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Fusion gene ID: 12660 |
FusionGeneSummary for FAM177A1_AP4S1 |
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Fusion gene information | Fusion gene name: FAM177A1_AP4S1 | Fusion gene ID: 12660 | Hgene | Tgene | Gene symbol | FAM177A1 | AP4S1 | Gene ID | 283635 | 11154 |
Gene name | family with sequence similarity 177 member A1 | adaptor related protein complex 4 subunit sigma 1 | |
Synonyms | C14orf24 | AP47B|CLA20|CLAPS4|CPSQ6|SPG52 | |
Cytomap | 14q13.2 | 14q12 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM177A1 | AP-4 complex subunit sigma-1AP-4 adapter complex subunit sigma-1AP-4 adaptor complex subunit sigma-1adaptor related protein complex 4 sigma 1 subunitclathrin-associated/assembly/adaptor protein, sigma 4sigma-4-adaptin | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8N128 | Q9Y587 | |
Ensembl transtripts involved in fusion gene | ENST00000396472, ENST00000382406, ENST00000280987, ENST00000554052, | ENST00000542754, ENST00000313566, ENST00000216366, ENST00000334725, ENST00000554609, ENST00000554345, | |
Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 3 X 3 X 3=27 |
# samples | 6 | 3 | |
** MAII score | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FAM177A1 [Title/Abstract] AND AP4S1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-70-6722-01A | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000396472 | ENST00000542754 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000396472 | ENST00000313566 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000396472 | ENST00000216366 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000396472 | ENST00000334725 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000396472 | ENST00000554609 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000396472 | ENST00000554345 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
In-frame | ENST00000382406 | ENST00000542754 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000382406 | ENST00000313566 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000382406 | ENST00000216366 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000382406 | ENST00000334725 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000382406 | ENST00000554609 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000382406 | ENST00000554345 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
In-frame | ENST00000280987 | ENST00000542754 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000280987 | ENST00000313566 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000280987 | ENST00000216366 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000280987 | ENST00000334725 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000280987 | ENST00000554609 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
5CDS-intron | ENST00000280987 | ENST00000554345 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
3UTR-3CDS | ENST00000554052 | ENST00000542754 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
3UTR-intron | ENST00000554052 | ENST00000313566 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
3UTR-intron | ENST00000554052 | ENST00000216366 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
3UTR-intron | ENST00000554052 | ENST00000334725 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
3UTR-intron | ENST00000554052 | ENST00000554609 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
3UTR-intron | ENST00000554052 | ENST00000554345 | FAM177A1 | chr14 | 35515834 | + | AP4S1 | chr14 | 31549779 | + |
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FusionProtFeatures for FAM177A1_AP4S1 |
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Hgene | Tgene |
FAM177A1 | AP4S1 |
Component of the adaptor protein complex 4 (AP-4).Adaptor protein complexes are vesicle coat components involvedboth in vesicle formation and cargo selection. They control thevesicular transport of proteins in different trafficking pathways(PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network(TGN) and may be involved in the targeting of proteins from thetrans-Golgi network (TGN) to the endosomal-lysosomal system. It isalso involved in protein sorting to the basolateral membrane inepithelial cells and the proper asymmetric localization ofsomatodendritic proteins in neurons. AP-4 is involved in therecognition and binding of tyrosine-based sorting signals found inthe cytoplasmic part of cargos, but may also recognize other typesof sorting signal (Probable). {ECO:0000269|PubMed:10066790,ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790,ECO:0000305|PubMed:10436028}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >FAM177A1 | chr14:35515834 | chr14:31549779 | ENST00000280987 | + | 1 | 5 | 136_173 | 55 | 237 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >FAM177A1 | chr14:35515834 | chr14:31549779 | ENST00000382406 | + | 2 | 6 | 136_173 | 32 | 214 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >FAM177A1 | chr14:35515834 | chr14:31549779 | ENST00000396472 | + | 3 | 7 | 136_173 | 32 | 214 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for FAM177A1_AP4S1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_FAM177A1_ENST00000396472_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_79aa >In-frame_FAM177A1_ENST00000382406_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_79aa >In-frame_FAM177A1_ENST00000280987_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_102aa MEVGLPAITLFLTSASSPVVATTMDQEPVGGVERGEAVAASGAAAAAAFGESAGQSELDIMFNLDKVHIILDEMVLNGCIVETNRARILA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_FAM177A1_ENST00000396472_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_237nt ATGGACCAGGAGCCAGTGGGCGGTGTGGAACGAGGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCA GGGCAGAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACT >In-frame_FAM177A1_ENST00000382406_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_237nt ATGGACCAGGAGCCAGTGGGCGGTGTGGAACGAGGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCA GGGCAGAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACT >In-frame_FAM177A1_ENST00000280987_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_306nt ATGGAAGTGGGCTTACCGGCCATTACCCTCTTTCTCACCAGCGCCAGCAGCCCTGTGGTGGCGACGACGATGGACCAGGAGCCAGTGGGC GGTGTGGAACGAGGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCAGGGCAGAGTGAATTAGATATA ATGTTTAATTTGGATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACTAACAGGGCAAGAATTCTTGCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_FAM177A1_ENST00000396472_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_1273nt AAGAAAATTGTAATTTGATATTTAATTGCCACTTTGGAAAATAAAATCATGCATTTATAAATATCCCACAAAGTTTTAGTAATAAAGATT GTTGATTGCCCTGCTTGCCAGTAAGAAGGAAGAGATTTTGAATACATATAATGCAGAACTGTGTTGTTTATGAATGCCAATTCATGAAGT CTTAACAATTGGTTCTTTATTTTTGTTTTCAATTTATGGCCGAGTTTGGTTTTGCTGTTTTGGACTGTCTCAACTCCCTGCTGATGCCAC CATACAGAGTCAGATCAGCAACCACATCCCATCACTAGCCTTTGAAGTACAACGACACAGCTGTCTTCATTTTACAAGTGCAAAAACCGA GGTCCTGCGGGGTGACTGCCCCAGACGCCGCTGGTGACGGGCTGCGCCGAGGTCGAGACGCCAGGCTTCAGCGCCAGCAGCCCTGTGGTG GCGACGACGATGGACCAGGAGCCAGTGGGCGGTGTGGAACGAGGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGG GAATCTGCAGGGCAGAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATT GTGGAAACTAACAGGGCAAGAATTCTTGCCCCTCTACTAATTCTTGATAAGATGTCAGAAAGCTGAAAGGAAGTCTCTTCGAGACAATAT GGATTTATCAGAAATGCGAGTACCGTGGAATACATCTCAACATGTTAACCCAGAAGAATCTGGAAGACCACAATTACAAAATGGGGTATC CTTCCAAAGACATTATAAATAGGCATTTTCCACAGTTCCTAAAAAGAAAACACAACTGTACTTTAAAATATGTACAAAGAAAAAAATTTC TTTAAACTGAGAGAGAAGTTTTATTTTCTAATTGTAAACATATCTGTCGCACTTTAAATTCTGTTGAGCACCTAAGGAACCCTTCTTGGT CTATGCTTCTTTTGCAAATTGAATTCAGGAATAGCAGGATGGTAGTGGGAAGAAAGTATGGCAGTTTTCCGTCAGCCAATAAAGTTTTAA AATTTAAACACAAGGCATTTTGAGTAACGCTGTTTTCTGAAAGCTATTTTTTTTTTTTTGAGACGGAGTCTAGTCTAGCTGTGTCACCTG GCACATTCTCGGCTCACTGCAACCTCCACTTCCGGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGAGCTGGGACTACAGGCATGCACCA >In-frame_FAM177A1_ENST00000382406_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_871nt AGGCGCGGCGCGAGGCGGGCGCTGGGCGGCGCCAGCAGCCCTGTGGTGGCGACGACGATGGACCAGGAGCCAGTGGGCGGTGTGGAACGA GGAGAAGCCGTCGCAGCCTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCAGGGCAGAGTGAATTAGATATAATGTTTAATTTG GATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACTAACAGGGCAAGAATTCTTGCCCCTCTACTAATT CTTGATAAGATGTCAGAAAGCTGAAAGGAAGTCTCTTCGAGACAATATGGATTTATCAGAAATGCGAGTACCGTGGAATACATCTCAACA TGTTAACCCAGAAGAATCTGGAAGACCACAATTACAAAATGGGGTATCCTTCCAAAGACATTATAAATAGGCATTTTCCACAGTTCCTAA AAAGAAAACACAACTGTACTTTAAAATATGTACAAAGAAAAAAATTTCTTTAAACTGAGAGAGAAGTTTTATTTTCTAATTGTAAACATA TCTGTCGCACTTTAAATTCTGTTGAGCACCTAAGGAACCCTTCTTGGTCTATGCTTCTTTTGCAAATTGAATTCAGGAATAGCAGGATGG TAGTGGGAAGAAAGTATGGCAGTTTTCCGTCAGCCAATAAAGTTTTAAAATTTAAACACAAGGCATTTTGAGTAACGCTGTTTTCTGAAA GCTATTTTTTTTTTTTTGAGACGGAGTCTAGTCTAGCTGTGTCACCTGGCACATTCTCGGCTCACTGCAACCTCCACTTCCGGGGTTCAA >In-frame_FAM177A1_ENST00000280987_chr14_35515834_+_AP4S1_ENST00000542754_chr14_31549779_+_944nt GCGGGTGAGTCCCACTTCCCGACAGCCTGGCTCGGCCAGCGACTGGGCGGGGAGACCAAGGATGGAAGTGGGCTTACCGGCCATTACCCT CTTTCTCACCAGCGCCAGCAGCCCTGTGGTGGCGACGACGATGGACCAGGAGCCAGTGGGCGGTGTGGAACGAGGAGAAGCCGTCGCAGC CTCGGGAGCTGCGGCCGCCGCGGCATTCGGGGAATCTGCAGGGCAGAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACATCAT TTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACTAACAGGGCAAGAATTCTTGCCCCTCTACTAATTCTTGATAAGATGTCAGA AAGCTGAAAGGAAGTCTCTTCGAGACAATATGGATTTATCAGAAATGCGAGTACCGTGGAATACATCTCAACATGTTAACCCAGAAGAAT CTGGAAGACCACAATTACAAAATGGGGTATCCTTCCAAAGACATTATAAATAGGCATTTTCCACAGTTCCTAAAAAGAAAACACAACTGT ACTTTAAAATATGTACAAAGAAAAAAATTTCTTTAAACTGAGAGAGAAGTTTTATTTTCTAATTGTAAACATATCTGTCGCACTTTAAAT TCTGTTGAGCACCTAAGGAACCCTTCTTGGTCTATGCTTCTTTTGCAAATTGAATTCAGGAATAGCAGGATGGTAGTGGGAAGAAAGTAT GGCAGTTTTCCGTCAGCCAATAAAGTTTTAAAATTTAAACACAAGGCATTTTGAGTAACGCTGTTTTCTGAAAGCTATTTTTTTTTTTTT GAGACGGAGTCTAGTCTAGCTGTGTCACCTGGCACATTCTCGGCTCACTGCAACCTCCACTTCCGGGGTTCAAGCGATTCTCCTGCCTCA |
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FusionGenePPI for FAM177A1_AP4S1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM177A1 | RHOJ, FAM204A, SLC27A2, C1orf27, SUGP1, UFSP2, EEF1A2, STEAP3, AAGAB, SLC4A1AP, FAM207A, SAR1B, TGS1, ARMCX3, DHX38, RIOK1, VPS13B, GTF2F2, DCUN1D5, OSTM1, GPKOW, C12orf43, CLCN7, DUSP22, MRPS31, NAPG, NCEH1 | AP4S1 | AP4E1, GRB2, APP, TEAD3, AFP, GTF2I, CEP104, GALNT2, MECP2, RPL10, SLC9A1, HLTF, TMPO, AP4M1, APPBP2, AP4B1, ENTHD2, GOLIM4, CDC73, C19orf52, SUV39H2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM177A1_AP4S1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM177A1_AP4S1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |