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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12661

FusionGeneSummary for FAM177A1_FAM177A1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM177A1_FAM177A1
Fusion gene ID: 12661
HgeneTgene
Gene symbol

FAM177A1

FAM177A1

Gene ID

283635

283635

Gene namefamily with sequence similarity 177 member A1family with sequence similarity 177 member A1
SynonymsC14orf24C14orf24
Cytomap

14q13.2

14q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM177A1protein FAM177A1
Modification date2018051920180519
UniProtAcc

Q8N128

Q8N128

Ensembl transtripts involved in fusion geneENST00000396472, ENST00000382406, 
ENST00000280987, ENST00000554052, 
ENST00000396472, ENST00000382406, 
ENST00000280987, ENST00000554052, 
Fusion gene scores* DoF score5 X 5 X 5=1257 X 7 X 4=196
# samples 69
** MAII scorelog2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM177A1 [Title/Abstract] AND FAM177A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA502988FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
ChiTaRS3.1N50523FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000396472ENST00000396472FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
5CDS-intronENST00000396472ENST00000382406FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
5CDS-3UTRENST00000396472ENST00000280987FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
5CDS-intronENST00000396472ENST00000554052FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
intron-3UTRENST00000382406ENST00000396472FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
intron-intronENST00000382406ENST00000382406FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
intron-3UTRENST00000382406ENST00000280987FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
intron-intronENST00000382406ENST00000554052FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
5CDS-3UTRENST00000280987ENST00000396472FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
5CDS-intronENST00000280987ENST00000382406FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
5CDS-3UTRENST00000280987ENST00000280987FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
5CDS-intronENST00000280987ENST00000554052FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
intron-3UTRENST00000554052ENST00000396472FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
intron-intronENST00000554052ENST00000382406FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
intron-3UTRENST00000554052ENST00000280987FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
intron-intronENST00000554052ENST00000554052FAM177A1chr14

35552584

+FAM177A1chr14

35552506

-
intron-3CDSENST00000396472ENST00000396472FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
intron-3CDSENST00000396472ENST00000382406FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
intron-3CDSENST00000396472ENST00000280987FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
intron-3UTRENST00000396472ENST00000554052FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
intron-3CDSENST00000382406ENST00000396472FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
intron-3CDSENST00000382406ENST00000382406FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
intron-3CDSENST00000382406ENST00000280987FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
intron-3UTRENST00000382406ENST00000554052FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
Frame-shiftENST00000280987ENST00000396472FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
Frame-shiftENST00000280987ENST00000382406FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
Frame-shiftENST00000280987ENST00000280987FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
5CDS-3UTRENST00000280987ENST00000554052FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
3UTR-3CDSENST00000554052ENST00000396472FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
3UTR-3CDSENST00000554052ENST00000382406FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
3UTR-3CDSENST00000554052ENST00000280987FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+
3UTR-3UTRENST00000554052ENST00000554052FAM177A1chr14

35515710

-FAM177A1chr14

35515804

+

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FusionProtFeatures for FAM177A1_FAM177A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM177A1

Q8N128

FAM177A1

Q8N128


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM177A1_FAM177A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM177A1_FAM177A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM177A1_FAM177A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM177A1_FAM177A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource