTCGAGGCCAAGCTGAAAGTTCTACTCTTTCTAGTGGAATATCAATAGGTAGCAGCGATGGTTCTGAACTAAGTGAAGAGACC TCATGGCCTGCTTTTGAAAGTTCTGCAGAATCAGAAGATTTGGCAGTACATTTATATCCAGGAGCTGTTACTATTCAAGGTGTTCTCAGG AGAAAAACTTTGTTAAAAGAAGGCAAAAAGCCTACAGTAGCATCTTGGACAAAATATTGGGCAGCTTTGTGTGGGACACAGCTTTTTTAC TATGCTGCCAAATCTCTAAAGGCTACCGAAAGAAAACATTTCAAATCAACATCCAATAAGAACGTATCTGTGATAGGATGGATGGTGATG ATGGCTGATGACCCTGAACATCCTGATCTCTTCCTGCTGACTGACTCTGAGAAAGGAAATTCGTACAAGTTTCAAGCTGGCAATAGAATG AATGCAATGTTATGGTTTAAGCATTTGAGTGCAGCCTGCCAAAGTAACAAACAACAGGTTCCTACAAACTTGATGACTTTTGAGTAGAAG CCTGAGAAAAAAAGAGAGGTGAACTGTTGCTTCTACGTGAGCATGAGGACCTGATAAAAGAGCGCCAGCTATAAACCATCCTGTGCCAGG AAGAGCCCAGAGGCTCTGTCTCAGTCGTTGGAGTTCTCAACCAAAAAAGCACTAATTTCAGGGAATGATTTGAGATATTCCCAGAGAACA AATTGGAGTTGCAAAACAAACTGCCATGAACCATGCTTCTTATCTCAGAACTGACCTGTGGAAACCACTGCCTTAAAAGAATGAAAGGAA |
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FusionGenePPI for FAM20B_RALGPS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FAM20B | ELAVL1, UBL4A, PEX19, TOR1A, SYNE4, P2RX4, GOLPH3, PHAX, ASPHD2, PVR, GALNT6, IPPK, SCN3B, LPAR1, CD79B, SPPL2B, CHRNA3, DKKL1 | RALGPS2 | YWHAZ, SFN, YWHAB, YWHAG, CGN, KCTD3, KIF13B, ZBTB21, KSR1, RTKN, GIGYF2, CDC25C, MAST3, GIGYF1, LPIN3, NF1, CBY1, LRFN1, DENND4C, PPM1H, CAMSAP2, SH3RF3, DENND1A, OSBPL6, INPP5E, SH3PXD2A, NADK, SRGAP2, HDAC4, TANC2, PTPN13, EIF4E2, SIPA1L1, RASAL2, KIAA1804 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM20B_RALGPS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM20B_RALGPS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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