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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12687

FusionGeneSummary for FAM193A_RGS12

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM193A_RGS12
Fusion gene ID: 12687
HgeneTgene
Gene symbol

FAM193A

RGS12

Gene ID

8603

6002

Gene namefamily with sequence similarity 193 member Aregulator of G protein signaling 12
SynonymsC4orf8|RES4-22-
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM193Aregulator of G-protein signaling 12regulator of G-protein signalling 12
Modification date2018051920180519
UniProtAcc

P78312

O14924

Ensembl transtripts involved in fusion geneENST00000545951, ENST00000382839, 
ENST00000324666, ENST00000502458, 
ENST00000505311, 		ENST00000543385, 
ENST00000336727, ENST00000344733, 
ENST00000382788, ENST00000306648, 
ENST00000338806, ENST00000508158, 
ENST00000538395, 
Fusion gene scores* DoF score10 X 8 X 8=6404 X 5 X 3=60
# samples 117
** MAII scorelog2(11/640*10)=-2.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM193A [Title/Abstract] AND RGS12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTHYMTCGA-ZB-A969-01AFAM193Achr4

2641586

+RGS12chr4

3415799

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000545951ENST00000543385FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000545951ENST00000336727FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000545951ENST00000344733FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000545951ENST00000382788FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000545951ENST00000306648FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000545951ENST00000338806FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000545951ENST00000508158FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000545951ENST00000538395FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000382839ENST00000543385FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000382839ENST00000336727FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000382839ENST00000344733FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000382839ENST00000382788FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000382839ENST00000306648FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000382839ENST00000338806FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000382839ENST00000508158FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000382839ENST00000538395FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000324666ENST00000543385FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000324666ENST00000336727FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000324666ENST00000344733FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000324666ENST00000382788FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000324666ENST00000306648FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000324666ENST00000338806FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000324666ENST00000508158FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000324666ENST00000538395FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000502458ENST00000543385FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000502458ENST00000336727FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000502458ENST00000344733FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000502458ENST00000382788FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000502458ENST00000306648FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000502458ENST00000338806FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000502458ENST00000508158FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000502458ENST00000538395FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000505311ENST00000543385FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000505311ENST00000336727FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000505311ENST00000344733FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000505311ENST00000382788FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000505311ENST00000306648FAM193Achr4

2641586

+RGS12chr4

3415799

+
Frame-shiftENST00000505311ENST00000338806FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000505311ENST00000508158FAM193Achr4

2641586

+RGS12chr4

3415799

+
5CDS-3UTRENST00000505311ENST00000538395FAM193Achr4

2641586

+RGS12chr4

3415799

+

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FusionProtFeatures for FAM193A_RGS12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM193A

P78312

RGS12

O14924


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM193A_RGS12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM193A_RGS12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM193AANKRD28, MDM4RGS12GNAI1, GNAI3, GNAI2, CUL4A, EEF1A1, ARL4C, MTNR1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM193A_RGS12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM193A_RGS12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRGS12C0036341Schizophrenia1CTD_human