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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12602

FusionGeneSummary for FAM160A1_IL15

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM160A1_IL15
Fusion gene ID: 12602
HgeneTgene
Gene symbol

FAM160A1

IL15

Gene ID

729830

3600

Gene namefamily with sequence similarity 160 member A1interleukin 15
Synonyms-IL-15
Cytomap

4q31.3

4q31.21

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM160A1interleukin-15
Modification date2018051920180520
UniProtAcc

Q05DH4

P40933

Ensembl transtripts involved in fusion geneENST00000508198, ENST00000435205, 
ENST00000505231, 
ENST00000320650, 
ENST00000296545, ENST00000514653, 
ENST00000529613, ENST00000477265, 
ENST00000394159, 
Fusion gene scores* DoF score7 X 5 X 5=1751 X 1 X 1=1
# samples 81
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: FAM160A1 [Title/Abstract] AND IL15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIL15

GO:0007260

tyrosine phosphorylation of STAT protein

12244150

TgeneIL15

GO:0032740

positive regulation of interleukin-17 production

16482511

TgeneIL15

GO:0035723

interleukin-15-mediated signaling pathway

24942581


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AN-A04C-01AFAM160A1chr4

152510078

+IL15chr4

142653891

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000508198ENST00000320650FAM160A1chr4

152510078

+IL15chr4

142653891

+
intron-3CDSENST00000508198ENST00000296545FAM160A1chr4

152510078

+IL15chr4

142653891

+
intron-3CDSENST00000508198ENST00000514653FAM160A1chr4

152510078

+IL15chr4

142653891

+
intron-3CDSENST00000508198ENST00000529613FAM160A1chr4

152510078

+IL15chr4

142653891

+
intron-3CDSENST00000508198ENST00000477265FAM160A1chr4

152510078

+IL15chr4

142653891

+
intron-3CDSENST00000508198ENST00000394159FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000435205ENST00000320650FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000435205ENST00000296545FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000435205ENST00000514653FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000435205ENST00000529613FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000435205ENST00000477265FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000435205ENST00000394159FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000505231ENST00000320650FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000505231ENST00000296545FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000505231ENST00000514653FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000505231ENST00000529613FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000505231ENST00000477265FAM160A1chr4

152510078

+IL15chr4

142653891

+
Frame-shiftENST00000505231ENST00000394159FAM160A1chr4

152510078

+IL15chr4

142653891

+

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FusionProtFeatures for FAM160A1_IL15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM160A1

Q05DH4

IL15

P40933

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15with components of IL-2R, including IL-2R beta and probably IL-2Rgamma but not IL-2R alpha.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM160A1_IL15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM160A1_IL15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM160A1AKTIP, HOOK3IL15APP, ZNRD1, STAT5B, TRAF3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM160A1_IL15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIL15P40933DB01327CefazolinInterleukin-15small moleculeapproved

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RelatedDiseases for FAM160A1_IL15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIL15C0004352Autistic Disorder1CTD_human
TgeneIL15C0007570Celiac Disease1CTD_human
TgeneIL15C0014175Endometriosis1CTD_human
TgeneIL15C0035228Respiratory Hypersensitivity1CTD_human
TgeneIL15C0949804Polyomavirus Infections1CTD_human