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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12665

FusionGeneSummary for FAM178B_PRRG1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM178B_PRRG1
Fusion gene ID: 12665
HgeneTgene
Gene symbol

FAM178B

PRRG1

Gene ID

51252

5638

Gene namefamily with sequence similarity 178 member Bproline rich and Gla domain 1
Synonyms-PRGP1
Cytomap

2q11.2

Xp21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM178Btransmembrane gamma-carboxyglutamic acid protein 1proline rich Gla (G-carboxyglutamic acid) 1proline-rich Gla (G-carboxyglutamic acid) polypeptide 1
Modification date2018051920180519
UniProtAcc

Q8IXR5

O14668

Ensembl transtripts involved in fusion geneENST00000327896, ENST00000417561, 
ENST00000490605, ENST00000393526, 
ENST00000470789, 		ENST00000378628, 
ENST00000491253, ENST00000543642, 
ENST00000542554, ENST00000449135, 
ENST00000463135, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: FAM178B [Title/Abstract] AND PRRG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ226718FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000327896ENST00000378628FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5UTR-intronENST00000327896ENST00000491253FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5UTR-intronENST00000327896ENST00000543642FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5UTR-5UTRENST00000327896ENST00000542554FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5UTR-5UTRENST00000327896ENST00000449135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5UTR-intronENST00000327896ENST00000463135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000417561ENST00000378628FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000417561ENST00000491253FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000417561ENST00000543642FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-5UTRENST00000417561ENST00000542554FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-5UTRENST00000417561ENST00000449135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000417561ENST00000463135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5CDS-intronENST00000490605ENST00000378628FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5CDS-intronENST00000490605ENST00000491253FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5CDS-intronENST00000490605ENST00000543642FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5CDS-5UTRENST00000490605ENST00000542554FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5CDS-5UTRENST00000490605ENST00000449135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
5CDS-intronENST00000490605ENST00000463135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000393526ENST00000378628FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000393526ENST00000491253FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000393526ENST00000543642FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-5UTRENST00000393526ENST00000542554FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-5UTRENST00000393526ENST00000449135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000393526ENST00000463135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000470789ENST00000378628FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000470789ENST00000491253FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000470789ENST00000543642FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-5UTRENST00000470789ENST00000542554FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-5UTRENST00000470789ENST00000449135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+
intron-intronENST00000470789ENST00000463135FAM178Bchr2

97651977

-PRRG1chrX

37245850

+

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FusionProtFeatures for FAM178B_PRRG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM178B

Q8IXR5

PRRG1

O14668


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM178B_PRRG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM178B_PRRG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM178BLRSAM1PRRG1NEDD4, NEDD4L, ELAVL1, FBXO25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM178B_PRRG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM178B_PRRG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource