![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 12588 |
FusionGeneSummary for FAM155A_NQO1 |
![]() |
Fusion gene information | Fusion gene name: FAM155A_NQO1 | Fusion gene ID: 12588 | Hgene | Tgene | Gene symbol | FAM155A | NQO1 | Gene ID | 728215 | 1728 |
Gene name | family with sequence similarity 155 member A | NAD(P)H quinone dehydrogenase 1 | |
Synonyms | - | DHQU|DIA4|DTD|NMOR1|NMORI|QR1 | |
Cytomap | 13q33.3 | 16q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein FAM155A | NAD(P)H dehydrogenase [quinone] 1DT-diaphoraseNAD(P)H dehydrogenase, quinone 1NAD(P)H:Quinone acceptor oxidoreductase type 1NAD(P)H:menadione oxidoreductase 1NAD(P)H:quinone oxidoreductase 1NAD(P)H:quinone oxireductaseazoreductasediaphorase (NADH/ | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | B1AL88 | P15559 | |
Ensembl transtripts involved in fusion gene | ENST00000375915, | ENST00000561500, ENST00000379047, ENST00000320623, ENST00000379046, ENST00000439109, ENST00000564043, | |
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 4 X 5 X 2=40 |
# samples | 5 | 5 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FAM155A [Title/Abstract] AND NQO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ220009 | FAM155A | chr13 | 108363730 | + | NQO1 | chr16 | 69744046 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000375915 | ENST00000561500 | FAM155A | chr13 | 108363730 | + | NQO1 | chr16 | 69744046 | - |
intron-3UTR | ENST00000375915 | ENST00000379047 | FAM155A | chr13 | 108363730 | + | NQO1 | chr16 | 69744046 | - |
intron-3UTR | ENST00000375915 | ENST00000320623 | FAM155A | chr13 | 108363730 | + | NQO1 | chr16 | 69744046 | - |
intron-intron | ENST00000375915 | ENST00000379046 | FAM155A | chr13 | 108363730 | + | NQO1 | chr16 | 69744046 | - |
intron-intron | ENST00000375915 | ENST00000439109 | FAM155A | chr13 | 108363730 | + | NQO1 | chr16 | 69744046 | - |
intron-intron | ENST00000375915 | ENST00000564043 | FAM155A | chr13 | 108363730 | + | NQO1 | chr16 | 69744046 | - |
Top |
FusionProtFeatures for FAM155A_NQO1 |
![]() |
Hgene | Tgene |
FAM155A | NQO1 |
The enzyme apparently serves as a quinone reductase inconnection with conjugation reactions of hydroquinons involved indetoxification pathways as well as in biosynthetic processes suchas the vitamin K-dependent gamma-carboxylation of glutamateresidues in prothrombin synthesis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FAM155A_NQO1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for FAM155A_NQO1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FAM155A_NQO1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | NQO1 | P15559 | DB00266 | Dicoumarol | NAD(P)H dehydrogenase [quinone] 1 | small molecule | approved |
Tgene | NQO1 | P15559 | DB00170 | Menadione | NAD(P)H dehydrogenase [quinone] 1 | small molecule | approved|nutraceutical |
Top |
RelatedDiseases for FAM155A_NQO1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NQO1 | C0028797 | Occupational Diseases | 4 | CTD_human |
Tgene | NQO1 | C0036341 | Schizophrenia | 3 | PSYGENET |
Tgene | NQO1 | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
Tgene | NQO1 | C0023895 | Liver diseases | 2 | CTD_human |
Tgene | NQO1 | C0027659 | Neoplasms, Experimental | 2 | CTD_human |
Tgene | NQO1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | NQO1 | C0004096 | Asthma | 1 | CTD_human |
Tgene | NQO1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | NQO1 | C0008370 | Cholestasis | 1 | CTD_human |
Tgene | NQO1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | NQO1 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Tgene | NQO1 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Tgene | NQO1 | C0019061 | Hemolytic-Uremic Syndrome | 1 | CTD_human |
Tgene | NQO1 | C0019080 | Hemorrhage | 1 | CTD_human |
Tgene | NQO1 | C0020456 | Hyperglycemia | 1 | CTD_human |
Tgene | NQO1 | C0022658 | Kidney Diseases | 1 | CTD_human |
Tgene | NQO1 | C0023470 | Myeloid Leukemia | 1 | CTD_human |
Tgene | NQO1 | C0026764 | Multiple Myeloma | 1 | CTD_human |
Tgene | NQO1 | C0028754 | Obesity | 1 | CTD_human |
Tgene | NQO1 | C0030354 | Papilloma | 1 | CTD_human |
Tgene | NQO1 | C0030567 | Parkinson Disease | 1 | CTD_human |
Tgene | NQO1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | NQO1 | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
Tgene | NQO1 | C0236663 | Alcohol withdrawal syndrome | 1 | PSYGENET |
Tgene | NQO1 | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | NQO1 | C0853193 | Bipolar I disorder | 1 | PSYGENET |
Tgene | NQO1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | NQO1 | C1846707 | SPINOCEREBELLAR ATAXIA 17 | 1 | CTD_human |
Tgene | NQO1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
Tgene | NQO1 | C2609414 | Acute kidney injury | 1 | CTD_human |