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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 12678

FusionGeneSummary for FAM189A1_GABRG3

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM189A1_GABRG3
Fusion gene ID: 12678
HgeneTgene
Gene symbol

FAM189A1

GABRG3

Gene ID

23359

2567

Gene namefamily with sequence similarity 189 member A1gamma-aminobutyric acid type A receptor gamma3 subunit
SynonymsTMEM228-
Cytomap

15q13.1

15q12

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM189A1transmembrane protein 228gamma-aminobutyric acid receptor subunit gamma-3GABA(A) receptor subunit gamma-3GABA(G) receptor, gamma 3gamma-aminobutyric acid (GABA) A receptor, gamma 3
Modification date2018051920180523
UniProtAcc

O60320

Q99928

Ensembl transtripts involved in fusion geneENST00000261275, ENST00000560050, 
ENST00000333743, ENST00000555083, 
ENST00000554786, 
Fusion gene scores* DoF score1 X 2 X 1=22 X 2 X 2=8
# samples 12
** MAII scorelog2(1/2*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: FAM189A1 [Title/Abstract] AND GABRG3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A43P-01AFAM189A1chr15

29544572

-GABRG3chr15

27571956

+
TCGALDBLCATCGA-FD-A43P-01AFAM189A1chr15

29488634

-GABRG3chr15

27571956

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261275ENST00000333743FAM189A1chr15

29544572

-GABRG3chr15

27571956

+
In-frameENST00000261275ENST00000555083FAM189A1chr15

29544572

-GABRG3chr15

27571956

+
5CDS-intronENST00000261275ENST00000554786FAM189A1chr15

29544572

-GABRG3chr15

27571956

+
intron-3CDSENST00000560050ENST00000333743FAM189A1chr15

29544572

-GABRG3chr15

27571956

+
intron-3CDSENST00000560050ENST00000555083FAM189A1chr15

29544572

-GABRG3chr15

27571956

+
intron-intronENST00000560050ENST00000554786FAM189A1chr15

29544572

-GABRG3chr15

27571956

+
In-frameENST00000261275ENST00000333743FAM189A1chr15

29488634

-GABRG3chr15

27571956

+
In-frameENST00000261275ENST00000555083FAM189A1chr15

29488634

-GABRG3chr15

27571956

+
5CDS-intronENST00000261275ENST00000554786FAM189A1chr15

29488634

-GABRG3chr15

27571956

+
intron-3CDSENST00000560050ENST00000333743FAM189A1chr15

29488634

-GABRG3chr15

27571956

+
intron-3CDSENST00000560050ENST00000555083FAM189A1chr15

29488634

-GABRG3chr15

27571956

+
intron-intronENST00000560050ENST00000554786FAM189A1chr15

29488634

-GABRG3chr15

27571956

+

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FusionProtFeatures for FAM189A1_GABRG3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM189A1

O60320

GABRG3

Q99928

GABA, the major inhibitory neurotransmitter in thevertebrate brain, mediates neuronal inhibition by binding to theGABA/benzodiazepine receptor and opening an integral chloridechannel.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM189A1chr15:29488634chr15:27571956ENST00000261275-41131_51174540TransmembraneHelical
HgeneFAM189A1chr15:29488634chr15:27571956ENST00000261275-41165_85174540TransmembraneHelical
HgeneFAM189A1chr15:29488634chr15:27571956ENST00000261275-41189_109174540TransmembraneHelical
HgeneFAM189A1chr15:29544572chr15:27571956ENST00000261275-31131_51129540TransmembraneHelical
HgeneFAM189A1chr15:29544572chr15:27571956ENST00000261275-31165_85129540TransmembraneHelical
HgeneFAM189A1chr15:29544572chr15:27571956ENST00000261275-31189_109129540TransmembraneHelical
TgeneGABRG3chr15:29488634chr15:27571956ENST00000333743+210338_44390468Topological domainCytoplasmic
TgeneGABRG3chr15:29488634chr15:27571956ENST00000555083+26338_44390254Topological domainCytoplasmic
TgeneGABRG3chr15:29544572chr15:27571956ENST00000333743+210338_44390468Topological domainCytoplasmic
TgeneGABRG3chr15:29544572chr15:27571956ENST00000555083+26338_44390254Topological domainCytoplasmic
TgeneGABRG3chr15:29488634chr15:27571956ENST00000333743+210255_27790468TransmembraneHelical
TgeneGABRG3chr15:29488634chr15:27571956ENST00000333743+210281_30390468TransmembraneHelical
TgeneGABRG3chr15:29488634chr15:27571956ENST00000333743+210315_33790468TransmembraneHelical
TgeneGABRG3chr15:29488634chr15:27571956ENST00000333743+210444_46790468TransmembraneHelical
TgeneGABRG3chr15:29488634chr15:27571956ENST00000555083+26255_27790254TransmembraneHelical
TgeneGABRG3chr15:29488634chr15:27571956ENST00000555083+26281_30390254TransmembraneHelical
TgeneGABRG3chr15:29488634chr15:27571956ENST00000555083+26315_33790254TransmembraneHelical
TgeneGABRG3chr15:29488634chr15:27571956ENST00000555083+26444_46790254TransmembraneHelical
TgeneGABRG3chr15:29544572chr15:27571956ENST00000333743+210255_27790468TransmembraneHelical
TgeneGABRG3chr15:29544572chr15:27571956ENST00000333743+210281_30390468TransmembraneHelical
TgeneGABRG3chr15:29544572chr15:27571956ENST00000333743+210315_33790468TransmembraneHelical
TgeneGABRG3chr15:29544572chr15:27571956ENST00000333743+210444_46790468TransmembraneHelical
TgeneGABRG3chr15:29544572chr15:27571956ENST00000555083+26255_27790254TransmembraneHelical
TgeneGABRG3chr15:29544572chr15:27571956ENST00000555083+26281_30390254TransmembraneHelical
TgeneGABRG3chr15:29544572chr15:27571956ENST00000555083+26315_33790254TransmembraneHelical
TgeneGABRG3chr15:29544572chr15:27571956ENST00000555083+26444_46790254TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM189A1chr15:29488634chr15:27571956ENST00000261275-411242_391174540Compositional biasNote=Pro-rich
HgeneFAM189A1chr15:29544572chr15:27571956ENST00000261275-311242_391129540Compositional biasNote=Pro-rich
HgeneFAM189A1chr15:29488634chr15:27571956ENST00000261275-411176_196174540TransmembraneHelical
HgeneFAM189A1chr15:29544572chr15:27571956ENST00000261275-311176_196129540TransmembraneHelical
TgeneGABRG3chr15:29488634chr15:27571956ENST00000333743+21018_25490468Topological domainExtracellular
TgeneGABRG3chr15:29488634chr15:27571956ENST00000555083+2618_25490254Topological domainExtracellular
TgeneGABRG3chr15:29544572chr15:27571956ENST00000333743+21018_25490468Topological domainExtracellular
TgeneGABRG3chr15:29544572chr15:27571956ENST00000555083+2618_25490254Topological domainExtracellular


Top

FusionGeneSequence for FAM189A1_GABRG3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FAM189A1_ENST00000261275_chr15_29544572_-_GABRG3_ENST00000333743_chr15_27571956_+_507aa
MPPAGGPRAPRPAALPRSLSRLRECPGRSRIVLALGATQMALGCLIVAVSFAALALTTSARVRHSCPFWAGFSVLLSGLIGVVSWKRPLS
LVITFFMLLSAVCVMLNLAGSILSCQNAQLVNSLEGCQLEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEA
HWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTE
IVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVT
VCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDG

>In-frame_FAM189A1_ENST00000261275_chr15_29544572_-_GABRG3_ENST00000555083_chr15_27571956_+_293aa
MPPAGGPRAPRPAALPRSLSRLRECPGRSRIVLALGATQMALGCLIVAVSFAALALTTSARVRHSCPFWAGFSVLLSGLIGVVSWKRPLS
LVITFFMLLSAVCVMLNLAGSILSCQNAQLVNSLEGCQLEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEA
HWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTE

>In-frame_FAM189A1_ENST00000261275_chr15_29488634_-_GABRG3_ENST00000333743_chr15_27571956_+_552aa
MPPAGGPRAPRPAALPRSLSRLRECPGRSRIVLALGATQMALGCLIVAVSFAALALTTSARVRHSCPFWAGFSVLLSGLIGVVSWKRPLS
LVITFFMLLSAVCVMLNLAGSILSCQNAQLVNSLEGCQLIKFDSVEVCVCCELQHQSSGCSNLGETLKLNPLQENCNAVRLTLKEYQIDI
FFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCP
LIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFW
IKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPE
RISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLF

>In-frame_FAM189A1_ENST00000261275_chr15_29488634_-_GABRG3_ENST00000555083_chr15_27571956_+_338aa
MPPAGGPRAPRPAALPRSLSRLRECPGRSRIVLALGATQMALGCLIVAVSFAALALTTSARVRHSCPFWAGFSVLLSGLIGVVSWKRPLS
LVITFFMLLSAVCVMLNLAGSILSCQNAQLVNSLEGCQLIKFDSVEVCVCCELQHQSSGCSNLGETLKLNPLQENCNAVRLTLKEYQIDI
FFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FAM189A1_ENST00000261275_chr15_29544572_-_GABRG3_ENST00000333743_chr15_27571956_+_1521nt
ATGCCTCCGGCCGGCGGCCCCCGAGCGCCGCGTCCCGCCGCGCTGCCCCGCAGCCTGTCCCGCCTGCGCGAGTGCCCGGGCCGCTCCCGC
ATCGTGCTGGCGCTCGGGGCCACGCAGATGGCGCTCGGATGCCTCATCGTGGCAGTCAGCTTCGCCGCGCTGGCGCTCACCACCTCGGCC
CGCGTCCGCCACTCCTGCCCCTTCTGGGCAGGCTTCTCGGTGCTGCTGTCGGGACTCATAGGTGTCGTCTCCTGGAAGAGGCCTCTCTCC
CTTGTGATAACCTTTTTCATGCTGCTTTCTGCAGTGTGTGTAATGCTGAATTTGGCTGGTTCAATTCTCTCTTGTCAGAATGCTCAGCTA
GTCAACTCCCTAGAAGGCTGCCAGTTGGAATACCAAATTGACATATTTTTTGCTCAGACCTGGACAGATAGTCGCCTTCGATTCAACAGC
ACAATGAAAATTCTTACTCTGAACAGCAACATGGTGGGGTTAATCTGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAGGCT
CACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGACGGGAAAATCCTTTACACTTTGAGGCTCACCATCAATGCTGAGTGC
CAGCTGCAGCTGCACAACTTCCCCATGGACGAACACTCCTGCCCGCTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATTTAT
AGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGGCGGCTTTATCAGTTTGACTTCATGGGCCTCAGAAACACCACAGAA
ATCGTGACAACGTCTGCAGGTGATTATGTTGTCATGACTATATATTTTGAATTGAGTAGAAGAATGGGATACTTCACCATTCAGACATAC
ATTCCCTGTATACTGACTGTGGTTTTATCCTGGGTGTCATTTTGGATCAAAAAAGATGCTACGCCAGCAAGAACAGCATTAGGCATCACC
ACGGTGCTGACCATGACCACCCTGAGCACCATCGCCAGGAAGTCCTTGCCACGCGTGTCCTACGTGACCGCCATGGACCTTTTTGTGACC
GTGTGCTTCCTGTTTGTCTTCGCCGCGCTGATGGAGTATGCCACCCTCAACTACTATTCCAGCTGTAGAAAACCAACCACCACGAAGAAG
ACAACATCGTTACTACATCCAGATTCCTCAAGATGGATTCCTGAGCGAATAAGCCTACAAGCCCCTTCCAACTATTCCCTCCTGGACATG
AGGCCACCACCAACTGCGATGATCACTTTAAACAATTCCGTTTACTGGCAGGAATTTGAAGATACCTGTGTCTATGAGTGTCTGGATGGC
AAAGACTGTCAGAGCTTCTTCTGCTGCTATGAAGAATGTAAATCAGGATCCTGGAGGAAAGGGCGTATTCACATAGACATCTTGGAGCTG

>In-frame_FAM189A1_ENST00000261275_chr15_29544572_-_GABRG3_ENST00000555083_chr15_27571956_+_879nt
ATGCCTCCGGCCGGCGGCCCCCGAGCGCCGCGTCCCGCCGCGCTGCCCCGCAGCCTGTCCCGCCTGCGCGAGTGCCCGGGCCGCTCCCGC
ATCGTGCTGGCGCTCGGGGCCACGCAGATGGCGCTCGGATGCCTCATCGTGGCAGTCAGCTTCGCCGCGCTGGCGCTCACCACCTCGGCC
CGCGTCCGCCACTCCTGCCCCTTCTGGGCAGGCTTCTCGGTGCTGCTGTCGGGACTCATAGGTGTCGTCTCCTGGAAGAGGCCTCTCTCC
CTTGTGATAACCTTTTTCATGCTGCTTTCTGCAGTGTGTGTAATGCTGAATTTGGCTGGTTCAATTCTCTCTTGTCAGAATGCTCAGCTA
GTCAACTCCCTAGAAGGCTGCCAGTTGGAATACCAAATTGACATATTTTTTGCTCAGACCTGGACAGATAGTCGCCTTCGATTCAACAGC
ACAATGAAAATTCTTACTCTGAACAGCAACATGGTGGGGTTAATCTGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAGGCT
CACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGACGGGAAAATCCTTTACACTTTGAGGCTCACCATCAATGCTGAGTGC
CAGCTGCAGCTGCACAACTTCCCCATGGACGAACACTCCTGCCCGCTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATTTAT
AGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGGCGGCTTTATCAGTTTGACTTCATGGGCCTCAGAAACACCACAGAA

>In-frame_FAM189A1_ENST00000261275_chr15_29488634_-_GABRG3_ENST00000333743_chr15_27571956_+_1656nt
ATGCCTCCGGCCGGCGGCCCCCGAGCGCCGCGTCCCGCCGCGCTGCCCCGCAGCCTGTCCCGCCTGCGCGAGTGCCCGGGCCGCTCCCGC
ATCGTGCTGGCGCTCGGGGCCACGCAGATGGCGCTCGGATGCCTCATCGTGGCAGTCAGCTTCGCCGCGCTGGCGCTCACCACCTCGGCC
CGCGTCCGCCACTCCTGCCCCTTCTGGGCAGGCTTCTCGGTGCTGCTGTCGGGACTCATAGGTGTCGTCTCCTGGAAGAGGCCTCTCTCC
CTTGTGATAACCTTTTTCATGCTGCTTTCTGCAGTGTGTGTAATGCTGAATTTGGCTGGTTCAATTCTCTCTTGTCAGAATGCTCAGCTA
GTCAACTCCCTAGAAGGCTGCCAGTTGATTAAGTTTGACAGTGTGGAGGTGTGTGTCTGCTGTGAGCTGCAGCACCAGTCGTCCGGCTGC
AGCAACCTCGGGGAGACGCTGAAGCTGAACCCGCTGCAGGAGAACTGCAACGCTGTGAGGCTGACCTTGAAGGAATACCAAATTGACATA
TTTTTTGCTCAGACCTGGACAGATAGTCGCCTTCGATTCAACAGCACAATGAAAATTCTTACTCTGAACAGCAACATGGTGGGGTTAATC
TGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAGGCTCACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGAC
GGGAAAATCCTTTACACTTTGAGGCTCACCATCAATGCTGAGTGCCAGCTGCAGCTGCACAACTTCCCCATGGACGAACACTCCTGCCCG
CTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATTTATAGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGG
CGGCTTTATCAGTTTGACTTCATGGGCCTCAGAAACACCACAGAAATCGTGACAACGTCTGCAGGTGATTATGTTGTCATGACTATATAT
TTTGAATTGAGTAGAAGAATGGGATACTTCACCATTCAGACATACATTCCCTGTATACTGACTGTGGTTTTATCCTGGGTGTCATTTTGG
ATCAAAAAAGATGCTACGCCAGCAAGAACAGCATTAGGCATCACCACGGTGCTGACCATGACCACCCTGAGCACCATCGCCAGGAAGTCC
TTGCCACGCGTGTCCTACGTGACCGCCATGGACCTTTTTGTGACCGTGTGCTTCCTGTTTGTCTTCGCCGCGCTGATGGAGTATGCCACC
CTCAACTACTATTCCAGCTGTAGAAAACCAACCACCACGAAGAAGACAACATCGTTACTACATCCAGATTCCTCAAGATGGATTCCTGAG
CGAATAAGCCTACAAGCCCCTTCCAACTATTCCCTCCTGGACATGAGGCCACCACCAACTGCGATGATCACTTTAAACAATTCCGTTTAC
TGGCAGGAATTTGAAGATACCTGTGTCTATGAGTGTCTGGATGGCAAAGACTGTCAGAGCTTCTTCTGCTGCTATGAAGAATGTAAATCA
GGATCCTGGAGGAAAGGGCGTATTCACATAGACATCTTGGAGCTGGACTCGTACTCCCGGGTCTTTTTCCCCACGTCCTTCCTGCTCTTT

>In-frame_FAM189A1_ENST00000261275_chr15_29488634_-_GABRG3_ENST00000555083_chr15_27571956_+_1014nt
ATGCCTCCGGCCGGCGGCCCCCGAGCGCCGCGTCCCGCCGCGCTGCCCCGCAGCCTGTCCCGCCTGCGCGAGTGCCCGGGCCGCTCCCGC
ATCGTGCTGGCGCTCGGGGCCACGCAGATGGCGCTCGGATGCCTCATCGTGGCAGTCAGCTTCGCCGCGCTGGCGCTCACCACCTCGGCC
CGCGTCCGCCACTCCTGCCCCTTCTGGGCAGGCTTCTCGGTGCTGCTGTCGGGACTCATAGGTGTCGTCTCCTGGAAGAGGCCTCTCTCC
CTTGTGATAACCTTTTTCATGCTGCTTTCTGCAGTGTGTGTAATGCTGAATTTGGCTGGTTCAATTCTCTCTTGTCAGAATGCTCAGCTA
GTCAACTCCCTAGAAGGCTGCCAGTTGATTAAGTTTGACAGTGTGGAGGTGTGTGTCTGCTGTGAGCTGCAGCACCAGTCGTCCGGCTGC
AGCAACCTCGGGGAGACGCTGAAGCTGAACCCGCTGCAGGAGAACTGCAACGCTGTGAGGCTGACCTTGAAGGAATACCAAATTGACATA
TTTTTTGCTCAGACCTGGACAGATAGTCGCCTTCGATTCAACAGCACAATGAAAATTCTTACTCTGAACAGCAACATGGTGGGGTTAATC
TGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAGGCTCACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGAC
GGGAAAATCCTTTACACTTTGAGGCTCACCATCAATGCTGAGTGCCAGCTGCAGCTGCACAACTTCCCCATGGACGAACACTCCTGCCCG
CTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATTTATAGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGG
CGGCTTTATCAGTTTGACTTCATGGGCCTCAGAAACACCACAGAAATCGTGACAACGTCTGCAGGTAGGAATTTACTGAAAGAGGCACAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_FAM189A1_ENST00000261275_chr15_29544572_-_GABRG3_ENST00000333743_chr15_27571956_+_1867nt
ATGCCTCCGGCCGGCGGCCCCCGAGCGCCGCGTCCCGCCGCGCTGCCCCGCAGCCTGTCCCGCCTGCGCGAGTGCCCGGGCCGCTCCCGC
ATCGTGCTGGCGCTCGGGGCCACGCAGATGGCGCTCGGATGCCTCATCGTGGCAGTCAGCTTCGCCGCGCTGGCGCTCACCACCTCGGCC
CGCGTCCGCCACTCCTGCCCCTTCTGGGCAGGCTTCTCGGTGCTGCTGTCGGGACTCATAGGTGTCGTCTCCTGGAAGAGGCCTCTCTCC
CTTGTGATAACCTTTTTCATGCTGCTTTCTGCAGTGTGTGTAATGCTGAATTTGGCTGGTTCAATTCTCTCTTGTCAGAATGCTCAGCTA
GTCAACTCCCTAGAAGGCTGCCAGTTGGAATACCAAATTGACATATTTTTTGCTCAGACCTGGACAGATAGTCGCCTTCGATTCAACAGC
ACAATGAAAATTCTTACTCTGAACAGCAACATGGTGGGGTTAATCTGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAGGCT
CACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGACGGGAAAATCCTTTACACTTTGAGGCTCACCATCAATGCTGAGTGC
CAGCTGCAGCTGCACAACTTCCCCATGGACGAACACTCCTGCCCGCTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATTTAT
AGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGGCGGCTTTATCAGTTTGACTTCATGGGCCTCAGAAACACCACAGAA
ATCGTGACAACGTCTGCAGGTGATTATGTTGTCATGACTATATATTTTGAATTGAGTAGAAGAATGGGATACTTCACCATTCAGACATAC
ATTCCCTGTATACTGACTGTGGTTTTATCCTGGGTGTCATTTTGGATCAAAAAAGATGCTACGCCAGCAAGAACAGCATTAGGCATCACC
ACGGTGCTGACCATGACCACCCTGAGCACCATCGCCAGGAAGTCCTTGCCACGCGTGTCCTACGTGACCGCCATGGACCTTTTTGTGACC
GTGTGCTTCCTGTTTGTCTTCGCCGCGCTGATGGAGTATGCCACCCTCAACTACTATTCCAGCTGTAGAAAACCAACCACCACGAAGAAG
ACAACATCGTTACTACATCCAGATTCCTCAAGATGGATTCCTGAGCGAATAAGCCTACAAGCCCCTTCCAACTATTCCCTCCTGGACATG
AGGCCACCACCAACTGCGATGATCACTTTAAACAATTCCGTTTACTGGCAGGAATTTGAAGATACCTGTGTCTATGAGTGTCTGGATGGC
AAAGACTGTCAGAGCTTCTTCTGCTGCTATGAAGAATGTAAATCAGGATCCTGGAGGAAAGGGCGTATTCACATAGACATCTTGGAGCTG
GACTCGTACTCCCGGGTCTTTTTCCCCACGTCCTTCCTGCTCTTTAACCTGGTCTACTGGGTTGGATACCTGTATCTCTAAGTGTTGCTC
AGAGTGAAGAGTGAAGAGCATTTGGTACACACTTGACCTTCTGTCGTCCCCAGACCAGTAGTGACCAATCGGGAGTAGCAAGGAAGGACA
CTGCCCAGTGTATCTTGTTATAAATGACCTTTCAGCAACACAGGAAGTACCCAGCAAAGGTTTCTATTATGTATTTTACACACACACATA
CATACACACACACAGCTAATTGAGTTTTAAAGTAATATTCTTGCTAATCCCTACTGAATTGTAGCTTGGTGTTGTTTCTGAATGGTTTTT

>In-frame_FAM189A1_ENST00000261275_chr15_29544572_-_GABRG3_ENST00000555083_chr15_27571956_+_1379nt
ATGCCTCCGGCCGGCGGCCCCCGAGCGCCGCGTCCCGCCGCGCTGCCCCGCAGCCTGTCCCGCCTGCGCGAGTGCCCGGGCCGCTCCCGC
ATCGTGCTGGCGCTCGGGGCCACGCAGATGGCGCTCGGATGCCTCATCGTGGCAGTCAGCTTCGCCGCGCTGGCGCTCACCACCTCGGCC
CGCGTCCGCCACTCCTGCCCCTTCTGGGCAGGCTTCTCGGTGCTGCTGTCGGGACTCATAGGTGTCGTCTCCTGGAAGAGGCCTCTCTCC
CTTGTGATAACCTTTTTCATGCTGCTTTCTGCAGTGTGTGTAATGCTGAATTTGGCTGGTTCAATTCTCTCTTGTCAGAATGCTCAGCTA
GTCAACTCCCTAGAAGGCTGCCAGTTGGAATACCAAATTGACATATTTTTTGCTCAGACCTGGACAGATAGTCGCCTTCGATTCAACAGC
ACAATGAAAATTCTTACTCTGAACAGCAACATGGTGGGGTTAATCTGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAGGCT
CACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGACGGGAAAATCCTTTACACTTTGAGGCTCACCATCAATGCTGAGTGC
CAGCTGCAGCTGCACAACTTCCCCATGGACGAACACTCCTGCCCGCTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATTTAT
AGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGGCGGCTTTATCAGTTTGACTTCATGGGCCTCAGAAACACCACAGAA
ATCGTGACAACGTCTGCAGGTAGGAATTTACTGAAAGAGGCACAGCTCTCAAAAGCCAGAGAGGCCTAAGGCCATATGTAGTCATATCCT
TAATGTACAAGCCTTTTGGGCAACCATGATACATAAGTGATATTTGAGACAAAACAAGTGATTCAAAGTGAAACTATGTTTTCATGTTTT
AATTGGTATGGGAGAGGGATGTTAGAAATAATTCATATTTTTGAATCCAGGCTGTGTTTGCATAATGTCTATAAACCTAGCTATAAACTT
AACCTAACTCATTACTGACCATATTTACATAAACCAATTTTGCTGATGGGGAGAGTTCTGCAAATTTCCACGTACATAAGAAGAATCAAA
TATTATTGAGAATCCACACATAAAAGAAGCTGGTGTGATATGTCCTTTGAGTTTCAATTGCTTTTATTTACTCTAAGTTTTATCTTTAAC
TTTGAGTTTCTTTTTCAATGATTGAAAGTAATTACCTACCAATTTGATTTTATGAAGTGATCATTATATGCATATTCAAAATCCTGTAAT

>In-frame_FAM189A1_ENST00000261275_chr15_29488634_-_GABRG3_ENST00000333743_chr15_27571956_+_2002nt
ATGCCTCCGGCCGGCGGCCCCCGAGCGCCGCGTCCCGCCGCGCTGCCCCGCAGCCTGTCCCGCCTGCGCGAGTGCCCGGGCCGCTCCCGC
ATCGTGCTGGCGCTCGGGGCCACGCAGATGGCGCTCGGATGCCTCATCGTGGCAGTCAGCTTCGCCGCGCTGGCGCTCACCACCTCGGCC
CGCGTCCGCCACTCCTGCCCCTTCTGGGCAGGCTTCTCGGTGCTGCTGTCGGGACTCATAGGTGTCGTCTCCTGGAAGAGGCCTCTCTCC
CTTGTGATAACCTTTTTCATGCTGCTTTCTGCAGTGTGTGTAATGCTGAATTTGGCTGGTTCAATTCTCTCTTGTCAGAATGCTCAGCTA
GTCAACTCCCTAGAAGGCTGCCAGTTGATTAAGTTTGACAGTGTGGAGGTGTGTGTCTGCTGTGAGCTGCAGCACCAGTCGTCCGGCTGC
AGCAACCTCGGGGAGACGCTGAAGCTGAACCCGCTGCAGGAGAACTGCAACGCTGTGAGGCTGACCTTGAAGGAATACCAAATTGACATA
TTTTTTGCTCAGACCTGGACAGATAGTCGCCTTCGATTCAACAGCACAATGAAAATTCTTACTCTGAACAGCAACATGGTGGGGTTAATC
TGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAGGCTCACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGAC
GGGAAAATCCTTTACACTTTGAGGCTCACCATCAATGCTGAGTGCCAGCTGCAGCTGCACAACTTCCCCATGGACGAACACTCCTGCCCG
CTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATTTATAGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGG
CGGCTTTATCAGTTTGACTTCATGGGCCTCAGAAACACCACAGAAATCGTGACAACGTCTGCAGGTGATTATGTTGTCATGACTATATAT
TTTGAATTGAGTAGAAGAATGGGATACTTCACCATTCAGACATACATTCCCTGTATACTGACTGTGGTTTTATCCTGGGTGTCATTTTGG
ATCAAAAAAGATGCTACGCCAGCAAGAACAGCATTAGGCATCACCACGGTGCTGACCATGACCACCCTGAGCACCATCGCCAGGAAGTCC
TTGCCACGCGTGTCCTACGTGACCGCCATGGACCTTTTTGTGACCGTGTGCTTCCTGTTTGTCTTCGCCGCGCTGATGGAGTATGCCACC
CTCAACTACTATTCCAGCTGTAGAAAACCAACCACCACGAAGAAGACAACATCGTTACTACATCCAGATTCCTCAAGATGGATTCCTGAG
CGAATAAGCCTACAAGCCCCTTCCAACTATTCCCTCCTGGACATGAGGCCACCACCAACTGCGATGATCACTTTAAACAATTCCGTTTAC
TGGCAGGAATTTGAAGATACCTGTGTCTATGAGTGTCTGGATGGCAAAGACTGTCAGAGCTTCTTCTGCTGCTATGAAGAATGTAAATCA
GGATCCTGGAGGAAAGGGCGTATTCACATAGACATCTTGGAGCTGGACTCGTACTCCCGGGTCTTTTTCCCCACGTCCTTCCTGCTCTTT
AACCTGGTCTACTGGGTTGGATACCTGTATCTCTAAGTGTTGCTCAGAGTGAAGAGTGAAGAGCATTTGGTACACACTTGACCTTCTGTC
GTCCCCAGACCAGTAGTGACCAATCGGGAGTAGCAAGGAAGGACACTGCCCAGTGTATCTTGTTATAAATGACCTTTCAGCAACACAGGA
AGTACCCAGCAAAGGTTTCTATTATGTATTTTACACACACACATACATACACACACACAGCTAATTGAGTTTTAAAGTAATATTCTTGCT
AATCCCTACTGAATTGTAGCTTGGTGTTGTTTCTGAATGGTTTTTGGATATTGGAAGCAGCCGCTGATTACCCTTGCAAAGAAATCTGTA

>In-frame_FAM189A1_ENST00000261275_chr15_29488634_-_GABRG3_ENST00000555083_chr15_27571956_+_1514nt
ATGCCTCCGGCCGGCGGCCCCCGAGCGCCGCGTCCCGCCGCGCTGCCCCGCAGCCTGTCCCGCCTGCGCGAGTGCCCGGGCCGCTCCCGC
ATCGTGCTGGCGCTCGGGGCCACGCAGATGGCGCTCGGATGCCTCATCGTGGCAGTCAGCTTCGCCGCGCTGGCGCTCACCACCTCGGCC
CGCGTCCGCCACTCCTGCCCCTTCTGGGCAGGCTTCTCGGTGCTGCTGTCGGGACTCATAGGTGTCGTCTCCTGGAAGAGGCCTCTCTCC
CTTGTGATAACCTTTTTCATGCTGCTTTCTGCAGTGTGTGTAATGCTGAATTTGGCTGGTTCAATTCTCTCTTGTCAGAATGCTCAGCTA
GTCAACTCCCTAGAAGGCTGCCAGTTGATTAAGTTTGACAGTGTGGAGGTGTGTGTCTGCTGTGAGCTGCAGCACCAGTCGTCCGGCTGC
AGCAACCTCGGGGAGACGCTGAAGCTGAACCCGCTGCAGGAGAACTGCAACGCTGTGAGGCTGACCTTGAAGGAATACCAAATTGACATA
TTTTTTGCTCAGACCTGGACAGATAGTCGCCTTCGATTCAACAGCACAATGAAAATTCTTACTCTGAACAGCAACATGGTGGGGTTAATC
TGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAGGCTCACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGAC
GGGAAAATCCTTTACACTTTGAGGCTCACCATCAATGCTGAGTGCCAGCTGCAGCTGCACAACTTCCCCATGGACGAACACTCCTGCCCG
CTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATTTATAGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGG
CGGCTTTATCAGTTTGACTTCATGGGCCTCAGAAACACCACAGAAATCGTGACAACGTCTGCAGGTAGGAATTTACTGAAAGAGGCACAG
CTCTCAAAAGCCAGAGAGGCCTAAGGCCATATGTAGTCATATCCTTAATGTACAAGCCTTTTGGGCAACCATGATACATAAGTGATATTT
GAGACAAAACAAGTGATTCAAAGTGAAACTATGTTTTCATGTTTTAATTGGTATGGGAGAGGGATGTTAGAAATAATTCATATTTTTGAA
TCCAGGCTGTGTTTGCATAATGTCTATAAACCTAGCTATAAACTTAACCTAACTCATTACTGACCATATTTACATAAACCAATTTTGCTG
ATGGGGAGAGTTCTGCAAATTTCCACGTACATAAGAAGAATCAAATATTATTGAGAATCCACACATAAAAGAAGCTGGTGTGATATGTCC
TTTGAGTTTCAATTGCTTTTATTTACTCTAAGTTTTATCTTTAACTTTGAGTTTCTTTTTCAATGATTGAAAGTAATTACCTACCAATTT


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FusionGenePPI for FAM189A1_GABRG3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM189A1CLK1GABRG3TP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM189A1_GABRG3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGABRG3Q99928DB00546AdinazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB00898EthanolGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB01594CinolazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB01595NitrazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved
TgeneGABRG3Q99928DB00683MidazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01215EstazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01559ClotiazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01567FludiazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01588PrazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB01589QuazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit
TgeneGABRG3Q99928DB00690FlurazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|investigational
TgeneGABRG3Q99928DB01558BromazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|investigational
TgeneGABRG3Q99928DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|investigational|vet_approved
TgeneGABRG3Q99928DB00801HalazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|illicit|withdrawn
TgeneGABRG3Q99928DB00231TemazepamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|investigational
TgeneGABRG3Q99928DB00897TriazolamGamma-aminobutyric acid receptor subunit gamma-3small moleculeapproved|investigational

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RelatedDiseases for FAM189A1_GABRG3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGABRG3C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGABRG3C3711376Isodicentric Chromosome 15 Syndrome1CTD_human