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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12578

FusionGeneSummary for FAM13B_FNIP2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM13B_FNIP2
Fusion gene ID: 12578
HgeneTgene
Gene symbol

FAM13B

FNIP2

Gene ID

51306

57600

Gene namefamily with sequence similarity 13 member Bfolliculin interacting protein 2
SynonymsARHGAP49|C5orf5|FAM13B1|KHCHP|N61FNIPL|MAPO1
Cytomap

5q31.2

4q32.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM13BGAP-like protein N61family with sequence similarity 13, member B1folliculin-interacting protein 2FNIP1-like proteinO6-methylguanine-induced apoptosis 1 protein
Modification date2018051920180519
UniProtAcc

Q9NYF5

Q9P278

Ensembl transtripts involved in fusion geneENST00000033079, ENST00000425075, 
ENST00000420893, 
ENST00000264433, 
ENST00000379346, ENST00000505445, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 2=32
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM13B [Title/Abstract] AND FNIP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFNIP2

GO:0000122

negative regulation of transcription by RNA polymerase II

21209915

TgeneFNIP2

GO:0001932

regulation of protein phosphorylation

18663353

TgeneFNIP2

GO:0006468

protein phosphorylation

18663353

TgeneFNIP2

GO:0031334

positive regulation of protein complex assembly

25126726

TgeneFNIP2

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19914239


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI056653FAM13Bchr5

137317967

+FNIP2chr4

159811962

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000033079ENST00000264433FAM13Bchr5

137317967

+FNIP2chr4

159811962

+
intron-intronENST00000033079ENST00000379346FAM13Bchr5

137317967

+FNIP2chr4

159811962

+
intron-intronENST00000033079ENST00000505445FAM13Bchr5

137317967

+FNIP2chr4

159811962

+
intron-intronENST00000425075ENST00000264433FAM13Bchr5

137317967

+FNIP2chr4

159811962

+
intron-intronENST00000425075ENST00000379346FAM13Bchr5

137317967

+FNIP2chr4

159811962

+
intron-intronENST00000425075ENST00000505445FAM13Bchr5

137317967

+FNIP2chr4

159811962

+
intron-intronENST00000420893ENST00000264433FAM13Bchr5

137317967

+FNIP2chr4

159811962

+
intron-intronENST00000420893ENST00000379346FAM13Bchr5

137317967

+FNIP2chr4

159811962

+
intron-intronENST00000420893ENST00000505445FAM13Bchr5

137317967

+FNIP2chr4

159811962

+

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FusionProtFeatures for FAM13B_FNIP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM13B

Q9NYF5

FNIP2

Q9P278

Acts as a co-chaperone of HSP90AA1. Inhibits the ATPaseactivity of HSP90AA1 leading to reduction in its chaperoneactivity. Facilitates the binding of client protein FLCN toHSP90AA1 (PubMed:27353360). May play a role in the signaltransduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energyand/or nutrient sensing through the AMPK and mTOR signalingpathways (PubMed:18403135). May regulate phosphorylation ofRPS6KB1 (PubMed:18663353). {ECO:0000250|UniProtKB:Q80TD3,ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353,ECO:0000269|PubMed:27353360}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM13B_FNIP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM13B_FNIP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM13B_FNIP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM13B_FNIP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource