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Fusion gene ID: 12686 |
FusionGeneSummary for FAM193A_PPP2R2C |
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Fusion gene information | Fusion gene name: FAM193A_PPP2R2C | Fusion gene ID: 12686 | Hgene | Tgene | Gene symbol | FAM193A | PPP2R2C | Gene ID | 8603 | 5522 |
Gene name | family with sequence similarity 193 member A | protein phosphatase 2 regulatory subunit Bgamma | |
Synonyms | C4orf8|RES4-22 | B55-GAMMA|B55gamma|IMYPNO|IMYPNO1|PR52|PR55G | |
Cytomap | 4p16.3 | 4p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM193A | protein phosphatase 2, regulatory subunit B, gammaPP2A, subunit B, B-gamma isoformPP2A, subunit B, B55-gamma isoformPP2A, subunit B, PR55-gamma isoformPP2A, subunit B, R2-gamma isoformgamma isoform of regulatory subunit B55, protein phosphatase 2pho | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | P78312 | Q9Y2T4 | |
Ensembl transtripts involved in fusion gene | ENST00000545951, ENST00000382839, ENST00000324666, ENST00000502458, ENST00000505311, | ENST00000506140, ENST00000515571, ENST00000382599, ENST00000507294, ENST00000314348, ENST00000335585, | |
Fusion gene scores | * DoF score | 10 X 8 X 8=640 | 4 X 5 X 4=80 |
# samples | 11 | 5 | |
** MAII score | log2(11/640*10)=-2.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FAM193A [Title/Abstract] AND PPP2R2C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-DH-A669-02A | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
TCGA | RV | LGG | TCGA-DH-A669-01A | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000545951 | ENST00000506140 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000545951 | ENST00000515571 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000545951 | ENST00000382599 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000545951 | ENST00000507294 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000545951 | ENST00000314348 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000545951 | ENST00000335585 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000382839 | ENST00000506140 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000382839 | ENST00000515571 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000382839 | ENST00000382599 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000382839 | ENST00000507294 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000382839 | ENST00000314348 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000382839 | ENST00000335585 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000324666 | ENST00000506140 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000324666 | ENST00000515571 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000324666 | ENST00000382599 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000324666 | ENST00000507294 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000324666 | ENST00000314348 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000324666 | ENST00000335585 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000502458 | ENST00000506140 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000502458 | ENST00000515571 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000502458 | ENST00000382599 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000502458 | ENST00000507294 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000502458 | ENST00000314348 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000502458 | ENST00000335585 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000505311 | ENST00000506140 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000505311 | ENST00000515571 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000505311 | ENST00000382599 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
Frame-shift | ENST00000505311 | ENST00000507294 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000505311 | ENST00000314348 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
5CDS-intron | ENST00000505311 | ENST00000335585 | FAM193A | chr4 | 2632896 | + | PPP2R2C | chr4 | 6335458 | - |
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FusionProtFeatures for FAM193A_PPP2R2C |
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Hgene | Tgene |
FAM193A | PPP2R2C |
The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM193A_PPP2R2C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM193A_PPP2R2C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM193A | ANKRD28, MDM4 | PPP2R2C | ARL2, TCP1, CCT2, PPP2R1A, CCT6A, CCT5, CCT7, CCT4, CCT8, CCT3, PPP2CA, PPP2R1B, CDCA4, BAG2, PPP2R2B, SLC25A3, HSPD1, BLNK, POLR3A, SIK2, IQGAP1, STRN, STRN3, STRN4, ZCCHC8, PDCL, SKA1, RBM7, ZNF746, SKA3, FAM122B, DCAF10, IER5, MTCL1, FAM122A, SERTAD4, REPIN1, ZNF114, KNG1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM193A_PPP2R2C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM193A_PPP2R2C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PPP2R2C | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | PPP2R2C | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |