![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 12690 |
FusionGeneSummary for FAM193A_TNIP2 |
![]() |
Fusion gene information | Fusion gene name: FAM193A_TNIP2 | Fusion gene ID: 12690 | Hgene | Tgene | Gene symbol | FAM193A | TNIP2 | Gene ID | 8603 | 79155 |
Gene name | family with sequence similarity 193 member A | TNFAIP3 interacting protein 2 | |
Synonyms | C4orf8|RES4-22 | ABIN2|FLIP1|KLIP | |
Cytomap | 4p16.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM193A | TNFAIP3-interacting protein 2A20-binding inhibitor of NF-kappaB activation-2fetal liver LKB1-interacting protein | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | P78312 | Q8NFZ5 | |
Ensembl transtripts involved in fusion gene | ENST00000545951, ENST00000382839, ENST00000324666, ENST00000502458, ENST00000505311, | ENST00000510267, ENST00000315423, ENST00000503235, ENST00000505186, | |
Fusion gene scores | * DoF score | 10 X 8 X 8=640 | 1 X 1 X 1=1 |
# samples | 11 | 1 | |
** MAII score | log2(11/640*10)=-2.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: FAM193A [Title/Abstract] AND TNIP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TNIP2 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 21784860 |
Tgene | TNIP2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12753905 |
Tgene | TNIP2 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 12933576 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-21-1082-01A | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000545951 | ENST00000510267 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000545951 | ENST00000315423 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000545951 | ENST00000503235 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-intron | ENST00000545951 | ENST00000505186 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000382839 | ENST00000510267 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000382839 | ENST00000315423 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000382839 | ENST00000503235 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-intron | ENST00000382839 | ENST00000505186 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000324666 | ENST00000510267 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000324666 | ENST00000315423 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000324666 | ENST00000503235 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-intron | ENST00000324666 | ENST00000505186 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000502458 | ENST00000510267 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000502458 | ENST00000315423 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000502458 | ENST00000503235 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-intron | ENST00000502458 | ENST00000505186 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000505311 | ENST00000510267 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000505311 | ENST00000315423 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-5UTR | ENST00000505311 | ENST00000503235 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
5CDS-intron | ENST00000505311 | ENST00000505186 | FAM193A | chr4 | 2702271 | + | TNIP2 | chr4 | 2749672 | - |
Top |
FusionProtFeatures for FAM193A_TNIP2 |
![]() |
Hgene | Tgene |
FAM193A | TNIP2 |
Inhibits NF-kappa-B activation by blocking theinteraction of RIPK1 with its downstream effector NEMO/IKBKG.Forms a ternary complex with NFKB1 and MAP3K8 but appears tofunction upstream of MAP3K8 in the TLR4 signaling pathway thatregulates MAP3K8 activation. Involved in activation of the MEK/ERKsignaling pathway during innate immune response; this functionseems to be stimulus- and cell type specific. Required forstability of MAP3K8. Involved in regulation of apoptosis inendothelial cells; promotes TEK agonist-stimulated endothelialsurvival. May act as transcriptional coactivator when translocatedto the nucleus. Enhances CHUK-mediated NF-kappa-B activationinvolving NF-kappa-B p50-p65 and p50-c-Rel complexes.{ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905,ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779,ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FAM193A_TNIP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for FAM193A_TNIP2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM193A | ANKRD28, MDM4 | TNIP2 | RELA, NFKB2, NFKB1, REL, MAP3K8, NCOR2, UBC, TNFAIP3, IKBKG, CHUK, IKBKB, STK11, SMARCD1, TEK, APP, FBXO25, MKNK1, EP300, CDKN1A, MAPK1, PSMD9, PDCD6IP, SRPK2, USP7, CLK1, XPO1, SMURF1, RAB11FIP4, DKK3, SSSCA1, C16orf71, RELB, CCDC40, EMILIN1, USP35 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FAM193A_TNIP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FAM193A_TNIP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |