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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12601

FusionGeneSummary for FAM160A1_FAM160A1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM160A1_FAM160A1
Fusion gene ID: 12601
HgeneTgene
Gene symbol

FAM160A1

FAM160A1

Gene ID

729830

729830

Gene namefamily with sequence similarity 160 member A1family with sequence similarity 160 member A1
Synonyms--
Cytomap

4q31.3

4q31.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM160A1protein FAM160A1
Modification date2018051920180519
UniProtAcc

Q05DH4

Q05DH4

Ensembl transtripts involved in fusion geneENST00000508198, ENST00000435205, 
ENST00000505231, 
ENST00000508198, 
ENST00000435205, ENST00000505231, 
Fusion gene scores* DoF score7 X 5 X 5=1751 X 2 X 1=2
# samples 82
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/2*10)=3.32192809488736
Context

PubMed: FAM160A1 [Title/Abstract] AND FAM160A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI005350FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
ChiTaRS3.1BF913771FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000508198ENST00000508198FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
intron-intronENST00000508198ENST00000435205FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
intron-intronENST00000508198ENST00000505231FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
intron-intronENST00000435205ENST00000508198FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
intron-intronENST00000435205ENST00000435205FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
intron-intronENST00000435205ENST00000505231FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
intron-intronENST00000505231ENST00000508198FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
intron-intronENST00000505231ENST00000435205FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
intron-intronENST00000505231ENST00000505231FAM160A1chr4

152538153

-FAM160A1chr4

152538665

-
intron-intronENST00000508198ENST00000508198FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+
intron-intronENST00000508198ENST00000435205FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+
intron-intronENST00000508198ENST00000505231FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+
intron-intronENST00000435205ENST00000508198FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+
intron-intronENST00000435205ENST00000435205FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+
intron-intronENST00000435205ENST00000505231FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+
intron-intronENST00000505231ENST00000508198FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+
intron-intronENST00000505231ENST00000435205FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+
intron-intronENST00000505231ENST00000505231FAM160A1chr4

152365059

+FAM160A1chr4

152364569

+

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FusionProtFeatures for FAM160A1_FAM160A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM160A1

Q05DH4

FAM160A1

Q05DH4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM160A1_FAM160A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM160A1_FAM160A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM160A1_FAM160A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM160A1_FAM160A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource