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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12690

FusionGeneSummary for FAM193A_TNIP2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM193A_TNIP2
Fusion gene ID: 12690
HgeneTgene
Gene symbol

FAM193A

TNIP2

Gene ID

8603

79155

Gene namefamily with sequence similarity 193 member ATNFAIP3 interacting protein 2
SynonymsC4orf8|RES4-22ABIN2|FLIP1|KLIP
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM193ATNFAIP3-interacting protein 2A20-binding inhibitor of NF-kappaB activation-2fetal liver LKB1-interacting protein
Modification date2018051920180522
UniProtAcc

P78312

Q8NFZ5

Ensembl transtripts involved in fusion geneENST00000545951, ENST00000382839, 
ENST00000324666, ENST00000502458, 
ENST00000505311, 
ENST00000510267, 
ENST00000315423, ENST00000503235, 
ENST00000505186, 
Fusion gene scores* DoF score10 X 8 X 8=6401 X 1 X 1=1
# samples 111
** MAII scorelog2(11/640*10)=-2.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: FAM193A [Title/Abstract] AND TNIP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNIP2

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

21784860

TgeneTNIP2

GO:0045944

positive regulation of transcription by RNA polymerase II

12753905

TgeneTNIP2

GO:2000352

negative regulation of endothelial cell apoptotic process

12933576


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-21-1082-01AFAM193Achr4

2702271

+TNIP2chr4

2749672

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000545951ENST00000510267FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000545951ENST00000315423FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000545951ENST00000503235FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-intronENST00000545951ENST00000505186FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000382839ENST00000510267FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000382839ENST00000315423FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000382839ENST00000503235FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-intronENST00000382839ENST00000505186FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000324666ENST00000510267FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000324666ENST00000315423FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000324666ENST00000503235FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-intronENST00000324666ENST00000505186FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000502458ENST00000510267FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000502458ENST00000315423FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000502458ENST00000503235FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-intronENST00000502458ENST00000505186FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000505311ENST00000510267FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000505311ENST00000315423FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-5UTRENST00000505311ENST00000503235FAM193Achr4

2702271

+TNIP2chr4

2749672

-
5CDS-intronENST00000505311ENST00000505186FAM193Achr4

2702271

+TNIP2chr4

2749672

-

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FusionProtFeatures for FAM193A_TNIP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM193A

P78312

TNIP2

Q8NFZ5

Inhibits NF-kappa-B activation by blocking theinteraction of RIPK1 with its downstream effector NEMO/IKBKG.Forms a ternary complex with NFKB1 and MAP3K8 but appears tofunction upstream of MAP3K8 in the TLR4 signaling pathway thatregulates MAP3K8 activation. Involved in activation of the MEK/ERKsignaling pathway during innate immune response; this functionseems to be stimulus- and cell type specific. Required forstability of MAP3K8. Involved in regulation of apoptosis inendothelial cells; promotes TEK agonist-stimulated endothelialsurvival. May act as transcriptional coactivator when translocatedto the nucleus. Enhances CHUK-mediated NF-kappa-B activationinvolving NF-kappa-B p50-p65 and p50-c-Rel complexes.{ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905,ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779,ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM193A_TNIP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM193A_TNIP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM193AANKRD28, MDM4TNIP2RELA, NFKB2, NFKB1, REL, MAP3K8, NCOR2, UBC, TNFAIP3, IKBKG, CHUK, IKBKB, STK11, SMARCD1, TEK, APP, FBXO25, MKNK1, EP300, CDKN1A, MAPK1, PSMD9, PDCD6IP, SRPK2, USP7, CLK1, XPO1, SMURF1, RAB11FIP4, DKK3, SSSCA1, C16orf71, RELB, CCDC40, EMILIN1, USP35


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM193A_TNIP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM193A_TNIP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource