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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12660

FusionGeneSummary for FAM177A1_AP4S1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM177A1_AP4S1
Fusion gene ID: 12660
HgeneTgene
Gene symbol

FAM177A1

AP4S1

Gene ID

283635

11154

Gene namefamily with sequence similarity 177 member A1adaptor related protein complex 4 subunit sigma 1
SynonymsC14orf24AP47B|CLA20|CLAPS4|CPSQ6|SPG52
Cytomap

14q13.2

14q12

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM177A1AP-4 complex subunit sigma-1AP-4 adapter complex subunit sigma-1AP-4 adaptor complex subunit sigma-1adaptor related protein complex 4 sigma 1 subunitclathrin-associated/assembly/adaptor protein, sigma 4sigma-4-adaptin
Modification date2018051920180519
UniProtAcc

Q8N128

Q9Y587

Ensembl transtripts involved in fusion geneENST00000396472, ENST00000382406, 
ENST00000280987, ENST00000554052, 
ENST00000542754, ENST00000313566, 
ENST00000216366, ENST00000334725, 
ENST00000554609, ENST00000554345, 
Fusion gene scores* DoF score5 X 5 X 5=1253 X 3 X 3=27
# samples 63
** MAII scorelog2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM177A1 [Title/Abstract] AND AP4S1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-70-6722-01AFAM177A1chr14

35515834

+AP4S1chr14

31549779

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000396472ENST00000542754FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000396472ENST00000313566FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000396472ENST00000216366FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000396472ENST00000334725FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000396472ENST00000554609FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000396472ENST00000554345FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
In-frameENST00000382406ENST00000542754FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000382406ENST00000313566FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000382406ENST00000216366FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000382406ENST00000334725FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000382406ENST00000554609FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000382406ENST00000554345FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
In-frameENST00000280987ENST00000542754FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000280987ENST00000313566FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000280987ENST00000216366FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000280987ENST00000334725FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000280987ENST00000554609FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
5CDS-intronENST00000280987ENST00000554345FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
3UTR-3CDSENST00000554052ENST00000542754FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
3UTR-intronENST00000554052ENST00000313566FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
3UTR-intronENST00000554052ENST00000216366FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
3UTR-intronENST00000554052ENST00000334725FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
3UTR-intronENST00000554052ENST00000554609FAM177A1chr14

35515834

+AP4S1chr14

31549779

+
3UTR-intronENST00000554052ENST00000554345FAM177A1chr14

35515834

+AP4S1chr14

31549779

+

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FusionProtFeatures for FAM177A1_AP4S1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM177A1

Q8N128

AP4S1

Q9Y587

Component of the adaptor protein complex 4 (AP-4).Adaptor protein complexes are vesicle coat components involvedboth in vesicle formation and cargo selection. They control thevesicular transport of proteins in different trafficking pathways(PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network(TGN) and may be involved in the targeting of proteins from thetrans-Golgi network (TGN) to the endosomal-lysosomal system. It isalso involved in protein sorting to the basolateral membrane inepithelial cells and the proper asymmetric localization ofsomatodendritic proteins in neurons. AP-4 is involved in therecognition and binding of tyrosine-based sorting signals found inthe cytoplasmic part of cargos, but may also recognize other typesof sorting signal (Probable). {ECO:0000269|PubMed:10066790,ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790,ECO:0000305|PubMed:10436028}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM177A1chr14:35515834chr14:31549779ENST00000280987+15136_17355237Coiled coilOntology_term=ECO:0000255
HgeneFAM177A1chr14:35515834chr14:31549779ENST00000382406+26136_17332214Coiled coilOntology_term=ECO:0000255
HgeneFAM177A1chr14:35515834chr14:31549779ENST00000396472+37136_17332214Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for FAM177A1_AP4S1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FAM177A1_ENST00000396472_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_79aa

>In-frame_FAM177A1_ENST00000382406_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_79aa

>In-frame_FAM177A1_ENST00000280987_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_102aa
MEVGLPAITLFLTSASSPVVATTMDQEPVGGVERGEAVAASGAAAAAAFGESAGQSELDIMFNLDKVHIILDEMVLNGCIVETNRARILA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FAM177A1_ENST00000396472_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_237nt
ATGGACCAGGAGCCAGTGGGCGGTGTGGAACGAGGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCA
GGGCAGAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACT

>In-frame_FAM177A1_ENST00000382406_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_237nt
ATGGACCAGGAGCCAGTGGGCGGTGTGGAACGAGGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCA
GGGCAGAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACT

>In-frame_FAM177A1_ENST00000280987_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_306nt
ATGGAAGTGGGCTTACCGGCCATTACCCTCTTTCTCACCAGCGCCAGCAGCCCTGTGGTGGCGACGACGATGGACCAGGAGCCAGTGGGC
GGTGTGGAACGAGGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCAGGGCAGAGTGAATTAGATATA
ATGTTTAATTTGGATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACTAACAGGGCAAGAATTCTTGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_FAM177A1_ENST00000396472_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_1273nt
AAGAAAATTGTAATTTGATATTTAATTGCCACTTTGGAAAATAAAATCATGCATTTATAAATATCCCACAAAGTTTTAGTAATAAAGATT
GTTGATTGCCCTGCTTGCCAGTAAGAAGGAAGAGATTTTGAATACATATAATGCAGAACTGTGTTGTTTATGAATGCCAATTCATGAAGT
CTTAACAATTGGTTCTTTATTTTTGTTTTCAATTTATGGCCGAGTTTGGTTTTGCTGTTTTGGACTGTCTCAACTCCCTGCTGATGCCAC
CATACAGAGTCAGATCAGCAACCACATCCCATCACTAGCCTTTGAAGTACAACGACACAGCTGTCTTCATTTTACAAGTGCAAAAACCGA
GGTCCTGCGGGGTGACTGCCCCAGACGCCGCTGGTGACGGGCTGCGCCGAGGTCGAGACGCCAGGCTTCAGCGCCAGCAGCCCTGTGGTG
GCGACGACGATGGACCAGGAGCCAGTGGGCGGTGTGGAACGAGGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGG
GAATCTGCAGGGCAGAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATT
GTGGAAACTAACAGGGCAAGAATTCTTGCCCCTCTACTAATTCTTGATAAGATGTCAGAAAGCTGAAAGGAAGTCTCTTCGAGACAATAT
GGATTTATCAGAAATGCGAGTACCGTGGAATACATCTCAACATGTTAACCCAGAAGAATCTGGAAGACCACAATTACAAAATGGGGTATC
CTTCCAAAGACATTATAAATAGGCATTTTCCACAGTTCCTAAAAAGAAAACACAACTGTACTTTAAAATATGTACAAAGAAAAAAATTTC
TTTAAACTGAGAGAGAAGTTTTATTTTCTAATTGTAAACATATCTGTCGCACTTTAAATTCTGTTGAGCACCTAAGGAACCCTTCTTGGT
CTATGCTTCTTTTGCAAATTGAATTCAGGAATAGCAGGATGGTAGTGGGAAGAAAGTATGGCAGTTTTCCGTCAGCCAATAAAGTTTTAA
AATTTAAACACAAGGCATTTTGAGTAACGCTGTTTTCTGAAAGCTATTTTTTTTTTTTTGAGACGGAGTCTAGTCTAGCTGTGTCACCTG
GCACATTCTCGGCTCACTGCAACCTCCACTTCCGGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGAGCTGGGACTACAGGCATGCACCA

>In-frame_FAM177A1_ENST00000382406_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_871nt
AGGCGCGGCGCGAGGCGGGCGCTGGGCGGCGCCAGCAGCCCTGTGGTGGCGACGACGATGGACCAGGAGCCAGTGGGCGGTGTGGAACGA
GGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCAGGGCAGAGTGAATTAGATATAATGTTTAATTTG
GATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACTAACAGGGCAAGAATTCTTGCCCCTCTACTAATT
CTTGATAAGATGTCAGAAAGCTGAAAGGAAGTCTCTTCGAGACAATATGGATTTATCAGAAATGCGAGTACCGTGGAATACATCTCAACA
TGTTAACCCAGAAGAATCTGGAAGACCACAATTACAAAATGGGGTATCCTTCCAAAGACATTATAAATAGGCATTTTCCACAGTTCCTAA
AAAGAAAACACAACTGTACTTTAAAATATGTACAAAGAAAAAAATTTCTTTAAACTGAGAGAGAAGTTTTATTTTCTAATTGTAAACATA
TCTGTCGCACTTTAAATTCTGTTGAGCACCTAAGGAACCCTTCTTGGTCTATGCTTCTTTTGCAAATTGAATTCAGGAATAGCAGGATGG
TAGTGGGAAGAAAGTATGGCAGTTTTCCGTCAGCCAATAAAGTTTTAAAATTTAAACACAAGGCATTTTGAGTAACGCTGTTTTCTGAAA
GCTATTTTTTTTTTTTTGAGACGGAGTCTAGTCTAGCTGTGTCACCTGGCACATTCTCGGCTCACTGCAACCTCCACTTCCGGGGTTCAA

>In-frame_FAM177A1_ENST00000280987_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_944nt
GCGGGTGAGTCCCACTTCCCGACAGCCTGGCTCGGCCAGCGACTGGGCGGGGAGACCAAGGATGGAAGTGGGCTTACCGGCCATTACCCT
CTTTCTCACCAGCGCCAGCAGCCCTGTGGTGGCGACGACGATGGACCAGGAGCCAGTGGGCGGTGTGGAACGAGGAGAAGCCGTCGCAGC
CTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCAGGGCAGAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACATCAT
TTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACTAACAGGGCAAGAATTCTTGCCCCTCTACTAATTCTTGATAAGATGTCAGA
AAGCTGAAAGGAAGTCTCTTCGAGACAATATGGATTTATCAGAAATGCGAGTACCGTGGAATACATCTCAACATGTTAACCCAGAAGAAT
CTGGAAGACCACAATTACAAAATGGGGTATCCTTCCAAAGACATTATAAATAGGCATTTTCCACAGTTCCTAAAAAGAAAACACAACTGT
ACTTTAAAATATGTACAAAGAAAAAAATTTCTTTAAACTGAGAGAGAAGTTTTATTTTCTAATTGTAAACATATCTGTCGCACTTTAAAT
TCTGTTGAGCACCTAAGGAACCCTTCTTGGTCTATGCTTCTTTTGCAAATTGAATTCAGGAATAGCAGGATGGTAGTGGGAAGAAAGTAT
GGCAGTTTTCCGTCAGCCAATAAAGTTTTAAAATTTAAACACAAGGCATTTTGAGTAACGCTGTTTTCTGAAAGCTATTTTTTTTTTTTT
GAGACGGAGTCTAGTCTAGCTGTGTCACCTGGCACATTCTCGGCTCACTGCAACCTCCACTTCCGGGGTTCAAGCGATTCTCCTGCCTCA


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FusionGenePPI for FAM177A1_AP4S1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM177A1RHOJ, FAM204A, SLC27A2, C1orf27, SUGP1, UFSP2, EEF1A2, STEAP3, AAGAB, SLC4A1AP, FAM207A, SAR1B, TGS1, ARMCX3, DHX38, RIOK1, VPS13B, GTF2F2, DCUN1D5, OSTM1, GPKOW, C12orf43, CLCN7, DUSP22, MRPS31, NAPG, NCEH1AP4S1AP4E1, GRB2, APP, TEAD3, AFP, GTF2I, CEP104, GALNT2, MECP2, RPL10, SLC9A1, HLTF, TMPO, AP4M1, APPBP2, AP4B1, ENTHD2, GOLIM4, CDC73, C19orf52, SUV39H2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM177A1_AP4S1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM177A1_AP4S1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource