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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12642

FusionGeneSummary for FAM168B_NDST1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM168B_NDST1
Fusion gene ID: 12642
HgeneTgene
Gene symbol

FAM168B

NDST1

Gene ID

130074

3340

Gene namefamily with sequence similarity 168 member BN-deacetylase and N-sulfotransferase 1
SynonymsMANIHSST|MRT46|NST1
Cytomap

2q21.1

5q33.1

Type of geneprotein-codingprotein-coding
Descriptionmyelin-associated neurite-outgrowth inhibitorprotein FAM168Bbifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1HSNST 1N-Deacetylase-N-sulfotransferase 1N-HSST 1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1N-deacetylase/N-sulfotransferase 1N-heparan sulfate sulfotransferase 1NDST-1[H
Modification date2018051920180519
UniProtAcc

A1KXE4

P52848

Ensembl transtripts involved in fusion geneENST00000409185, ENST00000389915, 
ENST00000523767, ENST00000261797, 
ENST00000521752, 
Fusion gene scores* DoF score5 X 7 X 2=703 X 3 X 3=27
# samples 73
** MAII scorelog2(7/70*10)=0log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM168B [Title/Abstract] AND NDST1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNDST1

GO:0015012

heparan sulfate proteoglycan biosynthetic process

9915799

TgeneNDST1

GO:0015014

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

9915799


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU631743FAM168Bchr2

131810549

+NDST1chr5

149937419

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000409185ENST00000523767FAM168Bchr2

131810549

+NDST1chr5

149937419

-
intron-3UTRENST00000409185ENST00000261797FAM168Bchr2

131810549

+NDST1chr5

149937419

-
intron-intronENST00000409185ENST00000521752FAM168Bchr2

131810549

+NDST1chr5

149937419

-
intron-intronENST00000389915ENST00000523767FAM168Bchr2

131810549

+NDST1chr5

149937419

-
intron-3UTRENST00000389915ENST00000261797FAM168Bchr2

131810549

+NDST1chr5

149937419

-
intron-intronENST00000389915ENST00000521752FAM168Bchr2

131810549

+NDST1chr5

149937419

-

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FusionProtFeatures for FAM168B_NDST1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM168B

A1KXE4

NDST1

P52848

Modulates neuronal axonal outgrowth by acting as anegative regulator of CDC42 and STAT3 and a positive regulator ofSTMN2. Positive regulator of CDC27 (By similarity). {ECO:0000250}. Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of theglycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcAdisaccharide repeating sugar backbone to make N-sulfatedheparosan, a prerequisite substrate for later modifications inheparin biosynthesis (PubMed:10758005, PubMed:12634318). Plays arole in determining the extent and pattern of sulfation of heparansulfate. Compared to other NDST enzymes, its presence isabsolutely required. Participates in biosynthesis of heparansulfate that can ultimately serve as L-selectin ligands, therebyplaying a role in inflammatory response (PubMed:10758005,PubMed:12634318). Required for the exosomal release of SDCBP, CD63and syndecan (PubMed:22660413). {ECO:0000269|PubMed:10758005,ECO:0000269|PubMed:12634318, ECO:0000269|PubMed:22660413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM168B_NDST1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM168B_NDST1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM168B_NDST1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM168B_NDST1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNDST1C0015393Eye Abnormalities1CTD_human
TgeneNDST1C0376634Craniofacial Abnormalities1CTD_human
TgeneNDST1C1955869Malformations of Cortical Development1CTD_human
TgeneNDST1C3714756Intellectual Disability1CTD_human;HPO
TgeneNDST1C4015283MENTAL RETARDATION, AUTOSOMAL RECESSIVE 461UNIPROT