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Fusion gene ID: 12602 |
FusionGeneSummary for FAM160A1_IL15 |
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Fusion gene information | Fusion gene name: FAM160A1_IL15 | Fusion gene ID: 12602 | Hgene | Tgene | Gene symbol | FAM160A1 | IL15 | Gene ID | 729830 | 3600 |
Gene name | family with sequence similarity 160 member A1 | interleukin 15 | |
Synonyms | - | IL-15 | |
Cytomap | 4q31.3 | 4q31.21 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM160A1 | interleukin-15 | |
Modification date | 20180519 | 20180520 | |
UniProtAcc | Q05DH4 | P40933 | |
Ensembl transtripts involved in fusion gene | ENST00000508198, ENST00000435205, ENST00000505231, | ENST00000320650, ENST00000296545, ENST00000514653, ENST00000529613, ENST00000477265, ENST00000394159, | |
Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 1 X 1 X 1=1 |
# samples | 8 | 1 | |
** MAII score | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: FAM160A1 [Title/Abstract] AND IL15 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IL15 | GO:0007260 | tyrosine phosphorylation of STAT protein | 12244150 |
Tgene | IL15 | GO:0032740 | positive regulation of interleukin-17 production | 16482511 |
Tgene | IL15 | GO:0035723 | interleukin-15-mediated signaling pathway | 24942581 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AN-A04C-01A | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000508198 | ENST00000320650 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
intron-3CDS | ENST00000508198 | ENST00000296545 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
intron-3CDS | ENST00000508198 | ENST00000514653 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
intron-3CDS | ENST00000508198 | ENST00000529613 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
intron-3CDS | ENST00000508198 | ENST00000477265 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
intron-3CDS | ENST00000508198 | ENST00000394159 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000435205 | ENST00000320650 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000435205 | ENST00000296545 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000435205 | ENST00000514653 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000435205 | ENST00000529613 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000435205 | ENST00000477265 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000435205 | ENST00000394159 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000505231 | ENST00000320650 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000505231 | ENST00000296545 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000505231 | ENST00000514653 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000505231 | ENST00000529613 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000505231 | ENST00000477265 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
Frame-shift | ENST00000505231 | ENST00000394159 | FAM160A1 | chr4 | 152510078 | + | IL15 | chr4 | 142653891 | + |
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FusionProtFeatures for FAM160A1_IL15 |
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Hgene | Tgene |
FAM160A1 | IL15 |
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15with components of IL-2R, including IL-2R beta and probably IL-2Rgamma but not IL-2R alpha. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM160A1_IL15 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM160A1_IL15 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM160A1 | AKTIP, HOOK3 | IL15 | APP, ZNRD1, STAT5B, TRAF3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM160A1_IL15 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IL15 | P40933 | DB01327 | Cefazolin | Interleukin-15 | small molecule | approved |
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RelatedDiseases for FAM160A1_IL15 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IL15 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | IL15 | C0007570 | Celiac Disease | 1 | CTD_human |
Tgene | IL15 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | IL15 | C0035228 | Respiratory Hypersensitivity | 1 | CTD_human |
Tgene | IL15 | C0949804 | Polyomavirus Infections | 1 | CTD_human |