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Fusion gene ID: 12599 |
FusionGeneSummary for FAM160A1_CCNA2 |
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Fusion gene information | Fusion gene name: FAM160A1_CCNA2 | Fusion gene ID: 12599 | Hgene | Tgene | Gene symbol | FAM160A1 | CCNA2 | Gene ID | 729830 | 890 |
Gene name | family with sequence similarity 160 member A1 | cyclin A2 | |
Synonyms | - | CCN1|CCNA | |
Cytomap | 4q31.3 | 4q27 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM160A1 | cyclin-A2cyclin-A | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q05DH4 | P20248 | |
Ensembl transtripts involved in fusion gene | ENST00000508198, ENST00000435205, ENST00000505231, | ENST00000274026, | |
Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 4 X 1 X 1=4 |
# samples | 8 | 6 | |
** MAII score | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/4*10)=3.90689059560852 | |
Context | PubMed: FAM160A1 [Title/Abstract] AND CCNA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CCNA2 | GO:0000086 | G2/M transition of mitotic cell cycle | 1312467 |
Tgene | CCNA2 | GO:0016572 | histone phosphorylation | 11746698 |
Tgene | CCNA2 | GO:0044843 | cell cycle G1/S phase transition | 1312467 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-BC-A3KG-01A | FAM160A1 | chr4 | 152403800 | + | CCNA2 | chr4 | 122742246 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000508198 | ENST00000274026 | FAM160A1 | chr4 | 152403800 | + | CCNA2 | chr4 | 122742246 | - |
5UTR-3CDS | ENST00000435205 | ENST00000274026 | FAM160A1 | chr4 | 152403800 | + | CCNA2 | chr4 | 122742246 | - |
intron-3CDS | ENST00000505231 | ENST00000274026 | FAM160A1 | chr4 | 152403800 | + | CCNA2 | chr4 | 122742246 | - |
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FusionProtFeatures for FAM160A1_CCNA2 |
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Hgene | Tgene |
FAM160A1 | CCNA2 |
Cyclin which controls both the G1/S and the G2/Mtransition phases of the cell cycle. Functions through theformation of specific serine/threonine protein kinase holoenzymecomplexes with the cyclin-dependent protein kinases CDK1 or CDK2.The cyclin subunit confers the substrate specificity of thesecomplexes and differentially interacts with and activates CDK1 andCDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM160A1_CCNA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM160A1_CCNA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM160A1 | AKTIP, HOOK3 | CCNA2 | BRCA1, CALM1, CDKN1C, CDKN1B, CDKN1A, FEN1, CDK1, CDK2, PCNA, CDC6, HERC5, E2F1, TP53, ITGB3BP, RBL2, RBL1, CKS1B, ORC1, ORC2, SKP2, UIMC1, RPA1, SP1, CDT1, KAT2B, CDC20, FZR1, ARID4A, UHRF2, DTNBP1, TRAF3IP1, EIF2AK2, RBPJP3, KRT1, PSMA6, HIST1H1A, CDK6, CDK4, RB1, ANAPC4, USP37, CUL1, COPS5, COPS6, CKS2, CCNA2, PSMD4, RAD23A, PRC1, TRIM33, CDK7, BRCA2, HIST1H1B, TP73, NFYA, NFYB, CTNNB1, POLA1, DYRK1A, CDK3, DYRK1B, CDK5, BIRC6, ANAPC11, SAMHD1, CDH2, CDC27, CKS1BP7, CCNA1, ELMSAN1, TICRR, HELB, TBC1D4, SCAPER, PHF8, GMNN, CREBBP, EP300, PKMYT1, PLEKHG2, MTBP, DNTTIP1, MAD2L1, BUB1B, NTAN1, KRAS, HIST1H2BG, OFD1, HDAC2, SKP1, SSB, TAF6, TAF7, TAF11, FXR1, CRIPT, USP6NL, PDCD6, SDCCAG3, SRRT, P3H2, FAM58A, ZC3H18, SLBP, PLA2G4A, CDC25A, SMTNL2, GIP, TXNDC11, FANCC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM160A1_CCNA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM160A1_CCNA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CCNA2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CCNA2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | CCNA2 | C3714756 | Intellectual Disability | 1 | CTD_human |