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Fusion gene ID: 12597 |
FusionGeneSummary for FAM160A1_ADAM2 |
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Fusion gene information | Fusion gene name: FAM160A1_ADAM2 | Fusion gene ID: 12597 | Hgene | Tgene | Gene symbol | FAM160A1 | ADAM2 | Gene ID | 729830 | 2515 |
Gene name | family with sequence similarity 160 member A1 | ADAM metallopeptidase domain 2 | |
Synonyms | - | CRYN1|CRYN2|CT15|FTNB|PH-30b|PH30|PH30-beta | |
Cytomap | 4q31.3 | 8p11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM160A1 | disintegrin and metalloproteinase domain-containing protein 2cancer/testis antigen 15fertilin subunit beta | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q05DH4 | Q99965 | |
Ensembl transtripts involved in fusion gene | ENST00000508198, ENST00000435205, ENST00000505231, | ENST00000347580, ENST00000379853, ENST00000265708, ENST00000521880, ENST00000523181, | |
Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 6 X 3 X 3=54 |
# samples | 8 | 6 | |
** MAII score | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/54*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FAM160A1 [Title/Abstract] AND ADAM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-ZJ-AB0I-01A | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000508198 | ENST00000347580 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
3UTR-3CDS | ENST00000508198 | ENST00000379853 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
3UTR-3CDS | ENST00000508198 | ENST00000265708 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
3UTR-3CDS | ENST00000508198 | ENST00000521880 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
3UTR-intron | ENST00000508198 | ENST00000523181 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
5UTR-3CDS | ENST00000435205 | ENST00000347580 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
5UTR-3CDS | ENST00000435205 | ENST00000379853 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
5UTR-3CDS | ENST00000435205 | ENST00000265708 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
5UTR-3CDS | ENST00000435205 | ENST00000521880 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
5UTR-intron | ENST00000435205 | ENST00000523181 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
intron-3CDS | ENST00000505231 | ENST00000347580 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
intron-3CDS | ENST00000505231 | ENST00000379853 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
intron-3CDS | ENST00000505231 | ENST00000265708 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
intron-3CDS | ENST00000505231 | ENST00000521880 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
intron-intron | ENST00000505231 | ENST00000523181 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
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FusionProtFeatures for FAM160A1_ADAM2 |
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Hgene | Tgene |
FAM160A1 | ADAM2 |
Sperm surface membrane protein that may be involved insperm-egg plasma membrane adhesion and fusion duringfertilization. Could have a direct role in sperm-zona binding ormigration of sperm from the uterus into the oviduct. Interactionswith egg membrane could be mediated via binding between itsdisintegrin-like domain to one or more integrins receptors on theegg. This is a non catalytic metalloprotease-like protein. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM160A1_ADAM2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM160A1_ADAM2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM160A1 | AKTIP, HOOK3 | ADAM2 | CLGN, CRYAB, DNM1, ASPHD2, C6orf120, ADAMTS2, LRRC3, TTN, LCLAT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM160A1_ADAM2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM160A1_ADAM2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |